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PLoS ONE, ISSN 1932-6203, 2014, Volume 9, Issue 1, p. e86629
Osteoblast apoptosis plays an important role in bone development and maintenance, and is in part responsible for osteoporosis in sex steroid deficiency,... 
TRANSCRIPTION FACTORS | APOPTOSIS | OXIDATIVE STRESS | CELL-CYCLE ENTRY | BONE-FORMATION | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | IN-VIVO | PARATHYROID-HORMONE | DEATH | P53 | Up-Regulation | Mice, Inbred C57BL | Forkhead Transcription Factors - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Animals | Forkhead Transcription Factors - metabolism | Gene Deletion | Cell Differentiation | Forkhead Box Protein O1 | Mice | Osteoblasts - cytology | Forkhead Box Protein O3 | Osteoblasts - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Osteogenesis | Apoptosis | Physiological aspects | Corticosteroids | DNA binding proteins | Tumor proteins | Cell culture | Oxidative stress | Transcription factors | Phosphorylation | Glucocorticoids | p53 Protein | Bromodeoxyuridine | AKT protein | Biology | Insulin-like growth factors | Kinases | Inactivation | Osteoblasts | Cell density | Proteins | Osteoporosis | Biomedical materials | Cell growth | FOXO1 protein | Bcl-x protein | Transgenic animals | Rodents | Surgery | Cell cycle | Aging | Forkhead protein | Insulin-like growth factor-binding protein 3 | Biocompatibility | Bones | Physiology | FOXO3 protein | University graduates | Osteocalcin | Deactivation | Gene expression | Insulin | DNA nucleotidylexotransferase | Osteoblastogenesis | Gadd45A protein | FasL protein | Cell death | Differentiation | BIM protein | PTEN protein
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, p. e78355
Approximately 30% of patients with Epstein-Barr virus (EBV)-positive advanced nasopharyngeal carcinoma (NPC) display chemoresistance to cisplatin-based... 
CANCER-CELLS | B-CELLS | SURVIVAL | MEMBRANE-PROTEIN 1 | MULTIDISCIPLINARY SCIENCES | EBV | MIR-21 | LATENCY | LIGAND | EXPRESSION | LINES | RNA-Binding Proteins - genetics | Carcinoma | Apoptosis - drug effects | Humans | Nasopharyngeal Neoplasms - virology | MicroRNAs - metabolism | Viral Matrix Proteins - pharmacology | Tetrazolium Salts | Forkhead Transcription Factors - metabolism | Luciferases | Thiazoles | Apoptosis Regulatory Proteins - genetics | Inhibitory Concentration 50 | Viral Matrix Proteins - metabolism | Colony-Forming Units Assay | Gene Expression Regulation, Neoplastic - drug effects | Nasopharyngeal Neoplasms - drug therapy | Real-Time Polymerase Chain Reaction | RNA-Binding Proteins - antagonists & inhibitors | Cell Line | Nasopharyngeal Carcinoma | Cisplatin - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Drug Resistance, Neoplasm - genetics | Fas Ligand Protein - antagonists & inhibitors | Cisplatin - therapeutic use | Signal Transduction - drug effects | Apoptosis Regulatory Proteins - antagonists & inhibitors | Fluorescent Antibody Technique | MicroRNAs - genetics | Fas Ligand Protein - genetics | Forkhead Box Protein O3 | Infection | Prognosis | MicroRNA | Tumor necrosis factor | Epstein-Barr virus | B cells | Health aspects | Cisplatin | Apoptosis | Cancer | Cell proliferation | Laboratories | Genes | Crosstalk | Chemoresistance | Viruses | Oncology | Homology | AKT protein | Infections | Metastasis | Proteins | Nasopharyngeal carcinoma | Disease resistance | Signal transduction | Coding | Tumor necrosis factor-TNF | Tumorigenesis | Bioindicators | FOXO3 protein | MiRNA | Ribonucleic acid--RNA | 1-Phosphatidylinositol 3-kinase | Membrane proteins | Medicine | Signaling | Chemotherapy | FasL protein | Cell death | MicroRNAs | Medical prognosis | Cell lines | Biomarkers | Ligands | Latent membrane protein 1 | RNA | Ribonucleic acid
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, p. e0125727
Arctigenin (ARG) has been previously reported to exert high biological activities including anti-inflammatory, antiviral and anticancer. In this study, the... 
