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Journal of Molecular Biology, ISSN 0022-2836, 05/2019, Volume 431, Issue 10, pp. 2040 - 2049
Leading-strand polymerase stalling at DNA damage impairs replication fork progression. Using biochemical approaches, we show this arises due to both slower... 
replication fork | DNA replication | DNA damage response | DNA repair | stalled fork | Proteins | Pyrimidines | DNA damage | DNA | Polymerization | Molecular biology | CPD, cyclobutane pyrimidine dimer | ssDNA, single-stranded DNA | THF, tetrahydrofuran | CMG, Cdc45–MCM–GINS | DDT, DNA damage tolerance | AB, abasic site
Journal Article
Nature, ISSN 0028-0836, 07/2018, Volume 559, Issue 7713, pp. 279 - 284
Accurate replication of DNA requires stringent regulation to ensure genome integrity. In human cells, thousands of origins of replication are coordinately... 
POLY(ADP-RIBOSE) POLYMERASE | REPAIR | PCNA | P21(WAF1/CIP1) | CELL NUCLEAR ANTIGEN | REPRESSION | MULTIDISCIPLINARY SCIENCES | PARP | INHIBITORS | CANCER | DAMAGE | DNA Damage - drug effects | DNA Replication - drug effects | Humans | Tumor Suppressor Protein p53 - metabolism | Poly (ADP-Ribose) Polymerase-1 - metabolism | Piperazines - pharmacology | Chromosome Structures - drug effects | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Phthalazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | DNA Replication - physiology | Time Factors | Cell Line, Tumor | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Genomic Instability - drug effects | Genetic research | DNA replication | Research | DNA damage | Oncology, Experimental | Cancer | Analysis | Genomics | DNA | Development and progression | Genomes | Tumor proteins | DNA repair | Cells | Phosphorylation | p53 Protein | Poly(ADP-ribose) | Kinases | ADP | Modulators | Replication forks | Genomic instability | Damage tolerance | Proteins | Ribose | Proliferating cell nuclear antigen | Cell cycle | Inhibition | Speed control | Lesions | Stalling | Deoxyribonucleic acid--DNA | Elongation | ADP-ribosylation | Stresses | Stability | Poly(ADP-ribose) polymerase | Gene expression | Velocity | Suppressors | Stress | Polymerase | DNA biosynthesis | Cyclin-dependent kinase inhibitor p21 | Replication origins | S phase | Replication | Instability | Control stability
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2012, Volume 47, Issue 3, pp. 444 - 456
Journal Article
Cell Reports, ISSN 2211-1247, 12/2018, Volume 25, Issue 12, pp. 3273 - 3282.e6
RAD51 paralogs are essential for maintenance of genomic integrity through protection of stalled replication forks and homology-directed repair (HDR) of... 
ribonucleotide reductase | ATR signaling | genome stability | fork slowing | replication stress | dNTP pools | RAD51 paralogs | RIBONUCLEOTIDE REDUCTASE | RAD51 PARALOGS | REPAIR | GENE | DNA-DAMAGE | FANCONI-ANEMIA | PROMOTES | BREAST | ATR | REVERSAL | CELL BIOLOGY
Journal Article
International Journal of Clinical and Experimental Medicine, ISSN 1940-5901, 07/2014, Volume 7, Issue 7, pp. 1781 - 1785
The transcription factor FOXP3 is specifically expressed in regulatory T (Treg) cells and appears to mediate immune surveillance. Indeed, FOXP3(+)Treg cells... 
Immunohistochemistry | Flow cytometry | Fork-head/winged helix transcription factor 3 | Regulatory T cells | Colorectal cancer | regulatory T cells | MEDICINE, RESEARCH & EXPERIMENTAL | SENTINEL LYMPH-NODE | TOLERANCE | REGULATORY T-CELLS | DEPLETION | flow cytometry | immunohistochemistry | fork-head/winged helix transcription factor 3
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2015, Volume 60, Issue 2, pp. 268 - 279
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 03/2019, Volume 294, Issue 12, pp. 4331 - 4344
Mitochondrial DNA (mtDNA) replication uses a simple core machinery similar to those of bacterial viruses and plasmids, but its components are challenging to... 
genome stability | DNA replication | locomotor dysfunction | RNA | mtDNA | mitochondria | replication fork | RNase H | heteroduplex | genomic instability | insect rnh1 | ribonuclease | REGRESSION | ALTERNATIVE OXIDASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | R-LOOPS | ACCESSORY SUBUNIT | BINDING PROTEIN | MAINTENANCE | POLYMERASE-GAMMA | TFAM | EMBRYOGENESIS | DNA and Chromosomes
Journal Article
Brain, ISSN 0006-8950, 02/2019, Volume 142, Issue 2, pp. 334 - 343
Progressive myelopathy is the most frequent and disabling manifestation of adrenoleukodystrophy, but a lack of quantitative natural history data is hampering... 
spinal cord disease | adrenoleukodystrophy | natural history | myelopathy | TUNING FORK | VALIDATION | SPINAL-CORD | RELIABILITY | X-LINKED ADRENOLEUKODYSTROPHY | NEUROSCIENCES | CLINICAL NEUROLOGY | IMPAIRMENT | TRANSPLANTATION | INDIVIDUALS | SCALE | ADRENOMYELONEUROPATHY
Journal Article
Genes and Development, ISSN 0890-9369, 08/2007, Volume 21, Issue 15, pp. 1921 - 1936
Journal Article
Journal Article