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Publication DateJournal of hepatology, ISSN 0168-8278, 2012, Volume 58, Issue 1, pp. 155 - 168
Gastroenterology and Hepatology | Gallstones | Liver cancer | Bile acids | Fatty liver disease | Cholestasis | Liver regeneration | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Animals | Carrier Proteins - metabolism | Cholestasis - metabolism | Membrane Glycoproteins - metabolism | Humans | Liver - metabolism | Bile Acids and Salts - metabolism | Liver Diseases - metabolism | Liver Regeneration - physiology | Receptors, Cytoplasmic and Nuclear - metabolism | Drug resistance in microorganisms | Corticosteroids | Glucagon | Calcifediol | Ursodiol | Deoxycholic acid | Epidermal growth factor | Vitamin D | Physiological aspects | Fibroblast growth factors | Alfacalcidol | Index Medicus | IBABP (FABP6, ILBP), intestinal bile acid-binding protein, fatty acid-binding protein 6 | PFIC, progressive familial intrahepatic cholestasis | TNFα, tumor necrosis factor α | 3 (human) | SRC2, p160 steroid receptor coactivator | NAFLD, non-alcoholic fatty liver disease | BA, bile acid | bile acid receptor | 8, cholesterol efflux pump, ATP-binding cassette, subfamily G, member 5 | UDCA, ursodeoxycholic acid | LRH-1 (NR5A2), liver receptor homolog-1 | LCA, lithocholic acid | LXRα (NR1H3), liver X receptor alpha | PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma | OSTαβ, organic solute transporter alpha | ABCG5 | AMPK, AMP activated protein kinase | NASH, non-alcoholic steatohepatitis | SHP (NR0B2), short heterodimer partner | OATP1A2 (SLCO1A2, OATP1, OATP-A, SLC21A3), solute carrier organic anion transporter family, member 1A2 | EGFR, epidermal growth factor receptor | IL6, interleukin 6 | TGR5, G protein-coupled bile acid receptor | PH, partial hepatectomy | AE2, anion exchanger 2 | PSC, primary sclerosing cholangitis | OATP1B1 (SLCO1B1, OATP2, OATP-C, SLC21A6), solute carrier organic anion transporter family, member 1B1 | RARα (NR1B1), retinoic acid receptor alpha | GLP-1, glucagon like peptide 1 | VDR (NR1I1), vitamin D receptor. Please note that for the convenience of better readability and clarity, abbreviations for transporters and nuclear receptors were capitalized throughout this article when symbols were identical for human and rodents | MRP2 (ABCC2), multidrug resistance-associated protein 2, ATP-binding cassette, subfamily C, member 2 | NTCP (SLC10A1), sodium | CAR (NR1I3), constitutive androstane receptor | taurocholate cotransporting polypeptide, solute carrier family 10, member 1 | PPARα (NR1C1), peroxisome proliferator-activated receptor alpha | Review | GR (NR3C1), glucocorticoid receptor | Bile acids, Cholestasis, Fatty liver disease, Gallstones, Liver regeneration, Liver cancer | 19, fibroblast growth factor 15 | Mdr2 | ICP, intrahepatic cholestasis of pregnancy | BRIC, benign recurrent intrahepatic cholestasis | OATP1B3 (SLCO1B3, OATP8, SLC21A8), solute carrier organic anion transporter family, member 1B3 | MRP3 (ABCC3), multidrug resistance-associated protein 3, ATP-binding cassette, subfamily C, member 3 | beta | MDR1 (ABCB1), p-glycoprotein, ATP-binding cassette, subfamily B, member 1 | norUDCA, norursodeoxycholic acid | 6-ECDCA, 6-ethylchenodeoxycholic acid | FXR (NR1H4), farnesoid X receptor | BCRP (ABCG2), breast cancer resistance protein, ATP-binding cassette, subfamily G, member 2 | HNF4α (NR2A1), hepatocyte nuclear factor 4 alpha | PBC, primary biliary cirrhosis | MDR3 (ABCB4), multidrug resistance protein 2 (rodents) | HNF1α, hepatocyte nuclear factor 1 alpha | NR, nuclear receptor | FGF15 | RXRα (NR2B1), retinoid X receptor alpha | PXR (NR1I2), pregnane X receptor | BSEP (ABCB11), bile salt export pump | HCC, hepatocellular carcinoma | MRP4 (ABCC4), multidrug resistance-associated protein 4, ATP-binding cassette, subfamily C, member 4 | TPN, total parenteral nutrition
