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Developmental Biology, ISSN 0012-1606, 02/2016, Volume 410, Issue 2, pp. 202 - 212
Fragile-syndrome is the most commonly inherited cause of autism and mental disabilities. The Fmr1 (Fragile-Mental Retardation 1) gene is essential in humans... 
Trailer hitch | Translational repression | Zfrp8 | FMRP
Journal Article
11/2009
Fragile X syndrome (FXS) is caused by the lack of fragile X mental retardation protein (FMRP). The animal model of FXS, Fmr1 knockout (KO) mice, shows... 
ERK1/2 | hippocampus | FMRP | glycine | LTP | synaptic plasticity | 0317
Dissertation
by Zhang, FR and Kang, Y and Wang, ML and Li, YJ and Xu, TL and Yang, W and Song, HJ and Wu, H and Shu, Q and Jin, P
HUMAN MOLECULAR GENETICS, ISSN 0964-6906, 11/2018, Volume 27, Issue 22, pp. 3936 - 3950
N-6-methyladenosine (m(6)A) is the most prevalent internal modification of mammalian messenger RNAs (mRNAs) and long non-coding RNAs. The biological functions... 
N-6-METHYLADENOSINE | METHYLATION | FMRP | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | NUCLEAR-RNA | IDENTIFICATION | TRANSLATION | POLYRIBOSOMES | BINDING | FAT MASS | REVEALS
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 07/2018, Volume 46, Issue 12, pp. 5894 - 5901
Abstract The RGG domain, defined as closely spaced Arg-Gly-Gly repeats, is a DNA and RNA-binding domain in various nucleic acid-binding proteins. Translocated... 
RNA | SPECIFICITY | RECOGNITION | FMRP | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEOLIN | PROTEINS | MOTIF | Chemical Biology and Nucleic Acid Chemistry
Journal Article
Acta neuropathologica, ISSN 0001-6322, 2016, Volume 132, Issue 2, pp. 175 - 196
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective treatment available. An increasing number of genetic causes of ALS... 
Pathology | Neurosciences | Medicine & Public Health | FMRP | FUS | TDP-43 | Amyotrophic lateral sclerosis | Motor neuron | C9orf72 | WILD-TYPE | REPEAT EXPANSION | FRONTOTEMPORAL DEMENTIA | DNA-DAMAGE | AMYOTROPHIC-LATERAL-SCLEROSIS | PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | NEGATIVE REGULATOR | AUTOPHAGY RECEPTOR | MESSENGER-RNAS | HEXANUCLEOTIDE REPEAT | NUCLEOCYTOPLASMIC TRANSPORT | Adaptor Proteins, Vesicular Transport - genetics | Fragile X Mental Retardation Protein - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Motor Neurons - pathology | Ataxin-2 - genetics | DNA-Binding Proteins - metabolism | Ataxin-2 - metabolism | Guanine Nucleotide Exchange Factors - metabolism | C9orf72 Protein | Neurons - metabolism | Eye Proteins - genetics | Disease Models, Animal | Guanine Nucleotide Exchange Factors - genetics | Amyotrophic Lateral Sclerosis - genetics | Mice, Inbred C57BL | Mutant Proteins - genetics | RNA-Binding Protein FUS - genetics | Mutant Proteins - metabolism | Mitochondria - metabolism | RNA-Binding Protein FUS - metabolism | DNA-Binding Proteins - genetics | Motor Neurons - metabolism | Animals | Eye Proteins - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Fragile X Mental Retardation Protein - genetics | Proteins | Nervous system diseases | RNA | Proteolysis | Comparative analysis | Protein binding | Original Paper
Journal Article
NEURON, ISSN 0896-6273, 02/2003, Volume 37, Issue 3, pp. 417 - 431
The Fragile X mental retardation-1 (Fmr1) gene encodes a multifunctional protein, FMRP, with intrinsic RNA binding activity. We have developed an approach,... 
LOCALIZATION | MESSENGER-RNA | FRAGILE-X | PROTEIN FMRP | KNOCKOUT MICE | IDENTIFICATION | TRANSLATION | BINDING | EXPRESSION | NEUROSCIENCES | X MENTAL-RETARDATION
Journal Article
Behavior genetics, 05/2018, Volume 48, Issue 3, p. 198
A previous study of exome-sequenced schizophrenia cases and controls reported an excess of singleton, gene-disruptive variants among cases, concentrated in... 
Genetic Predisposition to Disease | Sweden | Schizophrenia - genetics | Humans | Databases, Genetic | Synapses - genetics | Case-Control Studies | Gene Ontology | Whole Exome Sequencing
Journal Article
MOLECULAR BRAIN, ISSN 1756-6606, 07/2019, Volume 12, Issue 1, pp. 65 - 14
Journal Article
NEUROPHARMACOLOGY, ISSN 0028-3908, 01/2015, Volume 88, pp. 48 - 54
An increasing number of studies implicate the GABA(A)ergic system in the pathophysiology of the fragile X syndrome, a frequent cause of intellectual disability... 
Ganaxolone | Targeted treatment | NEUROTRANSMISSION | FMRP | RECEPTOR | IDENTIFICATION | NEUROSCIENCES | Gaboxadol | INHIBITION | HYPEREXCITABILITY | GABA(A) receptor | MOUSE MODEL | BEHAVIORAL DEFICITS | GABA | PHARMACOLOGY & PHARMACY | Fragile X syndrome | EXPRESSION
Journal Article
TRANSLATIONAL PSYCHIATRY, ISSN 2158-3188, 06/2013, Volume 3
Fragile X mental retardation protein (FMRP) is an RNA-binding protein that targets similar to 5% of all mRNAs expressed in the brain. Previous work by our... 
AUTISM | FMRP | PSYCHIATRY | DEVELOPING RAT-BRAIN | GABR rho 2 | SPINAL-CORD | SUBUNITS | schizophrenia | X MENTAL-RETARDATION | PREFRONTAL CORTEX | GABR theta | bipolar disorder | UNDEREXPRESSION | POLYMORPHISMS | MOUSE MODEL | mGluR5
Journal Article