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Science, ISSN 0036-8075, 3/2008, Volume 319, Issue 5868, pp. 1391 - 1394
Staphylococcus aureus produces hospital- and community-acquired infections, with methicillin-resistant S. aureus posing a serious public health threat. The... 
Carotenoids | Virulence | Pigments | Squalene | Ligands | Reports | Biosynthesis | Infections | Diphosphates | Cholesterols | Staphylococcus aureus | TARGET | SQUALENE SYNTHASE INHIBITOR | MULTIDISCIPLINARY SCIENCES | Organothiophosphorus Compounds - therapeutic use | Virulence - drug effects | Polyisoprenyl Phosphates - chemistry | Sesquiterpenes - metabolism | Humans | Bacterial Proteins - chemistry | Molecular Sequence Data | Crystallography, X-Ray | Enzyme Inhibitors - chemical synthesis | Organothiophosphorus Compounds - pharmacology | Farnesyl-Diphosphate Farnesyltransferase - chemistry | Anti-Bacterial Agents - therapeutic use | Anti-Bacterial Agents - chemistry | Staphylococcal Infections - microbiology | Organothiophosphorus Compounds - chemical synthesis | Staphylococcus aureus - metabolism | Amino Acid Sequence | Bacterial Proteins - antagonists & inhibitors | Cell Line | Staphylococcal Infections - drug therapy | Sesquiterpenes - chemistry | Enzyme Inhibitors - metabolism | Organothiophosphorus Compounds - metabolism | Protein Structure, Secondary | Farnesyl-Diphosphate Farnesyltransferase - isolation & purification | Enzyme Inhibitors - pharmacology | Polyisoprenyl Phosphates - metabolism | Staphylococcus aureus - pathogenicity | Farnesyl-Diphosphate Farnesyltransferase - metabolism | Anti-Bacterial Agents - chemical synthesis | Animals | Farnesyl-Diphosphate Farnesyltransferase - antagonists & inhibitors | Xanthophylls - biosynthesis | Bacterial Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Mice | Cholesterol - biosynthesis | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Bacterial Proteins - isolation & purification | Prevention | Physiological aspects | Staphylococcus aureus infections | Anticholesteremic agents | Enzymes | Inhibitor drugs | Rodents | Bacteria | Biochemistry | Drug resistance | Cholesterol
Journal Article
PLoS Pathogens, ISSN 1553-7366, 2014, Volume 10, Issue 5, p. e1004114
Trypanosomatid parasites are the causative agents of many neglected tropical diseases and there is currently considerable interest in targeting endogenous... 
MECHANISM | NITROGEN-CONTAINING BISPHOSPHONATES | TRYPANOSOMA-CRUZI | MICROBIOLOGY | CRYSTALLOGRAPHY | MODEL | FARNESYL DIPHOSPHATE SYNTHASE | IN-VITRO | VIROLOGY | ISOPRENOID BIOSYNTHESIS | INHIBITORS | CHOLESTEROL-BIOSYNTHESIS | PARASITOLOGY | Polyisoprenyl Phosphates - chemistry | Sesquiterpenes - metabolism | Humans | Cercopithecus aethiops | Crystallography, X-Ray | Trypanocidal Agents - chemistry | Trypanosoma cruzi - enzymology | Farnesyl-Diphosphate Farnesyltransferase - chemistry | Enzyme Inhibitors - chemistry | Trypanocidal Agents - therapeutic use | Vero Cells | Molecular Targeted Therapy - methods | Trypanocidal Agents - metabolism | Sesquiterpenes - chemistry | Enzyme Inhibitors - metabolism | Quinuclidines - pharmacology | Enzyme Inhibitors - pharmacology | Models, Molecular | Diphosphonates - metabolism | Enzyme Inhibitors - therapeutic use | Polyisoprenyl Phosphates - metabolism | Farnesyl-Diphosphate Farnesyltransferase - metabolism | Animals | Trypanocidal Agents - pharmacology | Farnesyl-Diphosphate Farnesyltransferase - antagonists & inhibitors | Diphosphonates - chemistry | Chagas Disease - drug therapy | Protein Binding | Quinuclidines - chemistry | Quinuclidines - metabolism | Diphosphonates - pharmacology | Phosphonates | Physiological aspects | Squalene | Chagas' disease | Diagnosis | Research | Drug therapy | Health aspects | Research & development | Protozoa | R&D | Disease | Sterols | Ligands | Biosynthesis | Parasites | Tropical diseases | Cholesterol
Journal Article
Journal Article
Journal Article
Protein Expression and Purification, ISSN 1046-5928, 02/2017, Volume 130, pp. 63 - 72
Journal Article
Journal Article
Journal Article