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Cell Stem Cell, ISSN 1934-5909, 05/2012, Volume 10, Issue 5, pp. 544 - 555
Journal Article
Cell, ISSN 0092-8674, 2007, Volume 130, Issue 5, pp. 811 - 823
Estrogen prevents osteoporotic bone loss by attenuating bone resorption; however, the molecular basis for this is unknown. Here, we report a critical role for... 
HUMDISEASE | DEVBIO | SIGNALING | ANDROGEN RECEPTOR | APOPTOSIS | RESORPTION | DISEASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | MASS | MECHANISMS | DEFICIENT MICE | OSTEOPETROSIS | EXPRESSION | OSTEOPOROSIS | CELL BIOLOGY | Fas Ligand Protein - metabolism | Male | fas Receptor - metabolism | Bone Remodeling - drug effects | Selective Estrogen Receptor Modulators - therapeutic use | Estrogen Receptor alpha - metabolism | Female | Integrases - metabolism | Mice, Inbred DBA | Cell Differentiation | Estradiol - metabolism | Osteoclasts - pathology | Bone Density | Cathepsin K | Ovariectomy | Signal Transduction | Bone Diseases, Metabolic - prevention & control | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Osteoclasts - metabolism | Estrogen Receptor alpha - deficiency | Mice, Knockout | Bone Diseases, Metabolic - metabolism | Estrogen Receptor alpha - drug effects | Phenotype | Animals | Estrogen Receptor alpha - genetics | Cathepsins - genetics | Cathepsins - metabolism | Tamoxifen - therapeutic use | Tamoxifen - pharmacology | Mice | Bone Diseases, Metabolic - physiopathology | Fas Ligand Protein - genetics | Integrases - genetics | Selective Estrogen Receptor Modulators - pharmacology | Osteoclasts - drug effects | Apoptosis | Index Medicus | Cathepsins | Antigens, CD95 | Estradiol | Life Sciences | Estrogen Receptor alpha | Biochemistry, Molecular Biology | Tamoxifen | Bone Diseases, Metabolic | Integrases | Fas Ligand Protein | Selective Estrogen Receptor Modulators | Osteoclasts | Molecular biology | Bone Remodeling
Journal Article
Journal Article
Cell Host & Microbe, ISSN 1931-3128, 01/2014, Volume 15, Issue 1, pp. 23 - 35
Cellular inhibitors of apoptosis proteins (cIAPs) are essential regulators of cell death and immunity. The corresponding contributions of IAPs to infectious... 
CELLS | INFLAMMASOME ACTIVATION | PROGRAMMED NECROSIS | ACUTE LUNG INJURY | RECEPTOR | MICROBIOLOGY | DEATH | RIP1 KINASE | VIROLOGY | FAS | MICE | TNF-ALPHA | PARASITOLOGY | Influenza A Virus, H1N1 Subtype - immunology | Inhibitor of Apoptosis Proteins - genetics | Humans | Orthomyxoviridae Infections - complications | Baculoviral IAP Repeat-Containing 3 Protein | Respiratory Mucosa - virology | Fas Ligand Protein - immunology | Necrosis - immunology | Orthomyxoviridae Infections - genetics | Respiratory Mucosa - pathology | Inhibitor of Apoptosis Proteins - deficiency | Lung - virology | Fas Ligand Protein - deficiency | Respiratory Mucosa - immunology | TNF-Related Apoptosis-Inducing Ligand - deficiency | Necrosis - mortality | Receptor-Interacting Protein Serine-Threonine Kinases - immunology | Lung - pathology | Signal Transduction | Gene Expression Regulation | Necrosis - complications | Homeostasis - immunology | TNF-Related Apoptosis-Inducing Ligand - immunology | Immunity, Innate | Mice, Knockout | Host-Pathogen Interactions | Ubiquitin-Protein Ligases | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Orthomyxoviridae Infections - mortality | Survival Analysis | Inhibitor of Apoptosis Proteins - immunology | Mice | Necrosis - genetics | Protein Kinase Inhibitors - pharmacology | Fas Ligand Protein - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors | TNF-Related Apoptosis-Inducing Ligand - genetics | Lung - immunology | Orthomyxoviridae Infections - immunology | Influenza viruses | Proteins | Antiviral agents | Influenza | Mortality | Health aspects | Phosphotransferases | Necrosis | Apoptosis | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e78355 - e78355
Approximately 30% of patients with Epstein-Barr virus (EBV)-positive advanced nasopharyngeal carcinoma (NPC) display chemoresistance to cisplatin-based... 
