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fxr (193) 193
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receptors, cytoplasmic and nuclear - metabolism (106) 106
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Journal of Hepatology, ISSN 0168-8278, 2012, Volume 58, Issue 1, pp. 155 - 168
Summary Bile acid (BA) transporters are critical for maintenance of the enterohepatic BA circulation where BAs exert their multiple physiological functions... 
Gastroenterology and Hepatology | Gallstones | Liver cancer | Bile acids | Fatty liver disease | Cholestasis | Liver regeneration | RAT-LIVER | SALT EXPORT PUMP | GROWTH-FACTOR 19 | ORGANIC ANION TRANSPORTERS | 90-PERCENT PARTIAL-HEPATECTOMY | URSODEOXYCHOLIC ACID | PRIMARY BILIARY-CIRRHOSIS | FARNESOID-X-RECEPTOR | GASTROENTEROLOGY & HEPATOLOGY | PHOSPHOLIPID-ASSOCIATED CHOLELITHIASIS | FAMILIAL INTRAHEPATIC CHOLESTASIS | Animals | Carrier Proteins - metabolism | Cholestasis - metabolism | Membrane Glycoproteins - metabolism | Humans | Liver - metabolism | Bile Acids and Salts - metabolism | Liver Diseases - metabolism | Liver Regeneration - physiology | Receptors, Cytoplasmic and Nuclear - metabolism | Drug resistance in microorganisms | Corticosteroids | Glucagon | Calcifediol | Ursodiol | Deoxycholic acid | Epidermal growth factor | Vitamin D | Physiological aspects | Fibroblast growth factors | Alfacalcidol | IBABP (FABP6, ILBP), intestinal bile acid-binding protein, fatty acid-binding protein 6 | PFIC, progressive familial intrahepatic cholestasis | TNFα, tumor necrosis factor α | 3 (human) | SRC2, p160 steroid receptor coactivator | NAFLD, non-alcoholic fatty liver disease | BA, bile acid | bile acid receptor | 8, cholesterol efflux pump, ATP-binding cassette, subfamily G, member 5 | UDCA, ursodeoxycholic acid | LRH-1 (NR5A2), liver receptor homolog-1 | LCA, lithocholic acid | LXRα (NR1H3), liver X receptor alpha | PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma | OSTαβ, organic solute transporter alpha | ABCG5 | AMPK, AMP activated protein kinase | NASH, non-alcoholic steatohepatitis | SHP (NR0B2), short heterodimer partner | OATP1A2 (SLCO1A2, OATP1, OATP-A, SLC21A3), solute carrier organic anion transporter family, member 1A2 | EGFR, epidermal growth factor receptor | IL6, interleukin 6 | TGR5, G protein-coupled bile acid receptor | PH, partial hepatectomy | AE2, anion exchanger 2 | PSC, primary sclerosing cholangitis | OATP1B1 (SLCO1B1, OATP2, OATP-C, SLC21A6), solute carrier organic anion transporter family, member 1B1 | RARα (NR1B1), retinoic acid receptor alpha | GLP-1, glucagon like peptide 1 | VDR (NR1I1), vitamin D receptor. Please note that for the convenience of better readability and clarity, abbreviations for transporters and nuclear receptors were capitalized throughout this article when symbols were identical for human and rodents | MRP2 (ABCC2), multidrug resistance-associated protein 2, ATP-binding cassette, subfamily C, member 2 | NTCP (SLC10A1), sodium | CAR (NR1I3), constitutive androstane receptor | taurocholate cotransporting polypeptide, solute carrier family 10, member 1 | PPARα (NR1C1), peroxisome proliferator-activated receptor alpha | Review | GR (NR3C1), glucocorticoid receptor | Bile acids, Cholestasis, Fatty liver disease, Gallstones, Liver regeneration, Liver cancer | 19, fibroblast growth factor 15 | Mdr2 | ICP, intrahepatic cholestasis of pregnancy | BRIC, benign recurrent intrahepatic cholestasis | OATP1B3 (SLCO1B3, OATP8, SLC21A8), solute