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1. Full Text Gemfibrozil and fenofibrate, food and drug administration-approved lipid-lowering drugs, up-regulate tripeptidyl-peptidase 1 in brain cells via peroxisome proliferator-activated receptor α: Implications for late infantile batten disease therapy
by Ghosh, Arunava and Corbett, Grant T and Gonzalez, Frank J and Pahan, Kalipada
The Journal of biological chemistry, ISSN 0021-9258, 11/2012, Volume 287, Issue 46, pp. 38922 - 38935
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Neuronal Ceroid-Lipofuscinoses - drug therapy | Up-Regulation | Retinoid X Receptor alpha - metabolism | Serine Proteases - biosynthesis | Humans | Neuronal Ceroid-Lipofuscinoses - metabolism | Gemfibrozil - pharmacology | Hypolipidemic Agents - pharmacology | Brain - drug effects | Brain - metabolism | Fenofibrate - pharmacology | Animals | Lysosomes - metabolism | Gene Expression Regulation, Developmental | Mice | Neurons - metabolism | PPAR alpha - metabolism | Aminopeptidases - biosynthesis | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - biosynthesis | Astrocytes - metabolism | Index Medicus | Gene Regulation | Lysosomes | Enzymology | Peroxisome Proliferator-activated Receptor (PPAR) | Astrocytes | Neurons
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2. Full Text Quercetin administration post‐weaning attenuates high‐fructose, high‐cholesterol diet‐induced hepatic steatosis in growing, female, Sprague Dawley rat pups
by Donaldson, Janine and Ngema, Mandisa and Nkomozepi, Pilani and Erlwanger, Kennedy
Journal of the science of food and agriculture, ISSN 0022-5142, 12/2019, Volume 99, Issue 15, pp. 6954 - 6961
quercetin | metabolic health | rat | liver | high‐fructose, high‐cholesterol diet | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Applied | Food Science & Technology | Agriculture, Multidisciplinary | Agriculture | Science & Technology | Fructose - adverse effects | Weaning | Cholesterol - blood | Cholesterol, Dietary - metabolism | Humans | Liver - metabolism | Non-alcoholic Fatty Liver Disease - etiology | Rats | Male | Non-alcoholic Fatty Liver Disease - metabolism | Rats, Sprague-Dawley | Fructose - metabolism | Non-alcoholic Fatty Liver Disease - drug therapy | Animals | Liver - drug effects | Triglycerides - blood | Quercetin - administration & dosage | Female | Cholesterol, Dietary - adverse effects | High cholesterol diet | Liver | Transaminase | Lipids | Statistical methods | Blood | Fatty liver | Rodents | Creatinine | Alanine | Liver diseases | Statistical analysis | Drinking behavior | Triglycerides | Cholesterol | Fructose | Steatosis | Fenofibrate | Urea | Organic chemistry | Diet | Quercetin | Alanine transaminase | Metabolic disorders | Index Medicus
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3. Full Text Metronomic Chemotherapy with the COMBAT Regimen in Advanced Pediatric Malignancies: A Multicenter Experience
by Zapletalova, D and André, N and Deak, L and Kyr, M and Bajciova, V and Mudry, P and Dubska, L and Demlova, R and Pavelka, Z and Zitterbart, K and Skotakova, J and Husek, K and Martincekova, A and Mazanek, P and Kepak, T and Doubek, M and Kutnikova, L and Valik, D and Sterba, J
Oncology, ISSN 0030-2414, 05/2012, Volume 82, Issue 5, pp. 249 - 260
Clinical Study | Tumor angiogenesis | Solid tumor | Children | Metronomic chemotherapy | Relapsed pediatric solid tumor | Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Multiple tumors. Solid tumors. Tumors in childhood (general aspects) | Medical sciences | Tumors | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Administration, Metronomic | Humans | Child, Preschool | Infant | Isotretinoin - administration & dosage | Male | Feasibility Studies | Young Adult | Angiogenesis Inhibitors - administration & dosage | Dacarbazine - analogs & derivatives | Adult | Female | Registries | Vitamin D - administration & dosage | Child | Dacarbazine - administration & dosage | Europe | Fenofibrate - administration & dosage | Etoposide - administration & dosage | Celecoxib | Neoplasms - drug therapy | Pyrazoles - administration & dosage | Adolescent | Sulfonamides - administration & dosage | Chemotherapy | Children & youth | Cancer | Index Medicus
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4. Full Text Denatured globular protein and bile salt-coated nanoparticles for poorly water-soluble drugs: Penetration across the intestinal epithelial barrier into the circulation system and enhanced oral bioavailability
