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Publication DateBBA - Molecular Cell Research, ISSN 0167-4889, 10/2016, Volume 1863, Issue 10, pp. 2422 - 2435
Carnitine is essential for the transfer of long-chain fatty acids across the inner mitochondrial membrane for subsequent β-oxidation. It can be synthesized by...
Newborn screening | Autism | SLC22A5 | Arrhythmia | OCTN2 | Carnitine | VECTORIAL ACYLATION | LIPID-METABOLISM | OCTN2 GENE | GENOTYPE-PHENOTYPE CORRELATIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | FAROE-ISLANDS | CELL BIOLOGY | SKELETAL-MUSCLE | ORGANIC CATION/CARNITINE TRANSPORTER | INSULIN-RESISTANCE | ACYL-COA SYNTHETASE | BINDING PROTEIN GENE | Organic Cation Transport Proteins - metabolism | Oxidation-Reduction | Fasting - physiology | Humans | Carnitine - metabolism | Caveolins - metabolism | Fatty Acid-Binding Proteins - metabolism | Neonatal Screening | Organ Specificity | Solute Carrier Family 22 Member 5 | Kidney - metabolism | Fatty Acid Transport Proteins - metabolism | Biological Transport | Carnitine - deficiency | Energy Metabolism | Age of Onset | Carnitine - therapeutic use | Adult | Mutation | Organic Cation Transport Proteins - genetics | Fatty Acids - metabolism | Infant, Newborn | Organic Cation Transport Proteins - deficiency | Heart | Physiological aspects | Oxidation-reduction reaction | Nucleotide sequencing | Fatty acids | DNA sequencing
Newborn screening | Autism | SLC22A5 | Arrhythmia | OCTN2 | Carnitine | VECTORIAL ACYLATION | LIPID-METABOLISM | OCTN2 GENE | GENOTYPE-PHENOTYPE CORRELATIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | FAROE-ISLANDS | CELL BIOLOGY | SKELETAL-MUSCLE | ORGANIC CATION/CARNITINE TRANSPORTER | INSULIN-RESISTANCE | ACYL-COA SYNTHETASE | BINDING PROTEIN GENE | Organic Cation Transport Proteins - metabolism | Oxidation-Reduction | Fasting - physiology | Humans | Carnitine - metabolism | Caveolins - metabolism | Fatty Acid-Binding Proteins - metabolism | Neonatal Screening | Organ Specificity | Solute Carrier Family 22 Member 5 | Kidney - metabolism | Fatty Acid Transport Proteins - metabolism | Biological Transport | Carnitine - deficiency | Energy Metabolism | Age of Onset | Carnitine - therapeutic use | Adult | Mutation | Organic Cation Transport Proteins - genetics | Fatty Acids - metabolism | Infant, Newborn | Organic Cation Transport Proteins - deficiency | Heart | Physiological aspects | Oxidation-reduction reaction | Nucleotide sequencing | Fatty acids | DNA sequencing
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Loading RightsNature Immunology, ISSN 1529-2908, 02/2016, Volume 17, Issue 3, pp. 216 - 217
ACTIVATION | INFLAMMATION | IMMUNOLOGY | Lectins, C-Type - drug effects | Carnitine O-Palmitoyltransferase - genetics | Arginase - drug effects | Arginase - metabolism | Enzyme Inhibitors - pharmacology | Oxygen Consumption - physiology | Mice, Knockout | Carnitine O-Palmitoyltransferase - antagonists & inhibitors | Intercellular Signaling Peptides and Proteins - metabolism | Lectins, C-Type - metabolism | Interleukin-4 - pharmacology | Macrophages - metabolism | Animals | Epoxy Compounds - pharmacology | Oxygen Consumption - drug effects | Oxidation-Reduction - drug effects | Glycolysis | Macrophages - drug effects | Mice | Fatty Acids - metabolism | Macrophages - immunology | Oxidative stress | Properties | Macrophages | Fatty acids | Health aspects
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Loading RightsNature Reviews Cancer, ISSN 1474-175X, 04/2013, Volume 13, Issue 4, pp. 227 - 232
Warburg suggested that the alterations in metabolism that he observed in cancer cells were due to the malfunction of mitochondria. In the past decade, we have...