CANCER-CELLS | B-CELLS | SURVIVAL | MEMBRANE-PROTEIN 1 | MULTIDISCIPLINARY SCIENCES | EBV | MIR-21 | LATENCY | LIGAND | EXPRESSION | LINES | RNA-Binding Proteins - genetics | Carcinoma | Apoptosis - drug effects | Humans | Nasopharyngeal Neoplasms - virology | MicroRNAs - metabolism | Viral Matrix Proteins - pharmacology | Tetrazolium Salts | Forkhead Transcription Factors - metabolism | Luciferases | Thiazoles | Apoptosis Regulatory Proteins - genetics | Inhibitory Concentration 50 | Viral Matrix Proteins - metabolism | Colony-Forming Units Assay | Gene Expression Regulation, Neoplastic - drug effects | Nasopharyngeal Neoplasms - drug therapy | Real-Time Polymerase Chain Reaction | RNA-Binding Proteins - antagonists & inhibitors | Cell Line | Nasopharyngeal Carcinoma | Cisplatin - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Drug Resistance, Neoplasm - genetics | Fas Ligand Protein - antagonists & inhibitors | Cisplatin - therapeutic use | Signal Transduction - drug effects | Apoptosis Regulatory Proteins - antagonists & inhibitors | Fluorescent Antibody Technique | MicroRNAs - genetics | Fas Ligand Protein - genetics | Forkhead Box Protein O3 | Infection | Prognosis | MicroRNA | Tumor necrosis factor | Epstein-Barr virus | B cells | Health aspects | Cisplatin | Apoptosis | Cancer | Cell proliferation | Laboratories | Genes | Crosstalk | Chemoresistance | Viruses | Oncology | Homology | AKT protein | Infections | Metastasis | Proteins | Nasopharyngeal carcinoma | Disease resistance | Signal transduction | Coding | Tumor necrosis factor-TNF | Tumorigenesis | Bioindicators | FOXO3 protein | MiRNA | Ribonucleic acid--RNA | 1-Phosphatidylinositol 3-kinase | Membrane proteins | Medicine | Signaling | Chemotherapy | FasL protein | Cell death | MicroRNAs | Medical prognosis | Cell lines | Biomarkers | Ligands | Latent membrane protein 1 | Index Medicus | RNA | Ribonucleic acid
Journal Article
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 2017, Volume 109, Issue 6, p. djw283
Background: Pancreatic cancer is one of the cancers where anti-PD-L1/PD-1 immunotherapy has been unsuccessful. What confers pancreatic cancer resistance to... 
TARGET GENES | ANTI-PD-L1 ANTIBODY | T-CELL IMMUNITY | ONCOLOGY | IFN-GAMMA | METHYLTRANSFERASE ACTIVITY | FACTOR-KAPPA-B | PROMOTES | TUMOR MICROENVIRONMENT | CHECKPOINT BLOCKADE | HISTONE | Neoplasm Transplantation | Myeloid-Lymphoid Leukemia Protein - metabolism | Tumor Escape | Pancreatic Neoplasms - metabolism | Epigenesis, Genetic | Humans | Programmed Cell Death 1 Receptor - analysis | Antibodies, Monoclonal - therapeutic use | Histone-Lysine N-Methyltransferase - analysis | RNA, Messenger - metabolism | Histone-Lysine N-Methyltransferase - antagonists & inhibitors | Immunotherapy | Female | Indoles - pharmacology | Myeloid-Lymphoid Leukemia Protein - analysis | Promoter Regions, Genetic | Histone-Lysine N-Methyltransferase - genetics | Carcinoma - immunology | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Programmed Cell Death 1 Receptor - metabolism | Pancreatic Neoplasms - genetics | Down-Regulation - drug effects | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Piperazines - pharmacology | Tumor Microenvironment - immunology | B7-H1 Antigen - metabolism | T-Lymphocytes, Cytotoxic - chemistry | Animals | Histone-Lysine N-Methyltransferase - metabolism | Myeloid-Lymphoid Leukemia Protein - genetics | Pancreatic Neoplasms - immunology | Cell Line, Tumor | Carcinoma - genetics | Carcinoma - therapy | Indoles - therapeutic use | B7-H1 Antigen - analysis | Mice | Carcinoma - metabolism | Fas Ligand Protein - genetics | DNA Methylation - drug effects | Myeloid-Lymphoid Leukemia Protein - antagonists & inhibitors | Pancreatic Neoplasms - therapy | Care and treatment | Pancreatic cancer | Genetic aspects | Diagnosis | Gene expression | Health aspects | Membrane proteins | Index Medicus
Journal Article
Leukemia, ISSN 0887-6924, 06/2015, Volume 29, Issue 6, pp. 1402 - 1413
The bridging integrator 1 (BIN1) tumor suppressor encodes multiple alternatively spliced isoforms implicated in DNA repair, cell-cycle control, apoptosis and... 
