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Nature, ISSN 0028-0836, 2013, Volume 501, Issue 7466, pp. 242 - 246
The tumour necrosis factor (TNF) family is crucial for immune homeostasis, cell death and inflammation. These cytokines are recognized by members of the TNF... 
PATHWAYS | TOLL-LIKE-RECEPTORS | NECROSIS-FACTOR RECEPTOR | PROTEIN | TRADD | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | SUPERFAMILY | BACTERIAL EFFECTOR | FAMILY | NLEB | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Tumor Necrosis Factor-alpha - metabolism | Protein Biosynthesis | Humans | Virulence | Receptor-Interacting Protein Serine-Threonine Kinases - chemistry | Male | NF-kappa B - metabolism | Receptors, Tumor Necrosis Factor, Type I - metabolism | fas Receptor - metabolism | Multiprotein Complexes - metabolism | Enteropathogenic Escherichia coli - metabolism | Enteropathogenic Escherichia coli - pathogenicity | Receptors, Tumor Necrosis Factor, Type I - chemistry | TNF Receptor-Associated Death Domain Protein - metabolism | Acylation | Disease Models, Animal | Protein Structure, Tertiary | Signal Transduction | Mice, Inbred C57BL | Fas-Associated Death Domain Protein - metabolism | Escherichia coli Infections - microbiology | Escherichia coli Proteins - metabolism | Escherichia coli Infections - metabolism | TNF-Related Apoptosis-Inducing Ligand - metabolism | Fas-Associated Death Domain Protein - chemistry | N-Acetylglucosaminyltransferases - metabolism | Multiprotein Complexes - chemistry | Animals | TNF Receptor-Associated Death Domain Protein - chemistry | Escherichia coli Infections - pathology | Virulence Factors - metabolism | Mice | HeLa Cells | Arginine - metabolism | Apoptosis | Death Domain Receptor Signaling Adaptor Proteins - metabolism | Arginine | Cytokines | Cell death | Tumor necrosis factor | Escherichia coli | Genetic aspects | Research | Properties | Salmonella | Microbiology | Kinases | Bacteriology
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 501, Issue 7466, pp. 247 - 251
Successful infection by enteric bacterial pathogens depends on the ability of the bacteria to colonize the gut, replicate in host tissues and disseminate to... 
SYSTEM | INDUCED APOPTOSIS | ROLES | MULTIDISCIPLINARY SCIENCES | DISEASE | CITROBACTER-RODENTIUM | VIRULENCE | PROTEINS | NLEB | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Fas Ligand Protein - metabolism | Humans | fas Receptor - deficiency | Caspase 8 - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - chemistry | Male | Citrobacter rodentium - pathogenicity | fas Receptor - metabolism | Enteropathogenic Escherichia coli - metabolism | Enteropathogenic Escherichia coli - pathogenicity | Cell Death | HEK293 Cells | Female | TNF Receptor-Associated Death Domain Protein - metabolism | Protein Structure, Tertiary | Citrobacter rodentium - physiology | Signal Transduction | Fas-Associated Death Domain Protein - metabolism | Escherichia coli Infections - microbiology | Gastrointestinal Tract - microbiology | Escherichia coli Proteins - metabolism | Escherichia coli Infections - metabolism | Fas-Associated Death Domain Protein - chemistry | N-Acetylglucosaminyltransferases - metabolism | Fas Ligand Protein - antagonists & inhibitors | Animals | TNF Receptor-Associated Death Domain Protein - chemistry | Escherichia coli Infections - pathology | Virulence Factors - metabolism | Mice | Enzyme Activation | HeLa Cells | Cell receptors | Bacterial infections | Pathogenic microorganisms | Microbiology | Physiological aspects | Research | Stomach diseases | Proteins | Yeast | Microscopy | Rodents | Infections | Kinases | Apoptosis | EPEC | apoptosis | caspase-8 | death domain
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2016, Volume 64, Issue 2, pp. 236 - 250
Caspase-8 activation can be triggered by death receptor-mediated formation of the death-inducing signaling complex (DISC) and by the inflammasome adaptor ASC.... 
caspase-8 | DED | MC159 | cFLIP | DISC | Fas | death domain | FADD | vFLIP | filament | APOPTOSIS | ACTIVATION | IMMUNE-SYSTEM | INHIBITION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | UNIFIED MODEL | EFFECTOR DOMAIN | CELL-DEATH | CELL BIOLOGY | Death Domain Receptor Signaling Adaptor Proteins - chemistry | Apoptosis - drug effects | Cytoskeletal Proteins - genetics | Humans | Caspase 8 - metabolism | Caspase 8 - chemistry | CASP8 and FADD-Like Apoptosis Regulating Protein - chemistry | Death Domain Receptor Signaling Adaptor Proteins - genetics | Recombinant Fusion Proteins - metabolism | Viral Proteins - metabolism | Caspase 8 - genetics | Transfection | Cytoskeletal Proteins - metabolism | Protein Interaction Domains and Motifs | Binding Sites | CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism | Death Effector Domain | Fas-Associated Death Domain Protein - genetics | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | CASP8 and FADD-Like Apoptosis Regulating Protein - genetics | Jurkat Cells | Viral Proteins - chemistry | Fas-Associated Death Domain Protein - metabolism | Viral Proteins - genetics | fas Receptor - pharmacology | Cytoskeletal Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Plasmids - metabolism | Fas-Associated Death Domain Protein - chemistry | Cryoelectron Microscopy | Sequence Homology, Amino Acid | Sequence Alignment | Protein Conformation, beta-Strand | CARD Signaling Adaptor Proteins | Plasmids - chemistry | Protein Binding | Recombinant Fusion Proteins - genetics | Death Domain Receptor Signaling Adaptor Proteins - metabolism | Autoimmunity | Medical colleges | Skin diseases | Molecular biology | Analysis | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2011, Volume 43, Issue 3, pp. 432 - 448
A better understanding of the mechanisms through which anticancer drugs exert their effects is essential to improve combination therapies. While studying how... 