by He, Wei and Yang, Ke and Fan, Lifang and Lv, Yaqi and Jin, Zhu and Zhu, Shumin and Qin, Chao and Wang, Yiao and Yin, Lifang
International journal of pharmaceutics, ISSN 0378-5173, 11/2015, Volume 495, Issue 1, pp. 9 - 18
Absorption mechanism | Nanoemulsions | Insoluble drug | Pharmacokinetics | Globular protein | Solidification | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Nanoparticles - chemistry | Soybean Proteins - pharmacokinetics | Emulsions - adverse effects | Humans | Bile Acids and Salts - chemistry | Drug Carriers - administration & dosage | Biological Availability | Fenofibrate - chemistry | Soybean Proteins - chemistry | Drug Carriers - chemistry | Intestinal Absorption | Tissue Distribution | Emulsions - administration & dosage | Bile Acids and Salts - administration & dosage | Protein Denaturation | Water - chemistry | Bile Acids and Salts - pharmacokinetics | Caco-2 Cells | Cell Survival - drug effects | Soybean Proteins - administration & dosage | Administration, Oral | Emulsions - chemistry | Nanoparticles - ultrastructure | Solubility | Fenofibrate - administration & dosage | Rats | Chemistry, Pharmaceutical | Fenofibrate - blood | Particle Size | Fenofibrate - pharmacokinetics | Animals | Suspensions - pharmacokinetics | Drug Carriers - pharmacokinetics | Nanoparticles - administration & dosage | Emulsions - pharmacokinetics | Drugs | Drug delivery systems | Analysis | Gastrointestinal system | Vehicles | Index Medicus
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5. Full Text Design of Lipid-Based Formulations for Oral Administration of Poorly Water-Soluble Drugs: Precipitation of Drug after Dispersion of Formulations in Aqueous Solution
by Mohsin, Kazi and Long, Michelle A and Pouton, Colin W
Journal of pharmaceutical sciences, ISSN 0022-3549, 10/2009, Volume 98, Issue 10, pp. 3582 - 3595
SEDDS | lipid formulation classification system | oral drug delivery | SMEDDS | self-emulsifying systems | self-emulsifying drug delivery systems | drug precipitation | self‐emulsifying systems | self‐emulsifying drug delivery systems | Drug precipitation | Lipid formulation classification system | Self-emulsifying systems | Oral drug delivery | Selfemulsifying drug delivery systems | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Pharmaceutical technology. Pharmaceutical industry | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Water | Solvents | Excipients | Emulsions | Solubility | Fenofibrate - administration & dosage | Electric Conductivity | Chromatography, High Pressure Liquid | Fenofibrate - chemistry | Chemistry, Pharmaceutical | Lipids - chemistry | Solutions | Hypolipidemic Agents - administration & dosage | Pharmaceutical Preparations - chemistry | Hypolipidemic Agents - chemistry | Index Medicus
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6. Full Text Severe hypoglycemia in users of sulfonylurea antidiabetic agents and antihyperlipidemics
by Leonard, CE and Bilker, WB and Brensinger, CM and Han, X and Flory, JH and Flockhart, DA and Gagne, JJ and Cardillo, S and Hennessy, S
Clinical pharmacology and therapeutics, ISSN 0009-9236, 05/2016, Volume 99, Issue 5, pp. 538 - 547
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Hypoglycemia - epidemiology | Glipizide - administration & dosage | Humans | Middle Aged | Glipizide - adverse effects | Male | Fenofibrate - adverse effects | Incidence | Drug Interactions | Hypoglycemic Agents - administration & dosage | Female | Retrospective Studies | Sulfonylurea Compounds - administration & dosage | Glyburide - administration & dosage | Hypoglycemia - chemically induced | Glyburide - adverse effects | Severity of Illness Index | Hypolipidemic Agents - adverse effects | Fenofibrate - administration & dosage | Sulfonylurea Compounds - adverse effects | Algorithms | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Hypolipidemic Agents - administration & dosage | Aged | Hypoglycemic Agents - adverse effects | Cohort Studies | Care and treatment | Dosage and administration | Management | Hypoglycemia | Hypoglycemic sulfonylureas | Sulfonylurea compounds | Risk factors | Public health | Index Medicus | Abridged Index Medicus | drug interactions | fibric acids | sulfonylurea compounds | hypoglycemia | cohort studies | hydroxymethylglutaryl-CoA reductase inhibitors | Medicaid | pharmacoepidemiology | propensity score
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7. Full Text A phase II trial of a multi‐agent oral antiangiogenic (metronomic) regimen in children with recurrent or progressive cancer
