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spemann organizer (51) 51
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Clinical Cancer Research, ISSN 1078-0432, 04/2006, Volume 12, Issue 7, pp. 2109 - 2116
Purpose: Aberrant promoter hypermethylation of Wnt-antagonist genes contributes to the pathogenesis of several cancers. We hypothesized that combined... 
secreted frizzled-related protein-1, 2, 4 and 5 | Wnt inhibitory factor-1 | Dickkopf family proteins-3 | bladder cancer | methylation | INACTIVATION | HUMAN PROSTATE-CANCER | PROMOTER HYPERMETHYLATION | SFRP GENES | METHYLATION | INHIBITORY FACTOR-I | ONCOLOGY | SIGNALING PATHWAY | COLORECTAL-CANCER | TUMOR-SUPPRESSOR GENES | URINE | Intercellular Signaling Peptides and Proteins - analysis | Multivariate Analysis | Carrier Proteins - urine | Urinary Bladder Neoplasms - diagnosis | Carcinoma, Transitional Cell - urine | Humans | Proto-Oncogene Proteins - urine | Membrane Proteins - urine | Repressor Proteins - analysis | Membrane Proteins - analysis | DNA Methylation | Urinary Bladder Neoplasms - genetics | Biomarkers, Tumor - urine | Proto-Oncogene Proteins - analysis | Sensitivity and Specificity | Eye Proteins - genetics | Carrier Proteins - analysis | Carcinoma, Transitional Cell - genetics | Repressor Proteins - urine | Urinary Bladder Neoplasms - urine | Biomarkers, Tumor - analysis | Membrane Proteins - genetics | Carcinoma, Transitional Cell - diagnosis | RNA, Messenger - genetics | Intercellular Signaling Peptides and Proteins - genetics | Intercellular Signaling Peptides and Proteins - urine | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Eye Proteins - analysis | Reverse Transcriptase Polymerase Chain Reaction | Sequence Analysis, DNA | Carrier Proteins - genetics | Adaptor Proteins, Signal Transducing | Biomarkers, Tumor - genetics | Eye Proteins - urine | Urinary Bladder - physiology
Journal Article
Expert Opinion on Therapeutic Targets, ISSN 1472-8222, 04/2009, Volume 13, Issue 4, pp. 485 - 496
Background: There is a need to develop new bone anabolic agents because current bone regeneration regimens have limitations. The Wingless-type MMTV integration... 
Osteoporosis | Sfrp1 | Sclerostin | GSK-3 | SOST | Dkk1 | OSTEOBLAST DIFFERENTIATION | GLYCOGEN-SYNTHASE KINASE-3 | BETA-CATENIN | NEGATIVE REGULATOR | DKK1-MEDIATED INHIBITION | IN-VIVO | RECEPTOR-RELATED PROTEIN-5 | PHARMACOLOGY & PHARMACY | FRIZZLED-RELATED PROTEIN-1 | HEALTHY POSTMENOPAUSAL WOMEN | VAN-BUCHEM-DISEASE | Bone Morphogenetic Proteins - antagonists & inhibitors | Bone Morphogenetic Proteins - physiology | Humans | Glycogen Synthase Kinase 3 beta | Osteoporosis - drug therapy | LDL-Receptor Related Proteins - genetics | Intercellular Signaling Peptides and Proteins - physiology | beta Catenin - biosynthesis | Membrane Proteins - deficiency | Bone Diseases - drug therapy | Membrane Proteins - physiology | LDL-Receptor Related Proteins - deficiency | Intercellular Signaling Peptides and Proteins - deficiency | Drug Evaluation, Preclinical | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Low Density Lipoprotein Receptor-Related Protein-5 | Membrane Proteins - genetics | Osteoblasts - drug effects | Osteoblasts - physiology | Osteogenesis - drug effects | Bone Resorption - drug therapy | Intercellular Signaling Peptides and Proteins - genetics | Bone Diseases - physiopathology | Organ Specificity | Regeneration - physiology | LDL-Receptor Related Proteins - physiology | beta Catenin - genetics | Mice, Knockout | Gene Expression Regulation - drug effects | Animals | Membrane Proteins - antagonists & inhibitors | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | Genetic Markers - physiology | Mice | Protein Kinase Inhibitors - pharmacology | Wnt Proteins - physiology | Wnt Proteins - antagonists & inhibitors | Fractures, Bone - drug therapy
Journal Article
Applied Biochemistry and Biotechnology, ISSN 0273-2289, 2/2015, Volume 175, Issue 4, pp. 2087 - 2103
Secreted frizzled-related proteins (sFRPs) constitute a family of proteins, which impede the Wnt signaling pathway. Upregulation of the Wnt cascade is one of... 
