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Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2280 - 14
Defects in DNA repair can cause various genetic diseases with severe pathological phenotypes. Fanconi anemia ( FA) is a rare disease characterized by bone... 
UBIQUITINATION | DAMAGE RESPONSE | CHROMATIN | CROSS-LINK REPAIR | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | HOMOLOGOUS RECOMBINATION | BRCA1 | ENRICHMENT ANALYSIS | ASSOCIATION | Genetic Therapy | Ubiquitin-Specific Proteases - genetics | Fanconi Anemia Complementation Group D2 Protein - genetics | Fanconi Anemia - metabolism | Humans | DNA Repair - physiology | DNA Repair - genetics | Fanconi Anemia Complementation Group C Protein - genetics | Fanconi Anemia Complementation Group A Protein - genetics | Fanconi Anemia Complementation Group D2 Protein - deficiency | Fanconi Anemia Complementation Group A Protein - metabolism | Fanconi Anemia Complementation Group Proteins - metabolism | Ubiquitination | Fanconi Anemia Complementation Group G Protein - genetics | Ubiquitin-Specific Proteases - deficiency | Fanconi Anemia Complementation Group G Protein - deficiency | BRCA1 Protein - metabolism | Fanconi Anemia - genetics | Ubiquitin-Specific Proteases - metabolism | Chromosomal Instability | Rad51 Recombinase - metabolism | Cell Line | Fanconi Anemia Complementation Group Proteins - deficiency | Fanconi Anemia Complementation Group Proteins - genetics | Fanconi Anemia Complementation Group G Protein - metabolism | Gene Knockout Techniques | Fanconi Anemia Complementation Group C Protein - metabolism | Fanconi Anemia Complementation Group D2 Protein - metabolism | Fanconi Anemia Complementation Group A Protein - deficiency | CRISPR-Cas Systems | Fanconi Anemia Complementation Group C Protein - deficiency | Fanconi Anemia - therapy | DNA Damage | Histones - metabolism | Mutation
Journal Article
Science, ISSN 0036-8075, 7/2010, Volume 329, Issue 5988, pp. 219 - 223
Journal Article
Blood, ISSN 0006-4971, 05/2013, Volume 121, Issue 22, pp. e138 - 148
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2007, Volume 117, Issue 5, pp. 1440 - 1449
The Fanconi anemia (FA) pathway maintains genomic stability in replicating cells. Some sporadic breast, ovarian, pancreatic, and hematological. tumors are... 
NUCLEAR ACCUMULATION | MEDICINE, RESEARCH & EXPERIMENTAL | POLY(ADP-RIBOSE) POLYMERASE | BRCA PATHWAY | THERAPEUTIC STRATEGY | DNA-DAMAGE RESPONSE | PANCREATIC-CANCER | PROTEINS FANCA | ACUTE MYELOID-LEUKEMIA | HOMOLOGOUS RECOMBINATION | OVARIAN-CANCER | Protein-Serine-Threonine Kinases - deficiency | Tumor Suppressor Proteins - antagonists & inhibitors | Fanconi Anemia - metabolism | Humans | Fanconi Anemia Complementation Group C Protein - genetics | Fanconi Anemia Complementation Group C Protein - physiology | DNA-Binding Proteins - deficiency | Cell Cycle Proteins - antagonists & inhibitors | Fanconi Anemia Complementation Group G Protein - genetics | Fanconi Anemia Complementation Group G Protein - deficiency | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Fanconi Anemia - genetics | DNA-Binding Proteins - antagonists & inhibitors | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Signal Transduction - genetics | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Mice, Knockout | Animals | Cell Line, Tumor | Fanconi Anemia Complementation Group C Protein - deficiency | Fanconi Anemia Complementation Group G Protein - physiology | Mice | DNA Damage | HeLa Cells | Cell Line, Transformed | Prevention | Care and treatment | Research | Analysis | Fanconi's anemia
Journal Article
Blood, ISSN 0006-4971, 10/2013, Volume 122, Issue 18, pp. 3206 - 3209
Journal Article
Human Gene Therapy, ISSN 1043-0342, 02/2015, Volume 26, Issue 2, pp. 114 - 126
Journal Article
Journal Article
Blood, ISSN 0006-4971, 07/2012, Volume 120, Issue 2, pp. 323 - 334
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 8, p. e22911
The Fanconi anemia (FA) gene family is a recent addition to the complex network of proteins that respond to and repair certain types of DNA damage in the human... 
