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Publication DateJournal of Hepatology, ISSN 0168-8278, 2012, Volume 58, Issue 1, pp. 155 - 168
Summary Bile acid (BA) transporters are critical for maintenance of the enterohepatic BA circulation where BAs exert their multiple physiological functions...
Gastroenterology and Hepatology | Gallstones | Liver cancer | Bile acids | Fatty liver disease | Cholestasis | Liver regeneration | RAT-LIVER | SALT EXPORT PUMP | GROWTH-FACTOR 19 | ORGANIC ANION TRANSPORTERS | 90-PERCENT PARTIAL-HEPATECTOMY | URSODEOXYCHOLIC ACID | PRIMARY BILIARY-CIRRHOSIS | FARNESOID-X-RECEPTOR | GASTROENTEROLOGY & HEPATOLOGY | PHOSPHOLIPID-ASSOCIATED CHOLELITHIASIS | FAMILIAL INTRAHEPATIC CHOLESTASIS | Animals | Carrier Proteins - metabolism | Cholestasis - metabolism | Membrane Glycoproteins - metabolism | Humans | Liver - metabolism | Bile Acids and Salts - metabolism | Liver Diseases - metabolism | Liver Regeneration - physiology | Receptors, Cytoplasmic and Nuclear - metabolism | Drug resistance in microorganisms | Corticosteroids | Glucagon | Calcifediol | Ursodiol | Deoxycholic acid | Epidermal growth factor | Vitamin D | Physiological aspects | Fibroblast growth factors | Alfacalcidol | IBABP (FABP6, ILBP), intestinal bile acid-binding protein, fatty acid-binding protein 6 | PFIC, progressive familial intrahepatic cholestasis | TNFα, tumor necrosis factor α | 3 (human) | SRC2, p160 steroid receptor coactivator | NAFLD, non-alcoholic fatty liver disease | BA, bile acid | bile acid receptor | 8, cholesterol efflux pump, ATP-binding cassette, subfamily G, member 5 | UDCA, ursodeoxycholic acid | LRH-1 (NR5A2), liver receptor homolog-1 | LCA, lithocholic acid | LXRα (NR1H3), liver X receptor alpha | PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma | OSTαβ, organic solute transporter alpha | ABCG5 | AMPK, AMP activated protein kinase | NASH, non-alcoholic steatohepatitis | SHP (NR0B2), short heterodimer partner | OATP1A2 (SLCO1A2, OATP1, OATP-A, SLC21A3), solute carrier organic anion transporter family, member 1A2 | EGFR, epidermal growth factor receptor | IL6, interleukin 6 | TGR5, G protein-coupled bile acid receptor | PH, partial hepatectomy | AE2, anion exchanger 2 | PSC, primary sclerosing cholangitis | OATP1B1 (SLCO1B1, OATP2, OATP-C, SLC21A6), solute carrier organic anion transporter family, member 1B1 | RARα (NR1B1), retinoic acid receptor alpha | GLP-1, glucagon like peptide 1 | VDR (NR1I1), vitamin D receptor. Please note that for the convenience of better readability and clarity, abbreviations for transporters and nuclear receptors were capitalized throughout this article when symbols were identical for human and rodents | MRP2 (ABCC2), multidrug resistance-associated protein 2, ATP-binding cassette, subfamily C, member 2 | NTCP (SLC10A1), sodium | CAR (NR1I3), constitutive androstane receptor | taurocholate cotransporting polypeptide, solute carrier family 10, member 1 | PPARα (NR1C1), peroxisome proliferator-activated receptor alpha | Review | GR (NR3C1), glucocorticoid receptor | Bile acids, Cholestasis, Fatty liver disease, Gallstones, Liver regeneration, Liver cancer | 19, fibroblast growth factor 15 | Mdr2 | ICP, intrahepatic cholestasis of pregnancy | BRIC, benign recurrent intrahepatic cholestasis | OATP1B3 (SLCO1B3, OATP8, SLC21A8), solute carrier organic anion transporter family, member 1B3 | MRP3 (ABCC3), multidrug resistance-associated protein 3, ATP-binding cassette, subfamily C, member 3 | beta | MDR1 (ABCB1), p-glycoprotein, ATP-binding cassette, subfamily B, member 1 | norUDCA, norursodeoxycholic acid | 6-ECDCA, 6-ethylchenodeoxycholic acid | FXR (NR1H4), farnesoid X receptor | BCRP (ABCG2), breast cancer resistance protein, ATP-binding cassette, subfamily G, member 2 | HNF4α (NR2A1), hepatocyte nuclear factor 4 alpha | PBC, primary biliary cirrhosis | MDR3 (ABCB4), multidrug resistance protein 2 (rodents) | HNF1α, hepatocyte nuclear factor 1 alpha | NR, nuclear receptor | FGF15 | RXRα (NR2B1), retinoid X receptor alpha | PXR (NR1I2), pregnane X receptor | BSEP (ABCB11), bile salt export pump | HCC, hepatocellular carcinoma | MRP4 (ABCC4), multidrug resistance-associated protein 4, ATP-binding cassette, subfamily C, member 4 | TPN, total parenteral nutrition
