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1. Full Text Distinct effects of human glioblastoma immunoregulatory molecules programmed cell death ligand-1 (PDL-1) and indoleamine 2,3-dioxygenase (IDO) on tumour-specific T cell functions
by Avril, Tony and Saikali, Stéphan and Vauleon, Elodie and Jary, Anne and Hamlat, Abderrahmane and De Tayrac, Marie and Mosser, Jean and Quillien, Véronique
Journal of neuroimmunology, ISSN 0165-5728, 2010, Volume 225, Issue 1, pp. 22 - 33
Neurology | Allergy and Immunology | IDO | Immunomodulation | Immunotherapy | Glioblastoma | TGF-β | PDL-1 | T cells | Neurosciences | Immunology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Fas Ligand Protein - metabolism | Flow Cytometry - methods | Transforming Growth Factor beta2 - metabolism | Humans | HLA Antigens - genetics | Interferon-gamma - metabolism | Indoleamine-Pyrrole 2,3,-Dioxygenase - pharmacology | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | Antigens, CD - metabolism | Histocompatibility Antigens Class I - metabolism | T-Lymphocytes - drug effects | Antigens, Neoplasm - metabolism | Cytotoxicity, Immunologic - drug effects | B7-H1 Antigen | Oligonucleotide Array Sequence Analysis - methods | Gene Expression Profiling - methods | Lectins - pharmacology | Histocompatibility Antigens Class I - genetics | HLA-G Antigens | HLA Antigens - metabolism | Gene Expression Regulation - drug effects | Glioblastoma - immunology | Glioblastoma - pathology | Cell Line, Tumor | Antigens, CD - pharmacology | MART-1 Antigen | T-Lymphocytes - immunology | Cell Proliferation - drug effects | HLA-A2 Antigen - metabolism | Cytotoxicity, Immunologic - immunology | Fas Ligand Protein - genetics | Interferon-gamma - pharmacology | Cell research | Histocompatibility antigens | Messenger RNA | HLA histocompatibility antigens | Lectins | Biochemistry | Transforming growth factors | Glioblastoma multiforme | Apoptosis | Index Medicus | Cell Proliferation | Oligonucleotide Array Sequence Analysis | Histocompatibility Antigens Class I | Gene Expression Profiling | Life Sciences | Flow Cytometry | Neoplasm Proteins | Transforming Growth Factor beta2 | Interferon-gamma | Antigens, Neoplasm | T-Lymphocytes | Gene Expression Regulation | Fas Ligand Protein | HLA-A2 Antigen | Indoleamine-Pyrrole 2,3,-Dioxygenase | HLA Antigens | RNA, Messenger | Antigens, CD | Cytotoxicity, Immunologic | Cancer
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2. Full Text Cancer-associated fibroblasts induce antigen-specific deletion of CD8 + T Cells to protect tumour cells
by Lakins, Matthew A and Ghorani, Ehsan and Munir, Hafsa and Martins, Carla P and Shields, Jacqueline D
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 948 - 9
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fas Ligand Protein - metabolism | Antigens, Neoplasm - immunology | Cell Survival | Mice, Inbred C57BL | Programmed Cell Death 1 Ligand 2 Protein - metabolism | Cancer-Associated Fibroblasts - pathology | Animals | Cross-Priming - immunology | Proteolysis | Female | CD8-Positive T-Lymphocytes - immunology | Cytoprotection | Cytotoxicity, Immunologic | Antigens | Immune response | CD8 antigen | Crosstalk | Cytotoxicity | Lymphocytes T | FasL protein | Immune checkpoint | Clonal deletion | Lymphocytes | Stromal cells | Fibroblasts | Tumors | Cancer | Index Medicus
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3. Full Text CD30-redirected chimeric antigen receptor T cells target CD30+ and CD30- embryonal carcinoma via antigen-dependent and fas/fasl interactions
by Hong, Lee K and Hong, Lee K and Chen, Yuhui and Smith, Christof C and Montgomery, Stephanie A and Montgomery, Stephanie A and Vincent, Benjamin G and Dotti, Gianpietro and Dotti, Gianpietro and Savoldo, Barbara and Savoldo, Barbara
Cancer immunology research, ISSN 2326-6066, 10/2018, Volume 6, Issue 10, pp. 1274 - 1287
Oncology | Immunology | Life Sciences & Biomedicine | Science & Technology | Testicular Neoplasms - therapy | Immunotherapy, Adoptive | Humans | Ki-1 Antigen - immunology | Male | Mice, SCID | Fas Ligand Protein - immunology | Xenograft Model Antitumor Assays | fas Receptor - immunology | Animals | Receptors, Chimeric Antigen - immunology | Cell Line, Tumor | Mice, Inbred NOD | T-Lymphocytes - immunology | Neoplasms, Germ Cell and Embryonal - therapy | Index Medicus
