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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2010, Volume 107, Issue 50, pp. 21337 - 21342
Journal Article
Oncogene, ISSN 0950-9232, 09/2004, Volume 23, Issue 41, pp. 6900 - 6913
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 05/2007, Volume 211, Issue 2, pp. 533 - 543
Zoledronic acid (ZOL) has proved activity in bone metastases from prostate cancer through inhibition of mevalonate pathway and of prenylation of intracellular... 
ZOLEDRONIC ACID | GERANYLGERANYLTRANSFERASE-I INHIBITORS | PHYSIOLOGY | MYELOMA CELL-LINES | BONE METASTASES | NITROGEN-CONTAINING BISPHOSPHONATES | FARNESYL PYROPHOSPHATE SYNTHASE | INDUCE APOPTOSIS | MEDIATED APOPTOSIS | FARNESYLTRANSFERASE INHIBITORS | TRANSFERASE INHIBITORS | CELL BIOLOGY | Prostatic Neoplasms - metabolism | Adenocarcinoma - pathology | Apoptosis - drug effects | Humans | ras Proteins - metabolism | Male | Antineoplastic Agents - therapeutic use | Quinolones - pharmacology | Extracellular Signal-Regulated MAP Kinases - metabolism | Dose-Response Relationship, Drug | Proto-Oncogene Proteins c-bcl-2 - metabolism | Adenocarcinoma - metabolism | Caspases - metabolism | Time Factors | Quinolones - therapeutic use | Diphosphonates - therapeutic use | bcl-Associated Death Protein - metabolism | Antineoplastic Agents - pharmacology | Imidazoles - therapeutic use | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Prostatic Neoplasms - drug therapy | Prostatic Neoplasms - pathology | Imidazoles - pharmacology | Enzyme Activation - drug effects | Adenocarcinoma - drug therapy | Apoptosis Regulatory Proteins - metabolism | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Diphosphonates - pharmacology
Journal Article
Journal Article
Genes and Development, ISSN 0890-9369, 08/2008, Volume 22, Issue 16, pp. 2178 - 2188
The AKT-mTOR pathway harbors several known and putative oncogenes and tumor suppressors. In a phenotypic screen for lymphomagenesis, we tested candidate genes... 
Oncogenesis | Translation | Mouse model | Akt | MAMMALIAN TARGET | mouse model | C-MYC | TRANSLATION INITIATION | DEVELOPMENTAL BIOLOGY | MTOR | FARNESYL TRANSFERASE INHIBITOR | FARNESYLTRANSFERASE INHIBITORS | CELL BIOLOGY | MESSENGER-RNAS | ONCOGENIC RAS | MALIGNANT-TRANSFORMATION | oncogenesis | GROWTH | GENETICS & HEREDITY | translation | Phosphorylation | Antibiotics, Antineoplastic - pharmacology | Humans | Multiprotein Complexes | PTEN Phosphohydrolase - physiology | Eukaryotic Initiation Factor-4E - metabolism | Ras Homolog Enriched in Brain Protein | RNA, Messenger - metabolism | Mechanistic Target of Rapamycin Complex 1 | Lymphoma - metabolism | Proteins | Tumor Suppressor Protein p53 - physiology | Farnesyltranstransferase - metabolism | Proto-Oncogene Proteins c-myc - physiology | Piperidines - pharmacology | Cellular Senescence | Female | Lymphoma - pathology | Farnesyltranstransferase - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - metabolism | Immunosuppressive Agents - pharmacology | Fibroblasts - metabolism | Signal Transduction | Mice, Inbred C57BL | RNA, Messenger - genetics | Cells, Cultured | Immunophenotyping | Neuropeptides - metabolism | Gene Dosage | Reverse Transcriptase Polymerase Chain Reaction | Sirolimus - pharmacology | Blotting, Western | Mice, Knockout | Monomeric GTP-Binding Proteins - antagonists & inhibitors | Transcription Factors - metabolism | Animals | Monomeric GTP-Binding Proteins - metabolism | Fibroblasts - cytology | Mice | Pyridines - pharmacology | TOR Serine-Threonine Kinases | Cell Transformation, Neoplastic - pathology | Doxorubicin - pharmacology | Neuropeptides - antagonists & inhibitors | Antimitotic agents | Research | Chemical properties | Antineoplastic agents | Guanosine triphosphatase | Transferases | Research Paper
Journal Article
Scientific Reports, ISSN 2045-2322, 03/2017, Volume 7, Issue 1, p. 44841
Journal Article
British Journal of Cancer, ISSN 0007-0920, 03/2011, Volume 104, Issue 6, pp. 1038 - 1048
BACKGROUND: Pancreatic cancer (PC) harbours an activated point mutation (Kras(G12D)) in the Kras proto-oncogene that has been demonstrated to promote the... 
RNA INTERFERENCE | DUCTAL ADENOCARCINOMA | TUMOR-SUPPRESSOR GENE | FARNESYLTRANSFERASE INHIBITORS | pancreatic cancer | THERAPY | invasion | CODON-12 MUTATIONS | ONCOLOGY | metastasis | KI-RAS GENE | motility | activated Kras | GROWTH-FACTOR | EXPRESSION | CARCINOMA
Journal Article
Protein Science, ISSN 0961-8368, 02/2017, Volume 26, Issue 2, pp. 242 - 257
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2013, Volume 8, Issue 9, p. e73616
Recent studies have suggested that aberrant K-ras signaling is responsible for triggering immunological responses and inflammation-driven tumorigenesis.... 
CELL LUNG-CANCER | INTESTINAL INFLAMMATION | RESPONSES | COLONY-STIMULATING FACTOR | INTERFERON-GAMMA | PATHWAY | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | PROMOTES | FARNESYLTRANSFERASE INHIBITORS | DEVELOPMENTAL DISORDERS | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Apoptosis - drug effects | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Colorectal Neoplasms - genetics | Humans | Middle Aged | Cell Survival - genetics | Apoptosis - genetics | Male | Gene Expression Profiling | Interferon-gamma - metabolism | Interleukins - metabolism | Dose-Response Relationship, Drug | Interleukin-23 - genetics | Interleukins - genetics | Interleukin-23 - metabolism | Aged, 80 and over | Adult | Female | Interferon-gamma - genetics | Colorectal Neoplasms - metabolism | Caco-2 Cells | Cell Survival - drug effects | Polyenes - pharmacology | Interleukin-17 - genetics | Proto-Oncogene Proteins - genetics | Signal Transduction - genetics | Reverse Transcriptase Polymerase Chain Reaction | Disease Progression | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Interleukin-17 - metabolism | Polyunsaturated Alkamides - pharmacology | Aged | Mutation | Colorectal Neoplasms - pathology | Neoplasm Staging | Laboratories | Chemical engineering | Genes | Crosstalk | Lung cancer | Interleukin | Colorectal carcinoma | Colorectal cancer | Interleukin 22 | Interleukin 23 | Biology | Kinases | Medical schools | K-Ras protein | Cell growth | Immunology | Interleukins | Intestine | Tumor necrosis factor-TNF | Tumorigenesis | Inhibition | Cytokines | Granulocyte-macrophage colony-stimulating factor | Cell division | Inflammation | Patients | Interleukin 17 | Signaling | Pancreatic cancer | γ-Interferon | Interferon | Aberration | Viability | Cancer | Apoptosis
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 11/2019, Volume 58, Issue 11, pp. 2052 - 2064
Journal Article
Journal Article