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1. Full Text Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury
by Baeck, Christer and Wehr, Alexander and Karlmark, Karlin Raja and Heymann, Felix and Vucur, Mihael and Gassler, Nikolaus and Huss, Sebastian and Klussmann, Sven and Eulberg, Dirk and Luedde, Tom and Trautwein, Christian and Tacke, Frank
Gut, ISSN 0017-5749, 03/2012, Volume 61, Issue 3, pp. 416 - 426
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Biological and medical sciences | Medical sciences | Liver - pathology | Carbon Tetrachloride | Liver Cirrhosis, Experimental - etiology | Bone Marrow Cells - physiology | Male | Chemical and Drug Induced Liver Injury, Chronic - drug therapy | Liver Cirrhosis, Experimental - prevention & control | Non-alcoholic Fatty Liver Disease | Chemokine CCL2 - physiology | Bone Marrow Cells - drug effects | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury, Chronic - complications | Macrophages - physiology | Aptamers, Nucleotide - pharmacology | Drug Evaluation, Preclinical - methods | Acute Disease | Cytokines - metabolism | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Fatty Liver - prevention & control | Aptamers, Nucleotide - therapeutic use | Chemotaxis - drug effects | Chemical and Drug Induced Liver Injury, Chronic - pathology | Disease Progression | Fatty Liver - drug therapy | Animals | Chemical and Drug Induced Liver Injury - complications | Chemical and Drug Induced Liver Injury - drug therapy | Macrophages - drug effects | Mice | Chemokine CCL2 - antagonists & inhibitors | Fatty Liver - etiology | Care and treatment | Liver diseases | Fibrosis | Models | Research | Macrophages | Chemokine receptors | Studies | Cytokines | Polyethylene glycol | Rodents | Liver | Clinical trials | Tumor necrosis factor-TNF | Inflammation | Diabetes | Metabolic disorders | Chemokines | Immunohistochemistry | CC chemokine receptors | Flow cytometry | Animal models | Leukocyte migration | RNA | Carbon tetrachloride | Oligonucleotides | Blood | Metastases | Interleukin 6 | Fatty liver | CCR2 protein | Degeneration | Lipogenesis | Digestive tract | steatosis | Injuries | Triglycerides | CCL4 protein | Chemotaxis | Diets | Monocytes | gamma -Interferon | Monocyte chemoattractant protein 1 | Index Medicus | Abridged Index Medicus
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2. Full Text A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches
by Seki, Ekihiro and Brenner, David A and Karin, Michael
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2012, Volume 143, Issue 2, pp. 307 - 320
Gastroenterology and Hepatology | c-Jun | MAPK | Acetaminophen | TNF | Insulin Resistance | Hepatocellular Carcinoma | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Acetaminophen - adverse effects | Liver Transplantation | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | Metabolic Syndrome - metabolism | Liver - physiopathology | Metabolic Syndrome - drug therapy | MAP Kinase Signaling System | Carcinoma, Hepatocellular - drug therapy | Analgesics, Non-Narcotic - adverse effects | Cell Death | Biomarkers - metabolism | Liver Regeneration | Fatty Liver - metabolism | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Liver - metabolism | Liver Neoplasms - drug therapy | Fatty Liver - drug therapy | Animals | Chemical and Drug Induced Liver Injury - metabolism | Protein Kinase Inhibitors - therapeutic use | Chemical and Drug Induced Liver Injury - drug therapy | JNK Mitogen-Activated Protein Kinases - physiology | Liver Neoplasms - metabolism | Liver - physiology | Liver Diseases - drug therapy | Mice | Primary Graft Dysfunction - metabolism | Liver Diseases - physiopathology | Liver Diseases - metabolism | Carcinoma, Hepatocellular - metabolism | Enzymes | Medical colleges | Platelet-derived growth factor | Liver diseases | Isoenzymes | Genes | Liver | Development and progression | Transforming growth factors | Fatty acids | Liver cancer | Epidermal growth factor | Interleukins | DNA | Genetically modified organisms | Physiological aspects | Insulin resistance | Tumor proteins | Mitogens | Protein kinases | Tumors | Index Medicus | Abridged Index Medicus | acetaminophen | insulin resistance | hepatocellular carcinoma
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3. Full Text Gender differences in liver disease and the drug-dose gender gap
by Buzzetti, Elena and Parikh, Pathik M and Gerussi, Alessio and Tsochatzis, Emmanuel
Pharmacological research, ISSN 1043-6618, 06/2017, Volume 120, pp. 97 - 108
Systematic review | Gender | Liver toxicity | Liver disease | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Hepatitis - epidemiology | Non-alcoholic Fatty Liver Disease - pathology | Liver - pathology | Humans | Liver Diseases - pathology | Male | Hemochromatosis - drug therapy | Hemochromatosis - pathology | Dose-Response Relationship, Drug | Hepatitis - drug therapy | Liver Neoplasms - epidemiology | Liver - drug effects | Female | Liver Neoplasms - pathology | Budd-Chiari Syndrome - drug therapy | Chemical and Drug Induced Liver Injury - pathology | Liver Neoplasms - drug therapy | Hepatitis - pathology | Budd-Chiari Syndrome - epidemiology | Budd-Chiari Syndrome - pathology | Chemical and Drug Induced Liver Injury - epidemiology | Liver Diseases - epidemiology | Non-alcoholic Fatty Liver Disease - drug therapy | Chemical and Drug Induced Liver Injury - drug therapy | Sex Factors | Liver Diseases - drug therapy | Hemochromatosis - epidemiology | Non-alcoholic Fatty Liver Disease - epidemiology | Female-male relations | Liver diseases | Epidemiology | Index Medicus
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4. Full Text Non-alcoholic steatohepatitis: Emerging molecular targets and therapeutic strategies
by Musso, Giovanni and Cassader, Maurizio and Gambino, Roberto
Nature reviews. Drug discovery, ISSN 1474-1776, 04/2016, Volume 15, Issue 4, pp. 249 - 274
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Liver Cirrhosis - drug therapy | Liver - pathology | Humans | Liver - metabolism | Non-alcoholic Fatty Liver Disease - immunology | Medication Therapy Management | Inflammation - immunology | Non-alcoholic Fatty Liver Disease - metabolism | Non-alcoholic Fatty Liver Disease - physiopathology | Autophagy - drug effects | Non-alcoholic Fatty Liver Disease - drug therapy | Transcription Factors - metabolism | Inflammation - metabolism | Immunity, Cellular - drug effects | Liver - drug effects | Inflammation - drug therapy | Liver Cirrhosis - metabolism | Lipotropic Agents - pharmacology | Oxidative Stress - drug effects | Energy Metabolism - drug effects | Oxidative stress | Care and treatment | Transcription factors | Usage | Liver diseases | Analysis | Liver | Transplantation | Risk factors | Index Medicus
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