X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (1229) 1229
Book Review (214) 214
Publication (208) 208
Book Chapter (15) 15
Conference Proceeding (11) 11
Dissertation (7) 7
Book / eBook (3) 3
Government Document (2) 2
Trade Publication Article (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
fxr (917) 917
index medicus (865) 865
animals (547) 547
humans (521) 521
mice (383) 383
nuclear receptor (344) 344
receptors, cytoplasmic and nuclear - metabolism (344) 344
liver (292) 292
male (290) 290
bile acids (280) 280
biochemistry & molecular biology (276) 276
farnesoid x receptor (274) 274
farnesoid-x-receptor (233) 233
identification (224) 224
bile acids and salts - metabolism (221) 221
expression (210) 210
receptors, cytoplasmic and nuclear - genetics (209) 209
metabolism (202) 202
activation (196) 196
liver - metabolism (187) 187
bile-acids (181) 181
pharmacology & pharmacy (179) 179
gastroenterology & hepatology (175) 175
bile (171) 171
cholesterol (171) 171
receptors, cytoplasmic and nuclear - agonists (168) 168
ligands (163) 163
mice, inbred c57bl (161) 161
homeostasis (150) 150
deoxycholic acid (145) 145
nuclear receptors (140) 140
physiological aspects (140) 140
bile acid (130) 130
female (125) 125
cholestasis (121) 121
chemistry, medicinal (120) 120
gene expression (119) 119
bile-acid (117) 117
article (114) 114
orphan nuclear receptor (114) 114
analysis (112) 112
cell biology (109) 109
lipid metabolism (99) 99
endocrinology & metabolism (97) 97
gene-expression (97) 97
mice, knockout (96) 96
rats (93) 93
rodents (89) 89
acids (88) 88
liver - drug effects (85) 85
glucose (84) 84
obesity (84) 84
signal transduction (83) 83
inflammation (82) 82
liver diseases (82) 82
obeticholic acid (77) 77
biophysics (73) 73
disease (73) 73
hep g2 cells (73) 73
research (72) 72
isoxazoles - pharmacology (71) 71
chenodeoxycholic acid - pharmacology (70) 70
tgr5 (70) 70
gastroenterology and hepatology (69) 69
liver - pathology (68) 68
gene expression regulation (67) 67
health aspects (67) 67
ursodeoxycholic acid (64) 64
disease models, animal (62) 62
fxr, farnesoid x receptor (62) 62
cell line, tumor (61) 61
chenodeoxycholic acid (61) 61
hepatocytes - metabolism (61) 61
lipids (61) 61
bile-acid receptor (60) 60
rna, messenger - metabolism (60) 60
salt export pump (59) 59
transcription factors - metabolism (59) 59
dna-binding proteins - metabolism (58) 58
insulin-resistance (58) 58
medicine, research & experimental (58) 58
physiology (57) 57
receptors, cytoplasmic and nuclear - physiology (57) 57
cells, cultured (56) 56
review (56) 56
cell line (55) 55
gene (54) 54
digestive system (53) 53
cholesterol - metabolism (52) 52
genes (51) 51
protein binding (51) 51
proteins (51) 51
apoptosis (50) 50
genetic aspects (50) 50
multidisciplinary sciences (50) 50
receptors (50) 50
chemistry, organic (49) 49
chenodeoxycholic acid - analogs & derivatives (49) 49
fatty liver-disease (49) 49
glucose metabolism (47) 47
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (1230) 1230
Japanese (9) 9
Korean (7) 7
Chinese (6) 6
French (3) 3
Spanish (2) 2
German (1) 1
Persian (1) 1
Polish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
BBA - Molecular Basis of Disease, ISSN 0925-4439, 01/2018, Volume 1864, Issue 1, pp. 45 - 59
The Farnesoid X receptor (FXR) is a nuclear receptor activated by bile acids (BAs). BAs are amphipathic molecules that serve as fat solubilizers in the... 
FXR | Nutrient metabolism | Inflammation | Bile acids | Proliferation | Autophagy
Journal Article
American Journal of Translational Research, 2016, Volume 8, Issue 11, pp. 5118 - 5124
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 11/2019, Volume 194, pp. 105460 - 105460
The bile acid receptor Farnesoid-X-Receptor alpha (FXRα), a member of the nuclear receptor superfamily, is well known for its roles in the enterohepatic tract.... 
Testis | FXRα | hCG signaling | Leydig | Steroidogenesis | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2019, Volume 294, Issue 21, pp. 8529 - 8542
The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of bile acid-activated transcription factors and an important regulator of cell... 
FXR | ACTIVATION | colorectal cancer | bile acid | transcriptional regulation | BIOCHEMISTRY & MOLECULAR BIOLOGY | FXR response element | RISK | IDENTIFICATION | transcriptional repression | INDUCED PROLIFERATION | GENE | matrix metalloproteinase (MMP) | TRANSACTIVATION | oncogenesis | nuclear receptor | INHIBITORS | CHOLECYSTECTOMY | tumor suppressor gene | BILE-ACIDS | gene promoter
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2018, Volume 28, Issue 17, pp. 2879 - 2884
In continuation of our drug discovery program on hyperlipidemia, a series of novel isoxazole-chenodeoxycholic acid hybrids were designed, synthesized and... 