Biochemistry, general | Characterization | Biotechnology | Chemistry | Glutathione agarose affinity chromatography | GST tagged | Chemotherapeutic drugs | Secreted frizzled-related protein | Wnt | Combination therapy | Recombinant protein expression | GST-FUSION PROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | OVARIAN CANCERS | WNT ANTAGONIST SFRP1 | MONOCLONAL-ANTIBODY | CELL-LINES | BREAST-CANCER | GASTRIC-CANCER | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EPIGENETIC INACTIVATION | COLORECTAL-CANCER | STRUCTURE PREDICTION | Recombinant Fusion Proteins - pharmacology | Inclusion Bodies - chemistry | Humans | Intercellular Signaling Peptides and Proteins - chemistry | Octoxynol - chemistry | Membrane Proteins - pharmacology | Recombinant Fusion Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Wnt Proteins - genetics | MCF-7 Cells | Cloning, Molecular | Escherichia coli - metabolism | Female | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Sarcosine - analogs & derivatives | Cell Survival - drug effects | Gene Expression | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Solubility | Cisplatin - pharmacology | Recombinant Fusion Proteins - chemistry | Plasmids - metabolism | Wnt Proteins - chemistry | Drug Synergism | Membrane Proteins - chemistry | Escherichia coli - genetics | Intercellular Signaling Peptides and Proteins - pharmacology | Plasmids - chemistry | Sarcosine - chemistry | Recombinant Fusion Proteins - genetics | Molecular Docking Simulation | Structural Homology, Protein | HeLa Cells | Doxorubicin - pharmacology | Cysteine | Chemotherapy | Surface active agents | Analysis | Escherichia coli | Health aspects | Recombinant proteins | Chromatography | Cervical cancer | Nanotechnology | Cancer | Signal transduction | Protein expression | Cellular biology | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2015, Volume 468, Issue 3, pp. 507 - 518
To avoid malformation and disease, tissue development and homoeostasis are co-ordinated precisely in time and space. Secreted Frizzled-related protein 3... 
A disintegrin and metalloprotease 17 (ADAM17) | SNPs (single nucleotide polymorphisms) | Frizzled-related protein gene (FRZB) | Metalloprotease | Secreted Frizzled-related proteins (sFRPs) | Osteoarthritis | Interleukin-6 receptor (IL-6R) | Ectodomain shedding | DOMAIN | ectodomain shedding | CANCER CELLS | osteoarthritis | BIOCHEMISTRY & MOLECULAR BIOLOGY | secreted Frizzled-related proteins (sFRPs) | WNT ANTAGONIST | NECROSIS-FACTOR-ALPHA | interleukin-6 receptor (IL-6R) | INHIBITION | FRZB | SOLUBLE INTERLEUKIN-6 | HIP OSTEOARTHRITIS | metalloprotease | CONVERTING-ENZYME | SPEMANN ORGANIZER | ADAM17 Protein | Osteoarthritis, Hip - metabolism | Receptors, Interleukin-6 - chemistry | Up-Regulation | Humans | Proteins - secretion | HEK293 Cells | Cell Membrane - metabolism | Protein Interaction Domains and Motifs | Chondrocytes - secretion | Peptide Fragments - genetics | Chondrocytes - metabolism | Recombinant Proteins - metabolism | Genetic Predisposition to Disease | Peptide Fragments - metabolism | Mutagenesis, Site-Directed | ADAM Proteins - chemistry | Receptors, Interleukin-6 - genetics | Down-Regulation | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Osteoarthritis, Hip - genetics | Proteins - genetics | ADAM Proteins - metabolism | Peptide Fragments - chemistry | Proteins - metabolism | Mutant Proteins - chemistry | Cell Line, Tumor | Proteins - chemistry | ADAM Proteins - genetics | Amino Acid Substitution | Receptors, Interleukin-6 - metabolism
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, p. e44902
Background: Myocilin is a gene linked to the most prevalent form of glaucoma, a major blinding disease. The trabecular meshwork (TM), a specialized eye tissue,... 
