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Nature (London), ISSN 1476-4687, 05/2006, Volume 441, Issue 7092, pp. 523 - 527
Journal Article
Molecular medicine reports, ISSN 1791-2997, 10/2015, Volume 12, Issue 4, pp. 5100 - 5108
8-bromo-7-methoxychrysin (BrMC), a novel chrysin analog, was reported to have anti-cancer activities. The aim of the present study was to investigate the... 
8-bromo-7-methoxychrysin | Akt | Forkhead box O3a | Bim | Apoptosis | Ovarian cancer | Oncology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | RNA, Small Interfering - genetics | Epithelial Cells - metabolism | Apoptosis - drug effects | Epithelial Cells - drug effects | Humans | Gene Expression Regulation, Neoplastic | Proto-Oncogene Proteins c-akt - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Forkhead Transcription Factors - metabolism | Proto-Oncogene Proteins - agonists | Apoptosis Regulatory Proteins - genetics | Female | Ovary - drug effects | Antineoplastic Agents - pharmacology | Flavonoids - pharmacology | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Ovary - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Ovary - pathology | Forkhead Transcription Factors - agonists | Signal Transduction | Membrane Proteins - genetics | Gene Silencing | Epithelial Cells - pathology | Proto-Oncogene Proteins - genetics | Cisplatin - pharmacology | Forkhead Transcription Factors - genetics | Membrane Proteins - agonists | Apoptosis Regulatory Proteins - metabolism | Drug Resistance, Neoplasm - genetics | Membrane Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - agonists | Apoptosis Regulatory Proteins - antagonists & inhibitors | Apoptosis Regulatory Proteins - agonists | Cell Line, Tumor | Forkhead Box Protein O3 | Proto-Oncogene Proteins c-bcl-2 - genetics | RNA, Small Interfering - metabolism
Journal Article
PloS one, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, pp. e39586 - e39586
... death, independent of p53. CHOP (C/EBP homologous protein also known as GADD153; gene name Ddit3), a critical initiator of ER stress-induced apoptosis, was found... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Transcription Factor CHOP - genetics | Apoptosis - drug effects | Neurons - cytology | Bcl-2-Like Protein 11 | Forkhead Transcription Factors - metabolism | Telencephalon - drug effects | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Neurons - metabolism | Neurons - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - physiology | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Tumor Suppressor Proteins - metabolism | Telencephalon - metabolism | Telencephalon - cytology | Membrane Proteins - genetics | Proto-Oncogene Proteins - genetics | Forkhead Transcription Factors - genetics | Apoptosis Regulatory Proteins - metabolism | Animals | Signal Transduction - drug effects | Tunicamycin - pharmacology | Signal Transduction - physiology | Mice | Apoptosis - physiology | Forkhead Box Protein O3 | Transcription Factor CHOP - metabolism | Endoplasmic Reticulum Stress - physiology | Nervous system diseases | Parkinson's disease | Huntington's chorea | Neurons | Tumor proteins | Protein kinases | Apoptosis | Phosphorylation | Transcription factors | Transcription | p53 Protein | Tunicamycin | Homology | AKT protein | CCAAT/enhancer-binding protein | Kinases | Proteins | Signal transduction | Mitochondria | Cell activation | Cell growth | Cascades | Rodents | Forkhead protein | Alzheimer's disease | Movement disorders | Deoxyribonucleic acid--DNA | FOXO3 protein | Stresses | Neurodegenerative diseases | Mortality | Gene expression | Stress | Neurological diseases | Pathology | Signaling | Cell death | Endoplasmic reticulum | CHOP protein | BIM protein | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
PloS one, ISSN 1932-6203, 09/2013, Volume 8, Issue 9, pp. e73875 - e73875
...+-dependent protein deacetylase, decreases ROS levels and participates in cell survival under oxidative stress conditions... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Sirtuin 1 - metabolism | AMP-Activated Protein Kinases - metabolism | Superoxide Dismutase - genetics | Cell Proliferation | Reactive Oxygen Species - metabolism | Oxidative Stress | Apoptosis - drug effects | Humans | Apoptosis - genetics | Stilbenes - pharmacology | Sirtuin 1 - genetics | Antimycin A - pharmacology | Tumor Suppressor Protein p53 - genetics | Gene Knockdown Techniques | Forkhead Transcription Factors - metabolism | Superoxide Dismutase - metabolism | Cell Line | Hydrogen Peroxide - pharmacology | Tumor Suppressor Protein p53 - metabolism | Enzyme Activation - drug effects | Forkhead Transcription Factors - genetics | Hydrogen Peroxide - metabolism | Animals | Forkhead Box Protein O1 | Mice | Forkhead Box Protein O3 | Niacinamide | Oxidative stress | Ionizing radiation | Resveratrol | DNA binding proteins | Tumor proteins | Apoptosis | Transcription factors | p53 Protein | Superoxide dismutase | Kinases | Modulators | Muscular dystrophy | Proteins | Mitochondria | FOXO1 protein | Rodents | Antimycin A | Aging | FOXO4 protein | Forkhead protein | FOXO3 protein | Heart failure | Immunoglobulins | Oxygen | Cell survival | Pharmacology | siRNA | Survival | SIRT1 protein | NAD | Medicine | Deacetylation | Cell death | Tumor suppressor genes | Nicotinamide | Mutation | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, pp. e83312 - e83312
