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1. Full Text Effects of the oral, direct factor Xa inhibitor apixaban on routine coagulation assays and anti‐FXa assays
by Hillarp, A and Gustafsson, K. M and Faxälv, L and Strandberg, K and Baghaei, F and Fagerberg Blixter, I and Berndtsson, M and Lindahl, T. L and Sahlgrenska akademin and Göteborgs universitet and Gothenburg University and Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin and Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine and Sahlgrenska Academy
Journal of thrombosis and haemostasis, ISSN 1538-7933, 09/2014, Volume 12, Issue 9, pp. 1545 - 1553
factor Xa | anticogaulants | analysis | apixaban | blood coagulation tests | Blood coagulation tests | Factor Xa | Anticogaulants | Analysis | Apixaban | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Protein C - chemistry | Factor Xa - chemistry | Factor Xa Inhibitors - chemistry | Reproducibility of Results | Administration, Oral | Humans | Prothrombin Time | Phospholipids - chemistry | Calibration | False Positive Reactions | Healthy Volunteers | Morpholines - chemistry | Lupus Coagulation Inhibitor - chemistry | Protein S - chemistry | International Normalized Ratio | Rivaroxaban | Pyrazoles - chemistry | Blood Coagulation - drug effects | Partial Thromboplastin Time | Pyridones - chemistry | Thiophenes - chemistry | Lupus | Medical examination | Thrombin | Protein C | Thromboembolism | Blood | Index Medicus | ENOXAPARIN | Other Basic Medicine | TESTS | factorXa | ANTICOAGULANTS | HEALTHY-SUBJECTS | SAFETY | RIVAROXABAN | PREVENTION | ACUTE CORONARY SYNDROME | DABIGATRAN | VENOUS THROMBOEMBOLISM | Annan medicinsk grundvetenskap | Medicin och hälsovetenskap
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2. Full Text Protein‐Templated Formation of an Inhibitor of the Blood Coagulation Factor Xa through a Background‐Free Amidation Reaction
by Jaegle, Mike and Steinmetzer, Torsten and Rademann, Jörg
Angewandte Chemie (International ed.), ISSN 1433-7851, 03/2017, Volume 56, Issue 13, pp. 3718 - 3722
fragment-based drug discovery | peptide bond formation | amide bond formation | enzyme inhibitors | protein-templated reactions | Amides - pharmacology | Factor Xa - chemistry | Factor Xa Inhibitors - chemistry | Amides - chemical synthesis | Benzamidines - chemical synthesis | Dipeptides - pharmacology | Humans | Benzamidines - pharmacology | Dipeptides - chemistry | Drug Discovery | Benzamidines - chemistry | Esterification | Factor Xa - metabolism | Factor Xa Inhibitors - chemical synthesis | Chemistry Techniques, Synthetic - methods | Amides - chemistry | Ligands | Dipeptides - chemical synthesis | Molecular Docking Simulation | Factor Xa Inhibitors - pharmacology | Enzyme inhibitors | Drug discovery | Peptides | Mass spectrometry | Protein binding | Index Medicus | Communications | Communication
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3. Full Text Molecular interaction site on procoagulant myosin for factor Xa?dependent prothrombin activation
by Deguchi, Hiroshi and Guo, Zihan and Hayat, Mohammed and Pflimlin, Elsa and Lear, Sam and Shen, Weijun and Griffin, John H
The Journal of biological chemistry, ISSN 0021-9258, 10/2019, Volume 294, Issue 41, pp. 15176 - 15181
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Rabbits | Animals | Humans | Models, Molecular | Protein Binding | Myosins - metabolism | Protein Conformation | Myosins - chemistry | Prothrombin - metabolism | Binding Sites | Factor Xa - metabolism | Index Medicus | thrombin | coagulation factor | myosin | peptides | factor Xa | skeletal muscle | Accelerated Communications
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4. Full Text Antithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation
by Adams, Ty E and Li, Wei and Huntington, James A and Johnson, Daniel JD
