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Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 01/2011, Volume 108, Issue 4, pp. 1609 - 1614
Radiation therapy can result in bone injury with the development of fractures and often can lead to delayed and nonunion of bone. There is no prevention or... 
Femur | Free radicals | Stem cells | Irradiation | Bone marrow | Bones | Physical trauma | Bone marrow cells | Radiation damage | Mesenchymal stem cells | CFU-fibroblast | Self-renewal | Angiography | Repopulation | Differentiation | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Femur - pathology | Leukocyte Common Antigens - metabolism | Mesenchymal Stromal Cells - radiation effects | Blood Vessels - pathology | Bone Marrow - radiation effects | Blood Vessels - radiation effects | Radiation Injuries, Experimental - etiology | Free Radicals - metabolism | Antigens, Ly - metabolism | Colony-Forming Units Assay | Membrane Proteins - metabolism | Radiation Injuries, Experimental - metabolism | Osteoblasts - radiation effects | Femur - metabolism | Mice, Inbred C57BL | Bone Marrow Cells - pathology | Mesenchymal Stromal Cells - metabolism | Thiobarbituric Acid Reactive Substances - metabolism | Bone Marrow Cells - radiation effects | Radiation Injuries, Experimental - pathology | Fibroblasts - pathology | Femur - radiation effects | Integrin beta1 - metabolism | Osteoblasts - pathology | Animals | Fibroblasts - radiation effects | Bone Marrow - pathology | Mice | Mesenchymal Stromal Cells - pathology | Bone Marrow Cells - metabolism | Physiological aspects | Complications and side effects | Stem cell research | Care and treatment | Radiotherapy | Studies | Fractures | Medical imaging | Rodents | Physiology | Radiation therapy | Index Medicus | Biological Sciences | repopulation | differentiation | self-renewal | angiography
Journal Article
Nature medicine, ISSN 1546-170X, 06/2012, Volume 18, Issue 7, pp. 1095 - 1101
Insulin-like growth factor 1 (IGF-1), the most abundant growth factor in the bone matrix, maintains bone mass in adulthood. We now report that IGF-1 released... 
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Bone Matrix - metabolism | Immunohistochemistry | Mesenchymal Stromal Cells - enzymology | Bone and Bones - pathology | Receptor, IGF Type 1 - metabolism | Insulin-Like Growth Factor I - pharmacology | Femur - pathology | TOR Serine-Threonine Kinases - metabolism | Cell Count | Humans | Aging - drug effects | Insulin-Like Growth Factor Binding Protein 3 - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Femur - diagnostic imaging | Insulin Receptor Substrate Proteins - metabolism | X-Ray Microtomography | Bone and Bones - drug effects | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Bone Matrix - drug effects | Bone and Bones - metabolism | Insulin-Like Growth Factor I - administration & dosage | Bone Resorption - metabolism | Insulin-Like Growth Factor Binding Protein 3 - administration & dosage | Receptor, IGF Type 1 - deficiency | Proto-Oncogene Proteins c-akt - metabolism | Femur - growth & development | Mesenchymal Stromal Cells - drug effects | Bone Resorption - blood | Osteoblasts - enzymology | Osteoblasts - drug effects | Osteogenesis - drug effects | Rats | Enzyme Activation - drug effects | Mice, Knockout | Bone Resorption - diagnostic imaging | Osteoblasts - pathology | Organ Size - drug effects | Animals | Cell Differentiation - drug effects | Bone Resorption - pathology | Mice | Mesenchymal Stromal Cells - pathology | Insulin-Like Growth Factor I - metabolism | Aging - metabolism | Physiological aspects | Research | Insulin-like growth factor 1 | Protein kinases | Stem cells | Bone marrow | Insulin-like growth factors | Index Medicus
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 06/2005, Volume 280, Issue 22, pp. 21162 - 21168
Journal Article
Nature medicine, ISSN 1546-170X, 10/2014, Volume 20, Issue 11, pp. 1270 - 1278
Osteogenesis during bone modeling and remodeling is coupled with angiogenesis. A recent study showed that a specific vessel subtype, strongly positive for CD31... 
