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PLoS ONE, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, pp. e39586 - e39586
Endoplasmic reticulum (ER) stress-induced apoptosis has been implicated in various neurodegenerative diseases including Parkinson Disease, Alzheimer Disease... 
MITOCHONDRIAL APOPTOSIS | TRANSCRIPTION FACTOR CHOP | UNFOLDED PROTEIN RESPONSE | INDUCED APOPTOSIS | KINASE | BIOLOGY | GENE-EXPRESSION | SYMPATHETIC NEURONS | DEATH | ENDOPLASMIC-RETICULUM STRESS | BH3-ONLY PROTEINS | Transcription Factor CHOP - genetics | Apoptosis - drug effects | Neurons - cytology | Bcl-2-Like Protein 11 | Forkhead Transcription Factors - metabolism | Telencephalon - drug effects | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Neurons - metabolism | Neurons - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - physiology | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Tumor Suppressor Proteins - metabolism | Telencephalon - metabolism | Telencephalon - cytology | Membrane Proteins - genetics | Proto-Oncogene Proteins - genetics | Forkhead Transcription Factors - genetics | Apoptosis Regulatory Proteins - metabolism | Animals | Signal Transduction - drug effects | Tunicamycin - pharmacology | Signal Transduction - physiology | Mice | Apoptosis - physiology | Forkhead Box Protein O3 | Transcription Factor CHOP - metabolism | Endoplasmic Reticulum Stress - physiology | Nervous system diseases | Parkinson's disease | Huntington's chorea | Neurons | Tumor proteins | Protein kinases | Apoptosis | Phosphorylation | Transcription factors | Transcription | p53 Protein | Tunicamycin | Homology | AKT protein | CCAAT/enhancer-binding protein | Kinases | Proteins | Signal transduction | Mitochondria | Cell activation | Cell growth | Cascades | Rodents | Forkhead protein | Alzheimer's disease | Movement disorders | Deoxyribonucleic acid--DNA | FOXO3 protein | Stresses | Neurodegenerative diseases | Mortality | Gene expression | Stress | Neurological diseases | Pathology | Signaling | Cell death | Endoplasmic reticulum | CHOP protein | BIM protein | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 9, pp. e73875 - e73875
Excessive reactive oxygen species (ROS) induce apoptosis and are associated with various diseases and with aging. SIRT1 (sirtuin-1), an NAD+-dependent protein... 
TRANSCRIPTION FACTORS | HEART | HSIR2(SIRT1) | RESVERATROL | PROMOTES CELL-SURVIVAL | ACTIVATION | DEACETYLASE | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | MUSCULAR-DYSTROPHY | EXPRESSION | Sirtuin 1 - metabolism | AMP-Activated Protein Kinases - metabolism | Superoxide Dismutase - genetics | Cell Proliferation | Reactive Oxygen Species - metabolism | Oxidative Stress | Apoptosis - drug effects | Humans | Apoptosis - genetics | Stilbenes - pharmacology | Sirtuin 1 - genetics | Antimycin A - pharmacology | Tumor Suppressor Protein p53 - genetics | Gene Knockdown Techniques | Forkhead Transcription Factors - metabolism | Superoxide Dismutase - metabolism | Cell Line | Hydrogen Peroxide - pharmacology | Tumor Suppressor Protein p53 - metabolism | Enzyme Activation - drug effects | Forkhead Transcription Factors - genetics | Hydrogen Peroxide - metabolism | Animals | Forkhead Box Protein O1 | Mice | Forkhead Box Protein O3 | Niacinamide | Oxidative stress | Ionizing radiation | Resveratrol | DNA binding proteins | Tumor proteins | Apoptosis | NADPH | Transcription factors | p53 Protein | Superoxide dismutase | Kinases | Modulators | Muscular dystrophy | Proteins | Mitochondria | FOXO1 protein | Rodents | Antimycin A | Aging | FOXO4 protein | Forkhead protein | FOXO3 protein | Heart failure | Stresses | Immunoglobulins | Cell survival | Pharmacology | siRNA | Survival | SIRT1 protein | Stress | NAD | Medicine | Deacetylation | Cell death | Tumor suppressor genes | Nicotinamide | Mutation | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 05/2006, Volume 441, Issue 7092, pp. 523 - 527
The proto-oncogene AKT (also known as PKB) is activated in many human cancers, mostly owing to loss of the PTEN tumour suppressor. In such tumours, AKT becomes... 
