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The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 02/2018, Volume 141, Issue 2, pp. 704 - 717.e5
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 5, pp. 1629 - 1640.e2
Background Gain-of-function (GOF) mutations in the human signal transducer and activator of transcription 1 (STAT1) manifest in immunodeficiency and... 
Allergy and Immunology | IFN-γ | autoimmunity | follicular T helper cell | TH1 cell | STAT1 gain of function | TH17 cell | T helper cell polarization | ruxolitinib | T | 17 cell | 1 cell | T(H)1 cell | IMMUNOLOGY | CHRONIC MUCOCUTANEOUS CANDIDIASIS | DEFICIENCY | INBORN-ERRORS | IMMUNE DYSREGULATION | IFN-gamma | ALLERGY | T(H)17 cell | DNA | DISEASE | IL-17 IMMUNITY | DIFFERENTIATION | BINDING | IMMUNODEFICIENCY | Th1 Cells - drug effects | Purpura, Thrombocytopenic, Idiopathic - genetics | Candidiasis, Chronic Mucocutaneous - genetics | Humans | Candidiasis, Chronic Mucocutaneous - immunology | Anemia, Hemolytic, Autoimmune - genetics | STAT1 Transcription Factor - genetics | Th1 Cells - immunology | STAT1 Transcription Factor - immunology | Janus Kinases - antagonists & inhibitors | Th17 Cells - drug effects | Purpura, Thrombocytopenic, Idiopathic - immunology | Anemia, Hemolytic, Autoimmune - immunology | Th17 Cells - immunology | Female | Protein Kinase Inhibitors - pharmacology | Mutation | Child | Autoimmunity - drug effects | Cytokines - immunology | Pyrazoles - pharmacology | Autoimmunity | Medical colleges | Immunodeficiency | Stem cells | Bone marrow | Genetic aspects | Transplantation | Interferon | Genetic transcription | Cell differentiation | Polarization | Phosphorylation | Candidiasis | Inhibitor drugs | Transcription | Syngeneic grafts | Differentiation (biology) | Helper cells | Bone marrow transplantation | Stem cell transplantation | Infections | Lymphocytes T | Dephosphorylation | Kinases | Immunology | Lymphocytes | Janus kinase | Remission | Drug therapy | Stat1 protein | Chronic mucocutaneous candidiasis | Functional analysis | Disease control | Patients | Hemopoiesis | Inhibitors | Kinetics | Autoimmune diseases
Journal Article
Diabetes, ISSN 0012-1797, 12/2015, Volume 64, Issue 12, pp. 4285 - 4297
Activation of AMPK suppresses inflammation, but the underlying mechanisms remain poorly understood. This study was designed to characterize the molecular... 
METABOLIC SYNDROME | JAK/STAT PATHWAY | DIABETIC HEART | PROTEIN-KINASE | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | MAP KINASE PHOSPHATASE-1 | ANGIOTENSIN-II | ENDOPLASMIC-RETICULUM STRESS | PROTEASOME FUNCTION | CARDIAC AUTOPHAGY | Vasculitis - metabolism | AMP-Activated Protein Kinases - metabolism | Muscle, Smooth, Vascular - metabolism | Dual Specificity Phosphatase 1 - antagonists & inhibitors | Humans | Vasculitis - pathology | Muscle, Smooth, Vascular - immunology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Vasculitis - immunology | STAT1 Transcription Factor - metabolism | Protein Processing, Post-Translational - drug effects | RNA Interference | STAT1 Transcription Factor - agonists | Angiotensin II - adverse effects | Phosphorylation - drug effects | Vasculitis - chemically induced | Muscle, Smooth, Vascular - drug effects | Recombinant Proteins - metabolism | Dual Specificity Phosphatase 1 - genetics | AMP-Activated Protein Kinases - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Recombinant Proteins - chemistry | Interferon-gamma - adverse effects | Random Allocation | Enzyme Activation - drug effects | STAT1 Transcription Factor - genetics | STAT1 Transcription Factor - antagonists & inhibitors | AMP-Activated Protein Kinases - chemistry | Aorta, Thoracic | Mice, Knockout | Muscle, Smooth, Vascular - pathology | Animals | Dual Specificity Phosphatase 1 - chemistry | MAP Kinase Signaling System - drug effects | Dual Specificity Phosphatase 1 - metabolism | AMP-Activated Protein Kinases - genetics | Molecular mechanics | Genetically modified mice | Inflammation | Research | Protein kinases | Risk factors | Complications
Journal Article
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 06/2018, Volume 141, Issue 6, pp. 2142 - 2155.e5
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 05/2018, Volume 141, Issue 5, pp. 1844 - 1853.e2
Sumoylation is a posttranslational reversible modification of cellular proteins through the conjugation of small ubiquitin-related modifier (SUMO) and... 
Signal transducer and activator of transcription 1 | IFN-γ | sumoylation | small ubiquitin-related modifier | gain of function | Rhodococcus species infection | MOLECULAR-DYNAMICS | OF-FUNCTION MUTATIONS | IMMUNOLOGY | CHRONIC MUCOCUTANEOUS CANDIDIASIS | SOLUBILITY | IFN-gamma | ALLERGY | STAT1 MUTATIONS | INFECTION | SUMO-1 CONJUGATION | PARACRYSTALS | I-TASSER | Cell Line | Sumoylation - genetics | Transcriptional Activation - genetics | Gene Expression - genetics | Candidiasis, Chronic Mucocutaneous - genetics | Gain of Function Mutation - immunology | Humans | Cercopithecus aethiops | Ubiquitin - genetics | Mutation - genetics | STAT1 Transcription Factor - genetics | Esophageal Squamous Cell Carcinoma - genetics | Phosphorylation - genetics | Animals | Transfection - methods | Esophageal Neoplasms - genetics | SUMO-1 Protein - genetics | Transcription, Genetic - genetics | COS Cells | Circuit components | Proteins | Genetic aspects | Genetic transcription | Proteases | Analysis | Ubiquitin | Phosphorylation | Candidiasis | Immunoprecipitation | Disease | Transcription | Laboratories | Chronic infection | Immunoblotting | Rhodococcus | Kinases | Phosphatase | Experiments | SUMO protein | Signal transduction | Transfection | Stat1 protein | Deoxyribonucleic acid--DNA | Squamous cell carcinoma | Cytokines | Chronic mucocutaneous candidiasis | Hypothyroidism | Gene expression | Patients | Molecular chains | Mutants | Esophagus | γ-Interferon | Cell lines | Mutation | Conjugation | Scabies
Journal Article
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, ISSN 0363-6135, 03/2017, Volume 312, Issue 3, pp. H478 - H484
Ischemic preconditioning (IPC), i.e., brief episodes of nonlethal myocardial ischemia-reperfusion (I/R) before sustained ischemia with subsequent reperfusion,... 
INJURY SALVAGE KINASE | MYOCARDIUM | PATHWAYS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | STAT3 | REPERFUSION INJURY | MITOCHONDRIAL-FUNCTION | ischemic preconditioning | PROTECTS | HEART | pigs | INHIBITION | PERIPHERAL VASCULAR DISEASE | GENERATION | CARDIOPROTECTION | Ischemia | Physiological aspects | Cellular signal transduction
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 140, Issue 1, pp. 232 - 241
Journal Article
Journal Article
Current opinion in pediatrics, ISSN 1040-8703, 12/2018, Volume 30, Issue 6, pp. 821 - 828
Journal Article