INTERFERON | SMAD4 | PROTEIN | FA-C CELLS | PATHWAY | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | GROWTH | ENHANCER | IDENTIFICATION | K-BOX | Humans | Fanconi Anemia Complementation Group L Protein - genetics | Fanconi Anemia Complementation Group Proteins - genetics | Fanconi Anemia Complementation Group E Protein - genetics | Transcription Factors - genetics | Fanconi Anemia Complementation Group C Protein - genetics | Fanconi Anemia Complementation Group F Protein - genetics | Promoter Regions, Genetic - genetics | Fanconi Anemia Complementation Group A Protein - genetics | Transcription Factors - metabolism | Fanconi Anemia Complementation Group G Protein - genetics | HEK293 Cells | Electrophoretic Mobility Shift Assay | Fanconi Anemia - genetics | HeLa Cells | Binding Sites | DNA Helicases - genetics | Regulatory Elements, Transcriptional - genetics | Transforming Growth Factor beta | Promoters (Genetics) | Genes | Genomics | Genetic aspects | Genomes | DNA binding proteins | Genetic transcription | Fanconi's anemia | Smad protein | Transcription factors | Biological evolution | DNA damage | Evolutionary genetics | Regulatory sequences | Kinases | DNA repair | Proteins | E2F protein | Conserved sequence | Pathways | Deoxyribonucleic acid--DNA | CpG islands | Anemia | Activator protein 1 | YY1 protein | siRNA | Gene expression | Fanconi syndrome | Promoters | Insects | Plasmids | MicroRNAs | Electrophoretic mobility | Binding sites | Deoxyribonucleic acid | DNA
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2005, Volume 11, Issue 20, pp. 7508 - 7515
Purpose: BRCA2, FANCC , and FANCG gene mutations are present in a subset of pancreatic cancer. Defects in these genes could lead to hypersensitivity to... 
BRCA1, BRCA2 | Xenograft models | DNA damage and repair mechanisms | Pharmacogenetics/pharmacogenomics | Gastrointestinal cancers: other | GENE-MUTATIONS | LUNG-CANCER | FUNCTIONAL-ACTIVITY | ONCOLOGY | ABL TYROSINE KINASE | MITOMYCIN-C | PANCREATIC-CANCER | RANDOMIZED-TRIAL | PHASE-II | COMPLEMENTATION GROUP | CARCINOMA | Paclitaxel - pharmacology | Apoptosis - drug effects | Cross-Linking Reagents - pharmacology | Humans | Deoxycytidine - pharmacology | Chlorambucil - pharmacology | Fanconi Anemia Complementation Group C Protein - genetics | Dose-Response Relationship, Drug | Pancreatic Neoplasms - drug therapy | Caspases - metabolism | Fanconi Anemia Complementation Group G Protein - genetics | Time Factors | Cross-Linking Reagents - therapeutic use | Fanconi Anemia Complementation Group G Protein - deficiency | Inhibitory Concentration 50 | Female | Antineoplastic Agents - pharmacology | Melphalan - pharmacology | Cell Survival - drug effects | Fanconi Anemia Complementation Group Proteins - deficiency | Mitomycin - therapeutic use | Pancreatic Neoplasms - pathology | Fanconi Anemia Complementation Group Proteins - genetics | Etoposide - pharmacology | Pancreatic Neoplasms - genetics | Cisplatin - pharmacology | Xenograft Model Antitumor Assays - methods | Mitomycin - pharmacology | Animals | Mice, Nude | Cell Line, Tumor | Fanconi Anemia Complementation Group C Protein - deficiency | BRCA2 Protein - deficiency | Fluorouracil - pharmacology | Mice | Vinblastine - pharmacology | Mutation | Cell Cycle - drug effects | BRCA2 Protein - genetics | Deoxycytidine - analogs & derivatives | Doxorubicin - pharmacology
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 10/2012, Volume 17, Issue 8, pp. 183 - 1098
Journal Article