FXR | Hybrids | 3T3-L1 adipocytes | Hyperlipidemia | SREBP-1c | TRIGLYCERIDE | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | IDENTIFICATION | ORPHAN NUCLEAR RECEPTOR | THERAPY | FXR AGONIST | BIOLOGICAL EVALUATION | AGENTS | DERIVATIVES | BILE-ACIDS | Index Medicus
Journal Article
Circulation research, ISSN 0009-7330, 6/2013, Volume 112, Issue 12, pp. 1602 - 1612
Journal Article
Molecular Metabolism, ISSN 2212-8778, 11/2019, Volume 29, pp. 1 - 11
Roux-en-Y gastric bypass surgery (RYGB) improves the first phase of glucose-stimulated insulin secretion (GSIS) in patients with type 2 diabetes. How it does... 
FXR | RYGB | TRPA1 | Diabetes | Insulin secretion
Journal Article
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 12/2017, Volume 1862, Issue 12, pp. 1520 - 1533
Ageing is a major risk factor for various forms of liver and gastrointestinal (GI) disease and genetic background may contribute to the pathogenesis of these... 
FXR | Lipidomics | XBP1 | Intestinal homeostasis | Ageing | Pla2G6 | Index Medicus
Journal Article
Diabetes, ISSN 0012-1797, 06/2012, Volume 61, Issue 6, pp. 1479 - 1489
Type 2 diabetes mellitus is associated with alterations in bile acid (BA) signaling. The aim of our study was to test whether pancreatic beta-cells contribute... 
DIABETES-MELLITUS | FXR | GLUCOSE-HOMEOSTASIS | METABOLISM | ISLETS | LIVER | ENDOCRINOLOGY & METABOLISM | SENSITIVITY | LIGAND | EXPRESSION | PROTECTS
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 12/2018, Volume 28, Issue 23-24, pp. 3726 - 3730
Our group has previously reported a series of isoflavone derivatives with antidyslipidemic activity. With this background, a series of isoflavone analogs of... 
GW4064 | Isoflavone | Lipid accumulation | FXR agonist | Dyslipidemia | ENZYME-ACTIVITIES | FXR | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | IDENTIFICATION | GENISTEIN | NUCLEAR RECEPTOR | FATTY-ACID ESTERS | GLUCOSE | BIOLOGICAL EVALUATION | FARNESOID-X-RECEPTOR | BILE-ACIDS | RNA | Gene expression | Isoflavones
Journal Article
DIGESTIVE DISEASES, ISSN 0257-2753, 2017, Volume 35, Issue 3, pp. 246 - 250
Background:The gut microbiota has a substantial impact on health and disease. The human gut microbiota influences the development and progression of metabolic... 
GERMFREE-RATS | BACTERIA | FXR antagonism | FXR agonisnn | NUCLEAR RECEPTOR | CONJUGATION | OBESITY | LIGANDS | METABOLIC DISEASES | Humanized mouse models | TAURINE | GASTROENTEROLOGY & HEPATOLOGY | N-ACYLTRANSFERASE | EXPRESSION
Journal Article
Autophagy, ISSN 1554-8627, 06/2018, Volume 14, Issue 6, pp. 1011 - 1027
The primary cilia are evolutionarily conserved microtubule-based cellular organelles that perceive metabolic status and thus link the sensory system to... 
kidney | NR1H4/FXR | autophagy | PPARA | ciliogenesis | VERTEBRATE DEVELOPMENT | RENAL CYSTOGENESIS | POLYCYSTIC KIDNEY-DISEASE | NUCLEAR RECEPTORS | ACTIVATED RECEPTOR-ALPHA | DIABETIC-NEPHROPATHY | CELL BIOLOGY | TARGETED DISRUPTION | CYST FORMATION | PEROXISOME PROLIFERATORS | PRIMARY CILIA
Journal Article
Nuclear Receptor Signaling, ISSN 1550-7629, 10/2018, Volume 15, pp. 1550762918801070 - 1550762918801070
Androgens and androgen receptor (AR, NR3C4) clearly play a crucial role in prostate cancer progression. Besides, the link between metabolic disorders and the... 
FXR | prostate cancer | SHP | lipid metabolism | LXR
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 09/2016, Volume 30, Issue 9, pp. 3146 - 3154
Hepatitis B virus (HBV) and bile salt metabolism seem tightly connected. HBV enters hepatocytes by binding to sodium taurocholate cotransporting polypeptide... 
OBETICHOLIC ACID | cccDNA | NUCLEAR RECEPTORS | PGC-1-ALPHA | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | AUTOPHAGY | NATURAL-HISTORY | FXR agonist | CCCDNA FUNCTION | FXR-ALPHA | CELL BIOLOGY | bile salt | BIOLOGY | nuclear receptor | INFECTION | MINICHROMOSOME
Journal Article