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Loading RightsBioorganic & medicinal chemistry letters, ISSN 0960-894X, 2008, Volume 18, Issue 15, pp. 4339 - 4343
FXR X-ray co-crystal structure | FXR | GW 4064 | Bile acid receptor | Farnesoid X receptor agonist | GSK8062 | NR1H4 | Naphthoic acid | Nuclear receptor modulator | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Medical sciences | Digestive system | Pharmacology. Drug treatments | Transcription Factors - chemistry | Cholestasis - metabolism | Carboxylic Acids - chemical synthesis | Molecular Conformation | Crystallography, X-Ray | Stomach - metabolism | Structure-Activity Relationship | Isoxazoles - chemical synthesis | DNA-Binding Proteins - agonists | Carboxylic Acids - chemistry | Receptors, Cytoplasmic and Nuclear - chemistry | Molecular Structure | Cholestasis - drug therapy | Stomach - drug effects | Carboxylic Acids - pharmacology | Disease Models, Animal | Naphthalenes - chemical synthesis | Naphthalenes - chemistry | Administration, Oral | Rats | Receptors, Cytoplasmic and Nuclear - agonists | Isoxazoles - chemistry | DNA-Binding Proteins - chemistry | Haplorhini | Naphthalenes - pharmacology | Isoxazoles - pharmacology | Cholestasis - pathology | Animals | Dogs | Mice | Transcription Factors - agonists | High technology industry | Bile acids | Index Medicus
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Loading RightsBioorganic & medicinal chemistry letters, ISSN 0960-894X, 2011, Volume 21, Issue 4, pp. 1206 - 1213
Farnesoid X receptor | FXR X-ray co-crystal structure | FXR | GW 4064 | Bile acid receptor | GSK8062 | NR1H4 GSK2324 | Nuclear receptor modulator | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Medical sciences | General and cellular metabolism. Vitamins | Pharmacology. Drug treatments | Isoxazoles - pharmacokinetics | Naphthalenes - chemistry | Protein Structure, Tertiary | Humans | Molecular Conformation | Quinolines - chemistry | Rats | Crystallography, X-Ray | Receptors, Cytoplasmic and Nuclear - agonists | Isoxazoles - chemistry | Isoxazoles - chemical synthesis | Quinolines - chemical synthesis | Quinolines - pharmacokinetics | Animals | Dogs | Fluorescence Resonance Energy Transfer | Ligands | Weight Gain - drug effects | Mice | Blood Glucose - metabolism | Diabetes Mellitus, Experimental - metabolism | Binding Sites | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
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Loading RightsBioorganic & medicinal chemistry letters, ISSN 0960-894X, 06/2009, Volume 19, Issue 11, pp. 2969 - 2973
FXR X-ray co-crystal structure | GW4064 | FXR | Bile acid receptor | Farnesoid X receptor agonist | NR1H4 | Nuclear receptor modulator | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Miscellaneous | Medical sciences | Pharmacology. Drug treatments | Isoxazoles - pharmacology | Animals | Fluorescence Resonance Energy Transfer | Rats | Crystallography, X-Ray | Receptors, Cytoplasmic and Nuclear - agonists | Structure-Activity Relationship | Isoxazoles - chemistry | Isoxazoles - chemical synthesis | Receptors, Cytoplasmic and Nuclear - metabolism | Physiological aspects | Deoxycholic acid | Index Medicus | GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE | OXAZOLES | SYNTHESIS | BIOLOGICAL FUNCTIONS | RECEPTORS | BASIC BIOLOGICAL SCIENCES
