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1. Full Text Positional differences in reactive hyperemia provide insight into initial phase of exercise hyperemia
by Jasperse, Jeffrey L and Shoemaker, J. Kevin and Gray, Eric J and Clifford, Philip S
Journal of Applied Physiology, ISSN 8750-7587, 09/2015, Volume 119, Issue 5, pp. 569 - 575
Studies have reported a greater blood flow response to muscle contractions when the limb is below the heart compared with above the heart, and these results... 
Skeletal muscle pump | Functional hyperemia | Muscle contraction | Muscle blood flow | BODY POSITION | muscle contraction | SPORT SCIENCES | PHYSIOLOGY | skeletal muscle pump | RAPID VASODILATION | HUMAN FOREARM | functional hyperemia | PUMP | MUSCLE BLOOD-FLOW | SKELETAL-MUSCLE | RHYTHMIC EXERCISE | muscle blood flow | NITRIC-OXIDE | BRIEF CONTRACTION | PERFUSION-PRESSURE | Humans | Rats | Male | Physical Conditioning, Animal - physiology | Plethysmography - methods | Rats, Sprague-Dawley | Blood Pressure Determination - methods | Animals | Hyperemia - physiopathology | Muscle Contraction - physiology | Muscle, Skeletal - physiopathology | Adult | Female | Blood Pressure - physiology | Exercise - physiology | Vasodilation - physiology | Regional Blood Flow - physiology | Brachial Artery - physiology
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2. Full Text Vascular Compartmentalization of Functional Hyperemia from the Synapse to the Pia
by Rungta, Ravi L and Chaigneau, Emmanuelle and Osmanski, Bruno-Félix and Charpak, Serge
Neuron, ISSN 0896-6273, 07/2018, Volume 99, Issue 2, pp. 362 - 375.e4
Functional hyperemia, a regional increase of blood flow triggered by local neural activation, is used to map brain activity in health and disease. However, the... 
blood-brain barrier | microvascular | endothelium | calcium | anesthetized | CBF | neurovascular coupling | neuron | awake | odor | glia | in vivo | hyperpolarization | gap junction | functional imaging | astrocyte | glutamate | neurovascular unit | in vivo | RESPONSES | GAP-JUNCTIONS | OLFACTORY-BULB | CAPILLARY PERICYTES | OLIGODENDROCYTE PRECURSOR CELLS | IN-VIVO | MUSCLE | CEREBRAL-BLOOD-FLOW | NEUROSCIENCES | BRAIN | COMMUNICATION | Glutamate | Neurons | Endothelium | Neurophysiology | Calcium signalling | Neuroimaging | Odors | Brain mapping | Functional magnetic resonance imaging | Pericytes | Smooth muscle | Hyperemia | Capillaries | Velocity | Blood flow
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3. Full Text Maximal hyperemia in the assessment of fractional flow reserve: Intracoronary adenosine versus intracoronary sodium nitroprusside versus intravenous adenosine: The NASCI (nitroprussiato versus adenosina nelle stenosi coronariche intermedie) study
by Leone, Antonio Maria and Porto, Italo and De Caterina, Alberto Ranieri and Basile, Eloisa and Aurelio, Andrea and Gardi, Andrea and Russo, Dolores and Laezza, Domenico and Niccoli, Giampaolo and Burzotta, Francesco and Trani, Carlo and Mazzari, Mario Attilio and Mongiardo, Rocco and Rebuzzi, Antonio Giuseppe and Crea, Filippo
JACC: Cardiovascular Interventions, ISSN 1936-8798, 04/2012, Volume 5, Issue 4, pp. 402 - 408
Objectives: This study sought to compare increasing doses of intracoronary (IC) adenosine or IC sodium nitroprusside versus intravenous (IV) adenosine for... 