Gastroenterology and Hepatology | Gallstones | Liver cancer | Bile acids | Fatty liver disease | Cholestasis | Liver regeneration | RAT-LIVER | SALT EXPORT PUMP | GROWTH-FACTOR 19 | ORGANIC ANION TRANSPORTERS | 90-PERCENT PARTIAL-HEPATECTOMY | URSODEOXYCHOLIC ACID | PRIMARY BILIARY-CIRRHOSIS | FARNESOID-X-RECEPTOR | GASTROENTEROLOGY & HEPATOLOGY | PHOSPHOLIPID-ASSOCIATED CHOLELITHIASIS | FAMILIAL INTRAHEPATIC CHOLESTASIS | Animals | Carrier Proteins - metabolism | Cholestasis - metabolism | Membrane Glycoproteins - metabolism | Humans | Liver - metabolism | Bile Acids and Salts - metabolism | Liver Diseases - metabolism | Liver Regeneration - physiology | Receptors, Cytoplasmic and Nuclear - metabolism | Drug resistance in microorganisms | Corticosteroids | Glucagon | Calcifediol | Ursodiol | Deoxycholic acid | Epidermal growth factor | Vitamin D | Physiological aspects | Fibroblast growth factors | Alfacalcidol | IBABP (FABP6, ILBP), intestinal bile acid-binding protein, fatty acid-binding protein 6 | PFIC, progressive familial intrahepatic cholestasis | TNFα, tumor necrosis factor α | 3 (human) | SRC2, p160 steroid receptor coactivator | NAFLD, non-alcoholic fatty liver disease | BA, bile acid | bile acid receptor | 8, cholesterol efflux pump, ATP-binding cassette, subfamily G, member 5 | UDCA, ursodeoxycholic acid | LRH-1 (NR5A2), liver receptor homolog-1 | LCA, lithocholic acid | LXRα (NR1H3), liver X receptor alpha | PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma | OSTαβ, organic solute transporter alpha | ABCG5 | AMPK, AMP activated protein kinase | NASH, non-alcoholic steatohepatitis | SHP (NR0B2), short heterodimer partner | OATP1A2 (SLCO1A2, OATP1, OATP-A, SLC21A3), solute carrier organic anion transporter family, member 1A2 | EGFR, epidermal growth factor receptor | IL6, interleukin 6 | TGR5, G protein-coupled bile acid receptor | PH, partial hepatectomy | AE2, anion exchanger 2 | PSC, primary sclerosing cholangitis | OATP1B1 (SLCO1B1, OATP2, OATP-C, SLC21A6), solute carrier organic anion transporter family, member 1B1 | RARα (NR1B1), retinoic acid receptor alpha | GLP-1, glucagon like peptide 1 | VDR (NR1I1), vitamin D receptor. Please note that for the convenience of better readability and clarity, abbreviations for transporters and nuclear receptors were capitalized throughout this article when symbols were identical for human and rodents | MRP2 (ABCC2), multidrug resistance-associated protein 2, ATP-binding cassette, subfamily C, member 2 | NTCP (SLC10A1), sodium | CAR (NR1I3), constitutive androstane receptor | taurocholate cotransporting polypeptide, solute carrier family 10, member 1 | PPARα (NR1C1), peroxisome proliferator-activated receptor alpha | Review | GR (NR3C1), glucocorticoid receptor | Bile acids, Cholestasis, Fatty liver disease, Gallstones, Liver regeneration, Liver cancer | 19, fibroblast growth factor 15 | Mdr2 | ICP, intrahepatic cholestasis of pregnancy | BRIC, benign recurrent intrahepatic cholestasis | OATP1B3 (SLCO1B3, OATP8, SLC21A8), solute carrier organic anion transporter family, member 1B3 | MRP3 (ABCC3), multidrug resistance-associated protein 3, ATP-binding cassette, subfamily C, member 3 | beta | MDR1 (ABCB1), p-glycoprotein, ATP-binding cassette, subfamily B, member 1 | norUDCA, norursodeoxycholic acid | 6-ECDCA, 6-ethylchenodeoxycholic acid | FXR (NR1H4), farnesoid X receptor | BCRP (ABCG2), breast cancer resistance protein, ATP-binding cassette, subfamily G, member 2 | HNF4α (NR2A1), hepatocyte nuclear factor 4 alpha | PBC, primary biliary cirrhosis | MDR3 (ABCB4), multidrug resistance protein 2 (rodents) | HNF1α, hepatocyte nuclear factor 1 alpha | NR, nuclear receptor | FGF15 | RXRα (NR2B1), retinoid X receptor alpha | PXR (NR1I2), pregnane X receptor | BSEP (ABCB11), bile salt export pump | HCC, hepatocellular carcinoma | MRP4 (ABCC4), multidrug resistance-associated protein 4, ATP-binding cassette, subfamily C, member 4 | TPN, total parenteral nutrition
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Loading RightsAmerican Journal of Physiology - Regulatory, Integrative and Comparative Physiology, ISSN 0363-6119, 09/2007, Volume 293, Issue 3, pp. 1400 - 1409
The nuclear receptor FXRα (NR1H4) plays a pivotal role in maintaining bile salt and lipid homeostasis by functioning as a bile salt sensor in mammals. In...