PROTEIN-KINASE-A | NON-SECRETION | OPEN-ANGLE GLAUCOMA | SIGNALING PATHWAY | ER STRESS | MULTIDISCIPLINARY SCIENCES | AQUEOUS-HUMOR | OUTFLOW FACILITY | EXTRACELLULAR-MATRIX | INTRAOCULAR-PRESSURE | BETA-CATENIN | Cytoskeletal Proteins - genetics | Humans | Middle Aged | Trabecular Meshwork - drug effects | Actins - metabolism | Glycoproteins - metabolism | Maleimides - pharmacology | Wnt Proteins - metabolism | Young Adult | Transfection | Adult | Cytoskeletal Proteins - metabolism | Indoles - pharmacology | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Eye Proteins - genetics | Trabecular Meshwork - cytology | Caco-2 Cells | Cyclic AMP-Dependent Protein Kinases - metabolism | Glycoproteins - genetics | Focal Adhesions - drug effects | Phenotype | Eye Proteins - metabolism | Signal Transduction - drug effects | Trabecular Meshwork - metabolism | Focal Adhesions - metabolism | Proteins - pharmacology | Mutation | Glaucoma | Genetic aspects | Cyclic adenylic acid | Muscle proteins | Actin | Protein kinases | Protein kinase A | Phosphorylation | Frizzled-related protein | Wnt protein | Frizzled protein | Frizzled-related protein 1 | Genes | Activation | Phalloidin | Kinases | Inactivation | Cell adhesion & migration | Fibers | Proteins | Signal transduction | Biological effects | Stresses | Phenotypes | Deactivation | RhoA protein | Stress | Mutants | Signaling
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, p. e37823
Background: The Dishevelled (Dvl) and Dishevelled-associated activator of morphogenesis 1 (Daam1) pathway triggered by Wnt5a regulates cellular polarity during... 
CONVERGENT EXTENSION MOVEMENTS | SIGNALING PATHWAY | BIOLOGY | CANONICAL WNT PATHWAY | TUMOR-SUPPRESSOR | BETA-CATENIN | UP-REGULATION | DISHEVELLED PHOSPHORYLATION | VERTEBRATE GASTRULATION | FRIZZLED-RELATED PROTEINS | TYROSINE KINASE ROR2 | Proto-Oncogene Proteins - metabolism | RNA, Small Interfering - genetics | Signal Transduction | Humans | rhoA GTP-Binding Protein - metabolism | Phosphoproteins - genetics | Wnt-5a Protein | Phosphoproteins - metabolism | Wnt Proteins - metabolism | Breast - metabolism | Breast Neoplasms - metabolism | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Female | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Dishevelled Proteins | Breast - pathology | Cell Movement | Development and progression | Breast cancer | Metastasis | Reproductive health | Phosphorylation | Frizzled-related protein | Motility | Wnt protein | Leukocyte migration | Laboratories | Frizzled protein | Activation | Neuroblastoma | Cell adhesion & migration | Skin cancer | Morphogenesis | Cell activation | Polarity | Physiology | Pretreatment | Dishevelled protein | Melanoma | RhoA protein | siRNA | Mutants | Signaling | Insects | Plasmids | Pancreatic cancer | Breast | Secreted frizzled-related protein 2 | Cell migration | Cancer | Tumors
Journal Article