FORKHEAD TRANSCRIPTION FACTOR | APOPTOSIS | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | MUTATION | PTEN | MICE | FOXO3A | CELL-SURVIVAL | PML | PHOSPHATASES | Phosphorylation | Phosphoprotein Phosphatases - metabolism | Transcription Factors - deficiency | Neoplasm Proteins - metabolism | Cell Nucleus - enzymology | Tumor Suppressor Proteins - deficiency | Nuclear Proteins - deficiency | Tumor Suppressor Proteins - genetics | Female | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | PTEN Phosphohydrolase - genetics | PTEN Phosphohydrolase - deficiency | Tumor Suppressor Proteins - metabolism | Cells, Cultured | Nuclear Proteins - metabolism | Transcription Factors - genetics | Protein Transport | Transcription Factors - metabolism | Animals | Mice | Neoplasm Proteins - deficiency | Promyelocytic Leukemia Protein | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Membranes | Transcription factors | Inhibitor drugs | Pathogenesis | Oncology | AKT protein | Inactivation | Rodents | Cell cycle | Forkhead protein | Tumorigenesis | Null cells | FOXO3 protein | Phenotypes | Deactivation | Medical treatment | Cell membranes | Cell membranes (biology) | Sterility | Mutants | Cyclin-dependent kinase inhibitor p27 | Mutation | Prostate | PTEN protein | Tumors | Cancer | Apoptosis | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e78355 - e78355
Approximately 30% of patients with Epstein-Barr virus (EBV)-positive advanced nasopharyngeal carcinoma (NPC) display chemoresistance to cisplatin-based... 
CANCER-CELLS | B-CELLS | SURVIVAL | MEMBRANE-PROTEIN 1 | MULTIDISCIPLINARY SCIENCES | EBV | MIR-21 | LATENCY | LIGAND | EXPRESSION | LINES | RNA-Binding Proteins - genetics | Carcinoma | Apoptosis - drug effects | Humans | Nasopharyngeal Neoplasms - virology | MicroRNAs - metabolism | Viral Matrix Proteins - pharmacology | Tetrazolium Salts | Forkhead Transcription Factors - metabolism | Luciferases | Thiazoles | Apoptosis Regulatory Proteins - genetics | Inhibitory Concentration 50 | Viral Matrix Proteins - metabolism | Colony-Forming Units Assay | Gene Expression Regulation, Neoplastic - drug effects | Nasopharyngeal Neoplasms - drug therapy | Real-Time Polymerase Chain Reaction | RNA-Binding Proteins - antagonists & inhibitors | Cell Line | Nasopharyngeal Carcinoma | Cisplatin - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Drug Resistance, Neoplasm - genetics | Fas Ligand Protein - antagonists & inhibitors | Cisplatin - therapeutic use | Signal Transduction - drug effects | Apoptosis Regulatory Proteins - antagonists & inhibitors | Fluorescent Antibody Technique | MicroRNAs - genetics | Fas Ligand Protein - genetics | Forkhead Box Protein O3 | Infection | Prognosis | MicroRNA | Tumor necrosis factor | Epstein-Barr virus | B cells | Health aspects | Cisplatin | Apoptosis | Cancer | Cell proliferation | Laboratories | Genes | Crosstalk | Chemoresistance | Viruses | Oncology | Homology | AKT protein | Infections | Metastasis | Proteins | Nasopharyngeal carcinoma | Disease resistance | Signal transduction | Coding | Tumor necrosis factor-TNF | Tumorigenesis | Bioindicators | FOXO3 protein | MiRNA | Ribonucleic acid--RNA | 1-Phosphatidylinositol 3-kinase | Membrane proteins | Medicine | Signaling | Chemotherapy | FasL protein | Cell death | MicroRNAs | Medical prognosis | Cell lines | Biomarkers | Ligands | Latent membrane protein 1 | Index Medicus | RNA | Ribonucleic acid
Journal Article
PLoS ONE, ISSN 1932-6203, 2014, Volume 9, Issue 1, pp. e86629 - e86629
Osteoblast apoptosis plays an important role in bone development and maintenance, and is in part responsible for osteoporosis in sex steroid deficiency,... 