Structure/function relationship | Nuclear receptor | ACID RECEPTOR | FXR | PHYSIOLOGY | structure/function relationship | ALPHA | BAYESIAN PHYLOGENETIC INFERENCE | IDENTIFICATION | ORPHAN NUCLEAR RECEPTOR | BETA | EXPORT PUMP | nuclear receptor | EXPRESSION | BINDING
Structure/function relationship | Nuclear receptor | ACID RECEPTOR | FXR | PHYSIOLOGY | structure/function relationship | ALPHA | BAYESIAN PHYLOGENETIC INFERENCE | IDENTIFICATION | ORPHAN NUCLEAR RECEPTOR | BETA | EXPORT PUMP | nuclear receptor | EXPRESSION | BINDING
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Loading RightsMolecular Aspects of Medicine, ISSN 0098-2997, 06/2014, Volume 37, Issue 100, pp. 57 - 76
Hepatobiliary bile salt (BS) transporters are critical determinants of BS homeostasis controlling intracellular concentrations of BSs and their enterohepatic...
Nuclear receptors | ATB-binding cassette transporters | Cholestasis | ORGANIC-SOLUTE-TRANSPORTER | MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | VITAMIN-D-RECEPTOR | NA+/TAUROCHOLATE-COTRANSPORTING POLYPEPTIDE | ORPHAN NUCLEAR RECEPTOR | EXPORT PUMP BSEP | CONSTITUTIVE ANDROSTANE RECEPTOR | PRIMARY BILIARY-CIRRHOSIS | ALPHA-OST-BETA | FARNESOID-X-RECEPTOR | FAMILIAL INTRAHEPATIC CHOLESTASIS | Cholestasis - genetics | Transcriptional Activation - genetics | Cholestasis - therapy | Humans | Gene Expression Regulation | Bile Acids and Salts - metabolism | Symporters - metabolism | Organic Anion Transporters, Sodium-Dependent - genetics | Cholestasis - pathology | ATP-Binding Cassette Transporters - genetics | Biological Transport | ATP Binding Cassette Subfamily B Member 11 | Membrane Transport Proteins - genetics | Symporters - genetics | ATP-Binding Cassette Transporters - metabolism | Membrane Transport Proteins - metabolism | Organic Anion Transporters, Sodium-Dependent - metabolism | Genetic aspects | Genetic transcription | MAF, musculo-aponeurotic fibrosacroma | TNF-α, tumor necrosis factor alpha | NDRG2, NMYC downstrean-regulated gene 2 | RARα (NR1B1), retinoic acid receptor | IL-6, interleukin 6 | ABC, ATP-binding cassette | DCA, deoxycholic acid | GGT, gamma-glutamyl transpeptidase | CARM1, co-activator-associated arginine methyltransferase 1 | SRC2, steroid receptor co-activator 2 | TCDCA, taurochenodeoxycholic acid | MRP2 (ABCC2), multidrug resistance-associated protein 2 | SREBP1, sterol regulatory element-binding protein 1 | ASBT (SLC10A2), apical sodium-dependent bile acid transporter | CA, cholic acid | UDCA, ursodeoxycholic acid | FGF15, fibroblast growth factor 19 | MARE, MAF recognition element | TβMCA, β-tauromuricholic acid | VDR (NR1I1), vitamin D receptor | CBDL, common bile duct ligation | STAT-5, signal transducer and activator of transcription 5 | MCL-1, myeloid cell leukemia factor 1 | PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma | FXRE, FXR response element | LXR (NR1H3), liver X receptor | CtBP, C-terminal binding protein | OSTβ (SLC51A | SHP (NR0B2), short heterodimer partner | PL, phospholipid | BCRP (ABCG2), breast cancer resistance protein | TUDCA, tauroursodeoxycholic acid | OATP, organic anion transporting polypeptide | TCA, taurocholic acid | NTCP (SLC10A1), Na+-taurocholate cotransporting polypeptide solute carrier family 10 member 1 | PSC, primary sclerosing cholangitis | LRH1 (NR5A2), liver receptor homologue 1 | LPS, lipopolysaccharide | MRP3 (ABCC3), multidrug resistance-associated protein 3 | SLC51B), organic solute transporter alpha | TGR5, G protein coupled bile acid receptor | MDR2 (ABCB4), multidrug resistance protein 2 | FXR, farnesoid X receptor (NR1H4) | IR-1, inverse repeat 1 | OCA, obeticholic acid | MRP4 (ABCC4), multidrug resistance-associated protein 4 | AE2 (SLC4A2), anion exchanger 2 | NF-κB, nuclear factor kappa-B | CCl4, carbone tetrachloride | AMPK, AMP-activated protein kinase | ALP, alkaline phosphatase | PPARα (NR1C1), peroxisome proliferator-activated receptor alpha | Review | DILI, drug-induced liver injury | JNK, c-Jun N-terminal kinase | GR (NR3C1), glucocorticoid receptor | BS, bile salt | IL-1β, interleukin-1 beta | cAMP, cyclic adenosine monophosphate | PGC-1α, peroxisome proliferator-activated receptor gamma coactivator-1 alpha | RXRα (NR2B1), retinoid X receptor | VPAC-1, vasoactive intestinal polypeptide activated receptor | ASCOM, activating signal cointegrator-2-containing complex | ICP, intrahepatic cholestasis of pregnancy | GCA, glycocholic acid | MDR1 (ABCB1), multidrug resistance protein 1 | NRF2, nuclear factor erythroid 2-related factor 2 | beta | ALT, alanine aminotransferase | LCA, litocholic acid | BRIC2, benign recurrent intrahepatic cholestasis type 2 | OSTα | CDCA, chenodeoxycholic acid | PBC, primary biliary cirrhosis | HNF1α, hepatocyte nuclear factor 1 alpha | GRE, glucocorticoid response element | TαMCA, α-tauromuricholic acid | FGF19 | PFIC2, progressive familial intrahepatic cholestasis type 2 | PXR (NR1I2), pregnane X receptor | BSEP (ABCB11), bile salt export pump | TPN, total parenteral nutrition | HNF4α, hepatocyte nuclear factor 4 alpha
Nuclear receptors | ATB-binding cassette transporters | Cholestasis | ORGANIC-SOLUTE-TRANSPORTER | MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | VITAMIN-D-RECEPTOR | NA+/TAUROCHOLATE-COTRANSPORTING POLYPEPTIDE | ORPHAN NUCLEAR RECEPTOR | EXPORT PUMP BSEP | CONSTITUTIVE ANDROSTANE RECEPTOR | PRIMARY BILIARY-CIRRHOSIS | ALPHA-OST-BETA | FARNESOID-X-RECEPTOR | FAMILIAL INTRAHEPATIC CHOLESTASIS | Cholestasis - genetics | Transcriptional Activation - genetics | Cholestasis - therapy | Humans | Gene Expression Regulation | Bile Acids and Salts - metabolism | Symporters - metabolism | Organic Anion Transporters, Sodium-Dependent - genetics | Cholestasis - pathology | ATP-Binding Cassette Transporters - genetics | Biological Transport | ATP Binding Cassette Subfamily B Member 11 | Membrane Transport Proteins - genetics | Symporters - genetics | ATP-Binding Cassette Transporters - metabolism | Membrane Transport Proteins - metabolism | Organic Anion Transporters, Sodium-Dependent - metabolism | Genetic aspects | Genetic transcription | MAF, musculo-aponeurotic fibrosacroma | TNF-α, tumor necrosis factor alpha | NDRG2, NMYC downstrean-regulated gene 2 | RARα (NR1B1), retinoic acid receptor | IL-6, interleukin 6 | ABC, ATP-binding cassette | DCA, deoxycholic acid | GGT, gamma-glutamyl transpeptidase | CARM1, co-activator-associated arginine methyltransferase 1 | SRC2, steroid receptor co-activator 2 | TCDCA, taurochenodeoxycholic acid | MRP2 (ABCC2), multidrug resistance-associated protein 2 | SREBP1, sterol regulatory element-binding protein 1 | ASBT (SLC10A2), apical sodium-dependent bile acid transporter | CA, cholic acid | UDCA, ursodeoxycholic acid | FGF15, fibroblast growth factor 19 | MARE, MAF recognition element | TβMCA, β-tauromuricholic acid | VDR (NR1I1), vitamin D receptor | CBDL, common bile duct ligation | STAT-5, signal transducer and activator of transcription 5 | MCL-1, myeloid cell leukemia factor 1 | PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma | FXRE, FXR response element | LXR (NR1H3), liver X receptor | CtBP, C-terminal binding protein | OSTβ (SLC51A | SHP (NR0B2), short heterodimer partner | PL, phospholipid | BCRP (ABCG2), breast cancer resistance protein | TUDCA, tauroursodeoxycholic acid | OATP, organic anion transporting polypeptide | TCA, taurocholic acid | NTCP (SLC10A1), Na+-taurocholate cotransporting polypeptide solute carrier family 10 member 1 | PSC, primary sclerosing cholangitis | LRH1 (NR5A2), liver receptor homologue 1 | LPS, lipopolysaccharide | MRP3 (ABCC3), multidrug resistance-associated protein 3 | SLC51B), organic solute transporter alpha | TGR5, G protein