CANCER-CELLS | TRANSCRIPTION FACTORS | IN-VITRO | INDUCED APOPTOSIS | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIA | DEATH | NF-KAPPA-B | BCL-2 FAMILY-MEMBERS | KINASE ACTIVATION | P53 | Tumor Necrosis Factor-alpha - metabolism | Fas Ligand Protein - metabolism | Caspase 9 - genetics | Caspase 9 - metabolism | Furans - pharmacology | Humans | Tumor Necrosis Factor-alpha - genetics | bcl-2-Associated X Protein - agonists | Caspase 3 - metabolism | Gene Expression Regulation, Neoplastic | NF-kappa B - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Membrane Potential, Mitochondrial - drug effects | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | fas Receptor - metabolism | Lignans - pharmacology | Proto-Oncogene Proteins c-akt - genetics | Tumor Necrosis Factor-alpha - agonists | Proto-Oncogene Proteins c-bcl-2 - metabolism | Caspase 3 - genetics | Fas Ligand Protein - agonists | fas Receptor - genetics | Proto-Oncogene Proteins c-akt - metabolism | bcl-2-Associated X Protein - genetics | NF-kappa B - antagonists & inhibitors | Signal Transduction | Cytochromes c - metabolism | bcl-2-Associated X Protein - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Organ Specificity | Hep G2 Cells | fas Receptor - agonists | Phosphatidylinositol 3-Kinases - genetics | Poly(ADP-ribose) Polymerases - metabolism | Poly(ADP-ribose) Polymerases - genetics | NF-kappa B - genetics | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Antineoplastic Agents, Phytogenic - pharmacology | Fas Ligand Protein - genetics | Proto-Oncogene Proteins c-bcl-2 - genetics | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Apoptosis | Antiviral agents | Mitochondrial DNA | Liver diseases | Hepatoma | Tumor proteins | Cytochrome | Veterinary colleges | Bax protein | Bcl-2 protein | Toxicity | p53 Protein | Cytotoxicity | Hepatocellular carcinoma | AKT protein | Activation | Kinases | Caspase-3 | ADP | Liver cancer | Mitochondria | Ribose | Tumor necrosis factor-TNF | Membrane potential | Translocation | NF-κB protein | Deactivation | Caspase | Inflammation | Tumor cell lines | Tumor necrosis factor-α | Nuclear transport | 1-Phosphatidylinositol 3-kinase | Cytochrome c | Polymerase | Caspase-8 | FasL protein | Tumor necrosis factor | Cell lines | Caspase-9
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 03/2017, Volume 232, Issue 3, pp. 526 - 539
T11TS induced apoptosis of glioma‐associated brain endothelial cells and its effect on glioma angiogenesis. 
IN-VITRO | ACTIVATION | PHYSIOLOGY | PATHWAY | MITOCHONDRIA | BAX | GROWTH-FACTOR | CYTOCHROME-C RELEASE | EXPRESSION | TUMOR-SUPPRESSOR P53 | PERMEABILITY TRANSITION | CELL BIOLOGY | Fas Ligand Protein - metabolism | Apoptosis - drug effects | Glycopeptides - administration & dosage | Brain Neoplasms - pathology | Male | Membrane Potential, Mitochondrial - drug effects | fas Receptor - metabolism | Neovascularization, Pathologic - pathology | Caspases - metabolism | Glioma - pathology | Angiogenesis Inhibitors - therapeutic use | Female | BH3 Interacting Domain Death Agonist Protein - metabolism | Cytochromes c - metabolism | Membrane Glycoproteins - pharmacology | Fas-Associated Death Domain Protein - metabolism | Tumor Suppressor Protein p53 - metabolism | bcl-2-Associated X Protein - metabolism | Angiogenesis Inhibitors - pharmacology | Rats | Brain Neoplasms - drug therapy | Glycopeptides - therapeutic use | Membrane Glycoproteins - administration & dosage | Animals | Membrane Glycoproteins - therapeutic use | Models, Biological | Neovascularization, Pathologic - drug therapy | Cytosol - metabolism | Sheep | Enzyme Activation | Endothelial Cells - pathology | Glycopeptides - pharmacology | Endothelial Cells - drug effects | Antimitotic agents | Gliomas | Brain tumors | Drug therapy | Tumor proteins | Antineoplastic agents | Apoptosis | Endothelium | Cytochrome | Intervention | Neuroimaging | Brain | Bax protein | Bcl-2 protein | p53 Protein | Staining | Raf protein | Immunoblotting | AKT protein | Cytosol | Proteins | FADD protein | Angiogenesis | Signal transduction | Mitochondria | Rodents | Glioma cells | Membrane potential | Extracellular signal-regulated kinase | Caspase | Endothelial cells | 1-Phosphatidylinositol 3-kinase | Cytochrome c | Studies | FasL protein | Antiangiogenics | Nitric oxide | Bcl protein | In vivo methods and tests | Regulatory proteins | Tumors
Journal Article
Seminars in Cancer Biology, ISSN 1044-579X, 06/2018, Volume 50, pp. 77 - 89
The FOXO3 and FOXM1 forkhead box transcription factors, functioning downstream of the essential PI3K-Akt, Ras-ERK and JNK/p38MAPK signalling cascades, are... 