CASPASE INHIBITORS | TUMOR-NECROSIS-FACTOR | LIGASE ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | ALPHA-DEPENDENT APOPTOSIS | TRAIL-INDUCED APOPTOSIS | TNF-ALPHA | CHEMOTHERAPEUTIC DRUGS | NF-KAPPA-B | CELL-DEATH | CELL BIOLOGY | CASP8 and FADD-Like Apoptosis Regulating Protein - physiology | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Humans | Caspase 8 - metabolism | Nuclear Pore Complex Proteins - chemistry | Caspase 8 - chemistry | Inhibitor of Apoptosis Proteins - physiology | Nuclear Pore Complex Proteins - physiology | Antineoplastic Agents - pharmacology | CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism | Fas-Associated Death Domain Protein - physiology | RNA-Binding Proteins - physiology | Signal Transduction | CASP8 and FADD-Like Apoptosis Regulating Protein - genetics | Nuclear Pore Complex Proteins - metabolism | RNA-Binding Proteins - chemistry | Fas-Associated Death Domain Protein - metabolism | Etoposide - pharmacology | Mitochondria - metabolism | Caspase 8 - physiology | Fas-Associated Death Domain Protein - chemistry | Cell Line, Tumor | Ligands | Apoptosis - physiology | DNA Damage | Enzyme Activation | RNA-Binding Proteins - metabolism | Ubiquitin | Green design | Oncology, Experimental | Internet service providers | Research | Sustainable development | Cancer
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2012, Volume 287, Issue 15, pp. 12455 - 12468
Autophagy and apoptosis are two evolutionarily conserved processes that regulate cell fate in response to cytotoxic stress. However, the functional... 
PROGRAMMED CELL-DEATH | INHIBITION | BECLIN-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIF-1 | MITOCHONDRIA | DEGRADATION | MEDIATED CLEAVAGE | MACROAUTOPHAGY | CHLOROQUINE | SPHINGOSINE KINASE | Death Domain Receptor Signaling Adaptor Proteins - physiology | Autophagy-Related Proteins | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Humans | Protein Multimerization | Caspase 3 - metabolism | Caspase 8 - metabolism | Leukemia, Myeloid, Acute | Autophagy | Heat-Shock Proteins - genetics | Cell Membrane - metabolism | Tumor Cells, Cultured | Pyrazoles - pharmacology | Cell Survival - drug effects | Hydrazines - pharmacology | Lysosome-Associated Membrane Glycoproteins - metabolism | Heat-Shock Proteins - metabolism | Cells, Cultured | Fas-Associated Death Domain Protein - metabolism | Ubiquitin-Conjugating Enzymes - genetics | Mitochondria - metabolism | Mitochondria - drug effects | Gene Knockout Techniques | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Protein Transport | Cell Membrane - enzymology | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Animals | Autophagy-Related Protein 5 | Ubiquitin-Conjugating Enzymes - metabolism | Adaptor Proteins, Signal Transducing - genetics | Protein Binding | Mice | Enzyme Activation | Adaptor Proteins, Signal Transducing - metabolism | Apoptosis | Caspase-8 | Bortezomib | Cell Death | Caspase | Sphingolipid | SKI-I | p62 | Sequestosome 1 | Atg5 | Cell Biology
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 06/2015, Volume 6, Issue 1, p. 7515
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7516, pp. 90 - 94
Necroptosis has emerged as an important pathway of programmed cell death in embryonic development, tissue homeostasis, immunity and inflammation(1-8). RIPK1 is... 
CHRONIC INTESTINAL INFLAMMATION | CELLS | KAPPA-B ACTIVATION | NECROSIS-FACTOR RECEPTOR | MULTIDISCIPLINARY SCIENCES | IN-VIVO | KINASE | ALPHA-DEPENDENT APOPTOSIS | MICE | SKIN INFLAMMATION | DELETION | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Inflammation - pathology | Skin - cytology | Epithelial Cells - metabolism | Skin - metabolism | Caspase 8 - metabolism | Homeostasis | Paneth Cells - pathology | Male | Intestines - metabolism | Receptors, Tumor Necrosis Factor, Type I - metabolism | Necrosis | Receptors, Tumor Necrosis Factor, Type I - deficiency | Inflammation - metabolism | Female | Epithelial Cells - cytology | Skin - pathology | Paneth Cells - metabolism | Intestines - pathology | Cell Survival | Fas-Associated Death Domain Protein - metabolism | Fas-Associated Death Domain Protein - deficiency | Epithelial Cells - pathology | Mice, Knockout | Keratinocytes - pathology | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Keratinocytes - metabolism | Mice | Receptor-Interacting Protein Serine-Threonine Kinases - deficiency | Myeloid Differentiation Factor 88 - metabolism | Apoptosis | Intestines - cytology | Physiological aspects | Physiological research | Inflammation | Research | Protein kinases | Pathology | Antibiotics | Rodents | Skin | Kinases
Journal Article
Journal Article