adenosine | intermediate coronary stenosis | sodium nitroprusside | fractional flow reserve | ARTERY STENOSES | CARDIAC & CARDIOVASCULAR SYSTEMS | NO-REFLOW | PRESSURE MEASUREMENTS | FUNCTIONAL SEVERITY | HUMANS | FOLLOW-UP | ANGIOPLASTY | ACUTE MYOCARDIAL-INFARCTION | CONTINUOUS-INFUSION | INTERVENTION | Predictive Value of Tests | Prospective Studies | Humans | Middle Aged | Fractional Flow Reserve, Myocardial - drug effects | Male | Atrioventricular Block - chemically induced | Dose-Response Relationship, Drug | Cardiac Catheterization | Rome | Adenosine - adverse effects | Female | Coronary Stenosis - diagnostic imaging | Severity of Illness Index | Nitroprusside - administration & dosage | Adenosine - administration & dosage | Nitroprusside - adverse effects | Myocardial Perfusion Imaging - methods | Coronary Angiography | Algorithms | Coronary Stenosis - physiopathology | Hyperemia - physiopathology | Aged | Infusions, Intravenous | Vasodilator Agents - adverse effects | Vasodilator Agents - administration & dosage | Coronary Stenosis - diagnosis | Infusions, Intra-Arterial | Injections, Intra-Arterial
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4. Full Text Oscillatory lower body negative pressure impairs task related functional hyperemia in healthy volunteers
by Stewart, Julian M and Balakrishnan, Keshawadhana and Visintainer, Paul and Del Pozzi, Andrew T and Messer, Zachary R and Terilli, Courtney and Medow, Marvin S
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 03/2016, Volume 310, Issue 6, pp. H775 - H784
Neurovascular coupling refers to the link between an increase in neural activity in response to a task and an increase in cerebral blood flow denoted... 
Functional hyperemia | Lower body negative pressure | Neurovascular coupling | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | MYOGENIC MECHANISMS | neurovascular coupling | functional hyperemia | CEREBROVASCULAR REGULATION | SPECTRUM ANALYSIS | ASTROCYTES | AUTOREGULATION | LOW-FREQUENCY OSCILLATIONS | lower body negative pressure | MOTOR IMAGERY PARADIGMS | PERIPHERAL VASCULAR DISEASE | CEREBRAL-BLOOD-FLOW | POSTURAL TACHYCARDIA SYNDROME | BRAIN | Cerebrovascular Circulation - physiology | Humans | Lower Body Negative Pressure - methods | Male | Healthy Volunteers | Young Adult | Hyperemia - diagnostic imaging | Ultrasonography, Doppler, Transcranial | Hyperemia - physiopathology | Blood Flow Velocity | Middle Cerebral Artery - physiopathology | Adult | Female | Postural Orthostatic Tachycardia Syndrome - physiopathology | Middle Cerebral Artery - diagnostic imaging | Regional blood flow | Blood pressure | Regulation | Health aspects | Methods | Integrative Cardiovascular Physiology and Pathophysiology
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5. Full Text A physiological model for interpretation of arterial spin labeling reactive hyperemia of calf muscles
by Chen, Hou-Jen and Wright, Graham A
PLoS ONE, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, p. e0183259
To characterize and interpret arterial spin labeling (ASL) reactive hyperemia of calf muscles for a better understanding of the microcirculation in peripheral... 
RESPONSES | MATHEMATICAL-MODEL | INTERSTITIAL ADENOSINE | CONTRACTION | MULTIDISCIPLINARY SCIENCES | FLOW CHEMICAL-REGULATION | MAGNETIC-RESONANCE | BLOOD-FLOW | THEORETICAL-MODEL | HUMAN SKELETAL-MUSCLE | EXERCISE | Models, Theoretical | Peripheral Arterial Disease - physiopathology | Arteries - physiopathology | Humans | Hyperemia - physiopathology | Muscle, Skeletal - physiopathology | Adult | Spin Labels | Case-Control Studies | Muscle, Skeletal - blood supply | Physiological aspects | Microcirculation | Development and progression | Models | Research | Peripheral vascular diseases | Adenosine | Nuclear magnetic resonance--NMR | Thigh | Muscles | Labelling | Biophysics | Marking | Metabolism | Patients | Muscle contraction | Musculoskeletal system | Ischemia | Metabolites | Perfusion | Rodents | Spectrum analysis | Hypoxia | Physiology | Hyperemia | Microvasculature | Diabetes | Veins & arteries | NMR | Nuclear magnetic resonance
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6. Full Text Contribution of non‐endothelium‐dependent substances to exercise hyperaemia: are they O2 dependent?
by Marshall, Janice M and Ray, Clare J
The Journal of Physiology, ISSN 0022-3751, 12/2012, Volume 590, Issue 24, pp. 6307 - 6320
Abstract  This review considers the contributions to exercise hyperaemia of substances released into the interstitial fluid, with emphasis on whether they are... 