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4. Full Text Persistent antigen at vaccination sites induces tumor-specific CD8+ T cell sequestration, dysfunction and deletion
by Hailemichael, Yared and Dai, Zhimin and Jaffarzad, Nina and Ye, Yang and Medina, Miguel A and Huang, Xue-Fei and Dorta-Estremera, Stephanie M and Greeley, Nathaniel R and Nitti, Giovanni and Peng, Weiyi and Liu, Chengwen and Lou, Yanyan and Wang, Zhiqiang and Ma, Wencai and Rabinovich, Brian and Schluns, Kimberly S and Davis, Richard E and Hwu, Patrick and Overwijk, Willem W
Nature medicine, ISSN 1078-8956, 04/2013, Volume 19, Issue 4, pp. 465 - 472
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Cancer Vaccines - pharmacology | Mice, Inbred C57BL | Interferon-gamma - physiology | Antigen Presentation - immunology | Fas Ligand Protein - physiology | Cancer Vaccines - immunology | Animals | Apoptosis - immunology | Melanoma, Experimental - immunology | CD8-Positive T-Lymphocytes - drug effects | Female | Mice | CD8-Positive T-Lymphocytes - immunology | Antigens | T cell receptors | Vaccines | Peptides | Tumors | Cancer | Index Medicus
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5. Full Text IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4 + T cells
by Brown, Deborah M and Kamperschroer, Cris and Dilzer, Allison M and Roberts, Deborah M and Swain, Susan L
Cellular immunology, ISSN 0008-8749, 2009, Volume 257, Issue 1, pp. 69 - 79
Cytotoxicity | IL-2 | CD4 subsets | Peptide dose | Perforin | Immunology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Fas Ligand Protein - metabolism | Perforin - genetics | Ovalbumin - immunology | Dendritic Cells - immunology | Granzymes - metabolism | Th2 Cells - immunology | Interferon-gamma - metabolism | Th1 Cells - immunology | Fas Ligand Protein - immunology | CD4-Positive T-Lymphocytes - immunology | Th1 Cells - metabolism | T-Lymphocytes, Cytotoxic - drug effects | Interleukin-4 - pharmacology | Interleukin-2 - immunology | Peptide Fragments - immunology | Granzymes - immunology | Perforin - immunology | Dendritic Cells - metabolism | Cytokines - immunology | T-Lymphocytes, Cytotoxic - immunology | Cytokines - metabolism | Interleukin-4 - metabolism | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Mice, Transgenic | Hemagglutinins, Viral - immunology | Th2 Cells - metabolism | Mice, Knockout | Cell Differentiation - immunology | Interleukin-4 - immunology | Animals | T-Lymphocytes, Cytotoxic - metabolism | Cell Differentiation - drug effects | Interferon-gamma - immunology | Interleukin-2 - pharmacology | Antigens - immunology | Mice | Mice, Inbred BALB C | Perforin - metabolism | CD4-Positive T-Lymphocytes - drug effects | Cytotoxicity, Immunologic | Index Medicus | peptide dose | perforin | cytotoxicity
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6. Full Text Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector-Dependent
by Gomes-Silva, Diogo and Mukherjee, Malini and Srinivasan, Madhuwanti and Krenciute, Giedre and Dakhova, Olga and Zheng, Yueting and Cabral, Joaquim M.S and Rooney, Cliona M and Orange, Jordan S and Brenner, Malcolm K and Mamonkin, Maksim
Cell reports (Cambridge), ISSN 2211-1247, 10/2017, Volume 21, Issue 1, pp. 17 - 26
adoptive T cell therapy | 4-1BB | chimeric antigen receptor | costimulation | T cells | adoptive T cell therapy | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasm Transplantation | Humans | Mutant Chimeric Proteins - genetics | NF-kappa B - immunology | Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics | T-Lymphocytes - transplantation | Leukemia-Lymphoma, Adult T-Cell - immunology | Lentivirus - metabolism | fas Receptor - immunology | Cell Death | fas Receptor - genetics | Lentivirus - genetics | Receptors, Antigen, T-Cell - immunology | 4-1BB Ligand - immunology | T-Lymphocytes - pathology | 4-1BB Ligand - genetics | Antigens, Neoplasm - genetics | Genetic Vectors - chemistry | Signal Transduction | Antigens, Neoplasm - immunology | Cell Survival | Leukemia-Lymphoma, Adult T-Cell - genetics | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | Genetic Vectors - metabolism | Gene Expression Regulation, Leukemic | Leukemia-Lymphoma, Adult T-Cell - pathology | Gammaretrovirus - metabolism | Animals | Gammaretrovirus - genetics | NF-kappa B - genetics | Mice, Inbred NOD | Mutant Chimeric Proteins - immunology | T-Lymphocytes - immunology | Mice | Receptors, Antigen, T-Cell - genetics | Index Medicus | Chimeric antigen receptor