carrier organic anion transporter family, member 1B3 | MRP3 (ABCC3), multidrug resistance-associated protein 3, ATP-binding cassette, subfamily C, member 3 | beta | MDR1 (ABCB1), p-glycoprotein, ATP-binding cassette, subfamily B, member 1 | norUDCA, norursodeoxycholic acid | 6-ECDCA, 6-ethylchenodeoxycholic acid | FXR (NR1H4), farnesoid X receptor | BCRP (ABCG2), breast cancer resistance protein, ATP-binding cassette, subfamily G, member 2 | HNF4α (NR2A1), hepatocyte nuclear factor 4 alpha | PBC, primary biliary cirrhosis | MDR3 (ABCB4), multidrug resistance protein 2 (rodents) | HNF1α, hepatocyte nuclear factor 1 alpha | NR, nuclear receptor | FGF15 | RXRα (NR2B1), retinoid X receptor alpha | PXR (NR1I2), pregnane X receptor | BSEP (ABCB11), bile salt export pump | HCC, hepatocellular carcinoma | MRP4 (ABCC4), multidrug resistance-associated protein 4, ATP-binding cassette, subfamily C, member 4 | TPN, total parenteral nutrition
Journal Article
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, ISSN 0363-6119, 09/2007, Volume 293, Issue 3, pp. 1400 - 1409
The nuclear receptor FXRα (NR1H4) plays a pivotal role in maintaining bile salt and lipid homeostasis by functioning as a bile salt sensor in mammals. In... 
Structure/function relationship | Nuclear receptor | ACID RECEPTOR | FXR | PHYSIOLOGY | structure/function relationship | ALPHA | BAYESIAN PHYLOGENETIC INFERENCE | IDENTIFICATION | ORPHAN NUCLEAR RECEPTOR | BETA | EXPORT PUMP | nuclear receptor | EXPRESSION | BINDING
Journal Article
Molecular Aspects of Medicine, ISSN 0098-2997, 06/2014, Volume 37, Issue 100, pp. 57 - 76
Hepatobiliary bile salt (BS) transporters are critical determinants of BS homeostasis controlling intracellular concentrations of BSs and their enterohepatic... 
Nuclear receptors | ATB-binding cassette transporters | Cholestasis | ORGANIC-SOLUTE-TRANSPORTER | MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | VITAMIN-D-RECEPTOR | NA+/TAUROCHOLATE-COTRANSPORTING POLYPEPTIDE | ORPHAN NUCLEAR RECEPTOR | EXPORT PUMP BSEP | CONSTITUTIVE ANDROSTANE RECEPTOR | PRIMARY BILIARY-CIRRHOSIS | ALPHA-OST-BETA | FARNESOID-X-RECEPTOR | FAMILIAL INTRAHEPATIC CHOLESTASIS | Cholestasis - genetics | Transcriptional Activation - genetics | Cholestasis - therapy | Humans | Gene Expression Regulation | Bile Acids and Salts - metabolism | Symporters - metabolism | Organic Anion Transporters, Sodium-Dependent - genetics | Cholestasis - pathology | ATP-Binding Cassette Transporters - genetics | Biological Transport | ATP Binding Cassette Subfamily B Member 11 | Membrane Transport Proteins - genetics | Symporters - genetics | ATP-Binding Cassette Transporters - metabolism | Membrane Transport Proteins - metabolism | Organic Anion Transporters, Sodium-Dependent - metabolism | Genetic aspects | Genetic transcription | MAF, musculo-aponeurotic fibrosacroma | TNF-α, tumor necrosis factor alpha | NDRG2, NMYC downstrean-regulated gene 2 | RARα (NR1B1), retinoic acid receptor | IL-6, interleukin 6 | ABC, ATP-binding cassette | DCA, deoxycholic acid | GGT, gamma-glutamyl transpeptidase | CARM1, co-activator-associated arginine methyltransferase 1 | SRC2, steroid receptor co-activator 2 | TCDCA, taurochenodeoxycholic acid | MRP2 (ABCC2), multidrug resistance-associated protein 2 | SREBP1, sterol regulatory element-binding protein 1 | ASBT (SLC10A2), apical sodium-dependent bile acid transporter | CA, cholic acid | UDCA, ursodeoxycholic acid | FGF15, fibroblast growth factor 19 | MARE, MAF recognition element | TβMCA, β-tauromuricholic acid | VDR (NR1I1), vitamin D receptor | CBDL, common bile duct ligation | STAT-5, signal transducer and activator of transcription 5 | MCL-1, myeloid cell leukemia factor 1 | PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma | FXRE, FXR response element | LXR (NR1H3), liver X receptor | CtBP, C-terminal binding protein | OSTβ (SLC51A | SHP (NR0B2), short heterodimer partner | PL, phospholipid | BCRP (ABCG2), breast cancer resistance protein | TUDCA, tauroursodeoxycholic acid | OATP, organic anion transporting polypeptide | TCA, taurocholic acid | NTCP (SLC10A1), Na+-taurocholate cotransporting polypeptide solute carrier family 10 member 1 | PSC, primary sclerosing cholangitis | LRH1 (NR5A2), liver receptor homologue 1 | LPS, lipopolysaccharide | MRP3 (ABCC3), multidrug resistance-associated protein 3 | SLC51B), organic solute transporter alpha | TGR5, G protein coupled bile acid receptor | MDR2 (ABCB4), multidrug resistance protein 2 | FXR, farnesoid X receptor (NR1H4) | IR-1, inverse repeat 1 | OCA, obeticholic acid | MRP4 (ABCC4), multidrug resistance-associated protein 4 | AE2 (SLC4A2), anion exchanger 2 | NF-κB, nuclear factor kappa-B | CCl4, carbone tetrachloride | AMPK, AMP-activated protein kinase | ALP, alkaline phosphatase | PPARα (NR1C1), peroxisome proliferator-activated receptor alpha | Review | DILI, drug-induced liver injury | JNK, c-Jun N-terminal kinase | GR (NR3C1), glucocorticoid receptor | BS, bile salt | IL-1β, interleukin-1 beta | cAMP, cyclic adenosine monophosphate | PGC-1α, peroxisome proliferator-activated receptor gamma coactivator-1 alpha | RXRα (NR2B1), retinoid X receptor | VPAC-1, vasoactive intestinal polypeptide activated receptor | ASCOM, activating signal cointegrator-2-containing complex | ICP, intrahepatic cholestasis of pregnancy | GCA, glycocholic acid | MDR1 (ABCB1), multidrug resistance protein 1 | NRF2, nuclear factor erythroid 2-related factor 2 | beta | ALT, alanine aminotransferase | LCA, litocholic acid | BRIC2, benign recurrent intrahepatic cholestasis type 2 | OSTα | CDCA, chenodeoxycholic acid | PBC, primary biliary cirrhosis | HNF1α, hepatocyte nuclear factor 1 alpha | GRE, glucocorticoid response element | TαMCA, α-tauromuricholic acid | FGF19 | PFIC2, progressive familial intrahepatic cholestasis type 2 | PXR (NR1I2), pregnane X receptor | BSEP (ABCB11), bile salt export pump | TPN, total parenteral nutrition | HNF4α, hepatocyte nuclear factor 4 alpha
Journal Article
by Mao, JY and Chen, XQ and Li, WB and Li, J and Yang, H and Qian, JM and Li, JN
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, ISSN 1940-5901, 2018, Volume 11, Issue 8, pp. 8576 - 8584
Background: Down-regulation of farnesoid X Receptor (FXR, NR1H4 gene), a nuclear receptor of bile acids (BA), has been reported in colorectal carcinoma (CRC).... 
MEDICINE, RESEARCH & EXPERIMENTAL | FXR | VARIANTS | single nucleotide polymorphism | X RECEPTOR | Colorectal neoplasms | BILE-ACID RECEPTOR | farnesoid X-activated receptor | NUCLEAR RECEPTOR | COLON-CANCER | ORGANIC SOLUTE TRANSPORTER | DIET | intestinal polyps | ulcerative colitis | EXPRESSION
Journal Article
Journal Article
Hepatology, ISSN 0270-9139, 09/2012, Volume 56, Issue 3, pp. 1034 - 1043
Journal Article
Gastroenterology, ISSN 0016-5085, 2017, Volume 152, Issue 6, pp. 1462 - 1476.e10
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 06/2016, Volume 310, Issue 11, pp. G1044 - G1051
Journal Article