coupled bile acid receptor | MDR2 (ABCB4), multidrug resistance protein 2 | FXR, farnesoid X receptor (NR1H4) | IR-1, inverse repeat 1 | OCA, obeticholic acid | MRP4 (ABCC4), multidrug resistance-associated protein 4 | AE2 (SLC4A2), anion exchanger 2 | NF-κB, nuclear factor kappa-B | CCl4, carbone tetrachloride | AMPK, AMP-activated protein kinase | ALP, alkaline phosphatase | PPARα (NR1C1), peroxisome proliferator-activated receptor alpha | Review | DILI, drug-induced liver injury | JNK, c-Jun N-terminal kinase | GR (NR3C1), glucocorticoid receptor | BS, bile salt | IL-1β, interleukin-1 beta | cAMP, cyclic adenosine monophosphate | PGC-1α, peroxisome proliferator-activated receptor gamma coactivator-1 alpha | RXRα (NR2B1), retinoid X receptor | VPAC-1, vasoactive intestinal polypeptide activated receptor | ASCOM, activating signal cointegrator-2-containing complex | ICP, intrahepatic cholestasis of pregnancy | GCA, glycocholic acid | MDR1 (ABCB1), multidrug resistance protein 1 | NRF2, nuclear factor erythroid 2-related factor 2 | beta | ALT, alanine aminotransferase | LCA, litocholic acid | BRIC2, benign recurrent intrahepatic cholestasis type 2 | OSTα | CDCA, chenodeoxycholic acid | PBC, primary biliary cirrhosis | HNF1α, hepatocyte nuclear factor 1 alpha | GRE, glucocorticoid response element | TαMCA, α-tauromuricholic acid | FGF19 | PFIC2, progressive familial intrahepatic cholestasis type 2 | PXR (NR1I2), pregnane X receptor | BSEP (ABCB11), bile salt export pump | TPN, total parenteral nutrition | HNF4α, hepatocyte nuclear factor 4 alpha
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Loading RightsAquatic Toxicology, ISSN 0166-445X, 07/2010, Volume 98, Issue 3, pp. 245 - 255
The nuclear receptor farnesoid X receptor alpha (FXRα, NR1H4) is activated by bile acids in multiple species including mouse, rat, and human and in this study...
NR1H4 | Medaka | Nuclear receptor | Farnesoid X receptor alpha (FXRα | FXR | Farnesoid X receptor alpha (FXR alpha NR1H4) | BILE-ACID RECEPTOR | PROVIDES EVIDENCE | IDENTIFICATION | ORPHAN NUCLEAR RECEPTOR | EVOLUTION | DIETHYLNITROSAMINE | MARINE & FRESHWATER BIOLOGY | LIVER | TELEOST FISH | TOXICOLOGY | LIGAND | Amino Acid Sequence | Transcriptional Activation - genetics | Bile Acids and Salts - pharmacology | Humans | Transcriptional Activation - drug effects | Molecular Sequence Data | Genes, Reporter - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Animals | Protein Isoforms - metabolism | Transfection | Base Sequence | Titrimetry | Fresh Water | Oryzias - genetics | Binding Sites | Protein Isoforms - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Bile acids | Environmental health | Index Medicus
NR1H4 | Medaka | Nuclear receptor | Farnesoid X receptor alpha (FXRα | FXR | Farnesoid X receptor alpha (FXR alpha NR1H4) | BILE-ACID RECEPTOR | PROVIDES EVIDENCE | IDENTIFICATION | ORPHAN NUCLEAR RECEPTOR | EVOLUTION | DIETHYLNITROSAMINE | MARINE & FRESHWATER BIOLOGY | LIVER | TELEOST FISH | TOXICOLOGY | LIGAND | Amino Acid Sequence | Transcriptional Activation - genetics | Bile Acids and Salts - pharmacology | Humans | Transcriptional Activation - drug effects | Molecular Sequence Data | Genes, Reporter - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Animals | Protein Isoforms - metabolism | Transfection | Base Sequence | Titrimetry | Fresh Water | Oryzias - genetics | Binding Sites | Protein Isoforms - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Bile acids | Environmental health | Index Medicus
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Loading RightsINTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, ISSN 1940-5901, 2018, Volume 11, Issue 8, pp. 8576 - 8584
Background: Down-regulation of farnesoid X Receptor (FXR, NR1H4 gene), a nuclear receptor of bile acids (BA), has been reported in colorectal carcinoma (CRC)....