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Neovascularization, Physiologic - drug effects | Cell Count | Tartrate-Resistant Acid Phosphatase | Osteoclasts - secretion | Culture Media, Conditioned - pharmacology | Femur - diagnostic imaging | X-Ray Microtomography | Protease Inhibitors - pharmacology | Acid Phosphatase - metabolism | Mesenchymal Stromal Cells - cytology | Isoenzymes - metabolism | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Female | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cathepsin K - antagonists & inhibitors | Mesenchymal Stromal Cells - drug effects | Ovariectomy | Endothelial Cells - metabolism | Femur - metabolism | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Mice, Inbred C57BL | Osteogenesis - drug effects | Mesenchymal Stromal Cells - metabolism | Femur - drug effects | Cell Movement - drug effects | Animals | Cathepsin K - metabolism | Endothelial Cells - cytology | Proto-Oncogene Proteins c-sis - secretion | Osteoclasts - enzymology | Osteoclasts - drug effects | Endothelial Cells - drug effects | Platelet-derived growth factor | Growth | Analysis | Physiological aspects | Bones | Research | Osteoclasts (Biology) | Homeostasis | Angiogenesis | Cell growth | Blood platelets | Index Medicus
Journal Article
Toxicology and applied pharmacology, ISSN 0041-008X, 06/2018, Volume 348, pp. 85 - 98
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and other aryl hydrocarbon receptor (AhR) agonists have been shown to regulate bone development and remodeling in a... 
TCDD | AhR | Transmembrane glycoprotein NMB | Bone | Vitamin D | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - biosynthesis | Age Factors | Cancellous Bone - metabolism | Membrane Glycoproteins - metabolism | Tartrate-Resistant Acid Phosphatase - blood | Kidney - enzymology | Male | Cancellous Bone - drug effects | Adipocytes - drug effects | Femur - diagnostic imaging | X-Ray Microtomography | Dose-Response Relationship, Drug | Cancellous Bone - diagnostic imaging | Basic Helix-Loop-Helix Transcription Factors - metabolism | Time Factors | Bone Marrow - metabolism | Bone Resorption - metabolism | Receptors, Aryl Hydrocarbon - metabolism | Female | Bone Resorption - chemically induced | Bone Marrow - drug effects | Basic Helix-Loop-Helix Transcription Factors - agonists | Bone Marrow - physiopathology | Bone Resorption - physiopathology | Cancellous Bone - physiopathology | Adiposity - drug effects | Femur - metabolism | Mice, Inbred C57BL | Osteoblasts - drug effects | Osteogenesis - drug effects | Femur - drug effects | Femur - physiopathology | Calcitriol - blood | Osteoclasts - metabolism | Matrix Metalloproteinase 13 - metabolism | Receptors, Aryl Hydrocarbon - agonists | Animals | Cathepsin K - metabolism | Eye Proteins - metabolism | Adipocytes - metabolism | Polychlorinated Dibenzodioxins - toxicity | Osteoblasts - metabolism | Osteoclasts - drug effects | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, pp. e59402 - e59402
Tobacco smoking is an important risk factor for the development of several cancers, osteoporosis, and inflammatory diseases such as periodontitis. Nicotine is... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Vacuolar Proton-Translocating ATPases - genetics | Gene Expression - drug effects | Monocytes - cytology | Actins - metabolism | Tartrate-Resistant Acid Phosphatase | Male | Monocytes - metabolism | Osteoclasts - cytology | Vacuolar Proton-Translocating ATPases - metabolism | Actins - genetics | Nicotine - pharmacology | Acid Phosphatase - metabolism | Matrix Metalloproteinase 9 - metabolism | Bone Resorption - genetics | Isoenzymes - metabolism | Matrix Metalloproteinase 9 - genetics | Bone Resorption - metabolism | Bone Resorption - chemically induced | Tibia - metabolism | Cathepsin K - antagonists & inhibitors | Cell Line | Receptors, Nicotinic - metabolism | Bone Marrow Cells - cytology | Femur - metabolism | Isoenzymes - genetics | Mice, Inbred C57BL | Femur - drug effects | Tibia - drug effects | Osteoclasts - metabolism | Tibia - cytology | Cathepsin K - genetics | Vacuolar Proton-Translocating ATPases - antagonists & inhibitors | Actins - antagonists & inhibitors | Animals | Cathepsin K - metabolism | Bone Resorption - pathology | Femur - cytology | Mice | Cell Nucleus - drug effects | Receptors, Nicotinic - genetics | Acid Phosphatase - genetics | Bone Marrow Cells - metabolism | Osteoclasts - drug effects | Bungarotoxins - pharmacology | Osteoprogenitor cells | Cell culture | Health sciences | Tobacco smoking | Biochemistry | Kinases | Osteoblasts | Nuclei | Inflammatory diseases | Risk factors | Bone resorption | Osteoporosis | Receptors | Bungarotoxin | Actin | Acid resistance | Bone marrow | Extracellular matrix | Biocompatibility | TRANCE protein | University graduates | H+-transporting ATPase | Cathepsin K | Cytokines | Health risks | Dentistry | Gelatinase B | Osteoclastogenesis | Tobacco | Dental research | Osteoblastogenesis | Periodontitis | Oral hygiene | Morphology | Osteoclasts | Acid phosphatase (tartrate-resistant) | Nuclei (cytology) | Differentiation | Acid phosphatase | Nicotine | Smoking | Index Medicus
Journal Article