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Alcoholism: Clinical and Experimental Research, ISSN 0145-6008, 07/2012, Volume 36, Issue 7, pp. 1139 - 1147
Background: Correlative evidence indicates that apoptosis is associated with the progression of alcoholic liver disease. If apoptosis contributes to ethanol... 
Caspase | Necroptosis | Alcoholic Liver Disease | Cell Death | Bid | Cell death | Alcoholic liver disease | RAT-LIVER | ACTIVATION | ALCOHOLIC LIVER-DISEASE | INJURY | NONALCOHOLIC STEATOHEPATITIS | SUBSTANCE ABUSE | CELL-DEATH | DEATH-RECEPTOR | HEPATITIS | PAN-CASPASE INHIBITOR | CONTRIBUTES | BH3 Interacting Domain Death Agonist Protein - deficiency | Hepatitis, Alcoholic - prevention & control | Ethanol - toxicity | Apoptosis - drug effects | Hepatocytes - pathology | Fatty Liver, Alcoholic - prevention & control | Hepatocytes - metabolism | Fatty Liver, Alcoholic - metabolism | Hepatitis, Alcoholic - pathology | Female | Fatty Liver, Alcoholic - pathology | Hepatocytes - drug effects | Biomarkers - metabolism | Liver Diseases, Alcoholic - pathology | Hepatitis, Alcoholic - metabolism | Liver Cirrhosis, Alcoholic - pathology | Mice, Inbred C57BL | Inflammation Mediators - toxicity | Liver Diseases, Alcoholic - prevention & control | Carbon Tetrachloride - toxicity | Liver Cirrhosis, Alcoholic - prevention & control | Liver Diseases, Alcoholic - metabolism | Mice, Knockout | Animals | Mice | Apoptosis - physiology | Liver Cirrhosis, Alcoholic - metabolism | Keratin | Messenger RNA | Liver diseases | Actin | Analysis | Carbon tetrachloride | Fibrosis | Alcoholics | Aspartate | Muscle proteins | Apoptosis | Proteins | Smooth muscle | Kinases | Liver cirrhosis | Rodents | Index Medicus | cell death | necroptosis | caspase
Journal Article
Gastroenterology, ISSN 0016-5085, 2015, Volume 149, Issue 4, pp. 1030 - 1041.e6
Background & Aims Alcoholic steatohepatitis (ASH) is the progressive form of alcoholic liver disease and may lead to cirrhosis and hepatocellular carcinoma. We... 
Gastroenterology and Hepatology | Lipid Metabolism | Inflammation | Endoplasmic Reticulum | Translational Research | LEPTIN-DEFICIENT MICE | INJURY | FSP27 | MODEL | HEPATOSTEATOSIS | THERAPEUTIC TARGETS | PPAR-GAMMA | LIVER-DISEASE PATHOGENESIS | GASTROENTEROLOGY & HEPATOLOGY | HEPATIC STEATOSIS | CIDE PROTEINS | Up-Regulation | Liver - pathology | Reactive Oxygen Species - metabolism | Mitochondria, Liver - metabolism | Humans | Middle Aged | Hepatocytes - pathology | Male | Fatty Liver, Alcoholic - prevention & control | Hepatocytes - metabolism | Fatty Liver, Alcoholic - metabolism | PPAR gamma - metabolism | Fatty Liver, Alcoholic - genetics | Transfection | Liver - drug effects | RNA Interference | Time Factors | Adult | Female | Fatty Liver, Alcoholic - pathology | Hepatocytes - drug effects | Disease Models, Animal | Severity of Illness Index | Signal Transduction | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Profiling - methods | Binge Drinking | Mice, Knockout | Proteins - genetics | Cyclic AMP Response Element-Binding Protein - genetics | Animals | PPAR gamma - antagonists & inhibitors | Proteins - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Liver cancer | Liver cirrhosis | Alcoholism | Analysis | Liver | Index Medicus | Abridged Index Medicus | translational research | inflammation | endoplasmic reticulum | lipid metabolism
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2016, Volume 11, Issue 5, pp. e0155163 - e0155163
Although non-alcoholic and alcoholic fatty liver disease have been intensively studied, concerning pathophysiological mechanisms are still incompletely... 