MEDICINE, RESEARCH & EXPERIMENTAL | FXR | VARIANTS | single nucleotide polymorphism | X RECEPTOR | Colorectal neoplasms | BILE-ACID RECEPTOR | farnesoid X-activated receptor | NUCLEAR RECEPTOR | COLON-CANCER | ORGANIC SOLUTE TRANSPORTER | DIET | intestinal polyps | ulcerative colitis | EXPRESSION
MEDICINE, RESEARCH & EXPERIMENTAL | FXR | VARIANTS | single nucleotide polymorphism | X RECEPTOR | Colorectal neoplasms | BILE-ACID RECEPTOR | farnesoid X-activated receptor | NUCLEAR RECEPTOR | COLON-CANCER | ORGANIC SOLUTE TRANSPORTER | DIET | intestinal polyps | ulcerative colitis | EXPRESSION
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Breast Cancer Research and Treatment, ISSN 0167-6806, 6/2009, Volume 115, Issue 3, pp. 523 - 535
The farnesoid X receptor (FXR, NR1H4), a member of the nuclear receptor superfamily of ligand-dependent transcription factors, is normally produced in the...
Immunohistochemistry | Estrogen receptor | Ki-67 | Bile acids | Medicine & Public Health | NR1H4 | Oncology | Breast cancer | BILE-ACID | FXR | ACTIVATION | DIETARY-FAT | CYCLIN D1 | CYST FLUID | IDENTIFICATION | NUCLEAR RECEPTOR | CDK INHIBITORS | ONCOLOGY | PROGRESSION | Cell Proliferation | Immunoprecipitation | Neoplasm Invasiveness | Humans | Middle Aged | RNA, Messenger - genetics | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Immunoenzyme Techniques | Breast Neoplasms - metabolism | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Gastrointestinal Agents - pharmacology | Fluorescent Antibody Technique | Aged, 80 and over | Chenodeoxycholic Acid - pharmacology | Postmenopause | Adult | Estrogen Receptor alpha - metabolism | Female | Aged | Tumor Cells, Cultured | Receptors, Cytoplasmic and Nuclear - metabolism
Immunohistochemistry | Estrogen receptor | Ki-67 | Bile acids | Medicine & Public Health | NR1H4 | Oncology | Breast cancer | BILE-ACID | FXR | ACTIVATION | DIETARY-FAT | CYCLIN D1 | CYST FLUID | IDENTIFICATION | NUCLEAR RECEPTOR | CDK INHIBITORS | ONCOLOGY | PROGRESSION | Cell Proliferation | Immunoprecipitation | Neoplasm Invasiveness | Humans | Middle Aged | RNA, Messenger - genetics | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Immunoenzyme Techniques | Breast Neoplasms - metabolism | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Gastrointestinal Agents - pharmacology | Fluorescent Antibody Technique | Aged, 80 and over | Chenodeoxycholic Acid - pharmacology | Postmenopause | Adult | Estrogen Receptor alpha - metabolism | Female | Aged | Tumor Cells, Cultured | Receptors, Cytoplasmic and Nuclear - metabolism
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Loading RightsHepatology, ISSN 0270-9139, 09/2012, Volume 56, Issue 3, pp. 1034 - 1043
Activation of farnesoid X receptor (Fxr, Nr1h4) is a major mechanism in suppressing bile‐acid synthesis by reducing the expression levels of genes encoding key...