GLYCOLYSIS | ENERGY | INHIBITION | PROTEIN | ONCOLOGY | PATHWAY | GROWTH | FLUX | CELL-SURVIVAL | STRESS | CPT1C | Neoplasms - metabolism | Mutation - physiology | Neoplasms - therapy | Neoplasms - genetics | Humans | Signal Transduction - physiology | NADP - metabolism | Adenosine Triphosphate - biosynthesis | Energy Metabolism - physiology | Fatty Acids - metabolism | Molecular Targeted Therapy - methods | Physiological aspects | Biological oxidation (Metabolism) | Research | Genes | Cancer cells
GLYCOLYSIS | ENERGY | INHIBITION | PROTEIN | ONCOLOGY | PATHWAY | GROWTH | FLUX | CELL-SURVIVAL | STRESS | CPT1C | Neoplasms - metabolism | Mutation - physiology | Neoplasms - therapy | Neoplasms - genetics | Humans | Signal Transduction - physiology | NADP - metabolism | Adenosine Triphosphate - biosynthesis | Energy Metabolism - physiology | Fatty Acids - metabolism | Molecular Targeted Therapy - methods | Physiological aspects | Biological oxidation (Metabolism) | Research | Genes | Cancer cells
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Loading RightsAnnual Review of Physiology, ISSN 0066-4278, 2002, Volume 64, Issue 1, pp. 477 - 502
Genetic disorders of mitochondrial fatty acid beta-oxidation have been recognized within the last 20 years as important causes of morbidity and mortality,...
Inborn errors | Tissue specificity | Ketogenesis | Membrane transport | Carnitine | BETA-OXIDATION | PHYSIOLOGY | CHROMOSOMAL LOCALIZATION | ALPHA-SUBUNIT | SUDDEN-DEATH | tissue specificity | COA DEHYDROGENASE-DEFICIENCY | COENZYME-A DEHYDROGENASE | RAT-LIVER MITOCHONDRIA | inborn errors | TRIFUNCTIONAL PROTEIN | carnitine | membrane transport | ketogenesis | CHAIN L-3-HYDROXYACYL-COA DEHYDROGENASE | CARNITINE PALMITOYLTRANSFERASE-I | Lipid Metabolism, Inborn Errors - physiopathology | Animals | Lipid Metabolism, Inborn Errors - metabolism | Oxidation-Reduction | Fatty Acids - metabolism | Humans
Inborn errors | Tissue specificity | Ketogenesis | Membrane transport | Carnitine | BETA-OXIDATION | PHYSIOLOGY | CHROMOSOMAL LOCALIZATION | ALPHA-SUBUNIT | SUDDEN-DEATH | tissue specificity | COA DEHYDROGENASE-DEFICIENCY | COENZYME-A DEHYDROGENASE | RAT-LIVER MITOCHONDRIA | inborn errors | TRIFUNCTIONAL PROTEIN | carnitine | membrane transport | ketogenesis | CHAIN L-3-HYDROXYACYL-COA DEHYDROGENASE | CARNITINE PALMITOYLTRANSFERASE-I | Lipid Metabolism, Inborn Errors - physiopathology | Animals | Lipid Metabolism, Inborn Errors - metabolism | Oxidation-Reduction | Fatty Acids - metabolism | Humans
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Loading RightsAntioxidants & Redox Signaling, ISSN 1523-0864, 07/2013, Volume 19, Issue 3, pp. 269 - 284
Significance: Current lifestyles with high-energy diets and little exercise are triggering an alarming growth in obesity. Excess of adiposity is leading to...