BREAST-CANCER | TARGET | DEATH RECEPTOR | AHI-1 | GENE | ONCOLOGY | MYC-INTERACTING PROTEIN | BCR-ABL | MYCOSIS-FUNGOIDES | SEZARY-SYNDROME | HEMATOLOGY | EXPRESSION | Fas Ligand Protein - metabolism | Cell Proliferation | Humans | Lymphoma, T-Cell, Cutaneous - genetics | fas Receptor - metabolism | Case-Control Studies | Lymphoma, T-Cell, Cutaneous - metabolism | Flow Cytometry | Skin Neoplasms - mortality | Tumor Suppressor Proteins - genetics | fas Receptor - genetics | Tumor Cells, Cultured | Nuclear Proteins - genetics | CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism | Real-Time Polymerase Chain Reaction | Tumor Suppressor Proteins - metabolism | Lymphoma, T-Cell, Cutaneous - mortality | CASP8 and FADD-Like Apoptosis Regulating Protein - genetics | RNA, Messenger - genetics | Nuclear Proteins - metabolism | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Skin Neoplasms - metabolism | Animals | Cell Cycle | Skin Neoplasms - genetics | Adaptor Proteins, Signal Transducing - genetics | Fluorescent Antibody Technique | Mice, Inbred NOD | Mice | Adaptor Proteins, Signal Transducing - metabolism | Fas Ligand Protein - genetics | Apoptosis | Cellular proteins | Tumor suppressor genes | Development and progression | Genetic aspects | Lymphomas | Properties | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2009, Volume 119, Issue 1, pp. 182 - 192
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2013, Volume 288, Issue 16, pp. 11555 - 11571
Keratins 8 and 18 (K8/18) are simple epithelial cell-specific intermediate filament proteins. Keratins are essential for tissue integrity and are involved in... 
CARCINOMA-CELLS | ACTIVATION | X-LINKED INHIBITOR | INDUCED APOPTOSIS | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | AKT ISOFORMS | MESENCHYMAL TRANSITION | NF-KAPPA-B | TIGHT JUNCTION PROTEIN | Fas Ligand Protein - metabolism | Cisplatin - pharmacokinetics | Apoptosis - drug effects | Humans | Neoplasms, Glandular and Epithelial - metabolism | Apoptosis - genetics | Epithelial-Mesenchymal Transition - drug effects | NF-kappa B - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Epithelial-Mesenchymal Transition - genetics | Cell Movement - genetics | Proto-Oncogene Proteins c-akt - genetics | Gene Knockdown Techniques | Neoplasms, Glandular and Epithelial - genetics | Matrix Metalloproteinase 9 - genetics | Keratin-18 - biosynthesis | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Gene Expression Regulation, Neoplastic - genetics | Matrix Metalloproteinase 2 - biosynthesis | Neoplasms, Glandular and Epithelial - pathology | Matrix Metalloproteinase 9 - biosynthesis | Keratin-8 - genetics | Enzyme Activation - drug effects | Keratin-18 - genetics | Hep G2 Cells | Claudin-1 - biosynthesis | Phosphatidylinositol 3-Kinases - genetics | Up-Regulation - drug effects | Cell Movement - drug effects | Matrix Metalloproteinase 2 - genetics | NF-kappa B - genetics | Claudin-1 - genetics | HeLa Cells | Enzyme Activation - genetics | Fas Ligand Protein - genetics | Keratin-8 - biosynthesis | Index Medicus | Cell Migration | Claudin1 | Keratins | Cell Invasion | Phosphatidylinositol 3-Kinase | Epithelial-Mesenchymal Transition | Cancer Biology | Akt | NF-κB (NF-KB) | Cell Biology | Apoptosis
Journal Article