SIGNAL | FXR | ACTIVATION | HOMEOSTASIS | PHOSPHORYLATION | FEEDBACK-REGULATION | LIVER | CHOLESTEROL 7-ALPHA-HYDROXYLASE | GASTROENTEROLOGY & HEPATOLOGY | MOLECULAR-BASIS | NUCLEAR RECEPTOR | Gene Expression | Animals | Bile Acids and Salts - biosynthesis | Bile Acids and Salts - genetics | Receptors, Cytoplasmic and Nuclear - physiology | Mice | Mice, Knockout | Acids | Kinases | Gene expression | Rodents | Hepatology | Index Medicus | FGF15 | SHP | Bile Acids | MAPK
SIGNAL | FXR | ACTIVATION | HOMEOSTASIS | PHOSPHORYLATION | FEEDBACK-REGULATION | LIVER | CHOLESTEROL 7-ALPHA-HYDROXYLASE | GASTROENTEROLOGY & HEPATOLOGY | MOLECULAR-BASIS | NUCLEAR RECEPTOR | Gene Expression | Animals | Bile Acids and Salts - biosynthesis | Bile Acids and Salts - genetics | Receptors, Cytoplasmic and Nuclear - physiology | Mice | Mice, Knockout | Acids | Kinases | Gene expression | Rodents | Hepatology | Index Medicus | FGF15 | SHP | Bile Acids | MAPK
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Loading RightsGastroenterology, ISSN 0016-5085, 2017, Volume 152, Issue 6, pp. 1462 - 1476.e10
Background & Aims The nuclear receptor subfamily 1 group H member 4 (NR1H4 or farnesoid X receptor [FXR]) regulates bile acid synthesis, transport, and...
Gastroenterology and Hepatology | INT-747 | Cps1 | Glutamine Synthetase | Liver Proteome | BILE-ACID | FXR | HOMEOSTASIS | QUANTIFICATION | LIVER | ENERGY-METABOLISM | GASTROENTEROLOGY & HEPATOLOGY | TRANSCRIPTIONAL REGULATION | EXPRESSION | UREA | PROTEOMICS | Dietary Proteins - administration & dosage | Gene Expression | Glutamine - biosynthesis | Liver - enzymology | Rats, Wistar | Ammonia - metabolism | Liver - metabolism | Mice, Inbred C57BL | Metabolome | Rats | Bile Acids and Salts - metabolism | Male | Proteome | Receptors, Cytoplasmic and Nuclear - genetics | Chenodeoxycholic Acid - analogs & derivatives | Mice, Knockout | Animals | Hepatocytes | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Chenodeoxycholic Acid - pharmacology | Urea - metabolism | Mice | Receptors, Cytoplasmic and Nuclear - metabolism | Proteins | Glucose metabolism | Analysis | Liver | Physiological aspects | Amino acids | Deoxycholic acid | Liver diseases | Metabolites | Gene expression | Glutamine
Gastroenterology and Hepatology | INT-747 | Cps1 | Glutamine Synthetase | Liver Proteome | BILE-ACID | FXR | HOMEOSTASIS | QUANTIFICATION | LIVER | ENERGY-METABOLISM | GASTROENTEROLOGY & HEPATOLOGY | TRANSCRIPTIONAL REGULATION | EXPRESSION | UREA | PROTEOMICS | Dietary Proteins - administration & dosage | Gene Expression | Glutamine - biosynthesis | Liver - enzymology | Rats, Wistar | Ammonia - metabolism | Liver - metabolism | Mice, Inbred C57BL | Metabolome | Rats | Bile Acids and Salts - metabolism | Male | Proteome | Receptors, Cytoplasmic and Nuclear - genetics | Chenodeoxycholic Acid - analogs & derivatives | Mice, Knockout | Animals | Hepatocytes | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Chenodeoxycholic Acid - pharmacology | Urea - metabolism | Mice | Receptors, Cytoplasmic and Nuclear - metabolism | Proteins | Glucose metabolism | Analysis | Liver | Physiological aspects | Amino acids | Deoxycholic acid | Liver diseases | Metabolites | Gene expression | Glutamine
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Loading RightsJOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 04/2006, Volume 116, Issue 4, pp. 1102 - 1109
The bile acid receptor farnesoid X receptor (FXR; NR1H4) is a central regulator of bile acid and lipid metabolism. We show here that FXR plays a key regulatory...