TRANSCRIPTION FACTORS | APOPTOSIS | OXIDATIVE STRESS | CELL-CYCLE ENTRY | BONE-FORMATION | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | IN-VIVO | PARATHYROID-HORMONE | DEATH | P53 | Up-Regulation | Mice, Inbred C57BL | Forkhead Transcription Factors - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Animals | Forkhead Transcription Factors - metabolism | Gene Deletion | Cell Differentiation | Forkhead Box Protein O1 | Mice | Osteoblasts - cytology | Forkhead Box Protein O3 | Osteoblasts - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Osteogenesis | Apoptosis | Physiological aspects | Corticosteroids | DNA binding proteins | Tumor proteins | Cell culture | Oxidative stress | Transcription factors | Phosphorylation | Glucocorticoids | p53 Protein | Bromodeoxyuridine | AKT protein | Biology | Insulin-like growth factors | Kinases | Inactivation | Osteoblasts | Cell density | Proteins | Osteoporosis | Biomedical materials | Cell growth | FOXO1 protein | Bcl-x protein | Transgenic animals | Rodents | Surgery | Cell cycle | Aging | Forkhead protein | Insulin-like growth factor-binding protein 3 | Biocompatibility | Bones | Physiology | FOXO3 protein | University graduates | Osteocalcin | Deactivation | Gene expression | Insulin | DNA nucleotidylexotransferase | Osteoblastogenesis | Gadd45A protein | FasL protein | Cell death | Differentiation | BIM protein | PTEN protein | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, pp. e79739 - e79739
Aim: Cardiac microvascular endothelial cells (CMECs) dysfunction contributes to cardiovascular complications in diabetes, whereas, the underlying mechanism is... 
DIABETIC COMPLICATIONS | IN-VITRO | PATHWAY | MULTIDISCIPLINARY SCIENCES | DISEASE | INJURY | DYSFUNCTION | INDUCTION | PROTEINS | CANCER | FAMILY | Phosphorylation - physiology | RNA, Small Interfering - genetics | Reactive Oxygen Species - metabolism | Heart - physiology | Oxidative Stress - physiology | Microvessels - metabolism | bcl-X Protein - genetics | Apoptosis - genetics | Male | Proto-Oncogene Proteins c-akt - genetics | Endothelium, Vascular - physiology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Phosphorylation - genetics | Bcl-2-Like Protein 11 | Forkhead Transcription Factors - metabolism | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Endothelial Cells - physiology | Proto-Oncogene Proteins - metabolism | Endothelial Cells - metabolism | Membrane Proteins - genetics | Oxidative Stress - genetics | Rats | Proto-Oncogene Proteins - genetics | Forkhead Transcription Factors - genetics | Rats, Sprague-Dawley | Down-Regulation - genetics | Apoptosis Regulatory Proteins - metabolism | Microvessels - physiology | Animals | Endothelium, Vascular - metabolism | Glucose - metabolism | Apoptosis - physiology | Forkhead Box Protein O3 | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | DNA binding proteins | Glucose | Dextrose | Apoptosis | Endothelium | Heart | Oxidative stress | Reactive oxygen species | Transcription factors | Phosphorylation | Bcl-2 protein | AKT protein | Cardiovascular disease | Kinases | Accumulation | Western blotting | Proteins | Hyperglycemia | Rodents | Forkhead protein | Heart diseases | FOXO3 protein | Incubation | Internal medicine | Complications | Diabetes mellitus | Cardiomyocytes | siRNA | Endothelial cells | Medicine | MicroRNAs | Microvasculature | Diabetes | Laboratory animals | BIM protein | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, pp. e83312 - e83312
A number of studies have shown that apoptosis resistance can be observed in multiple human tumors; however the detailed mechanism remains unclear. In the... 