INTERSTITIAL METABOLITE RESPONSES | BLOOD-FLOW REGULATION | ARTERIOLAR DILATION | PHYSIOLOGY | IN-VIVO | SYSTEMIC HYPOXIA | NITRIC-OXIDE FORMATION | NEUROSCIENCES | HUMAN SKELETAL-MUSCLE | FUNCTIONAL HYPEREMIA | OXYGEN-UPTAKE | PROSTAGLANDIN SYNTHESIS | Phosphates | Lactates | Medical colleges | Exercise | Nitric oxide | Prostaglandins E | Physiological aspects | Cystic fibrosis | Endothelium | Adenosine | Rodents | From Rest to Maximal Exercise | Symposium Section Reviews | Blood Flow Regulation
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7. Full Text Oscillatory lower body negative pressure impairs working memory task-related functional hyperemia in healthy volunteers
by Merchant, Sana and Medow, Marvin S and Visintainer, Paul and Terilli, Courtney and Stewart, Julian M
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 2017, Volume 312, Issue 4, pp. H672 - H680
Neurovascular coupling (NVC) describes the link between an increase in task-related neural activity and increased cerebral blood flow denoted "functional... 
Functional hyperemia | Lower body negative pressure | Neurovascular coupling | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | MYOGENIC MECHANISMS | INFORMATION | neurovascular coupling | functional hyperemia | CEREBROVASCULAR REGULATION | SPECTRUM ANALYSIS | ASTROCYTES | AUTOREGULATION | LOW-FREQUENCY OSCILLATIONS | lower body negative pressure | PERIPHERAL VASCULAR DISEASE | CEREBRAL-BLOOD-FLOW | POSTURAL TACHYCARDIA SYNDROME | BRAIN | Psychomotor Performance | Memory Disorders - psychology | Humans | Lower Body Negative Pressure - psychology | Male | Cerebrovascular Circulation | Healthy Volunteers | Hyperemia - psychology | Young Adult | Hyperemia - diagnostic imaging | Arterial Pressure | Memory Disorders - etiology | Ultrasonography, Doppler, Transcranial | Hyperemia - physiopathology | Middle Cerebral Artery - physiopathology | Adult | Female | Hemodynamics | Memory, Short-Term
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8. Full Text Nitrate as a source of nitrite and nitric oxide during exercise hyperemia in rat skeletal muscle
by Piknova, Barbora and Park, Ji Won and Kwan (Jeff) Lam, Kai and Schechter, Alan N
Nitric Oxide, ISSN 1089-8603, 05/2016, Volume 55-56, pp. 54 - 61
The presence of nitric oxide (NO) synthase enzymes, mainly the NOS1 isoform, in skeletal muscle had been well established; however in the last decade it has... 
Nitrate | Exercise | Nitrite | Functional hyperemia | Nitric oxide | Skeletal muscle | BACTERIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | RELEASE | CELL BIOLOGY | SYNTHASE | XANTHINE-OXIDASE | REDUCTION | GENERATION | SAMPLES | BLOOD | Xanthine Dehydrogenase - metabolism | Nitrates - metabolism | Nitric Oxide - biosynthesis | Hyperemia - metabolism | Animals | Rats, Wistar | Nitrites - metabolism | Male | Muscle, Skeletal - metabolism | Physical Conditioning, Animal - physiology | Muscles | Enzymes | Vasodilators | functional hyperemia | exercise | nitric oxide | nitrite | nitrate | skeletal muscle
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9. Full Text Role of glial cells in regulating retinal blood flow during flicker-induced hyperemia in cats
by Song, Youngseok and Nagaoka, Taiji and Yoshioka, Takafumi and Nakabayashi, Seigo and Tani, Tomofumi and Yoshida, Akitoshi
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 11/2015, Volume 56, Issue 12, pp. 7551 - 7559
PURPOSE. To investigate how glial cells participate in retinal circulation during flicker stimulation in cats. METHODS. Using laser Doppler velocimetry, we... 
Retinal blood flow | Flicker-induced hyperemia | Gliotoxic compound | Retinal glial cells | Neurovascular coupling | DIABETIC-RETINOPATHY | OPTIC-NERVE HEAD | NADPH DIAPHORASE | NITRIC-OXIDE SYNTHASE | neurovascular coupling | AMINOADIPIC ACID | gliotoxic compound | OPEN-ANGLE GLAUCOMA | retinal blood flow | OPHTHALMOLOGY | retinal glial cells | flicker-induced hyperemia | ARTERIOLES | MULLER CELLS | FUNCTIONAL HYPEREMIA | BRAIN | Electroretinography | Immunohistochemistry | Cats | Neuroglia - pathology | Male | Laser-Doppler Flowmetry | Hyperemia - pathology | Animals | Hyperemia - physiopathology | Retinal Vessels - physiopathology | Female | Photic Stimulation | Regional Blood Flow - physiology | Disease Models, Animal
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10. Full Text Contraction‐evoked vasodilation and functional hyperaemia are compromised in branching skeletal muscle arterioles of young pre‐diabetic mice
by Novielli, N. M and Jackson, D. N
Acta Physiologica, ISSN 1748-1708, 06/2014, Volume 211, Issue 2, pp. 371 - 384
AimTo investigate the effects of pre-diabetes on microvascular network function in contracting skeletal muscle. We hypothesized that pre-diabetes compromises... 