TO-MESENCHYMAL TRANSITION | IN-VITRO | ACTIVATED PROTEIN-KINASE | STEM-LIKE CELLS | ONCOLOGY | DNA-DAMAGE RESPONSE | ESTROGEN-RECEPTOR-ALPHA | JUN NH2-TERMINAL KINASE | FOXO TRANSCRIPTION FACTORS | FORKHEAD BOX M1 | NEGATIVE BREAST-CANCER | DNA Repair - drug effects | Humans | Gene Expression Regulation, Neoplastic | Antineoplastic Agents - therapeutic use | Neoplasms - drug therapy | Cell Self Renewal - genetics | Forkhead Box Protein O3 - genetics | Drug Resistance, Neoplasm - genetics | Neoplasms - genetics | Forkhead Box Protein M1 - genetics | Cell Proliferation - drug effects | Neoplasms - pathology | Drug Resistance, Neoplasm - drug effects | AURKA, aurora kinase A | Fox, forkhead box | Bim, B-cell lymphoma 2 interacting mediator | EGF, epidermal growth factor | JNK | BRIP1, BRCA1-interacting protein-terminal helicase 1 | GICs, glioma-initiating cells | MCL, mantle cell lymphoma | PKB, protein kinase B | SCs, stem cells | LEF, T-cell factor | Skp2, S-phase kinase-associated protein 2 | SSBs, single-strand breaks | mTOR, mammalian target of rapamycin | NBS1, Nijmegen breakage syndrome 1 | stress activated protein kinase | MEK, mitogen-activated protein kinase kinase | PIP3, phosphatidylinositol- 3,4,5-trisphosphate | BER, base excision repair | lymphoid enhancer factor | VEGF, vascular endothelial growth factor | AML, acute myeloid leukaemia | ER+ve, estreogen receptor positive | EXO1, exonuclease 1 | EGFR, epidermal growth factor receptor | MDR1, multidrug resistance protein 1 | ChIP-seq, chromatin immunoprecipitation with massively parallel DNA sequencing | ABCB1, ATP-binding cassette sub-family B member 1 | TCF | SOD-2, superoxide dismutase | TKIs, tyrosine kinase inhibitors | PDK, phosphoinositide-dependent kinase | IFNɣ, interferon-ɣ | BRCA2, breast cancer-associated gene 2 | DDR, DNA damage response | Cks1, cyclin-dependent kinases regulatory subunit 1 | ESR1, estrogen receptor alpha gene | NHEJ, non-homologous end joining | XRCC1, X-ray cross-complementing group 1 | OTUB1, OUT domain-containing ubiquitin aldehyde-binding protein 1 | IGF, insulin growth factor | TRAIL, tumour necrosis factor-related apoptosis inducing ligand | ER, estrogen receptor | MRN, MER11-RAD50-NBS1 | BRCA1, breast cancer susceptibility gene product 1 | FasL, fas ligand | RTKs, receptor tyrosine kinases | Sox1, sex determining region Y box 2 | GADD45, DNA damage-inducible protein 45 | MMR, mismatch repair | PI3K, phosphatidylinositol 3-kinase | ROS, reactive oxygen species | NAMPT, nicotinamide-phosphribosyltransferase | miRs, Micro-RNAs | FHRE, forkhead response element | ATM, Ataxia-telangiectasia mutated | NER, nucleotide excision repair | ERK, extracellular signal-regulated kinase | HR, homologous recombination | AMPK, adenosine monophosphate-activated protein kinase | DSBs, double strands breaks | PA, Psammaplysene A | CML, chronic myeloid leukaemia | HCC, hepatocellular carcinoma | Mst1, macrophage stimulating 1 | Rb2, retinoblastoma-related p130 | SAPK, c-Jun N-terminal kinase | CSCs, cancer stem cells
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2014, Volume 9, Issue 12, p. e115603
Sustained inflammation may increase the susceptibility of hepatocytes to apoptotic cell death and therefore exacerbate liver damage. Here we report that the... 
BAX-DEPENDENT APOPTOSIS | TUMOR-NECROSIS-FACTOR | ACTIVATION | IMMUNE-SYSTEM | PROTEIN | PHOSPHORYLATION | JNK | MULTIDISCIPLINARY SCIENCES | LIVER | BIM | MEMBRANE PERMEABILIZATION | Caspase 7 - metabolism | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Interleukin-1beta - pharmacology | Apoptosis - drug effects | Cytochromes c - metabolism | Caspase 3 - metabolism | JNK Mitogen-Activated Protein Kinases - metabolism | NF-kappa B - metabolism | Hepatocytes - metabolism | Enzyme Activation - drug effects | Apoptosis Regulatory Proteins - metabolism | Tumor Necrosis Factor-alpha - pharmacology | Hepatocytes - cytology | Animals | Fas Ligand Protein - pharmacology | Bcl-2-Like Protein 11 | Models, Biological | Membrane Proteins - metabolism | Mice | BH3 Interacting Domain Death Agonist Protein - metabolism | Hepatocytes - drug effects | Cytochrome | Bcl-2 protein | Transcription | Liver | Interleukin | Activation | Kinases | Caspase-3 | Proteins | Mitochondria | Cell activation | Mathematical analysis | Rodents | Tumor necrosis factor-TNF | A20 protein | Mathematical models | Pretreatment | Deoxyribonucleic acid--DNA | Building management systems | NF-κB protein | Subpopulations | Incubation | Caspase | Poly(ADP-ribose) polymerase | JNK protein | Inflammation | IL-1β | Gene expression | Cytochrome c | Caspase-8 | Signaling | FasL protein | Hepatocytes | Cell death | Viability | BIM protein | Apoptosis | Deoxyribonucleic acid | DNA
Journal Article