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Loading RightsBioorganic & medicinal chemistry letters, ISSN 0960-894X, 2011, Volume 21, Issue 20, pp. 6154 - 6160
Farnesoid X receptor | FXR X-ray co-crystal structure | FXR | GW 4064 | Bile acid receptor | GSK8062 | GSK2324 | NR1H4 | Nuclear receptor modulator | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Medical sciences | General and cellular metabolism. Vitamins | Pharmacology. Drug treatments | Isoxazoles - pharmacology | Amino Acid Sequence | Cell Line | Animals | Humans | Molecular Conformation | Molecular Sequence Data | Receptors, Cytoplasmic and Nuclear - agonists | Stilbenes - chemistry | Isoxazoles - chemistry | Stilbenes - pharmacology | Receptors, Cytoplasmic and Nuclear - metabolism | Physiological aspects | Deoxycholic acid | Index Medicus
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Loading RightsCellular physiology and biochemistry, ISSN 1015-8987, 01/2017, Volume 41, Issue 1, pp. 323 - 338
IFN-I | NR1H4 | FXR | Monocytes | Bile acids | LCMV | Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | CD8-Positive T-Lymphocytes - cytology | Receptors, Cytoplasmic and Nuclear - deficiency | Transcriptional Activation - drug effects | Hepatocytes - metabolism | Kupffer Cells - virology | Lymphocytic Choriomeningitis - metabolism | Hepatocytes - cytology | CD8-Positive T-Lymphocytes - metabolism | Interferon Type I - metabolism | Kupffer Cells - metabolism | Lymphocytic choriomeningitis virus - physiology | Bile Acids and Salts - analysis | Lymphocytic Choriomeningitis - virology | Kupffer Cells - cytology | Lymphocytic Choriomeningitis - pathology | Mice, Inbred C57BL | Cells, Cultured | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Mice, Knockout | Isoxazoles - pharmacology | Up-Regulation - drug effects | Animals | Virus Replication | Mice | Receptors, Cytoplasmic and Nuclear - metabolism | Viruses | Acids | Liver | Rodents | Bile | Index Medicus
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Loading RightsAquatic toxicology, ISSN 0166-445X, 07/2010, Volume 98, Issue 3, pp. 245 - 255
NR1H4 | Medaka | Nuclear receptor | Farnesoid X receptor alpha (FXRα | Toxicology | Life Sciences & Biomedicine | Marine & Freshwater Biology | Science & Technology | Fundamental and applied biological sciences. Psychology | General aspects | Synecology | Fresh water ecosystems | Animal, plant and microbial ecology | Biological and medical sciences | Animal and plant ecology | Applied ecology | Ecotoxicology, biological effects of pollution | Amino Acid Sequence | Transcriptional Activation - genetics | Bile Acids and Salts - pharmacology | Humans | Transcriptional Activation - drug effects | Molecular Sequence Data | Genes, Reporter - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Animals | Protein Isoforms - metabolism | Transfection | Base Sequence | Titrimetry | Fresh Water | Oryzias - genetics | Binding Sites | Protein Isoforms - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Bile acids | Environmental health | Index Medicus
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Loading RightsMolecular aspects of medicine, ISSN 0098-2997, 06/2014, Volume 37, Issue 100, pp. 57 - 76