Forum Review Articles | SKELETAL-MUSCLE | ACTIVATED PROTEIN-KINASE | REACTIVE OXYGEN | MALONYL-COA | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | BROWN ADIPOSE-TISSUE | ACETYL-COA CARBOXYLASE | ENDOPLASMIC-RETICULUM STRESS | REGULATES FOOD-INTAKE | CARNITINE-PALMITOYLTRANSFERASE-I | INDUCED INSULIN-RESISTANCE | Obesity - drug therapy | Humans | Liver - metabolism | Adipose Tissue, White - metabolism | Lipid Metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Anti-Obesity Agents - therapeutic use | Obesity - metabolism | Oxidative Phosphorylation - drug effects | Animals | Hypothalamus - metabolism | Oxidation-Reduction - drug effects | Adipose Tissue, Brown - metabolism | Anti-Obesity Agents - pharmacology | Fatty Acids - metabolism | Physiological aspects | Obesity | Oxidation-reduction reaction | Mitochondria | Analysis | Obesitat | Metabolisme cel·lular | Cell metabolism | Mitocondris | Fatty acids | Àcids grassos | Forum Review
Forum Review Articles | SKELETAL-MUSCLE | ACTIVATED PROTEIN-KINASE | REACTIVE OXYGEN | MALONYL-COA | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | BROWN ADIPOSE-TISSUE | ACETYL-COA CARBOXYLASE | ENDOPLASMIC-RETICULUM STRESS | REGULATES FOOD-INTAKE | CARNITINE-PALMITOYLTRANSFERASE-I | INDUCED INSULIN-RESISTANCE | Obesity - drug therapy | Humans | Liver - metabolism | Adipose Tissue, White - metabolism | Lipid Metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Anti-Obesity Agents - therapeutic use | Obesity - metabolism | Oxidative Phosphorylation - drug effects | Animals | Hypothalamus - metabolism | Oxidation-Reduction - drug effects | Adipose Tissue, Brown - metabolism | Anti-Obesity Agents - pharmacology | Fatty Acids - metabolism | Physiological aspects | Obesity | Oxidation-reduction reaction | Mitochondria | Analysis | Obesitat | Metabolisme cel·lular | Cell metabolism | Mitocondris | Fatty acids | Àcids grassos | Forum Review
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Loading RightsCardiovascular Research, ISSN 0008-6363, 05/2011, Volume 90, Issue 2, pp. 202 - 209
In the advanced stages of heart failure, many key enzymes involved in myocardial energy substrate metabolism display various degrees of down-regulation. The...
Heart failure | Therapy | β-Oxidation | Fatty acid | Modulators | CARDIAC & CARDIOVASCULAR SYSTEMS | IDIOPATHIC DILATED CARDIOMYOPATHY | GLUCOSE-OXIDATION | beta-Oxidation | VENTRICULAR SYSTOLIC FUNCTION | FAILING HUMAN HEART | ACTIVATED-RECEPTOR-ALPHA | POSITRON-EMISSION-TOMOGRAPHY | ISCHEMIC CARDIOMYOPATHY | GENE-EXPRESSION | ENERGY-METABOLISM | CORONARY-ARTERY-DISEASE | Heart Failure - therapy | Animals | Oxidation-Reduction | Humans | Myocardium - metabolism | Heart Failure - metabolism | Ventricular Remodeling - physiology | Energy Metabolism - physiology | Fatty Acids - metabolism | Reviews | Spotlight on Metabolic Remodelling in Heart Failure
Heart failure | Therapy | β-Oxidation | Fatty acid | Modulators | CARDIAC & CARDIOVASCULAR SYSTEMS | IDIOPATHIC DILATED CARDIOMYOPATHY | GLUCOSE-OXIDATION | beta-Oxidation | VENTRICULAR SYSTOLIC FUNCTION | FAILING HUMAN HEART | ACTIVATED-RECEPTOR-ALPHA | POSITRON-EMISSION-TOMOGRAPHY | ISCHEMIC CARDIOMYOPATHY | GENE-EXPRESSION | ENERGY-METABOLISM | CORONARY-ARTERY-DISEASE | Heart Failure - therapy | Animals | Oxidation-Reduction | Humans | Myocardium - metabolism | Heart Failure - metabolism | Ventricular Remodeling - physiology | Energy Metabolism - physiology | Fatty Acids - metabolism | Reviews | Spotlight on Metabolic Remodelling in Heart Failure
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7.
Full Text
Current views of fatty acid oxidation and ketogenesis
: from organelles to point mutations
1999, Advances in experimental medicine and biology, ISBN 0306462001, Volume 466
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Loading RightsNature Communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, p. 6692
During activation, T cells undergo metabolic reprogramming, which imprints distinct functional fates. We determined that on PD-1 ligation, activated T cells...
ACTIVATION | LIPID-METABOLISM | MEMORY | SIGNALING PATHWAY | MULTIDISCIPLINARY SCIENCES | RESPIRATORY CAPACITY | CTLA-4 | CHRONIC VIRAL-INFECTION | TUMOR-GROWTH | EXPRESSION | DISEASE PROGRESSION | Carnitine O-Palmitoyltransferase - genetics | Oxidation-Reduction | Lymphocyte Activation | Humans | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Programmed Cell Death 1 Receptor - metabolism | Lipid Metabolism | Lipolysis | B7-H1 Antigen - pharmacology | Glycolysis | In Vitro Techniques | Fatty Acids - metabolism
ACTIVATION | LIPID-METABOLISM | MEMORY | SIGNALING PATHWAY | MULTIDISCIPLINARY SCIENCES | RESPIRATORY CAPACITY | CTLA-4 | CHRONIC VIRAL-INFECTION | TUMOR-GROWTH | EXPRESSION | DISEASE PROGRESSION | Carnitine O-Palmitoyltransferase - genetics | Oxidation-Reduction | Lymphocyte Activation | Humans | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Programmed Cell Death 1 Receptor - metabolism | Lipid Metabolism | Lipolysis | B7-H1 Antigen - pharmacology | Glycolysis | In Vitro Techniques | Fatty Acids - metabolism
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Loading RightsNature Medicine, ISSN 1078-8956, 06/2016, Volume 22, Issue 6, pp. 666 - 671
Cachexia is a devastating muscle-wasting syndrome that occurs in patients who have chronic diseases. It is most commonly observed in individuals with advanced...
