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DNA Repair, ISSN 1568-7864, 06/2015, Volume 30, pp. 1 - 10
AlkB proteins are evolutionary conserved Fe(II)/2-oxoglutarate-dependent dioxygenases, which remove alkyl and highly promutagenic etheno(ɛ)-DNA adducts, but... 
1,N6-Ethenoadenine | 3,N4-Ethenocytosine | 1,N2-Ethenoguanine | AlkB | DNA repair | Etheno adducts | 1,N | 3,N | Ethenoguanine | Ethenoadenine | Ethenocytosine | OBESITY-ASSOCIATED FTO | 3,N-4-Ethenocytosine | OXIDATIVE DEMETHYLATION | ESCHERICHIA-COLI | VINYL-CHLORIDE | PRIMARY SUBSTRATE | 1,N-6-Ethenoadenine | METHYLATION DAMAGE | 3-METHYLADENINE DNA | GENETICS & HEREDITY | 1,N-2-Ethenoguanine | TOXICOLOGY | TRANSFER-RNA | N-GLYCOSYLASE | ALKYLATION DAMAGE | AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase | Cytosine - analogs & derivatives | Dioxygenases - metabolism | Guanine - analogs & derivatives | Humans | Substrate Specificity | Xanthomonas campestris - genetics | Mixed Function Oxygenases - metabolism | DNA Adducts - metabolism | Guanine - metabolism | Cytosine - metabolism | DNA Repair Enzymes - metabolism | DNA Glycosylases - metabolism | Xanthomonas campestris - enzymology | Adenine - analogs & derivatives | Escherichia coli - enzymology | Streptomyces - genetics | DNA, Single-Stranded - metabolism | Escherichia coli Proteins - metabolism | DNA - metabolism | Rhizobium etli - enzymology | Bacteria - genetics | Rhizobium etli - genetics | Escherichia coli - genetics | DNA Repair | Mycobacterium tuberculosis - enzymology | AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase | Bacteria - enzymology | Bacterial Proteins - metabolism | Streptomyces - enzymology | Adenine - metabolism | Mycobacterium tuberculosis - genetics | Bacterial genetics | DNA | Index Medicus
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 12/2013, Volume 93, Issue 6, pp. 1061 - 1071
Journal Article
FEBS Letters, ISSN 0014-5793, 10/2008, Volume 582, Issue 23-24, pp. 3313 - 3319
The human obesity susceptibility gene, , encodes a protein that is homologous to the DNA repair AlkB protein. The AlkB family proteins utilize iron(II),... 
FTO | Oxidative demethylation | DNA/RNA repair | ethenocytosine | 1-meA | mFTO | 3-meT | 3-meU | ethenoadenine | 3-methyluracil | morpholino)ethanesulfonic acid | TFA | BSA | α-KG | bovine serium albumin | 1-meG | mouse FTO | HPLC | 3-methylcytosine | thiogalactopyranoside | hFTO | ethylene diamine tetraacetic acid | EDTA | α-ketoglutarate | isopropyl-β | human FTO | high performance liquid chromatography | trifluoroacetic acid | 3-meC | 3-methylthymine | 1-methyladenine | 1-methylguanine | IPTG | MES | HUMAN ALKB PROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | CRYSTAL-STRUCTURES | BACTERIAL | ADULT OBESITY | LESIONS | CELL BIOLOGY | BIOPHYSICS | GENE | MASS | REPAIR ENZYME ALKB | ALKYLATION DAMAGE | Thymine - chemistry | Oxidation-Reduction | DNA, Single-Stranded - metabolism | Humans | Thymine - analogs & derivatives | Recombinant Proteins - chemistry | Substrate Specificity | Alpha-Ketoglutarate-Dependent Dioxygenase FTO | DNA, Single-Stranded - chemistry | Mixed Function Oxygenases | Oxo-Acid-Lyases - chemistry | Animals | Proteins - metabolism | DNA Repair | Uracil - metabolism | Mice | Oxo-Acid-Lyases - metabolism | Proteins - chemistry | Methylation | Thymine - metabolism | Uracil - chemistry | RNA - metabolism | Uracil - analogs & derivatives | Proteins | Liquid chromatography | RNA | DNA | Ethylenediamines | Index Medicus | oxidative demethylation | RNA repair
Journal Article
Oman medical journal, ISSN 1999-768X, 01/2019, Volume 34, Issue 1, pp. 56 - 62
Obesity is a significant risk factor for a number of chronic diseases, including diabetes, cardiovascular diseases, and cancer. Obesity usually results from a... 
Obesity | Body mass index | Analysis | Genes | Body weight | Chronic diseases | Single nucleotide polymorphisms | Research | Cardiovascular diseases | Risk factors | Genetic Polymorphism | Original | FTO Protein, Human | Melanocortin-4 Receptor | Human | FTO Protein
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, pp. e49045 - e49045
The Fe(II)- and 2-oxoglutarate (2OG)-dependent dioxygenase AlkB from E. coli is a demethylase which repairs alkyl lesions in DNA, as well as RNA, through a... 
