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Diabetes care, ISSN 1935-5548, 2018, Volume 41, Issue 8, pp. 1732 - 1739
...%) 1,000 extra kcal/day of saturated (SAT) or unsaturated (UNSAT) fat or simple sugars (CARB) for 3 weeks. We measured IHTG (H-1-MRS), pathways contributing to IHTG... 
WOMEN | OBESITY | DIET | ACIDS | INSULIN-RESISTANCE | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | ENDOTOXEMIA | WEIGHT-GAIN | LIPOPROTEINS | ADIPOSE-TISSUE | Fatty Acids - adverse effects | Overweight - complications | Humans | Liver - metabolism | Middle Aged | Insulin Resistance | Non-alcoholic Fatty Liver Disease - etiology | Male | Dietary Fats, Unsaturated - adverse effects | Non-alcoholic Fatty Liver Disease - metabolism | Monosaccharides - adverse effects | Feeding Behavior - physiology | Adipose Tissue - metabolism | Overweight - metabolism | Carbohydrate Metabolism - physiology | Dietary Fats, Unsaturated - metabolism | Insulin - metabolism | Triglycerides - blood | Adult | Female | Monosaccharides - metabolism | Weight Gain | Fatty Acids - metabolism | Lipid Metabolism - physiology | Health aspects | Saturated fatty acids | Liver | Medical and Health Sciences | endotoxemia | monosaccharide | body weight gain | Dietary Fats, Unsaturated | Overweight | saturated fatty acid | female | obesity | Endocrinology and Diabetes | clinical trial | nonalcoholic fatty liver | liver | food composition | adipose tissue | physiology | Clinical Medicine | Conference Paper | metabolism | adult | sugar | edible oil | gene expression | male | complication | triacylglycerol | Fatty Acids | insulin | carbohydrate metabolism | Medicin och hälsovetenskap | lipid metabolism | feeding behavior | fatty acid | Klinisk medicin | Monosaccharides | ceramide derivative | unsaturated fatty acid | dietary intake | clinical article | Endokrinologi och diabetes | Non-alcoholic Fatty Liver Disease | human | insulin resistance | proton nuclear magnetic resonance | hyperinsulinemia | Triglycerides | middle aged | blood | controlled study | lipid blood level | lipolysis | macronutrient | high calorie diet
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 544, Issue 7649, pp. 185 - 190
.... Here we show that a deficiency in H3K4me3 methyltransferase, which extends lifespan, promotes fat accumulation in worms with a specific enrichment of mono-unsaturated fatty acids (MUFAs... 
LONGEVITY | GENE | RNA | DESATURASE | METABOLISM | MULTIDISCIPLINARY SCIENCES | CARDIOVASCULAR-DISEASE | MECHANISMS | IDENTIFICATION | EXPRESSION | SUBUNIT | Dietary Fats - metabolism | Up-Regulation | Intestinal Mucosa - metabolism | Histones - chemistry | Longevity - drug effects | Aging - drug effects | Histone-Lysine N-Methyltransferase - deficiency | Caenorhabditis elegans - physiology | Dietary Fats - pharmacology | Dietary Fats - administration & dosage | Lysine - metabolism | Germ Cells - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - deficiency | Fatty Acid Desaturases - genetics | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Caenorhabditis elegans - genetics | Down-Regulation | Fatty Acid Desaturases - metabolism | Fatty Acids, Unsaturated - pharmacology | Fatty Acids, Unsaturated - metabolism | Germ Cells - enzymology | Gene Expression Regulation, Enzymologic | Animals | Caenorhabditis elegans - drug effects | Histone-Lysine N-Methyltransferase - metabolism | Stearoyl-CoA Desaturase | Lipid Metabolism - drug effects | Histones - metabolism | Methylation | Longevity - physiology | Caenorhabditis elegans - enzymology | Aging - metabolism | Fatty Acids, Unsaturated - administration & dosage | Intestines - enzymology | Life spans (Biology) | Caenorhabditis elegans | Chromatin | Monounsaturated fatty acids | Lipid research | Physiological aspects | Research | Lipid metabolism | Studies | Enzymes | Metabolites | Lipids | Influence | Metabolism | Gene expression | Fatty acids | Stains & staining
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 22, pp. 8882 - 8887
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 1, p. e30571
.... Methodology/Principal Findings: Here we show that, in a mouse model of diet-induced obesity, partial substitution of the fatty acid component of the diet by flax seed oil (rich in C18:3) or olive oil (rich in C18:1... 