Nuclear receptors | ATB-binding cassette transporters | Cholestasis | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Cholestasis - genetics | Transcriptional Activation - genetics | Cholestasis - therapy | Humans | Gene Expression Regulation | Bile Acids and Salts - metabolism | Symporters - metabolism | Organic Anion Transporters, Sodium-Dependent - genetics | Cholestasis - pathology | ATP-Binding Cassette Transporters - genetics | Biological Transport | ATP Binding Cassette Subfamily B Member 11 | Membrane Transport Proteins - genetics | Symporters - genetics | ATP-Binding Cassette Transporters - metabolism | Membrane Transport Proteins - metabolism | Organic Anion Transporters, Sodium-Dependent - metabolism | Genetic aspects | Genetic transcription | Index Medicus | MAF, musculo-aponeurotic fibrosacroma | TNF-α, tumor necrosis factor alpha | NDRG2, NMYC downstrean-regulated gene 2 | RARα (NR1B1), retinoic acid receptor | IL-6, interleukin 6 | ABC, ATP-binding cassette | DCA, deoxycholic acid | GGT, gamma-glutamyl transpeptidase | CARM1, co-activator-associated arginine methyltransferase 1 | SRC2, steroid receptor co-activator 2 | TCDCA, taurochenodeoxycholic acid | MRP2 (ABCC2), multidrug resistance-associated protein 2 | SREBP1, sterol regulatory element-binding protein 1 | ASBT (SLC10A2), apical sodium-dependent bile acid transporter | CA, cholic acid | UDCA, ursodeoxycholic acid | FGF15, fibroblast growth factor 19 | MARE, MAF recognition element | TβMCA, β-tauromuricholic acid | VDR (NR1I1), vitamin D receptor | CBDL, common bile duct ligation | STAT-5, signal transducer and activator of transcription 5 | MCL-1, myeloid cell leukemia factor 1 | PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma | FXRE, FXR response element | LXR (NR1H3), liver X receptor | CtBP, C-terminal binding protein | 15 | OSTβ (SLC51A | SHP (NR0B2), short heterodimer partner | PL, phospholipid | BCRP (ABCG2), breast cancer resistance protein | TUDCA, tauroursodeoxycholic acid | OATP, organic anion transporting polypeptide | TCA, taurocholic acid | NTCP (SLC10A1), Na+-taurocholate cotransporting polypeptide solute carrier family 10 member 1 | PSC, primary sclerosing cholangitis | LRH1 (NR5A2), liver receptor homologue 1 | LPS, lipopolysaccharide | MRP3 (ABCC3), multidrug resistance-associated protein 3 | SLC51B), organic solute transporter alpha | TGR5, G protein coupled bile acid receptor | MDR2 (ABCB4), multidrug resistance protein 2 | FXR, farnesoid X receptor (NR1H4) | IR-1, inverse repeat 1 | OCA, obeticholic acid | MRP4 (ABCC4), multidrug resistance-associated protein 4 | AE2 (SLC4A2), anion exchanger 2 | NF-κB, nuclear factor kappa-B | CCl4, carbone tetrachloride | AMPK, AMP-activated protein kinase | ALP, alkaline phosphatase | PPARα (NR1C1), peroxisome proliferator-activated receptor alpha | Review | DILI, drug-induced liver injury | JNK, c-Jun N-terminal kinase | GR (NR3C1), glucocorticoid receptor | BS, bile salt | IL-1β, interleukin-1 beta | cAMP, cyclic adenosine monophosphate | PGC-1α, peroxisome proliferator-activated receptor gamma coactivator-1 alpha | RXRα (NR2B1), retinoid X receptor | VPAC-1, vasoactive intestinal polypeptide activated receptor | ASCOM, activating signal cointegrator-2-containing complex | ICP, intrahepatic cholestasis of pregnancy | GCA, glycocholic acid | MDR1 (ABCB1), multidrug resistance protein 1 | NRF2, nuclear factor erythroid 2-related factor 2 | beta | ALT, alanine aminotransferase | LCA, litocholic acid | BRIC2, benign recurrent intrahepatic cholestasis type 2 | OSTα | CDCA, chenodeoxycholic acid | PBC, primary biliary cirrhosis | HNF1α, hepatocyte nuclear factor 1 alpha | GRE, glucocorticoid response element | TαMCA, α-tauromuricholic acid | FGF19 | PFIC2, progressive familial intrahepatic cholestasis type 2 | PXR (NR1I2), pregnane X receptor | BSEP (ABCB11), bile salt export pump | TPN, total parenteral nutrition | HNF4α, hepatocyte nuclear factor 4 alpha
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