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Current Opinion in Cell Biology, ISSN 0955-0674, 2016, Volume 40, pp. 131 - 136
Common fragile sites (CFSs) are chromosomal regions characterized as hotspots for breakage and chromosomal rearrangements following DNA replication stress.... 
Internal Medicine | GENOMIC INSTABILITY | FHIT GENE | DNA-DAMAGE RESPONSE | TRANSCRIPTION | APHIDICOLIN | COMMON | CERVICAL TUMORS | ONCOGENE-INDUCED SENESCENCE | REPLICATION STRESS | FRA16D | CELL BIOLOGY | Genomic Instability | Animals | Neoplasms - genetics | Humans | Chromosome Fragile Sites | DNA Replication | Neoplasms - pathology | Oncogenes | Development and progression | DNA replication | Cancer
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 50, pp. 87431 - 87441
Breakage of the fragile site FRA16D disrupts the WWOX (WW Domain Containing Oxidoreductase) tumor suppressor gene in osteosarcoma. However, the frequency of... 
Osteosarcoma | WW-domain | PARTICL | FRA16D | GENE | FRAGILE SITES | TUMOR-SUPPRESSOR | EXPRESSION | CANCER | osteosarcoma | DELETION | REVEALS | CELL BIOLOGY
Journal Article
Urologic Oncology: Seminars and Original Investigations, ISSN 1078-1439, 02/2020, Volume 38, Issue 2, pp. 41.e1 - 41.e9
•To investigated WWOX SNPs to evaluate urothelial cell carcinoma (UCC) susceptibility.•Individuals who carried WWOX rs11545028 variants with susceptible to... 
WW domain-containing oxidoreductase gene | Urothelial cell carcinoma | Polymorphism | ACTIVATION | PROTEIN | RISK | FRA16D GENE | BREAST | BIOMARKERS | LUNG-CANCER | POLYMORPHISMS | ONCOLOGY | UROLOGY & NEPHROLOGY | TUMOR-SUPPRESSOR | EXPRESSION
Journal Article
Cancer Research, ISSN 0008-5472, 11/2004, Volume 64, Issue 22, pp. 8256 - 8261
The WWOX gene encodes a tumor suppressor WW domain-containing protein, Wwox. Alterations of WWOX have been demonstrated in multiple types of cancer, and... 
BREAST-CANCER | FACTOR AP-2 | ONCOLOGY | CHROMOSOMAL FRAGILE SITE | MAMMARY-CARCINOMA | GENE WWOX | DOMAIN-CONTAINING OXIDOREDUCTASE | IDENTIFICATION | EXPRESSION | FAMILY | FRA16D
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 04/2019, Volume 79, Issue 8, pp. 1784 - 1798
Journal Article
Cell Reports, ISSN 2211-1247, 04/2019, Volume 27, Issue 4, pp. 1151 - 1164.e5
Common fragile sites (CFSs) are genomic regions that display gaps and breaks in human metaphase chromosomes under replication stress and are often deleted in... 
CFS | Slx4 complex | common fragile site | replication fork stall | CtIP | cruciform structure | Sae2 | AT repeat | Mus81 endonuclease | FRA16D | STRUCTURE-SPECIFIC ENDONUCLEASE | RECOMBINATION | TRANSLOCATION | SLX4 | INVERTED REPEATS | MUTATION | DNA-REPAIR | SLX1-SLX4 | REPLICATION STRESS | CANCER | CELL BIOLOGY
Journal Article
Journal Article
ONCOTARGET, ISSN 1949-2553, 09/2017, Volume 8, Issue 42, pp. 71574 - 71586
Homologous recombination (HR) enables precise DNA repair after DNA double strand breaks (DSBs) using identical sequence templates, whereas homeologous... 
MOLECULAR CHARACTERIZATION | DIVERGED SEQUENCES | colorectal cancer | INSTABILITY | homeologous recombination | DIGESTIVE-TRACT CANCERS | mismatch repair | DOUBLE-STRAND BREAKS | MAMMALIAN-CELLS | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | homologous recombination | FRA16D
Journal Article