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Journal of Pharmaceutical Sciences, ISSN 0022-3549, 01/2019, Volume 108, Issue 1, pp. 714 - 724
This work scaled up a previously developed physiologically based pharmacokinetic model to predict the effects of anti-FcRn agents on the disposition of... 
FcRn | antibody FcRn inhibitor | PBPK model | CHEMISTRY, MEDICINAL | SCALE-UP | GAMMA-GLOBULIN | FAMILIAL HYPERCATABOLIC HYPOPROTEINEMIA | CHEMISTRY, MULTIDISCIPLINARY | CHARACTERIZE | FUNCTIONAL EXPRESSION | ENDOTHELIAL-CELLS | SERUM-LEVELS | PHARMACOLOGY & PHARMACY | MONOCLONAL-ANTIBODIES | RECEPTOR FCRN
Journal Article
American journal of reproductive immunology (New York, N.Y. : 1989), ISSN 1046-7408, 9/2018, Volume 80, Issue 3, pp. e12972 - e12972
Journal Article
HEPATOLOGY, ISSN 0270-9139, 12/2017, Volume 66, Issue 6, pp. 2091 - 2092
Journal Article
Analytical Biochemistry, ISSN 0003-2697, 11/2015, Volume 489, pp. 25 - 31
A cell-based assay and a solution neonatal Fc receptor (FcRn) binding assay were implemented for the characterization of an IgG 2 antibody after observation... 
HMWs | SEC | Aggregates | Antibody | FcRn binding
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 01/2019, Volume 108, Issue 1, pp. 701 - 713
There is a growing interest in developing inhibitors of the neonatal Fc-receptor, FcRn, for use in the treatment for humoral autoimmune conditions. We have... 
FcRn | pharmacokinetics | antibody drugs | FcRn inhibitor | pharmacodynamics | PBPK model | WILD-TYPE | CHEMISTRY, MEDICINAL | SCALE-UP | CRYSTAL-STRUCTURE | IGG | CHEMISTRY, MULTIDISCIPLINARY | I-RELATED RECEPTOR | ENDOTHELIAL-CELLS | PHARMACOLOGY & PHARMACY | MONOCLONAL-ANTIBODIES | HALF-LIVES | IMMUNOGLOBULIN-G
Journal Article
Trends in Pharmacological Sciences, ISSN 0165-6147, 10/2018, Volume 39, Issue 10, pp. 892 - 904
Journal Article
Journal of Immunological Methods, ISSN 0022-1759, 11/2018, Volume 462, pp. 101 - 105
The neonatal Fc receptor (FcRn) binds to the Fc domain of IgG in a pH-dependent manner, guides the intracellular movement of the bound antibodies and protects... 
FcRn | Cell-based assay | Transcytosis | Monoclonal antibody | Pharmacokinetics | HALF-LIFE | BIOCHEMICAL RESEARCH METHODS | IGG | IMMUNOLOGY | BINDING | RECEPTOR FCRN | Proteins | Fc receptors | Immunoglobulin G | Monoclonal antibodies | Health aspects | Biopharmaceutics | Electric properties
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 2014, Volume 5
Journal Article
American Journal of Immunology, ISSN 1553-619X, 03/2016, Volume 12, Issue 1, pp. 1 - 9
Journal Article
Journal Article
Journal Article