exercise | skeletal muscle | blood flow | diabetes | microcirculation | functional vasodilation | Microcirculation | Exercise | Functional vasodilation | Diabetes | Skeletal muscle | Blood flow | PHYSIOLOGY | OBESE ZUCKER RATS | STIMULATION CHARACTERISTICS | BLOOD-FLOW | IMMEDIATE EXERCISE HYPEREMIA | DIABETES-MELLITUS | IMPAIRED FASTING GLUCOSE | VASCULAR REACTIVITY | RAPID ONSET VASODILATATION | CARDIOVASCULAR RISK-FACTORS | HAMSTER CREMASTER MUSCLE | Mice, Inbred C57BL | Male | Hemodynamics - physiology | Animals | Prediabetic State - physiopathology | Arterioles - physiopathology | Hyperemia - physiopathology | Muscle Contraction - physiology | Muscle, Skeletal - physiopathology | Mice | Vasodilation - physiology | Diabetes Mellitus, Experimental - physiopathology | Muscle, Skeletal - blood supply | Blood vessels | Muscles | Dilatation | Vasodilators | Arteries | Prediabetic state
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11. Full Text Aβ 1-40-Related Reduction in Functional Hyperemia in Mouse Neocortex during Somatosensory Activation
by Kiyoshi Niwa and Linda Younkin and Christine Ebeling and Sherry K. Turner and David Westaway and Steven Younkin and Karen Hsiao Ashe and George A. Carlson and Costantino Iadecola
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2000, Volume 97, Issue 17, pp. 9735 - 9740
Peptides derived from proteolytic processing of the β -amyloid precursor protein (APP), including the amyloid-β peptide (Aβ ), play a critical role in the... 
Somatosensory cortex | Hypercapnia | Biological Sciences | Transgenic animals | Blood vessels | Mice | Hyperemia | Amyloids | Neocortex | Blood | Blood flow | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | VASOACTIVITY | AMYLOID PRECURSOR PROTEIN | GLUCOSE-UTILIZATION | NEUROTOXICITY | functional activation | beta-amyloid | CEREBRAL BLOOD-FLOW | cerebral blood flow | BETA-PROTEIN | Alzheimer's disease | BRAIN | TRANSGENIC MICE | PRESENILIN-1
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12. Full Text Aβ1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation
by Niwa, Kiyoshi and Younkin, Linda and Ebeling, Christine and Turner, Sherry K and Westaway, David and Younkin, Steven and Ashe, Karen Hsiao and Carlson, George A and Iadecola, Costantino
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2000, Volume 97, Issue 17, pp. 9735 - 9740
β-Amyloid | Cerebral blood flow | Alzheimer's disease | Functional activation
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13. Full Text Cyclooxygenase-2 Contributes to Functional Hyperemia in Whisker-Barrel Cortex
by Niwa, Kiyoshi and Araki, Eiichi and Morham, Scott G and Ross, M. Elizabeth and Iadecola, Costantino
Journal of Neuroscience, ISSN 0270-6474, 01/2000, Volume 20, Issue 2, pp. 763 - 770
The prostanoid-synthesizing enzyme cyclooxygenase-2 (COX-2) is expressed in selected cerebral cortical neurons and is involved in synaptic signaling. We sought... 
