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Nature, ISSN 0028-0836, 03/2011, Volume 471, Issue 7336, pp. 104 - 109
The effective use of targeted therapy is highly dependent on the identification of responder patient populations. Loss of FBW7, which encodes a... 
COMPLEX | PROTEIN | CANCERS | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | TUMOR-SUPPRESSOR | DEGRADATION | DIFFERENTIATION | FBW7 UBIQUITIN LIGASE
Journal Article
Journal of Cancer, ISSN 1837-9664, 2019, Volume 10, Issue 13, pp. 2942 - 2952
Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer worldwide. Long-term survival rates in patients with HNSCC have not increased... 
Journal Article
BLOOD, ISSN 0006-4971, 02/2019, Volume 133, Issue 8, pp. 830 - 839
NOTCH1 is mutated in 10% of chronic lymphocytic leukemia (CLL) patients and is associated with poor outcome. However, NOTCH1 activation is identified in... 
SURVIVAL | CELLS | COMPLEX | CYCLIN-E | PATHWAY | RESISTANCE | CHRONIC LYMPHOCYTIC-LEUKEMIA | DEGRADATION | HIF-1-ALPHA | FBW7 | HEMATOLOGY
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 12/2019, Volume 132, p. 104584
Intracranial atherosclerotic stenosis (ICAS), the most common cause of stroke worldwide, is associated with high risk of recurrent ischemic stroke. F-box and... 
Oxidative stress | FBW7 | Smooth muscle cells | NADPH oxidase | Nox1 | Intracranial atherosclerotic stenosis
Journal Article
Cancer Research, ISSN 0008-5472, 01/2019, Volume 79, Issue 1, pp. 133 - 145
Kras is a decisive oncogene in pancreatic ductal adenocarcinoma (PDAC). PIN1 is a key effector involved in the Kras/ERK axis, synergistically mediating various... 
MAINTENANCE | OXIDATIVE STRESS | NRF2 | ONCOLOGY | PHOSPHORYLATION | ONCOGENIC KRAS | PROLYL ISOMERASE PIN1 | DOWN-REGULATION | FBW7 | PROMOTES | BINDING
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2016, Volume 64, Issue 3, pp. 493 - 506
amplification in human cancers predicts poor prognosis and resistance to therapy. However, pharmacological strategies that directly target N-Myc, the protein... 
BI6727 | targeted therapy | ubiquitination | Myc | PLK1 | neuroblastoma | Fbw7 | small cell lung carcinoma | ABT199 | TARGETED THERAPY | INHIBITOR VOLASERTIB | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-MYC | C-MYC | F-BOX PROTEINS | AMPLIFIED NEUROBLASTOMA | AURORA KINASE | FBW7 UBIQUITIN LIGASE | CANCER-THERAPY | HUMAN NEUROBLASTOMA | CELL BIOLOGY | RNA, Small Interfering - genetics | Humans | Neuroblastoma - mortality | N-Myc Proto-Oncogene Protein - antagonists & inhibitors | Transcription, Genetic | Neurons - metabolism | Brain Neoplasms - mortality | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | Sulfonamides - pharmacology | Drug Synergism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Feedback, Physiological | Mice, Nude | Survival Analysis | Cell Line, Tumor | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | RNA, Small Interfering - metabolism | F-Box-WD Repeat-Containing Protein 7 | Neurons - pathology | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | N-Myc Proto-Oncogene Protein - genetics | Cell Cycle Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Antineoplastic Agents - pharmacology | Neurons - drug effects | Neuroblastoma - pathology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Pteridines - pharmacology | F-Box Proteins - metabolism | Neuroblastoma - genetics | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | N-Myc Proto-Oncogene Protein - metabolism | Neuroblastoma - drug therapy | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - genetics | Ubiquitin | Polo | Ligases | Lung cancer | Therapeutics | Homeopathy | Materia medica and therapeutics | Cancer
Journal Article
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 09/2017, Volume 16, Issue 9, pp. 1979 - 1988
Journal Article
by Kuai, XL and Li, L and Chen, R and Wang, KJJ and Chen, M and Cui, BH and Zhang, YX and Li, JQ and Zhu, HW and Zhou, H and Huang, JF and Qin, J and Wang, ZW and Wei, WY and Gao, DM
CANCER RESEARCH, ISSN 0008-5472, 09/2019, Volume 79, Issue 17, pp. 4387 - 4398
Gastric cancer is the third leading cause of cancer-related death worldwide. The regulatory mechanisms underlying gastric cancer cell proliferation are largely... 
APOPTOSIS | ONCOLOGY | FBXW7 | STATISTICS | PROGNOSIS | GROWTH | GENES | C-MYC | TUMOR-SUPPRESSOR | EXPRESSION | FBW7 UBIQUITIN LIGASE
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 05/2019, Volume 47, Issue 9, pp. 4476 - 4494
Abstract IRF1 (Interferon Regulatory Factor-1) is the prototype of the IRF family of DNA binding transcription factors. IRF1 protein expression is regulated by... 
CELLS | PROTEIN | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | DEGRADATION | TARGETS | FBW7 | IDENTIFICATION | LIGASE | Gene regulation, Chromatin and Epigenetics
Journal Article
by Zhu, JL and Li, Y and Chen, CY and Ma, JG and Sun, WR and Tian, ZX and Li, JX and Xu, JH and Liu, CS and Zhang, DY and Huang, CS and Huang, HS
NEOPLASIA, ISSN 1476-5586, 09/2017, Volume 19, Issue 9, pp. 672 - 683
BACKGROUND: Since invasive bladder cancer (BC) is one of the most lethal urological malignant tumors worldwide, understanding the molecular mechanisms that... 
BREAST-CANCER | ACTIVATION | INVASION | METASTASIS | ONCOLOGY | FBXW7 | PHOSPHORYLATION | TUMOR-SUPPRESSOR | RHO-GTPASES | FBW7 UBIQUITIN LIGASE | PTEN EXPRESSION
Journal Article
Cell Reports, ISSN 2211-1247, 07/2018, Volume 24, Issue 4, pp. 947 - 961.e7
Journal Article
NEOPLASIA, ISSN 1476-5586, 11/2016, Volume 18, Issue 11, pp. 666 - 673
Pancreatic cancers driven by KRAS mutations require additional mutations for tumor progression. The tumor suppressor FBXW7 is altered in pancreatic cancers,... 
COOPERATE | CARCINOGENESIS | ONCOLOGY | DUCTAL ADENOCARCINOMA | ONCOGENIC KRAS | HAPLOINSUFFICIENT TUMOR-SUPPRESSOR | FBW7 | CANCER | CARCINOMA | PROGRESSION | CHROMOSOMAL INSTABILITY
Journal Article