E3 LIGASE | APOPTOSIS | UBIQUITIN LIGASE CHIP | PROTEIN | CANCER CELLS | PROTEASOMAL DEGRADATION | MULTIDISCIPLINARY SCIENCES | BIM | PTEN | FOXO TRANSCRIPTION FACTORS | BCL-2 FAMILY | Humans | Gene Expression Regulation, Neoplastic | Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins c-akt - genetics | Breast Neoplasms - metabolism | Protein Isoforms - metabolism | Bcl-2-Like Protein 11 | Forkhead Transcription Factors - metabolism | Apoptosis Regulatory Proteins - genetics | Female | Transcription, Genetic | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins - metabolism | PTEN Phosphohydrolase - genetics | Signal Transduction | Cell Survival | Membrane Proteins - genetics | Ubiquitin-Protein Ligases - metabolism | PTEN Phosphohydrolase - metabolism | Proto-Oncogene Proteins - genetics | Forkhead Transcription Factors - genetics | Apoptosis Regulatory Proteins - metabolism | Phosphatidylinositol 3-Kinases - genetics | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | Forkhead Box Protein O1 | Ubiquitin-Protein Ligases - genetics | Apoptosis | Protein Isoforms - genetics | Heat shock proteins | Genetic transcription | DNA binding proteins | Transcription factors | AKT protein | Tissues | Proteins | Signal transduction | Epidermal growth factor | FOXO1 protein | Rodents | Surgery | Post-translation | FOXO4 protein | Forkhead protein | Inhibition | Telomerase | Deoxyribonucleic acid--DNA | FOXO3 protein | Immunoglobulins | Breast cancer | 1-Phosphatidylinositol 3-kinase | Signaling | Tumor suppressor genes | Hypoxia | Hsc70 protein | PTEN protein | Chip protein | BIM protein | Tumors | Cancer | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 5, pp. e19946 - e19946
The aim of this study was to investigate the mechanism through which Sphingosine kinase-1 (SPHK1) exerts its antiapoptosis activity in glioma cancer cells. We... 
BREAST-CANCER | SURVIVAL | FORKHEAD TRANSCRIPTION FACTOR | LUNG-CANCER | AKT ACTIVATION | HUMAN GLIOBLASTOMA CELLS | BIM | BIOLOGY | BCL-2 FAMILY-MEMBERS | UP-REGULATION | EXPRESSION | RNA, Small Interfering - genetics | Phosphorylation | Luciferases - metabolism | Humans | Brain Neoplasms - pathology | Brain Neoplasms - metabolism | Immunoenzyme Techniques | Proto-Oncogene Proteins c-akt - genetics | Glioma - metabolism | Glioma - genetics | Bcl-2-Like Protein 11 | Forkhead Transcription Factors - metabolism | Glioma - pathology | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Forkhead Transcription Factors - antagonists & inhibitors | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins - metabolism | Signal Transduction | Membrane Proteins - genetics | Phosphatidylinositol 3-Kinase | RNA, Messenger - genetics | Brain Neoplasms - genetics | Phosphotransferases (Alcohol Group Acceptor) - genetics | Proto-Oncogene Proteins - genetics | Forkhead Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Animals | Mice, Nude | Mice | Forkhead Box Protein O3 | Apoptosis | Development and progression | Gliomas | Sphingosine | Motility | Bax protein | Bcl-2 protein | Transcription | Laboratories | Brain tumors | Brain cancer | Colorectal cancer | AKT protein | Kinases | Inactivation | Cancer therapies | Tropical diseases | Proteins | Cell growth | Education | Rodents | Glioma cells | Cell cycle | Tumorigenesis | FOXO3 protein | Sphingosine kinase | Deactivation | RNA-mediated interference | Pharmacology | Disease control | Mcl-1 protein | 1-Phosphatidylinositol 3-kinase | Medicine | Ribonucleic acids | Hypoxia | In vivo methods and tests | BIM protein | Cancer | Tumors | Index Medicus
Journal Article