DIABETES-MELLITUS | MEDICINE, RESEARCH & EXPERIMENTAL | FXR | ACTIVATION | NEGATIVE FEEDBACK-REGULATION | INCREASED BETA-OXIDATION | INSULIN-RESISTANCE | GENE-EXPRESSION | MICE | BILE-ACID BIOSYNTHESIS | ORPHAN NUCLEAR RECEPTOR | Homeostasis | Muscle, Skeletal - metabolism | Muscle, Skeletal - cytology | DNA-Binding Proteins - metabolism | Kidney - metabolism | Time Factors | Gluconeogenesis | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | Lipid Metabolism | Mice, Transgenic | Kidney - cytology | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Transcription Factors - metabolism | Animals | Models, Biological | Cholic Acid - metabolism | Glucose - metabolism | Liver - cytology | Mice | Receptors, Cytoplasmic and Nuclear - metabolism | Suppression, Genetic | Medicine, Experimental | Common bile duct | Glucose metabolism | Medical research | Research | Bile ducts
DIABETES-MELLITUS | MEDICINE, RESEARCH & EXPERIMENTAL | FXR | ACTIVATION | NEGATIVE FEEDBACK-REGULATION | INCREASED BETA-OXIDATION | INSULIN-RESISTANCE | GENE-EXPRESSION | MICE | BILE-ACID BIOSYNTHESIS | ORPHAN NUCLEAR RECEPTOR | Homeostasis | Muscle, Skeletal - metabolism | Muscle, Skeletal - cytology | DNA-Binding Proteins - metabolism | Kidney - metabolism | Time Factors | Gluconeogenesis | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | Lipid Metabolism | Mice, Transgenic | Kidney - cytology | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Transcription Factors - metabolism | Animals | Models, Biological | Cholic Acid - metabolism | Glucose - metabolism | Liver - cytology | Mice | Receptors, Cytoplasmic and Nuclear - metabolism | Suppression, Genetic | Medicine, Experimental | Common bile duct | Glucose metabolism | Medical research | Research | Bile ducts
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Loading RightsAmerican Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 06/2016, Volume 310, Issue 11, pp. G1044 - G1051
Farnesoid X receptor (FXR, NR1H4) plays an important role in the regulation of bile acid homeostasis in liver and intestine and may exert protective effects...
Farnesoid X receptor | Drug-induced liver injury | Colonic adenocarcinoma | Bile-acid transporters | miR-192 | bile-acid transporters | drug-induced liver injury | FXR | PROFILES | PHYSIOLOGY | METASTASIS | farnesoid X receptor | PROLIFERATION | BILE-ACID RECEPTOR | PROGNOSTIC INDICATOR | NUCLEAR RECEPTOR | COLON-CANCER | colonic adenocarcinoma | HUMAN HEPATOCELLULAR-CARCINOMA | GASTROENTEROLOGY & HEPATOLOGY | Caco-2 Cells | Organic Anion Transporters, Sodium-Independent - genetics | Colonic Neoplasms - genetics | Adenocarcinoma - pathology | Cell Proliferation | Humans | Male | Receptors, Cytoplasmic and Nuclear - genetics | Colonic Neoplasms - metabolism | Adenocarcinoma - metabolism | Organic Anion Transporters, Sodium-Independent - metabolism | Colonic Neoplasms - pathology | Cell Line, Tumor | Female | Adenocarcinoma - genetics | MicroRNAs - genetics | 3' Untranslated Regions | Solute Carrier Organic Anion Transporter Family Member 1B3 | Receptors, Cytoplasmic and Nuclear - metabolism | Physiological aspects | Bile acids | Colon cancer | MicroRNA | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Gastroenterologi | Klinisk medicin | Gastroenterology and Hepatology
Farnesoid X receptor | Drug-induced liver injury | Colonic adenocarcinoma | Bile-acid transporters | miR-192 | bile-acid transporters | drug-induced liver injury | FXR | PROFILES | PHYSIOLOGY | METASTASIS | farnesoid X receptor | PROLIFERATION | BILE-ACID RECEPTOR | PROGNOSTIC INDICATOR | NUCLEAR RECEPTOR | COLON-CANCER | colonic adenocarcinoma | HUMAN HEPATOCELLULAR-CARCINOMA | GASTROENTEROLOGY & HEPATOLOGY | Caco-2 Cells | Organic Anion Transporters, Sodium-Independent - genetics | Colonic Neoplasms - genetics | Adenocarcinoma - pathology | Cell Proliferation | Humans | Male | Receptors, Cytoplasmic and Nuclear - genetics | Colonic Neoplasms - metabolism | Adenocarcinoma - metabolism | Organic Anion Transporters, Sodium-Independent - metabolism | Colonic Neoplasms - pathology | Cell Line, Tumor | Female | Adenocarcinoma - genetics | MicroRNAs - genetics | 3' Untranslated Regions | Solute Carrier Organic Anion Transporter Family Member 1B3 | Receptors, Cytoplasmic and Nuclear - metabolism | Physiological aspects | Bile acids | Colon cancer | MicroRNA | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Gastroenterologi | Klinisk medicin | Gastroenterology and Hepatology
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