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PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 9, p. e73875
Excessive reactive oxygen species (ROS) induce apoptosis and are associated with various diseases and with aging. SIRT1 (sirtuin-1), an NAD+-dependent protein... 
TRANSCRIPTION FACTORS | HEART | RESVERATROL | LONGEVITY | PROMOTES CELL-SURVIVAL | ACTIVATION | DEACETYLASE | MULTIDISCIPLINARY SCIENCES | SIR2-ALPHA | SIRTUINS | EXPRESSION | Sirtuin 1 - metabolism | AMP-Activated Protein Kinases - metabolism | Superoxide Dismutase - genetics | Cell Proliferation | Reactive Oxygen Species - metabolism | Oxidative Stress | Apoptosis - drug effects | Humans | Apoptosis - genetics | Stilbenes - pharmacology | Sirtuin 1 - genetics | Antimycin A - pharmacology | Tumor Suppressor Protein p53 - genetics | Gene Knockdown Techniques | Forkhead Transcription Factors - metabolism | Superoxide Dismutase - metabolism | Cell Line | Hydrogen Peroxide - pharmacology | Tumor Suppressor Protein p53 - metabolism | Enzyme Activation - drug effects | Forkhead Transcription Factors - genetics | Hydrogen Peroxide - metabolism | Animals | Forkhead Box Protein O1 | Mice | Forkhead Box Protein O3 | Niacinamide | Oxidative stress | Ionizing radiation | Resveratrol | DNA binding proteins | Tumor proteins | Apoptosis | NADPH | Transcription factors | p53 Protein | Superoxide dismutase | Kinases | Modulators | Muscular dystrophy | Proteins | Mitochondria | FOXO1 protein | Rodents | Antimycin A | Aging | FOXO4 protein | Forkhead protein | FOXO3 protein | Heart failure | Immunoglobulins | Cell survival | Pharmacology | siRNA | Survival | SIRT1 protein | NAD | Medicine | Deacetylation | Cell death | Tumor suppressor genes | Nicotinamide | Mutation
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, p. e83312
A number of studies have shown that apoptosis resistance can be observed in multiple human tumors; however the detailed mechanism remains unclear. In the... 
E3 LIGASE | APOPTOSIS | UBIQUITIN LIGASE CHIP | PROTEIN | CANCER CELLS | PROTEASOMAL DEGRADATION | MULTIDISCIPLINARY SCIENCES | BIM | PTEN | FOXO TRANSCRIPTION FACTORS | BCL-2 FAMILY | Humans | Gene Expression Regulation, Neoplastic | Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins c-akt - genetics | Breast Neoplasms - metabolism | Protein Isoforms - metabolism | Bcl-2-Like Protein 11 | Forkhead Transcription Factors - metabolism | Apoptosis Regulatory Proteins - genetics | Female | Transcription, Genetic | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins - metabolism | PTEN Phosphohydrolase - genetics | Signal Transduction | Cell Survival | Membrane Proteins - genetics | Ubiquitin-Protein Ligases - metabolism | PTEN Phosphohydrolase - metabolism | Proto-Oncogene Proteins - genetics | Forkhead Transcription Factors - genetics | Apoptosis Regulatory Proteins - metabolism | Phosphatidylinositol 3-Kinases - genetics | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | Forkhead Box Protein O1 | Ubiquitin-Protein Ligases - genetics | Apoptosis | Protein Isoforms - genetics | Heat shock proteins | Genetic transcription | DNA binding proteins | Transcription factors | AKT protein | Tissues | Proteins | Signal transduction | Epidermal growth factor | FOXO1 protein | Rodents | Surgery | Post-translation | FOXO4 protein | Forkhead protein | Inhibition | Telomerase | Deoxyribonucleic acid--DNA | FOXO3 protein | Immunoglobulins | Breast cancer | 1-Phosphatidylinositol 3-kinase | Signaling | Tumor suppressor genes | Hypoxia | Hsc70 protein | PTEN protein | Chip protein | BIM protein | Tumors | Cancer | Deoxyribonucleic acid | DNA
Journal Article
Molecular and cellular biology, ISSN 0270-7306, 2002, Volume 22, Issue 7, pp. 2025 - 2036
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
CANCER-CELLS | ACTIVATION | CAENORHABDITIS-ELEGANS | FAMILY MEMBER | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DAF-16 | GENE-TRANSFER | P130 | EXPRESSION | P27(KIP1) | CELL BIOLOGY | Up-Regulation | Cyclin-Dependent Kinases - metabolism | Humans | Protein-Serine-Threonine Kinases | Phosphatidylinositol 3-Kinases - metabolism | Blood Proteins - metabolism | Colonic Neoplasms - metabolism | DNA-Binding Proteins - metabolism | Proteins | RNA, Messenger - biosynthesis | Time Factors | Blood Proteins - genetics | Cellular Senescence | Gene Deletion | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Transcription, Genetic | Cyclin E | Electrophoretic Mobility Shift Assay | Tumor Cells, Cultured | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | RNA, Messenger - genetics | Cell Cycle Proteins - metabolism | Gene Expression Regulation | Transcription Factors - genetics | Blood Proteins - biosynthesis | Cyclin-Dependent Kinase Inhibitor p27 | Proto-Oncogene Proteins c-akt | Transcription Factors - metabolism | Animals | Cell Cycle | Colonic Neoplasms - pathology | Retinoblastoma-Like Protein p130 | Forkhead Box Protein O1 | Mice | Forkhead Transcription Factors | Forkhead protein | FOXO4 protein | FOXO3b protein | p130 protein | Cell Growth and Development
Journal Article
Journal of Structural Biology, ISSN 1047-8477, 2010, Volume 170, Issue 3, pp. 451 - 461
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 12, p. e15288
Background: Resveratrol, a naturally occurring phytopolyphenol compound, has attracted extensive interest in recent years because of its diverse... 