The EMBO journal, ISSN 0261-4189, 05/2006, Volume 25, Issue 9, pp. 2029 - 2037
Michaelis complex | fondaparinux | pentasaccharide | thrombosis | serpin | Serpin | Thrombosis | Fondaparinux | Pentasaccharide | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Factor Xa - chemistry | Fibrinolytic Agents - chemistry | Factor Xa - genetics | Antithrombin III - chemistry | Allosteric Regulation | Humans | Crystallography | Fibrinolytic Agents - pharmacology | Animals | Antithrombin III - antagonists & inhibitors | Protein Conformation | Heparin - chemistry | Heparin - pharmacology | Carbohydrates | Enzymes | Index Medicus
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5. Full Text Comparison of the effect of the anti‐Xa direct oral anticoagulants apixaban, edoxaban, and rivaroxaban on coagulation assays
by Gosselin, R and Grant, R. P and Adcock, D. M
International journal of laboratory hematology, ISSN 1751-5521, 10/2016, Volume 38, Issue 5, pp. 505 - 513
anticoagulants | APTT | Anti‐Xa DOAC | assays | PT | coagulation | Anticoagulants | Anti-Xa DOAC | Coagulation | Assays | Life Sciences & Biomedicine | Hematology | Science & Technology | Factor Xa Inhibitors - chemistry | Pyrazoles - chemistry | Partial Thromboplastin Time - methods | Administration, Oral | Pyridines - chemistry | Humans | Thiazoles - chemistry | Pyridones - chemistry | Rivaroxaban - chemistry | Prothrombin Time - methods | Medical examination | Prothrombin | Thrombin | Liquid chromatography | Comparative analysis | Muscle proteins | Mass spectrometry | Blood | Index Medicus
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6. Full Text Antithrombotic effects of factor Xa inhibition with DU-176b: Phase-I study of an oral, direct factor Xa inhibitor using an ex-vivo flow chamber
by Mohammad Urooj Zafar and David A. Vorchheimer and Juan Gaztanaga and Mauricio Velez and Daniel Yadegar and Pedro R. Moreno and Satoshi Kunitada and Juan Pagan and Valentin Fuster and Juan J. Badimon
Thrombosis and haemostasis, ISSN 0340-6245, 10/2007, Volume 98, Issue 4, pp. 883 - 888
Clinical trials | atherothrombosis | thrombosis | oral anticoagulants | factor X | coagulation inhibitors | New Technologies, Diagnostic Tools and Drugs | Coagulation inhibitors | Factor X | Atherothrombosis | Thrombosis | Oral anticoagulants | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Hematologic and hematopoietic diseases | Biological and medical sciences | Blood coagulation. Blood cells | Molecular and cellular biology | Medical sciences | Platelet diseases and coagulopathies | Factor Xa - chemistry | Antithrombin III - chemistry | Factor Xa Inhibitors | Humans | Prothrombin Time | Thrombosis - immunology | Stress, Mechanical | Anticoagulants - therapeutic use | Male | International Normalized Ratio | Fibrinolytic Agents - pharmacology | Antithrombin III - pharmacology | Time Factors | Blood Coagulation | Adult | Female | Thrombosis - drug therapy | Thrombin - metabolism | Thrombosis - therapy | Index Medicus
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7. Full Text Factor Xa Inhibitors: Next-Generation Antithrombotic Agents
by Pinto, Donald J. P and Smallheer, Joanne M and Cheney, Daniel L and Knabb, Robert M and Wexler, Ruth R
Journal of medicinal chemistry, ISSN 0022-2623, 09/2010, Volume 53, Issue 17, pp. 6243 - 6274
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Factor Xa Inhibitors | Administration, Oral | Humans | Models, Molecular | Anticoagulants - therapeutic use | Biological Availability | Clinical Trials as Topic | Structure-Activity Relationship | Animals | Anticoagulants - chemistry | Hemostasis | Anticoagulants - pharmacology | Drug Design | Protein Conformation | Thrombosis - blood | Thrombosis - prevention & control | Drug Evaluation, Preclinical | Index Medicus
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8. Full Text A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa
by Lu, Genmin and Deguzman, Francis R and Hollenbach, Stanley J and Karbarz, Mark J and Abe, Keith and Lee, Gail and Luan, Peng and Hutchaleelaha, Athiwat and Inagaki, Mayuko and Conley, Pamela B and Phillips, David R and Sinha, Uma
Nature medicine, ISSN 1078-8956, 04/2013, Volume 19, Issue 4, pp. 446 - 451
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Antidotes - pharmacology | Benzamides - antagonists & inhibitors | Hemostasis - drug effects | Rabbits | Factor Xa Inhibitors | Thiophenes - antagonists & inhibitors | Polysaccharides - antagonists & inhibitors | Mice, Inbred C57BL | Enoxaparin - antagonists & inhibitors | Rats | Male | Pyridones - antagonists & inhibitors | Recombinant Proteins - pharmacology | Anticoagulants - antagonists & inhibitors | Rats, Sprague-Dawley | Pyridines - antagonists & inhibitors | Dose-Response Relationship, Drug | Rivaroxaban | Hemorrhage - drug therapy | Animals | Factor Xa - pharmacology | Morpholines - antagonists & inhibitors | Mice | Pyrazoles - antagonists & inhibitors | Usage | Antidotes | Blood coagulation factors | Research | Analysis | Proteins | Pharmacology | Thrombolytic drugs | Coagulation | Index Medicus
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9. Full Text Synthesis, Docking, and In Vitro Anticoagulant Activity Assay of Hybrid Derivatives of Pyrrolo[3,2,1-ij]Quinolin-2(1H)-one as New Inhibitors of Factor Xa and Factor XIa
by Novichikhina, Nadezhda and Ilin, Ivan and Tashchilova, Anna and Sulimov, Alexey and Kutov, Danil and Ledenyova, Irina and Krysin, Mikhail and Shikhaliev, Khidmet and Gantseva, Anna and Gantseva, Ekaterina and Podoplelova, Nadezhda and Sulimov, Vladimir
Molecules (Basel, Switzerland), ISSN 1420-3049, 04/2020, Volume 25, Issue 8, p. 1889
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Anticoagulants | Factor Xa - chemistry | Factor Xa Inhibitors - chemistry | Quinolines - chemistry | Factor XIa - antagonists & inhibitors | Structure-Activity Relationship | Factor XIa - chemistry | Quinolines - chemical synthesis | Pyrroles - chemical synthesis | Hydrogen Bonding | Drug Design | Inhibitory Concentration 50 | Pyrroles - chemistry | Molecular Docking Simulation | Enzymes | Coagulation | Hydrocarbons | Amino acids | Derivatives | Bioavailability | Design | Inhibitors | Synthesis | Hydrogen bonds | Docking | Ligands | Coagulation factor Xa | In vitro methods and tests | Index Medicus | anticoagulants | molecular docking | factor Xa | pyrroloquinolinones | factor XIa
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10. Full Text Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor
by Wong, Pancras C and Pinto, Donald J. P and Zhang, Donglu
Journal of thrombosis and thrombolysis, ISSN 0929-5305, 5/2011, Volume 31, Issue 4, pp. 478 - 492
Anticoagulants | Medicine & Public Health | Hematology | Atrial fibrillation | Apixaban | Factor Xa | Cardiology | Thrombosis | Keywords apixaban | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Fibrinolytic Agents - chemistry | Pyrazoles - therapeutic use | Drug Discovery - history | Factor Xa Inhibitors | Pyridones - pharmacokinetics | Pyrazoles - history | History, 20th Century | Humans | Drug Evaluation, Preclinical - history | Fibrinolytic Agents - history | Enzyme Inhibitors - therapeutic use | Pyrazoles - chemistry | Animals | Enzyme Inhibitors - pharmacokinetics | Fibrinolytic Agents - pharmacokinetics | Enzyme Inhibitors - history | Enzyme Inhibitors - chemistry | Fibrinolytic Agents - therapeutic use | Pyridones - history | Pyridones - therapeutic use | Thromboembolism - drug therapy | Pyridones - chemistry | Pyrazoles - pharmacokinetics | Alkaloids | Aspirin | Medical examination | Pyridine | Metabolites | Thrombin | Anticoagulants (Medicine) | Sulfates | Thromboembolism | Blood | Index Medicus
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