CONFERS SUSCEPTIBILITY | INDUCED HEPATIC STEATOSIS | BINDING-PROTEIN P62/IGF2BP2-2 | HIGH-FAT DIET | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | NONALCOHOLIC STEATOHEPATITIS | FREE-CHOLESTEROL | DENK BODY FORMATION | INDUCED OBESITY | Non-alcoholic Fatty Liver Disease - pathology | Liver - pathology | Species Specificity | Diet, High-Fat - adverse effects | Ethanol - administration & dosage | Non-alcoholic Fatty Liver Disease - etiology | Male | Mice, 129 Strain | Fatty Liver, Alcoholic - metabolism | Fatty Acids, Nonesterified - metabolism | Fatty Liver, Alcoholic - genetics | Subcutaneous Fat - metabolism | Dietary Fats - administration & dosage | Fatty Liver, Alcoholic - pathology | Weight Gain | Disease Models, Animal | Biomarkers - metabolism | Liver Function Tests | Disease Susceptibility | Non-alcoholic Fatty Liver Disease - genetics | Fatty Liver, Alcoholic - etiology | Liver - metabolism | Mice, Inbred C57BL | Non-alcoholic Fatty Liver Disease - metabolism | Cholesterol - metabolism | Mice, Inbred Strains | Subcutaneous Fat - pathology | Aspartate Aminotransferases - metabolism | Triglycerides - metabolism | Animals | Mice | Alanine Transaminase - metabolism | Fatty liver | Diet | Physiological aspects | Development and progression | Models | Research | Risk factors | Biotechnology | Animal models | Dehydrogenases | Liver | Lipids | Alcohol | Biochemistry | Biology | High fat diet | Fatty acid composition | Rodents | Hepatology | Physiology | Carbohydrates | Liver diseases | Ethanol | Inflammation | Metabolism | Gene expression | Fatty acids | Feeding | Steatosis | Nutrition research | Pathology | Natural products | Pharmacy | Insulin resistance | Pharmaceuticals | Index Medicus
Journal Article
Hepatology, ISSN 0270-9139, 08/2018, Volume 68, Issue 2, pp. 496 - 514
Journal Article
Journal of Nutrition, ISSN 0022-3166, 2014, Volume 144, Issue 7, pp. 1009 - 1015
Ethanol consumption can lead to hepatic steatosis that contributes to late-stage liver diseases such as cirrhosis and hepatocellular carcinoma. In this study,... 
NUTRITION & DIETETICS | ACTIVATED PROTEIN-KINASE | FATTY-ACID SYNTHESIS | LIPID-METABOLISM | CHOLESTEROL | PHOSPHORYLATES | TRANSCRIPTION | GENE-EXPRESSION | STEATOHEPATITIS | INTERLEUKIN-22 | HEPATIC STEATOSIS | Hepatitis, Alcoholic - prevention & control | Liver - pathology | Ethanol - toxicity | Antioxidants - metabolism | Humans | Hepatocytes - pathology | Male | Fatty Liver, Alcoholic - prevention & control | Hepatocytes - metabolism | Fatty Liver, Alcoholic - metabolism | Liver - physiopathology | Hepatitis, Alcoholic - etiology | Liver Diseases, Alcoholic - etiology | Hepatitis, Alcoholic - pathology | Binge Drinking - physiopathology | Alcoholism - physiopathology | Fatty Liver, Alcoholic - pathology | Lipogenesis | Hepatocytes - drug effects | Disease Models, Animal | Liver Diseases, Alcoholic - pathology | Cell Line | Hepatitis, Alcoholic - metabolism | Luteolin - metabolism | Specific Pathogen-Free Organisms | Fatty Liver, Alcoholic - etiology | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Liver Diseases, Alcoholic - prevention & control | Luteolin - therapeutic use | Random Allocation | Liver Diseases, Alcoholic - metabolism | Antioxidants - therapeutic use | Animals | Mice | Dietary Supplements | Ethanol - antagonists & inhibitors | Physiological aspects | Flavonoids | Flavones | Bioflavonoids | Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
Cell Metabolism, ISSN 1550-4131, 03/2008, Volume 7, Issue 3, pp. 227 - 235
Alcohol-induced fatty liver, a major cause of morbidity, has been attributed to enhanced hepatic lipogenesis and decreased fat clearance of unknown mechanism.... 
HUMDISEASE | FIBROSIS | METABOLIC SYNDROME | STEATOSIS | PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | RATS | ETHANOL | MICE | DIET-INDUCED OBESITY | ACID SYNTHESIS | ABDOMINAL OBESITY | CELL BIOLOGY | Cannabinoid Receptor Modulators - metabolism | Up-Regulation | Liver - pathology | Liver - enzymology | Fatty Acid Synthases - metabolism | Coculture Techniques | Male | Fatty Liver, Alcoholic - prevention & control | Hepatocytes - metabolism | Fatty Liver, Alcoholic - metabolism | Arachidonic Acids - metabolism | Fatty Liver, Alcoholic - genetics | Lipogenesis - genetics | Liver - drug effects | Piperidines - pharmacology | Carnitine O-Palmitoyltransferase - metabolism | Fatty Liver, Alcoholic - pathology | Fatty Acids - metabolism | Lipoprotein Lipase - metabolism | Endocannabinoids | Sterol Regulatory Element Binding Protein 1 - metabolism | Disease Models, Animal | Pyrazoles - pharmacology | Ethanol | Oxidation-Reduction | Fatty Liver, Alcoholic - etiology | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Paracrine Communication - genetics | Glycerides - metabolism | Mice, Knockout | Receptor, Cannabinoid, CB1 - metabolism | Animals | Receptor, Cannabinoid, CB1 - genetics | Diet, Fat-Restricted | Lipogenesis - drug effects | Paracrine Communication - drug effects | Mice | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Index Medicus
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