GLUCOSE-HOMEOSTASIS | ENERGY | INHIBITION | FOOD-INTAKE | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | SENSITIVITY | LEPTIN RECEPTOR | ACCUMULATION | BRAIN | Gene Expression - drug effects | Rats, Wistar | Receptors, G-Protein-Coupled - metabolism | Immunoblotting | Male | Olive Oil | Inflammation - blood | Dietary Fats - administration & dosage | Obesity - etiology | Weight Gain - drug effects | Fatty Acids - blood | Hypothalamus - drug effects | Plant Oils - administration & dosage | Pro-Opiomelanocortin - genetics | Fatty Acids - metabolism | Fatty Acids, Omega-3 - administration & dosage | Dietary Fats - adverse effects | Fatty Acids - chemistry | Insulin Resistance | Rats | Obesity - physiopathology | Hypothalamus - pathology | Reverse Transcriptase Polymerase Chain Reaction | Inflammation - etiology | Nerve Tissue Proteins - genetics | Eating - drug effects | Animals | Hypothalamus - metabolism | Signal Transduction - drug effects | Obesity - prevention & control | Dietary Fats, Unsaturated - administration & dosage | Inflammation - prevention & control | Mice | Obesity | Brain | Unsaturated fatty acids | Diet | Analysis | Insulin resistance | Cellular signal transduction | Inflammation | Olive oil | Animal models | Adipose tissue | Laboratories | Proopiomelanocortin | Hypothalamus | Signal transduction | Rodents | Nutrients | Tumor necrosis factor-TNF | Flaxseed oil | Food | Medical research | Internal medicine | Neurons | Pharmacology | Injection | Metabolism | Insulin | Fatty acids | Medicine | Thermogenesis | Body mass | Food intake | Leptin | Oils & fats | Transduction | Diabetes | Flax
Journal Article
Prostaglandins, leukotrienes and essential fatty acids, ISSN 0952-3278, 2013, Volume 88, Issue 1, pp. 139 - 146
Abstract The conversion of the plant-derived omega-3 (n-3) α-linolenic acid (ALA, 18:3n-3) to the long-chain eicosapentaenoic acid... 
Endocrinology & Metabolism | Advanced Basic Science | Docosahexaenoic acid (DHA) | Alpha linolenic acid (ALA) | LA:ALA ratio | Linoleic acid (LA) | RAT-LIVER | CONVERSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMANS | CELL BIOLOGY | TERM INFANTS | VISUAL-ACUITY DEVELOPMENT | PLASMA | BIOSYNTHESIS | GROWTH | ENDOCRINOLOGY & METABOLISM | FISH-OIL | EICOSAPENTAENOIC ACID | Linoleic Acid - blood | Linoleic Acid - administration & dosage | Fatty Acids, Omega-6 - blood | Rats, Wistar | alpha-Linolenic Acid - analysis | Linoleic Acid - metabolism | Weaning | Safflower Oil - chemistry | Diet, High-Fat - adverse effects | Safflower Oil - metabolism | Male | Safflower Oil - administration & dosage | Linoleic Acid - adverse effects | Fatty Acids, Essential - deficiency | Fatty Acids, Essential - blood | Phospholipids - blood | Fatty Acids, Unsaturated - analysis | Phospholipids - metabolism | Plant Oils - administration & dosage | alpha-Linolenic Acid - administration & dosage | alpha-Linolenic Acid - blood | Fatty Acids, Essential - metabolism | Safflower Oil - adverse effects | Eicosapentaenoic Acid - metabolism | Phospholipids - chemistry | Rats | Fatty Acids, Omega-6 - metabolism | Linseed Oil - chemistry | Plant Oils - adverse effects | Eicosapentaenoic Acid - blood | Fatty Acids, Unsaturated - blood | Algorithms | Animals | Docosahexaenoic Acids - blood | Fatty Acids, Omega-6 - chemistry | Sunflower Oil | Linseed Oil - metabolism | Diet, Fat-Restricted | Fatty Acids, Unsaturated - adverse effects | Plant Oils - metabolism | alpha-Linolenic Acid - metabolism | Plant Oils - chemistry | Linseed Oil - administration & dosage | Docosahexaenoic Acids - metabolism | Fatty Acids, Omega-6 - adverse effects | Fatty Acids, Unsaturated - administration & dosage | Omega-3 fatty acids | Linolenic acids
Journal Article
2010, ISBN 0813815533, xiv, 268
Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids provides current research exploring the links among insulin, insulin receptors, polyunsaturated fatty acids, brain growth and disease... 