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7. Full Text Locally produced C5a binds to T cell expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis
by Lalli, Peter N and Strainic, Michael G and Yang, Min and Lin, Feng and Medof, M. Edward and Heeger, Peter S
Blood, ISSN 0006-4971, 09/2008, Volume 112, Issue 5, pp. 1759 - 1766
Life Sciences & Biomedicine | Hematology | Science & Technology | Receptor, Anaphylatoxin C5a - genetics | Complement Activation | CD55 Antigens - genetics | Complement C5a - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Complement C5a - biosynthesis | fas Receptor - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Mice, Inbred MRL lpr | T-Lymphocytes - metabolism | Isoenzymes - metabolism | Class Ib Phosphatidylinositol 3-Kinase | Complement C3 - genetics | Signal Transduction | Complement C3 - metabolism | Lymphocyte Activation | Mice, Inbred C57BL | Mice, Transgenic | Cell Survival - immunology | Antigen-Presenting Cells - immunology | Mice, Knockout | Animals | Apoptosis - immunology | T-Lymphocytes - cytology | Receptor, Anaphylatoxin C5a - deficiency | CD55 Antigens - metabolism | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Receptor, Anaphylatoxin C5a - metabolism | Index Medicus | Abridged Index Medicus | Immunobiology
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8. Full Text CD3+CD8+NKG2D+ T Lymphocytes Induce Apoptosis and Necroptosis in HLA‐Negative Cells via FasL–Fas Interaction
by Ivanova, Olga K and Sharapova, Tatiana N and Romanova, Elena A and Soshnikova, Natalia V and Sashchenko, Lidia P and Yashin, Denis V
Journal of cellular biochemistry, ISSN 0730-2312, 10/2017, Volume 118, Issue 10, pp. 3359 - 3366
APOPTOSIS | NKG2D | NECROPTOSIS | FasL | CYTOTOXITY | Fas | HUMAN LYMPHOCYTES | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | NK Cell Lectin-Like Receptor Subfamily K | CD3 Complex | Humans | Fas Ligand Protein - immunology | fas Receptor - immunology | Animals | Apoptosis - immunology | Neoplasms - immunology | K562 Cells | Mice | HLA Antigens | CD8-Positive T-Lymphocytes - immunology | Immunity, Cellular | Heat shock proteins | Antigens | T cells | Apoptosis | Tumor necrosis factor receptors | Cell culture | Fas antigen | CD8 antigen | Cytotoxicity | Lymphocytes T | Machinery | Proteins | Cell activation | Immunology | Interleukin 2 | Lymphocytes | CD25 antigen | Killing | Antigen presentation | Tumor cells | CD95 antigen | Mortality | Hsp70 protein | CD3 antigen | Switching | CD4 antigen | Major histocompatibility complex | FasL protein | Cell death | Histocompatibility antigen HLA | Cancer | Index Medicus
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9. Full Text Self-recognition of CD1 by γ/δ T cells: Implications for innate immunity
by Spada, Franca M and Grant, Ethan P and Peters, Peter J and Sugita, Masahiko and Melián, Augustín and Leslie, David S and Lee, Hoi K and Van Donselaar, Elly and Hanson, Dennis A and Krensky, Alan M and Majdic, Otto and Porcelli, Steven A and Morita, Craig T and Brenner, Michael B
The Journal of experimental medicine, ISSN 0022-1007, 03/2000, Volume 191, Issue 6, pp. 937 - 948
T lymphocytes | CD1 | Cytolysis | Granulysin | T cell antigen receptors γ/δ | Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | T-Lymphocyte Subsets - immunology | Cytotoxicity Tests, Immunologic | T-Lymphocyte Subsets - cytology | Anti-Infective Agents - metabolism | Humans | Molecular Sequence Data | Receptors, Antigen, T-Cell, gamma-delta - genetics | Th1 Cells - immunology | Gene Rearrangement, delta-Chain T-Cell Antigen Receptor | Th1 Cells - metabolism | Membrane Glycoproteins - physiology | Base Sequence | Pore Forming Cytotoxic Proteins | fas Receptor - physiology | Perforin | Amino Acid Sequence | Cell Line | Antigen-Presenting Cells - metabolism | Antigens, CD1 - biosynthesis | Receptors, Antigen, T-Cell, gamma-delta - metabolism | Lymphocyte Activation | Immunity, Innate | Antigen-Presenting Cells - immunology | Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor | Cell Differentiation - immunology | Receptors, Antigen, T-Cell, gamma-delta - physiology | T-Lymphocyte Subsets - metabolism | Antigens, CD1 - metabolism | T-Lymphocyte Subsets - microbiology | Antigens, Differentiation, T-Lymphocyte - biosynthesis | Cytotoxicity, Immunologic | CD1 antigen | Index Medicus | AIDS/HIV | cytolysis | T cell antigen receptors γ | δ | granulysin | Original
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