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Molecular Cell, ISSN 1097-2765, 01/2017, Volume 65, Issue 2, pp. 247 - 259
Monoubiquitination and deubiquitination of FANCD2:FANCI heterodimer is central to DNA repair in a pathway that is defective in the cancer predisposition... 
core complex | RING E3 | Fanconi anemia | FANCD2 | deubiquitination | FANCB | enzyme mechanism | monoubiquitination | DNA repair | NUCLEAR ACCUMULATION | MONOUBIQUITINATED FANCD2 | TARGETED DISRUPTION | COMPLEX | DNA-REPAIR PATHWAY | CROSS-LINK REPAIR | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEINS | DAMAGE | COMPLEMENTATION GROUP-B | LIGASE | CELL BIOLOGY | Fanconi Anemia Complementation Group D2 Protein - genetics | Fanconi Anemia - metabolism | Humans | Multiprotein Complexes | Protein Multimerization | Substrate Specificity | Fanconi Anemia Complementation Group A Protein - metabolism | DNA-Binding Proteins - metabolism | Fanconi Anemia Complementation Group Proteins - metabolism | Ubiquitination | Transfection | Time Factors | Fanconi Anemia - genetics | Ubiquitin-Specific Proteases - metabolism | Recombinant Proteins - metabolism | Cell Line | Fanconi Anemia Complementation Group Proteins - genetics | Nuclear Proteins - metabolism | Fanconi Anemia Complementation Group G Protein - metabolism | DNA - metabolism | Inhibitor of Differentiation Protein 2 - metabolism | DNA - genetics | Fanconi Anemia Complementation Group C Protein - metabolism | Fanconi Anemia Complementation Group D2 Protein - metabolism | Protein Binding | Fanconi Anemia Complementation Group L Protein - metabolism | Fanconi Anemia Complementation Group E Protein - metabolism | Ubiquitin | Chemotherapy | Ligases | Genomics | Research institutes | Cancer | Fanconi's anemia | Proteins | Medical research | Molecular genetics | Medicine, Experimental
Journal Article
Journal Article
Blood, ISSN 0006-4971, 09/2006, Volume 108, Issue 6, pp. 2072 - 2080
Journal Article
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 10/2010, Volume 191, Issue 2, pp. 249 - 257
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2015, Volume 290, Issue 34, pp. 20995 - 21006
The Fanconi Anemia (FA) DNArepair pathway is essential for the recognition and repair of DNA interstrand crosslinks (ICL). Inefficient repair of these ICL can... 
BINDING DOMAINS | MONOUBIQUITINATION | PCNA | REPLICATION | MECHANISM | UBE2T | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEFICIENT | ALDEHYDES | CORE COMPLEX | LIGASE | Xenopus Proteins - genetics | Humans | Ubiquitin - metabolism | Molecular Sequence Data | Fanconi Anemia Complementation Group L Protein - chemistry | Drosophila Proteins - metabolism | Fanconi Anemia Complementation Group Proteins - chemistry | Xenopus Proteins - chemistry | Fanconi Anemia Complementation Group Proteins - metabolism | Ubiquitination | Fanconi Anemia - genetics | Protein Interaction Domains and Motifs | Binding Sites | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Structure, Secondary | Signal Transduction | Xenopus laevis | Fanconi Anemia Complementation Group L Protein - genetics | Fanconi Anemia Complementation Group Proteins - genetics | Gene Expression Regulation | Ubiquitin - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Ubiquitin-Conjugating Enzymes - genetics | Recombinant Proteins - genetics | Ubiquitin - genetics | Drosophila Proteins - chemistry | Protein Folding | Sequence Alignment | Animals | Ubiquitin-Conjugating Enzymes - metabolism | DNA Repair | Protein Binding | Xenopus Proteins - metabolism | Drosophila Proteins - genetics | Fanconi Anemia Complementation Group L Protein - metabolism | Drosophila melanogaster | Protein Structure and Folding | nuclear magnetic resonance (NMR) | E3 ubiquitin ligase | DNA repair | isothermal titration calorimetry (ITC) | ubiquitin | structure
Journal Article
Journal of Biomedical Science, ISSN 1021-7770, 09/2015, Volume 22, Issue 1, p. 77
Background: Cisplatin is one of the most commonly used chemotherapy agent for lung cancer. The therapeutic efficacy of cisplatin is limited by the development... 
RNA interference | Fanconi anemia/BRCA pathway | Lung cancer | Cisplatin | Chemoresistance | Core complex | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | PROTEIN | CHEMOTHERAPY | CELL BIOLOGY | CROSS-LINK REPAIR | MUTATIONS | EXPRESSION | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Fanconi Anemia Complementation Group D2 Protein - genetics | Humans | Lung Neoplasms - metabolism | Fanconi Anemia Complementation Group F Protein - metabolism | Fanconi Anemia Complementation Group L Protein - genetics | Fanconi Anemia Complementation Group D2 Protein - antagonists & inhibitors | Lung Neoplasms - pathology | Signal Transduction - genetics | Cisplatin - pharmacology | Fanconi Anemia Complementation Group F Protein - genetics | Fanconi Anemia Complementation Group L Protein - antagonists & inhibitors | BRCA1 Protein - genetics | Drug Resistance, Neoplasm - genetics | BRCA1 Protein - antagonists & inhibitors | Fanconi Anemia Complementation Group D2 Protein - metabolism | RNA Interference | Signal Transduction - drug effects | BRCA1 Protein - metabolism | Fanconi Anemia Complementation Group F Protein - antagonists & inhibitors | Cell Line, Tumor | Fanconi Anemia Complementation Group L Protein - metabolism | Drug Resistance, Neoplasm - drug effects | RNA | DNA damage | Genes | Respiratory agents | Drug resistance | Antineoplastic agents | Fanconi's anemia | Antimitotic agents | Prevention | Chemotherapy | Cancer cells | Genetic research | Genetic aspects | Drug therapy | Health aspects | Cancer | Ribonucleic acid--RNA | Anemia
Journal Article
Blood, ISSN 0006-4971, 07/2012, Volume 120, Issue 2, pp. 323 - 334
Journal Article
Journal Article
Journal Article