Brain | Non-insulin-dependent diabetes | Pathophysiology | physiology | Metabolic Syndrome X | Metabolic syndrome | Metabolism | Essential fatty acids | Fatty Acids, Essential | Unsaturated fatty acids | Fatty Acids, Unsaturated | physiopathology | pharmacology | Insulin resistance | Nutrition | MEDICAL
Book
Lipids in health and disease, ISSN 1476-511X, 2019, Volume 18, Issue 1, pp. 53 - 12
... RAW264.7 cells with 18-carbon unsaturated fatty acids including oleic acid (OA, 18:1), linoleic acid (LA, 18:2), alpha-linolenic acid... 
CELLS | Mitochondrial membrane composition | BIOCHEMISTRY & MOLECULAR BIOLOGY | BARTH-SYNDROME | PALMITATE | HEART | NUTRITION & DIETETICS | 18-carbon unsaturated fatty acids | METABOLISM | DOCOSAHEXAENOIC ACID | Cardiolipin | Mass spectrometry | ALPHA-LINOLENIC ACID | Carnitine O-Palmitoyltransferase - genetics | Linoleic Acid - metabolism | Fatty Acids, Omega-3 - chemistry | alpha-Linolenic Acid - chemistry | Gene Expression Profiling | Structure-Activity Relationship | Mitochondrial Membranes - drug effects | alpha-Linolenic Acid - pharmacology | Oleic Acid - pharmacology | Biological Transport | Fatty Acids, Omega-3 - pharmacology | gamma-Linolenic Acid - chemistry | Carnitine O-Palmitoyltransferase - metabolism | Mitochondrial Membranes - chemistry | Linoleic Acid - pharmacology | Mitochondria - chemistry | gamma-Linolenic Acid - metabolism | Fatty Acid Desaturases - genetics | Oleic Acid - metabolism | Fatty Acids, Omega-3 - metabolism | Fatty Acid Desaturases - metabolism | Gene Expression Regulation | Linoleic Acid - chemistry | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondrial Membranes - metabolism | Animals | alpha-Linolenic Acid - metabolism | gamma-Linolenic Acid - pharmacology | RAW 264.7 Cells | Cardiolipins - biosynthesis | Mice | Oleic Acid - chemistry | Eukaryotes | Mitochondria | Research | Alzheimer's disease | Heart | Fish oils | Lipids | Mass spectroscopy | Membrane composition | Inflammation | Metabolism | Macrophages | Desaturase | Fatty acids | Carbon | Ovarian cancer | Linoleic acid | Linolenic acid | Metabolites | Oleic acid | Stem cells | Scientific imaging | Supplementation | Apoptosis | Structure-function relationships
Journal Article
Diabetes (New York, N.Y.), ISSN 1939-327X, 2009, Volume 59, Issue 2, pp. 386 - 396
Journal Article
PloS one, ISSN 1932-6203, 12/2012, Volume 7, Issue 12, p. e52838
Although evidence has shown the regulating effect of n-3 poly-unsaturated fatty acid (n-3 PUFA... 
PROTEIN-COUPLED RECEPTOR | INDUCED APOPTOSIS | PATHWAY | ADENYLYL-CYCLASE | MULTIDISCIPLINARY SCIENCES | LIPID RAFTS | GPR30 | PROLIFERATION | PLASMA-MEMBRANE | EXPRESSION | GENE-TRANSCRIPTION | Cyclic AMP-Dependent Protein Kinases - metabolism | Receptors, Estrogen - metabolism | ErbB Receptors - metabolism | Estrogens - pharmacology | Fatty Acids, Omega-3 - metabolism | Receptors, Estrogen - genetics | Receptors, G-Protein-Coupled - metabolism | Apoptosis - drug effects | Humans | Breast Neoplasms - metabolism | Estrogen Receptor beta - metabolism | Breast Neoplasms - genetics | Estrogen Receptor alpha - genetics | Estrogen Receptor beta - genetics | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Fatty Acids, Omega-3 - pharmacology | Cell Line, Tumor | Estrogen Receptor alpha - metabolism | Female | Cell Proliferation - drug effects | Receptors, G-Protein-Coupled - genetics | Estrogens - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Unsaturated fatty acids | Growth | Phenols | Cellular signal transduction | Cyclic adenylic acid | Breast cancer | G proteins | Saturated fatty acids | Estradiol | Omega-3 fatty acids | Apoptosis | Protein kinase A | Polyunsaturated fatty acids | Estrogens | Estrogen | Estrogen receptors | 17β-Estradiol | AKT protein | Kinases | Docosahexaenoic acid | Signal transduction | Receptors | Biological effects | Cell growth | Rodents | Stearic acid | Medical research | Epidermal growth factor receptors | Extracellular signal-regulated kinase | Fatty acids | Sex hormones | Signaling | Eicosapentaenoic acid | Cancer
Journal Article