AKT ACTIVITY | OXIDATIVE STRESS | IN-VITRO | BIM | BIOLOGY | FACTOR FKHR-L1 | CYCLE ARREST | TUMOR-GROWTH | EXPRESSION | PROGRESSION | P27(KIP1) | Prostatic Neoplasms - metabolism | Cell Proliferation | Humans | Gene Expression Regulation, Neoplastic | Morpholines - pharmacology | Male | Phosphatidylinositol 3-Kinases - metabolism | Stilbenes - pharmacology | Androstadienes - pharmacology | Forkhead Transcription Factors - metabolism | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Forkhead Box Protein O1 | Mutation | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Apoptosis | Prevention | Care and treatment | Growth | Resveratrol | Development and progression | DNA binding proteins | Prostate cancer | Cancer | TOR protein | Oxidative stress | Transcription factors | Phosphorylation | Leukemia | Colorectal cancer | AKT protein | Cytotoxicity | Activation | Cyclin D1 | Cancer therapies | Proteins | Angiogenesis | Signal transduction | Biological effects | FOXO1 protein | Rodents | Cooperation | Transcription activation | Cell cycle | Forkhead protein | Tumor necrosis factor-TNF | FOXO4 protein | Tumorigenesis | Inhibition | Deoxyribonucleic acid--DNA | FOXO3 protein | Translocation | Pharmacology | Gene expression | Nuclear transport | 1-Phosphatidylinositol 3-kinase | Mutants | Androgens | Molecular modelling | Overexpression | Inhibitors | Wortmannin | Pancreatic cancer | Cyclin-dependent kinase inhibitor p27 | Ligands | Prostate | BIM protein | PTEN protein | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
FEBS Letters, ISSN 0014-5793, 01/2014, Volume 588, Issue 1, pp. 92 - 98
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 8/2011, Volume 20, Issue 15, pp. 2928 - 2941
Ataxin-3 (ATXN3), the disease protein in spinocerebellar ataxia type 3 (SCA3), binds to target gene promoters and modulates transcription by interaction with... 
POLYGLUTAMINE-EXPANDED ATAXIN-3 | IN-VITRO | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIAL-FUNCTION | FOXO PROTEINS | GENETICS & HEREDITY | CELL-LINES | BINDING PROTEIN | KNOCKOUT MICE | TRANSCRIPTIONAL REGULATION | HUNTINGTONS-DISEASE | DISEASE PROTEIN ATAXIN-3 | Immunohistochemistry | Superoxide Dismutase - genetics | Immunoprecipitation | Reactive Oxygen Species - metabolism | Ataxin-3 | Machado-Joseph Disease - metabolism | Humans | Middle Aged | Cell Survival - genetics | Male | Ubiquitination - drug effects | Chromatin Immunoprecipitation | RNA Interference | HEK293 Cells | Nuclear Proteins - genetics | Repressor Proteins - metabolism | Superoxide Dismutase - metabolism | Cell Survival - drug effects | Cells, Cultured | Hydrogen Peroxide - pharmacology | Oxidative Stress - genetics | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Nerve Tissue Proteins - genetics | Blotting, Western | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Protein Binding | HeLa Cells | Oxidative Stress - drug effects | Ubiquitination - genetics | Machado-Joseph Disease - genetics | Enzymes | Oxidative stress | Pons | Reactive oxygen species | RNA-mediated interference | Cytotoxicity | Superoxide dismutase | Promoters | Antioxidants | Machado-Joseph disease | Ataxin | Cell death | FOXO4 protein | Forkhead protein | Manganese
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2018, Volume 13, Issue 6, p. e0197899
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, p. e101411
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, p. e32590
The serine/threonine kinase LKB1 is a tumour suppressor that regulates multiple biological pathways, including cell cycle control, cell polarity and energy... 
INACTIVATION | DNA-BINDING | ACTIVATED PROTEIN-KINASE | FACTOR AFX | METASTASIS | CANCER CELLS | SPECIFICITY | PEUTZ-JEGHERS-SYNDROME | MULTIDISCIPLINARY SCIENCES | FORKHEAD | IDENTIFICATION | Cell Line | Promoter Regions, Genetic | Gene Expression | Humans | Transcriptional Activation | CCAAT-Binding Factor - genetics | Gene Silencing | Protein-Serine-Threonine Kinases - genetics | Sp1 Transcription Factor - metabolism | Forkhead Transcription Factors - genetics | CCAAT-Binding Factor - metabolism | Chromatin Immunoprecipitation | Forkhead Transcription Factors - metabolism | Regulatory Elements, Transcriptional | Base Sequence | Transcription Initiation Site | Tumor Suppressor Proteins - genetics | Binding Sites | Promoters (Genetics) | Analysis | Luciferase | Physiological aspects | Genetic research | DNA binding proteins | Gene expression | Protein kinases | Tumors | Energy metabolism | Chromatin | Transcription factors | Phosphorylation | Gene regulation | Genomes | Insulin-like growth factors | Metastasis | Nucleotides | Gene deletion | Kinases | AMP-activated protein kinase | Proteins | LKB1 protein | Human papillomavirus | Clonal deletion | Rodents | Transcription activation | Cell cycle | Deletion | Fibroblasts | Polarity | Forkhead protein | FOXO4 protein | FOXO3 protein | Medical research | Deoxyribonuclease | AMP | Threonine | Functional analysis | Metabolism | Sp1 protein | Insulin | Electrophoretic mobility | Cell lines | Protein-serine/threonine kinase | Cervical cancer | Immunoprecipitation | Base pairs | Regulatory sequences | siRNA | Promoters
Journal Article