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Nature Medicine, ISSN 1078-8956, 08/2016, Volume 22, Issue 8, pp. 851 - 860
Single-agent immunotherapy has achieved limited clinical benefit to date in patients with pancreatic ductal adenocarcinoma (PDAC). This may be a result of the... 
MEDICINE, RESEARCH & EXPERIMENTAL | SKIN WOUND REPAIR | DUCTAL ADENOCARCINOMA | DECREASES GROWTH | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-INFILTRATING MACROPHAGES | 2 KNOCKOUT MICE | ACTIN CYTOSKELETAL REARRANGEMENT | TISSUE STIFFNESS | CELL BIOLOGY | FAK | ANTIGEN RECEPTOR | T-CELLS | Immunohistochemistry | Pancreatic Neoplasms - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | Tumor Microenvironment | Deoxycytidine - pharmacology | Immunoblotting | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Immunotherapy | Antimetabolites, Antineoplastic - pharmacology | Carcinoma, Pancreatic Ductal - immunology | Disease Models, Animal | Tumor Escape - immunology | Immunotherapy, Adoptive - methods | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Pancreatic Neoplasms - pathology | Reverse Transcriptase Polymerase Chain Reaction | Carcinoma, Pancreatic Ductal - pathology | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Disease Progression | Animals | Aminopyridines - pharmacology | Pancreatic Neoplasms - immunology | Fibrosis | Cell Proliferation - drug effects | Mice | CD8-Positive T-Lymphocytes - immunology | Deoxycytidine - analogs & derivatives | Molecular targeted therapy | Care and treatment | Pancreatic cancer | Patient outcomes | Innovations | Genetic aspects | Properties | Phosphotransferases | Methods | Kinases | Cell adhesion & migration | Index Medicus | pancreatic cancer | PDAC | CXCL12 | VS-4718 | immunotherapy | fibrosis | tumor microenvironment | PD-1
Journal Article
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 05/2009, Volume 20, Issue 9, pp. 2508 - 2519
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 04/2019, Volume 116, Issue 14, pp. 6766 - 6774
Journal Article
Journal Article
Cellular Signalling, ISSN 0898-6568, 01/2018, Volume 42, pp. 176 - 183
Focal adhesion kinase (FAK) integrates signaling from integrins, growth factor receptors and mechanical stress to control cell adhesion, motility, survival and... 
Feedback loop | Signaling | Optogenetics | Focal adhesion kinase | Cryptochrome 2 | Kinase inhibitor | MIGRATION | PAXILLIN | ACTIVATION | PHOSPHORYLATION | LIGHT | TRANSDUCTION | MAMMALIAN-CELLS | CANCER | CELL BIOLOGY | FAK | LIVING CELLS | Oligomers | Physiological aspects | Integrins | Index Medicus
Journal Article
Nature Neuroscience, ISSN 1097-6256, 11/2004, Volume 7, Issue 11, pp. 1204 - 1212
Netrins are a family of secreted molecules that are important for axonal outgrowth and guidance in the developing nervous system. However, the signaling... 
PROTEIN | TYROSINE PHOSPHORYLATION | DCC | SRC | COLORECTAL-CANCER | GROWTH-CONE ATTRACTION | RECEPTOR | GUIDANCE | AXON OUTGROWTH | NEUROSCIENCES | PHOSPHOLIPASE C-GAMMA | Neurites - physiology | Embryo, Mammalian | Protein-Tyrosine Kinases - metabolism | Cell Count | Humans | Male | Axons - physiology | Focal Adhesion Kinase 1 | Mucoproteins - pharmacology | Nerve Growth Factors - pharmacology | Drug Interactions | Time Factors | Neurons - metabolism | Phosphorylation - drug effects | Nerve Growth Factors - physiology | Neurites - drug effects | Blotting, Western - methods | Immunoprecipitation - methods | Enzyme Inhibitors - pharmacology | Rats | Coculture Techniques - methods | Chick Embryo | Mice, Knockout | Immunohistochemistry - methods | Tyrosine - metabolism | Signal Transduction - drug effects | Mice | Laminin - pharmacology | Spinal Cord - metabolism | Netrin-1 | Culture Media, Conditioned - pharmacology | Cerebral Cortex - cytology | Dose-Response Relationship, Drug | Protein-Tyrosine Kinases - genetics | Tubulin - metabolism | src-Family Kinases - metabolism | Female | Neurons - drug effects | Green Fluorescent Proteins - metabolism | Cells, Cultured | Gene Expression Regulation | Axons - drug effects | Focal Adhesion Protein-Tyrosine Kinases | Nerve Growth Factor - pharmacology | Enzyme Activation - drug effects | Pregnancy | Two-Hybrid System Techniques | Oncogene Proteins v-abl - metabolism | Animals | Receptor, trkA - metabolism | Signal Transduction - physiology | Tumor Suppressor Proteins | Physiological aspects | Research | Neurons | Protein kinases | Membrane proteins | Index Medicus
Journal Article
Journal Article