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Journal of Hepatology, ISSN 0168-8278, 2013, Volume 58, Issue 5, pp. 993 - 999
Journal Article
Gastroenterology, ISSN 0016-5085, 2014, Volume 146, Issue 3, pp. 801 - 811
Journal Article
Hepatology, ISSN 0270-9139, 08/2018, Volume 68, Issue 2, pp. 496 - 514
Journal Article
Gastroenterology, ISSN 0016-5085, 2015, Volume 149, Issue 4, pp. 1030 - 1041.e6
Background & Aims Alcoholic steatohepatitis (ASH) is the progressive form of alcoholic liver disease and may lead to cirrhosis and hepatocellular carcinoma. We... 
Gastroenterology and Hepatology | Lipid Metabolism | Inflammation | Endoplasmic Reticulum | Translational Research | LEPTIN-DEFICIENT MICE | INJURY | FSP27 | MODEL | HEPATOSTEATOSIS | THERAPEUTIC TARGETS | PPAR-GAMMA | LIVER-DISEASE PATHOGENESIS | GASTROENTEROLOGY & HEPATOLOGY | HEPATIC STEATOSIS | CIDE PROTEINS | Up-Regulation | Liver - pathology | Reactive Oxygen Species - metabolism | Mitochondria, Liver - metabolism | Humans | Middle Aged | Hepatocytes - pathology | Male | Fatty Liver, Alcoholic - prevention & control | Hepatocytes - metabolism | Fatty Liver, Alcoholic - metabolism | PPAR gamma - metabolism | Fatty Liver, Alcoholic - genetics | Transfection | Liver - drug effects | RNA Interference | Time Factors | Adult | Female | Fatty Liver, Alcoholic - pathology | Hepatocytes - drug effects | Disease Models, Animal | Severity of Illness Index | Signal Transduction | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Profiling - methods | Binge Drinking | Mice, Knockout | Proteins - genetics | Cyclic AMP Response Element-Binding Protein - genetics | Animals | PPAR gamma - antagonists & inhibitors | Proteins - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Liver cancer | Liver cirrhosis | Alcoholism | Analysis | Liver | Index Medicus | Abridged Index Medicus | translational research | inflammation | endoplasmic reticulum | lipid metabolism
Journal Article
Cell Metabolism, ISSN 1550-4131, 03/2008, Volume 7, Issue 3, pp. 227 - 235
Alcohol-induced fatty liver, a major cause of morbidity, has been attributed to enhanced hepatic lipogenesis and decreased fat clearance of unknown mechanism.... 
HUMDISEASE | FIBROSIS | METABOLIC SYNDROME | STEATOSIS | PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | RATS | ETHANOL | MICE | DIET-INDUCED OBESITY | ACID SYNTHESIS | ABDOMINAL OBESITY | CELL BIOLOGY | Cannabinoid Receptor Modulators - metabolism | Up-Regulation | Liver - pathology | Liver - enzymology | Fatty Acid Synthases - metabolism | Coculture Techniques | Male | Fatty Liver, Alcoholic - prevention & control | Hepatocytes - metabolism | Fatty Liver, Alcoholic - metabolism | Arachidonic Acids - metabolism | Fatty Liver, Alcoholic - genetics | Lipogenesis - genetics | Liver - drug effects | Piperidines - pharmacology | Carnitine O-Palmitoyltransferase - metabolism | Fatty Liver, Alcoholic - pathology | Fatty Acids - metabolism | Lipoprotein Lipase - metabolism | Endocannabinoids | Sterol Regulatory Element Binding Protein 1 - metabolism | Disease Models, Animal | Pyrazoles - pharmacology | Ethanol | Oxidation-Reduction | Fatty Liver, Alcoholic - etiology | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Paracrine Communication - genetics | Glycerides - metabolism | Mice, Knockout | Receptor, Cannabinoid, CB1 - metabolism | Animals | Receptor, Cannabinoid, CB1 - genetics | Diet, Fat-Restricted | Lipogenesis - drug effects | Paracrine Communication - drug effects | Mice | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Index Medicus
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 03/2010, Volume 298, Issue 3, pp. G364 - G374
Shen Z, Liang X, Rogers CQ, Rideout D, You M. Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty... 