YEATS DOMAIN | H3K79 METHYLATION | OBESITY-ASSOCIATED FTO | MIXED LINEAGE LEUKEMIA | OXIDATIVE DEMETHYLATION | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | DNA-DAMAGE | TRANSFER-RNA | PHD FINGER-BROMODOMAIN | FAMILY | Cell Line | Protein Binding - genetics | Gene Expression - genetics | HCT116 Cells | Humans | E1A-Associated p300 Protein - genetics | DNA Methylation - genetics | E1A-Associated p300 Protein - metabolism | Protein Structure, Tertiary - genetics | Dioxygenases | Carboxy-Lyases - genetics | DNA - genetics | Transcriptional Elongation Factors - metabolism | Cell Nucleus - metabolism | Cell Nucleus - genetics | AlkB Homolog 4, Lysine Demethylase | HEK293 Cells | Cell Line, Tumor | Transcription, Genetic | Carboxy-Lyases - metabolism | Transcriptional Elongation Factors - genetics | HeLa Cells | Chromatin - genetics | Enzymes | Chromatin | Genetic transcription | RNA | Genes | Transcription factors | Yeast | Transcription | Leukemia | Genomics | Escherichia coli | Homology | Biology | Iron | DNA repair | Proteins | Cell cycle | DNA methylation | Lesions | Localization | Deoxyribonucleic acid--DNA | Dioxygenase | RNA modification | Cloning | Maintenance | Mammals | Gene expression | Ribonucleic acid--RNA | Medical screening | Screens | Overexpression | Placenta | Epigenetics | a-Ketoglutaric acid | Index Medicus | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
by Kilpeläinen, Tuomas and Zillikens, Carola and Stancáková, Alena and Finucane, Francis and Ried, Janina and Langenberg, Claudia and Zhang, Weihua and Beckmann, Jacques and Luan, J and Vandenput, Liesbeth and Styrkarsdottir, Unnur and Zhou, Yanhua and Smith, Albert Vernon and Zhao, Jing Hua and Amin, Najaf and Vedantam, Sailaja and Shin, S.-Y and Haritunians, Talin and Fu, Mao and Feitosa, Mary Furlan and Kumari, Meena and Halldorsson, Bjarni and Tikkanen, Emmi and Mangino, Massimo and Hayward, Caroline and Song, Ci and Arnold, Alice and Oostra, Ben and Campbell, Harry and Cupples, Aienne and Davis, Kathryn and Döring, Angela and Eiriksdottir, Gudny and Estrada Gil, Karol and Fernández-Real, J.M and Garcia, Melissa and Gieger, Christian and Glazer, Nicole and Guiducci, Candace and Hofman, Albert and Humphries, Steve and Isomaa, Bo and Jacobs, Leonie and Jula, Antti and Karasik, David and Karlsson, Magnus and Khaw, Kay-Tee and Kim, Lauren and Kivimaki, Mika and Klopp, Norman and Kuhnel, Brigitte and Kuusisto, Johanna and Liu, Yongmei and Ljunggren, Ö and Lorentzon, Mattias and Luben, Robert and McKnight, Barbara and Mellström, Dan and Mitchell, Braxton and Mooser, Vincent and Moreno, J.M and Männistö, Satu and O'Connell, Jeffery and Pascoe, Laura and Peltonen, Leena Johanna and Peral, Belén and Perola, Markus and Psaty, Bruce and Salomaa, Veikko and Savage, David and Semple, Robert and Skaric-Juric, Tatjana and Sigurdsson, Gunnar and Spector, Timothy and Syvänen, A.-C and Talmud, Philippa and Thorleifsson, Gudmar and Thorsteinsdottir, Unnur and Uitterlinden, Ané and Tikka-Kleemola, Päivi and Vidal-Puig, Antonio and Wild, Sarah and Wright, Alan and Clegg, Deborah and Schadt, Eric and Wilson, James and Rudan, Igor and Ripatti, Samuli and Borecki, Ingrid and Shuldiner, Alan and Ingelsson, Erik and Jansson, J.O and Kaplan, Robert and Gudnason, Vilmundur and Harris, Tamara and Groop, Leif and Kiel, Douglas and Rivadeneira Ramirez, Fernando and Walker, Mark and Barroso, Inês and ... and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Molekylär medicin and Geriatrik and Uppsala universitet and Institutionen för medicinska vetenskaper and Institutionen för folkhälso- och vårdvetenskap
Nature Genetics, ISSN 1061-4036, 08/2011, Volume 43, Issue 8, pp. 753 - 760
Journal Article
Bipolar Disorders, ISSN 1398-5647, 09/2015, Volume 17, Issue 6, pp. 662 - 669
Journal Article
Medicinal Chemistry Research, ISSN 1054-2523, 3/2018, Volume 27, Issue 3, pp. 944 - 953
Journal Article