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | TUMOR-NECROSIS-FACTOR | METABOLISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | STIMULATES LIPOLYSIS | LIPASE | MICE | CELL BIOLOGY | Immunohistochemistry | Neoplasms - metabolism | Metabolomics | Humans | Middle Aged | Male | Muscle, Skeletal - metabolism | Gene Expression Profiling | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Stem Cells - metabolism | Neoplasms - complications | Epoxy Compounds - pharmacology | Muscle, Skeletal - drug effects | Cachexia - etiology | Female | p38 Mitogen-Activated Protein Kinases - metabolism | Cachexia - metabolism | Fatty Acids - metabolism | Disease Models, Animal | Cell Line | Cytokines - metabolism | Muscular Atrophy - metabolism | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Blotting, Western | p38 Mitogen-Activated Protein Kinases - drug effects | Animals | Cytokines - drug effects | Cell Line, Tumor | Aged | Mice | Oxidative Stress - drug effects | Complications and side effects | Prognosis | Fatty acid metabolism | Physiological aspects | Development and progression | Genetic aspects | Cachexia | Research | Atrophy, Muscular | Risk factors | Care and treatment | Diagnosis | Fatty acids | Health aspects | Oxidation | Muscular system | Stress response | Weight | Cancer
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | TUMOR-NECROSIS-FACTOR | METABOLISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | STIMULATES LIPOLYSIS | LIPASE | MICE | CELL BIOLOGY | Immunohistochemistry | Neoplasms - metabolism | Metabolomics | Humans | Middle Aged | Male | Muscle, Skeletal - metabolism | Gene Expression Profiling | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Stem Cells - metabolism | Neoplasms - complications | Epoxy Compounds - pharmacology | Muscle, Skeletal - drug effects | Cachexia - etiology | Female | p38 Mitogen-Activated Protein Kinases - metabolism | Cachexia - metabolism | Fatty Acids - metabolism | Disease Models, Animal | Cell Line | Cytokines - metabolism | Muscular Atrophy - metabolism | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Blotting, Western | p38 Mitogen-Activated Protein Kinases - drug effects | Animals | Cytokines - drug effects | Cell Line, Tumor | Aged | Mice | Oxidative Stress - drug effects | Complications and side effects | Prognosis | Fatty acid metabolism | Physiological aspects | Development and progression | Genetic aspects | Cachexia | Research | Atrophy, Muscular | Risk factors | Care and treatment | Diagnosis | Fatty acids | Health aspects | Oxidation | Muscular system | Stress response | Weight | Cancer
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Loading RightsTrends in Biochemical Sciences, ISSN 0968-0004, 11/2018, Volume 43, Issue 11, pp. 854 - 857
Mitochondrial fatty acid β-oxidation (FAO) is a major catabolic process that degrades long-chain fatty acids. Recent reports reveal a broad role for FAO in...
acetylation | immune cell | metabolism | cancer | endothelial cell | mitochondrion | BETA-OXIDATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | Neoplasms - metabolism | Animals | Fatty Acids - chemistry | T-Lymphocyte Subsets - pathology | Oxidation-Reduction | Endothelium, Vascular - metabolism | T-Lymphocyte Subsets - metabolism | Humans | Endothelium, Vascular - physiopathology | Neoplasms - physiopathology | Fatty Acids - metabolism | Oxidation-reduction reaction | Fatty acids
acetylation | immune cell | metabolism | cancer | endothelial cell | mitochondrion | BETA-OXIDATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | Neoplasms - metabolism | Animals | Fatty Acids - chemistry | T-Lymphocyte Subsets - pathology | Oxidation-Reduction | Endothelium, Vascular - metabolism | T-Lymphocyte Subsets - metabolism | Humans | Endothelium, Vascular - physiopathology | Neoplasms - physiopathology | Fatty Acids - metabolism | Oxidation-reduction reaction | Fatty acids
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