Signal transduction | Acetylation | Lipid metabolism | Transcriptional regulators | DIETARY SATURATED FAT | PHYSIOLOGY | ACTIVATED PROTEIN-KINASE | LIPID-METABOLISM | signal transduction | lipid metabolism | PHOSPHATIDATE PHOSPHOHYDROLASE | TNF-ALPHA PRODUCTION | INSULIN SENSITIVITY | acetylation | MAMMALIAN SIRTUIN-1 | ENERGY-EXPENDITURE | GENE-EXPRESSION | transcriptional regulators | GASTROENTEROLOGY & HEPATOLOGY | HEPATIC STEATOSIS | RNA, Small Interfering - genetics | Liver - pathology | Gene Expression - genetics | Tumor Necrosis Factor-alpha - genetics | Ion Channels - genetics | Male | Fatty Liver, Alcoholic - metabolism | Liver - drug effects | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Lipid Metabolism - genetics | Thiazolidinediones - pharmacology | PPAR gamma - genetics | Adiponectin - pharmacology | Liver - metabolism | Rats | Intra-Abdominal Fat - metabolism | Phosphatidate Phosphatase | Triglycerides - metabolism | Acetylation - drug effects | Signal Transduction - drug effects | Models, Biological | Cell Line, Tumor | Transaminases - blood | Mice | Transcription Factors | Histones - metabolism | AMP-Activated Protein Kinases - genetics | Acetyl-CoA Carboxylase - metabolism | Receptors, Adiponectin - genetics | Sirtuin 1 - metabolism | AMP-Activated Protein Kinases - metabolism | Gene Expression - drug effects | Mitochondrial Proteins - genetics | Adiponectin - physiology | Fatty Liver, Alcoholic - prevention & control | Sirtuin 1 - genetics | Fatty Liver, Alcoholic - blood | Thiazolidinediones - therapeutic use | Trans-Activators - genetics | Intra-Abdominal Fat - drug effects | Fatty Liver, Alcoholic - pathology | Nuclear Proteins - genetics | Mice, Inbred C57BL | Nuclear Proteins - metabolism | Ethanol - pharmacology | Animals | Lipid Metabolism - drug effects | Retinoid X Receptor alpha - genetics | Triglycerides - blood | Signal Transduction - physiology | Trans-Activators - metabolism | Uncoupling Protein 2 | Fatty liver | Physiological aspects | Cellular signal transduction | Research | Rosiglitazone maleate | Health aspects | Protein kinases | Ethanol | Metabolism | Fatty acids | Liver | Rodents | Index Medicus | Hormones and Signaling
Journal Article
Alcoholism: Clinical and Experimental Research, ISSN 0145-6008, 07/2012, Volume 36, Issue 7, pp. 1139 - 1147
Background: Correlative evidence indicates that apoptosis is associated with the progression of alcoholic liver disease. If apoptosis contributes to ethanol... 
Caspase | Necroptosis | Alcoholic Liver Disease | Cell Death | Bid | Cell death | Alcoholic liver disease | RAT-LIVER | ACTIVATION | ALCOHOLIC LIVER-DISEASE | INJURY | NONALCOHOLIC STEATOHEPATITIS | SUBSTANCE ABUSE | CELL-DEATH | DEATH-RECEPTOR | HEPATITIS | PAN-CASPASE INHIBITOR | CONTRIBUTES | BH3 Interacting Domain Death Agonist Protein - deficiency | Hepatitis, Alcoholic - prevention & control | Ethanol - toxicity | Apoptosis - drug effects | Hepatocytes - pathology | Fatty Liver, Alcoholic - prevention & control | Hepatocytes - metabolism | Fatty Liver, Alcoholic - metabolism | Hepatitis, Alcoholic - pathology | Female | Fatty Liver, Alcoholic - pathology | Hepatocytes - drug effects | Biomarkers - metabolism | Liver Diseases, Alcoholic - pathology | Hepatitis, Alcoholic - metabolism | Liver Cirrhosis, Alcoholic - pathology | Mice, Inbred C57BL | Inflammation Mediators - toxicity | Liver Diseases, Alcoholic - prevention & control | Carbon Tetrachloride - toxicity | Liver Cirrhosis, Alcoholic - prevention & control | Liver Diseases, Alcoholic - metabolism | Mice, Knockout | Animals | Mice | Apoptosis - physiology | Liver Cirrhosis, Alcoholic - metabolism | Keratin | Messenger RNA | Liver diseases | Actin | Analysis | Carbon tetrachloride | Fibrosis | Alcoholics | Aspartate | Muscle proteins | Apoptosis | Proteins | Smooth muscle | Kinases | Liver cirrhosis | Rodents | Index Medicus | cell death | necroptosis | caspase
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2015, Volume 125, Issue 4, pp. 1579 - 1590
Metabolic reprogramming is implicated in macrophage activation, but the underlying mechanisms are poorly understood. Here, we demonstrate that the NOTCH1... 
MEDICINE, RESEARCH & EXPERIMENTAL | GENE | CELL ACTIVATION | NITRIC-OXIDE SYNTHASE | INFLAMMATION | ALCOHOLIC LIVER-DISEASE | TRANSCRIPTION | ROS | DIFFERENTIATION | HYPOXIA | PYRUVATE-DEHYDROGENASE COMPLEX | Up-Regulation | Macrophage Activation - genetics | Reactive Oxygen Species - metabolism | Electron Transport - genetics | Liver Failure, Acute - etiology | Male | Pyruvate Dehydrogenase (Lipoamide)-Phosphatase - antagonists & inhibitors | Fatty Liver, Alcoholic - metabolism | Inflammation - metabolism | Receptor, Notch1 - deficiency | Pyruvate Dehydrogenase (Lipoamide)-Phosphatase - metabolism | Transcription, Genetic | Fatty Liver, Alcoholic - pathology | Macrophage Activation - physiology | Protein Structure, Tertiary | Pyruvate Dehydrogenase Complex - metabolism | Cell Line | Mice, Inbred C57BL | Gene Expression Regulation | Oxidative Phosphorylation | Fatty Liver, Alcoholic - immunology | Inflammation - immunology | Liver Failure, Acute - metabolism | Mitochondria - metabolism | Mice, Knockout | Feedback, Physiological | Animals | Endotoxemia - complications | Liver Failure, Acute - immunology | Liver Failure, Acute - pathology | Glucose - metabolism | Myeloid Cells - metabolism | Signal Transduction - physiology | Mice | Pyruvate Dehydrogenase (Lipoamide)-Phosphatase - genetics | Myeloid Cells - pathology | Nitric Oxide - metabolism | Receptor, Notch1 - physiology | Cell metabolism | Genetic research | Genetic aspects | Genetic transcription | Research | Macrophages | Properties | Liver diseases | Cytokines | Microscopy | Pilot projects | Rodents | Mitochondrial DNA | Metabolism | Gene expression | Index Medicus | Abridged Index Medicus | Hepatology | Inflammation | Immunology
Journal Article