by Robison, Nathan J and Campigotto, Federico and Chi, Susan N and Manley, Peter E and Turner, Christopher D and Zimmerman, Mary Ann and Chordas, Christine A and Werger, Annette M and Allen, Jeffrey C and Goldman, Stewart and Rubin, Joshua B and Isakoff, Michael S and Pan, Wilbur J and Khatib, Ziad A and Comito, Melanie A and Bendel, Anne E and Pietrantonio, Jay B and Kondrat, Laura and Hubbs, Shannon M and Neuberg, Donna S and Kieran, Mark W
Pediatric blood & cancer, ISSN 1545-5009, 04/2014, Volume 61, Issue 4, pp. 636 - 642
drug resistance | pediatric oncology | phase II clinical trials | angiogenesis | Pediatric oncology | Angiogenesis | Drug resistance | Phase II clinical trials | Pediatrics | Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Cyclophosphamide - administration & dosage | Prognosis | Prospective Studies | Follow-Up Studies | Humans | Child, Preschool | Neoplasm Recurrence, Local - drug therapy | Infant | Male | Neoplasm Recurrence, Local - pathology | Young Adult | Angiogenesis Inhibitors - therapeutic use | Adult | Female | Child | Fenofibrate - administration & dosage | Etoposide - administration & dosage | Survival Rate | Celecoxib | Thalidomide - administration & dosage | Neoplasms - drug therapy | Pyrazoles - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Neovascularization, Pathologic - drug therapy | Adolescent | Neoplasm Staging | Neoplasms - pathology | Sulfonamides - administration & dosage | Antimitotic agents | Chemotherapy | Relapse | Gliomas | Analysis | Leukemia | Clinical trials | Product development | Antineoplastic agents | Diseases | Cancer | Drug dosages | Cancer therapies | Tumors | Index Medicus | s
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8. Full Text The peroxisome proliferator-activated receptor alpha agonist fenofibrate attenuates alcohol self-administration in rats
by Haile, Colin N and Kosten, Therese A
Neuropharmacology, ISSN 0028-3908, 04/2017, Volume 116, pp. 364 - 370
Self-administration | Addiction | Ethanol | Drug seeking | Progressive ratio | Rats | Alcohol | Ethanol reinforcement | Peroxisome proliferator-activated receptors | PPARα | Pharmacology & Pharmacy | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Rats, Wistar | Conditioning, Operant - physiology | Ethanol - administration & dosage | Dose-Response Relationship, Drug | Reinforcement Schedule | Fenofibrate - pharmacology | Self Administration | Animals | Alcohol Deterrents - pharmacology | Conditioning, Operant - drug effects | Alcoholism - metabolism | Central Nervous System Depressants - administration & dosage | PPAR alpha - agonists | Alcoholism - drug therapy | Dietary Sucrose | PPAR alpha - metabolism | Hypercholesterolemia | Drinking of alcoholic beverages | Index Medicus
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9. Full Text Safety assessment of niacin in the US Food and Drug Administration's mini‐sentinel system
by Gagne, Joshua J and Houstoun, Monika and Reichman, Marsha E and Hampp, Christian and Marshall, James H and Toh, Sengwee
Pharmacoepidemiology and drug safety, ISSN 1053-8569, 01/2018, Volume 27, Issue 1, pp. 30 - 37
niacin | sentinel | bleeding | safety | pharmacoepidemiology | Pharmacology & Pharmacy | Public, Environmental & Occupational Health | Life Sciences & Biomedicine | Science & Technology | United States - epidemiology | Hyperlipidemias - blood | United States Food and Drug Administration - statistics & numerical data | Follow-Up Studies | Humans | Middle Aged | Male | Gastrointestinal Hemorrhage - epidemiology | Delayed-Action Preparations - administration & dosage | Fenofibrate - adverse effects | Incidence | Niacin - administration & dosage | Young Adult | Aged, 80 and over | Niacin - adverse effects | Adult | Female | Adverse Drug Reaction Reporting Systems - statistics & numerical data | Hypolipidemic Agents - adverse effects | Hyperlipidemias - drug therapy | Fenofibrate - administration & dosage | Gastrointestinal Hemorrhage - chemically induced | Delayed-Action Preparations - adverse effects | Intracranial Hemorrhages - chemically induced | Hypolipidemic Agents - administration & dosage | Cholesterol, HDL - blood | Intracranial Hemorrhages - epidemiology | Aged | Niacin | Analysis | Safety and security measures | Sensitivity analysis | Initiators | Sentinel system | Data processing | Hazards | Hemorrhage | Bleeding | Confidence intervals | Fenofibrate | Statistical models | Vitamin B | Lipoproteins (high density) | Index Medicus
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