...; however the detailed mechanism remains unclear. In the present study, we demonstrated that the abnormal overexpression of the C terminus of Hsc70-interacting protein (CHIP... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Humans | Gene Expression Regulation, Neoplastic | Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins c-akt - genetics | Breast Neoplasms - metabolism | Protein Isoforms - metabolism | Bcl-2-Like Protein 11 | Forkhead Transcription Factors - metabolism | Apoptosis Regulatory Proteins - genetics | Female | Transcription, Genetic | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins - metabolism | PTEN Phosphohydrolase - genetics | Signal Transduction | Cell Survival | Membrane Proteins - genetics | Ubiquitin-Protein Ligases - metabolism | PTEN Phosphohydrolase - metabolism | Proto-Oncogene Proteins - genetics | Forkhead Transcription Factors - genetics | Apoptosis Regulatory Proteins - metabolism | Phosphatidylinositol 3-Kinases - genetics | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | Forkhead Box Protein O1 | Ubiquitin-Protein Ligases - genetics | Apoptosis | Protein Isoforms - genetics | Heat shock proteins | Genetic transcription | DNA binding proteins | Transcription factors | AKT protein | Tissues | Proteins | Signal transduction | Epidermal growth factor | FOXO1 protein | Rodents | Surgery | Post-translation | FOXO4 protein | Forkhead protein | Inhibition | Telomerase | Deoxyribonucleic acid--DNA | FOXO3 protein | Immunoglobulins | Breast cancer | 1-Phosphatidylinositol 3-kinase | Signaling | Tumor suppressor genes | Hypoxia | Hsc70 protein | PTEN protein | Chip protein | BIM protein | Tumors | Cancer | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
PloS one, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e78355 - e78355
.... The Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1), a functional homologue of the tumor necrosis factor receptor family, contributes substantially... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | RNA-Binding Proteins - genetics | Carcinoma | Apoptosis - drug effects | Humans | Nasopharyngeal Neoplasms - virology | MicroRNAs - metabolism | Viral Matrix Proteins - pharmacology | Tetrazolium Salts | Forkhead Transcription Factors - metabolism | Luciferases | Thiazoles | Apoptosis Regulatory Proteins - genetics | Inhibitory Concentration 50 | Viral Matrix Proteins - metabolism | Colony-Forming Units Assay | Gene Expression Regulation, Neoplastic - drug effects | Nasopharyngeal Neoplasms - drug therapy | Real-Time Polymerase Chain Reaction | RNA-Binding Proteins - antagonists & inhibitors | Cell Line | Nasopharyngeal Carcinoma | Cisplatin - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Drug Resistance, Neoplasm - genetics | Fas Ligand Protein - antagonists & inhibitors | Cisplatin - therapeutic use | Signal Transduction - drug effects | Apoptosis Regulatory Proteins - antagonists & inhibitors | Fluorescent Antibody Technique | MicroRNAs - genetics | Fas Ligand Protein - genetics | Forkhead Box Protein O3 | Infection | Prognosis | MicroRNA | Tumor necrosis factor | Epstein-Barr virus | B cells | Health aspects | Cisplatin | Apoptosis | Cancer | Cell proliferation | Laboratories | Genes | Crosstalk | Chemoresistance | Viruses | Oncology | Homology | AKT protein | Infections | Metastasis | Proteins | Nasopharyngeal carcinoma | Disease resistance | Signal transduction | Coding | Tumor necrosis factor-TNF | miRNA | Tumorigenesis | Bioindicators | FOXO3 protein | Ribonucleic acid--RNA | 1-Phosphatidylinositol 3-kinase | Membrane proteins | Medicine | Signaling | Chemotherapy | FasL protein | Cell death | MicroRNAs | Medical prognosis | Biomarkers | Ligands | Latent membrane protein 1 | Index Medicus | RNA | Ribonucleic acid
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, pp. e79739 - e79739
Aim: Cardiac microvascular endothelial cells (CMECs) dysfunction contributes to cardiovascular complications in diabetes, whereas, the underlying mechanism is... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Phosphorylation - physiology | RNA, Small Interfering - genetics | Reactive Oxygen Species - metabolism | Heart - physiology | Oxidative Stress - physiology | Microvessels - metabolism | bcl-X Protein - genetics | Apoptosis - genetics | Male | Proto-Oncogene Proteins c-akt - genetics | Endothelium, Vascular - physiology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Phosphorylation - genetics | Bcl-2-Like Protein 11 | Forkhead Transcription Factors - metabolism | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Endothelial Cells - physiology | Proto-Oncogene Proteins - metabolism | Endothelial Cells - metabolism | Membrane Proteins - genetics | Oxidative Stress - genetics | Rats | Proto-Oncogene Proteins - genetics | Forkhead Transcription Factors - genetics | Rats, Sprague-Dawley | Down-Regulation - genetics | Apoptosis Regulatory Proteins - metabolism | Microvessels - physiology | Animals | Endothelium, Vascular - metabolism | Glucose - metabolism | Apoptosis - physiology | Forkhead Box Protein O3 | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | DNA binding proteins | Glucose | Dextrose | Apoptosis | Endothelium | Heart | Oxidative stress | Reactive oxygen species | Transcription factors | Phosphorylation | Bcl-2 protein | AKT protein | Cardiovascular disease | Kinases | Accumulation | Western blotting | Proteins | Hyperglycemia | Rodents | Forkhead protein | Heart diseases | FOXO3 protein | Oxygen | Incubation | Internal medicine | Complications | Diabetes mellitus | Cardiomyocytes | siRNA | Endothelial cells | Medicine | MicroRNAs | Microvasculature | Diabetes | Laboratory animals | BIM protein | Index Medicus
Journal Article