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1. Full Text Fatty acid synthase – Modern tumor cell biology insights into a classical oncology target
by Buckley, Douglas and Duke, Gregory and Heuer, Timothy S and O'Farrell, Marie and Wagman, Allan S and McCulloch, William and Kemble, George
Pharmacology & therapeutics (Oxford), ISSN 0163-7258, 09/2017, Volume 177, pp. 23 - 31
Fatty acid synthase | Oncoantigen | Lipogenesis | Palmitoylation | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Fatty Acid Synthases - antagonists & inhibitors | Neoplasms - metabolism | Animals | Prognosis | Fatty Acid Synthases - metabolism | Antigens, Neoplasm - immunology | Neoplasms - immunology | Humans | Fatty Acid Synthases - immunology | Oncogenes | Neoplasms - drug therapy | Medical research | Enzymes | Fatty acids | Cells | Carnitine | Monosaccharides | Chemotherapy | Synthesis | Epidermal growth factor | Cell death | Medicine, Experimental | Blood lipids | Saturated fatty acids | Protein kinases | Sugars | Cancer | Protein binding | Index Medicus
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2. Full Text Molecular pathways: Fatty acid synthase
by Jones, Suzanne F and Infante, Jeffrey R
Clinical cancer research, ISSN 1078-0432, 12/2015, Volume 21, Issue 24, pp. 5434 - 5438
Life Sciences & Biomedicine | Oncology | Science & Technology | Fatty Acid Synthases - antagonists & inhibitors | Neoplasms - metabolism | Animals | Fatty Acid Synthases - metabolism | Signal Transduction - drug effects | Humans | Translational Medical Research | Lipid Metabolism - drug effects | Antineoplastic Agents - pharmacology | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Neoplasms - drug therapy | Index Medicus
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3. Full Text Polyketide Synthase Modules Redefined
by Keatinge‐Clay, Adrian T
Angewandte Chemie (International ed.), ISSN 1433-7851, 04/2017, Volume 56, Issue 17, pp. 4658 - 4660
assembly lines | evolution-guided engineering | polyketides | enzymology | modules | Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Bacteria - metabolism | Bacteria - chemistry | Biocatalysis | Fatty Acid Synthases - metabolism | Acyl Carrier Protein - metabolism | Humans | Computational Biology | Substrate Specificity | Acyltransferases - metabolism | Bacteria - genetics | Polyketides - metabolism | Polyketide Synthases - chemistry | Polyketide Synthases - metabolism | Animals | Protein Engineering | Protein Domains | Bacteria - enzymology | Polyketide Synthases - genetics | Evolution, Molecular | Assembly lines | Polyketide synthase | Enzymology | Workers | Index Medicus
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4. Full Text Structure of the human β‐ketoacyl [ACP] synthase from the mitochondrial type II fatty acid synthase
by Christensen, Caspar Elo and Kragelund, Birthe B and von Wettstein‐Knowles, Penny and Henriksen, Anette
Protein science, ISSN 0961-8368, 02/2007, Volume 16, Issue 2, pp. 261 - 272
acyl binding | fatty acid synthesis | hexanoyl | X‐ray crystal structure | binding pockets | cerulenin | antibiotics | Hexanoyl | Antibiotics | Acyl binding | X-ray crystal structure | Cerulenin | Binding pockets | Fatty acid synthesis | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Structure, Tertiary | Amino Acid Sequence | Fatty Acid Synthases - metabolism | Protein Structure, Secondary | Humans | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | Structure-Activity Relationship | Cerulenin - chemistry | 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase - chemistry | Sequence Homology, Amino Acid | Cerulenin - metabolism | Sequence Alignment | Mitochondrial Proteins - metabolism | Mitochondrial Proteins - chemistry | Protein Binding | Binding Sites | Fatty Acid Synthases - chemistry | 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase - metabolism | Index Medicus
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5. Full Text Structure of a modular polyketide synthase
by Dutta, Somnath and Whicher, Jonathan R and Hansen, Douglas A and Hale, Wendi A and Chemler, Joseph A and Congdon, Grady R and Narayan, Alison R. H and Håkansson, Kristina and Sherman, David H and Smith, Janet L and Skiniotis, Georgios
Nature (London), ISSN 0028-0836, 2014, Volume 510, Issue 7506, pp. 512 - 517
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cryoelectron Microscopy | Catalytic Domain | Polyketide Synthases - chemistry | Polyketide Synthases - metabolism | Biocatalysis | Polyketide Synthases - ultrastructure | Models, Molecular | Streptomyces - enzymology | Macrolides - metabolism | Fatty Acid Synthases - chemistry | Proteins | Physiological aspects | Polyketides | Structure | Observations | Enzymes | Fourier transforms | Polypeptides | Microscopy | Chemical bonds | Carbon | Crystal structure | Index Medicus
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6. Full Text UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis
by Moon, Jong-Seok and Lee, Seonmin and Park, Mi-Ae and Siempos, Ilias I and Haslip, Maria and Lee, Patty J and Yun, Mijin and Kim, Chun K and Howrylak, Judie and Ryter, Stefan W and Nakahira, Kiichi and Choi, Augustine M. K
The Journal of clinical investigation, ISSN 0021-9738, 02/2015, Volume 125, Issue 2, pp. 665 - 680
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Fatty Acid Synthase, Type I - genetics | Fatty Acid Synthase, Type I - biosynthesis | Lipids - genetics | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Ion Channels - genetics | Caspase 1 - metabolism | Mitochondrial Proteins - genetics | Interleukin-1beta - genetics | Lipids - biosynthesis | Sepsis - pathology | Interleukin-1beta - metabolism | Mitochondrial Proteins - metabolism | Sepsis - metabolism | Macrophages - pathology | Down-Regulation - genetics | Inflammasomes - genetics | Sepsis - genetics | Mice, Knockout | Carrier Proteins - genetics | Enzyme Induction - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Sepsis - chemically induced | Ion Channels - metabolism | Caspase 1 - genetics | Sepsis - therapy | Mice | Uncoupling Protein 2 | Interleukin-18 - genetics | Interleukin-18 - metabolism | Cellular proteins | Immune response | Synthesis | Sepsis | Development and progression | Lipids | Genetic aspects | Properties | Enzymes | Cytokines | Pathogenesis | Mortality | Glucose | Metabolism | Gene expression | Fatty acids | Proteins | Studies | Metabolites | Consent | Rodents | Index Medicus | Abridged Index Medicus
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7. Full Text Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
by Menendez, Javier A and Lupu, Ruth
Nature reviews. Cancer, ISSN 1474-175X, 10/2007, Volume 7, Issue 10, pp. 763 - 777
Life Sciences & Biomedicine | Oncology | Science & Technology | Fatty Acid Synthases - antagonists & inhibitors | Fatty Acid Synthases - metabolism | Carcinoma in Situ - pathology | Neoplasm Invasiveness | Humans | Multienzyme Complexes - metabolism | Neoplasms - enzymology | Transcription Factors - genetics | AMP-Activated Protein Kinases | Neoplasms - drug therapy | Neoplasm Metastasis | Phenotype | Cell Death - genetics | Lipogenesis - genetics | Neoplasms - genetics | Glucose - metabolism | Antineoplastic Agents - pharmacology | Genes, BRCA1 | Neoplasms - pathology | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Fatty Acids - biosynthesis | Physiological aspects | Synthesis | Research | Fatty acids | Cancer | Index Medicus
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