Glucose use | Cerebral blood flow | Somatosensory activation | COX-2 knock-out mice | 2- deoxyglucose | NS-398 | Prostanoids | INDUCIBLE CYCLOOXYGENASE | STIMULATION | RAT | 2-deoxyglucose | SYNAPTIC ACTIVITY | GLUCOSE-UTILIZATION | NEUROSCIENCES | somatosensory activation | prostanoids | CEREBRAL BLOOD-FLOW | VASOACTIVE INTESTINAL POLYPEPTIDE | NITRIC-OXIDE | NEURONS | cerebral blood flow | glucose use | BRAIN | Cerebrovascular Circulation - physiology | Cyclooxygenase 2 | Nitrobenzenes - pharmacology | Brain - physiology | Regional Blood Flow - drug effects | Isoenzymes - metabolism | Blood Pressure - drug effects | Vibrissae - innervation | Bradykinin - pharmacology | Physical Stimulation | Prostaglandin-Endoperoxide Synthases - genetics | Acetylcholine - pharmacology | Cerebrovascular Circulation - drug effects | Isoenzymes - genetics | Synapses - physiology | Mice, Inbred C57BL | Functional Laterality | Isoenzymes - deficiency | Prostaglandin-Endoperoxide Synthases - deficiency | Organ Specificity | Sulfonamides - pharmacology | Carbon Dioxide - blood | Oxygen - blood | Cyclooxygenase Inhibitors - pharmacology | Mice, Knockout | Brain - drug effects | Somatosensory Cortex - physiology | Animals | Cyclooxygenase 2 Inhibitors | Prostaglandin-Endoperoxide Synthases - metabolism | Glucose - metabolism | Somatosensory Cortex - blood supply | Hyperemia | Mice
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14. Full Text Nox2-Derived Radicals Contribute to Neurovascular and Behavioral Dysfunction in Mice Overexpressing the Amyloid Precursor Protein
by Laibaik Park and Ping Zhou and Rose Pitstick and Carmen Capone and Josef Anrather and Erin H. Norris and Linda Younkin and Steven Younkin and George Carlson and Bruce S. McEwen and Costantino Iadecola
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2008, Volume 105, Issue 4, pp. 1347 - 1352
Alterations in cerebrovascular regulation related to vascular oxidative stress have been implicated in the mechanisms of Alzheimer's disease (AD), but their... 
Oxidases | Oxidative stress | Reactive oxygen species | Transcriptional regulatory elements | Transgenic animals | Protein precursors | Mice | Hyperemia | Amyloids | Alzheimers disease | tg2576 | Cerebral blood flow | Alzheimer's disease | MOUSE-BRAIN | ABNORMALITIES | REDUCES OXIDATIVE DAMAGE | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | BETA-PEPTIDE | MODEL | OXYGEN SPECIES MEDIATE | cerebral blood flow | CEREBRAL-BLOOD-FLOW | FUNCTIONAL HYPEREMIA | TRANSGENIC MICE | Hyperemia - metabolism | Membrane Glycoproteins - metabolism | Humans | Membrane Glycoproteins - biosynthesis | NADPH Oxidases - metabolism | Molecular Sequence Data | Male | Free Radicals - adverse effects | Cerebrovascular Circulation - genetics | Behavioral Symptoms - metabolism | Brain - metabolism | Brain - blood supply | Membrane Glycoproteins - antagonists & inhibitors | Free Radicals - metabolism | NADPH Oxidases - genetics | Female | NADPH Oxidases - biosynthesis | Behavioral Symptoms - physiopathology | Disease Models, Animal | Amino Acid Sequence | Maze Learning - physiology | Brain - physiopathology | Mice, Inbred C57BL | NADPH Oxidases - antagonists & inhibitors | Mice, Transgenic | NADPH Oxidase 2 | Membrane Glycoproteins - genetics | Mice, Knockout | Behavioral Symptoms - genetics | Amyloid beta-Protein Precursor - genetics | Animals | Hyperemia - physiopathology | Hyperemia - genetics | Amyloid beta-Protein Precursor - biosynthesis | Control | Radicals (Chemistry) | Cerebral circulation | Influence | Glycoproteins | Research | Neurovascular diseases | Properties | Index Medicus | Biological Sciences
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15. Full Text Contribution of intravascular versus interstitial purines and nitric oxide in the regulation of exercise hyperaemia in humans
by Hellsten, Y and Nyberg, M and Mortensen, S. P
The Journal of Physiology, ISSN 0022-3751, 10/2012, Volume 590, Issue 20, pp. 5015 - 5023
Abstract  The regulation of blood flow to skeletal muscle involves a complex interaction between several locally formed vasodilators that are produced both in... 
MUSCLE BLOOD-FLOW | PHYSIOLOGY | HUMAN LEG | OXYGEN DELIVERY | ENDOTHELIAL-CELLS | IN-VIVO | ADENOSINE | ERYTHROCYTE | INDUCED ATP RELEASE | NEUROSCIENCES | FUNCTIONAL SYMPATHOLYSIS | INDUCED VASODILATATION | Adenosine - physiology | Humans | Hyperemia - physiopathology | Nitric Oxide - physiology | Exercise - physiology | Muscle, Skeletal - physiology | Adenosine Triphosphate - physiology | Hypertension - physiopathology | Muscle, Skeletal - blood supply | Purines | Adenosine | Sports sciences | Exercise | Metabolites | Laws, regulations and rules | Nitric oxide | Physiological aspects | Muscles | Endothelium | Plasma | Musculoskeletal system | Rodents | Symposium Section Reviews | Red Blood Cell Mechanisms of Tissue Blood Flow Control
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