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Nature, ISSN 0028-0836, 09/2014, Volume 513, Issue 7518, pp. 436 - 439
Journal Article
Journal Article
WORLD JOURNAL OF GASTROENTEROLOGY, ISSN 1007-9327, 05/2007, Volume 13, Issue 17, pp. 2484 - 2489
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 07/2013, Volume 19, Issue 13, pp. 3693 - 3702
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 01/2017, Volume 35, Issue 2, pp. 157 - 157
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2016, Volume 113, Issue 8, pp. 2288 - 2293
Journal Article
Cancer, ISSN 0008-543X, 06/2018, Volume 124, Issue 11, pp. 2365 - 2372
BACKGROUND Hypertension (HTN) is an established class effect of vascular endothelial growth factor receptor (VEGFR) inhibition. In the phase 3 Study of (E7080)... 
exploratory analysis | treatment‐emergent hypertension | lenvatinib | differentiated thyroid cancer | efficacy | treatment-emergent hypertension | ONCOLOGY | BEVACIZUMAB | SUNITINIB | INHIBITOR | ANTITUMOR ACTIVITIES | ENDOTHELIAL GROWTH-FACTOR | Humans | Middle Aged | Radiation Tolerance | Hypertension - drug therapy | Male | Response Evaluation Criteria in Solid Tumors | Protein Kinase Inhibitors - adverse effects | Quinolines - administration & dosage | Thyroid Neoplasms - therapy | Young Adult | Chemotherapy, Adjuvant - adverse effects | Phenylurea Compounds - adverse effects | Hypertension - chemically induced | Placebos - adverse effects | Adult | Female | Hypertension - epidemiology | Hypertension - diagnosis | Blood Pressure Determination | Placebos - administration & dosage | Thyroid Neoplasms - mortality | Double-Blind Method | Kaplan-Meier Estimate | Survival Rate | Antihypertensive Agents - therapeutic use | Protein Kinase Inhibitors - administration & dosage | Iodine Radioisotopes - administration & dosage | Phenylurea Compounds - administration & dosage | Chemotherapy, Adjuvant - methods | Thyroid Gland - pathology | Progression-Free Survival | Aged | Quinolines - adverse effects | Thyroid Neoplasms - pathology | Clinical trials | Treatment outcome | Thyroid cancer | Drug therapy | Analysis | Hypertension | Fibroblast growth factor | Iodine radioisotopes | Effectiveness | Iodine 131 | Hazards | Patients | Survival | Stem cell factor | Vascular endothelial growth factor receptors | Rank tests | Confidence intervals | Ret protein | Statistical models | Stem cells | Fibroblast growth factor receptor 4 | Fibroblast growth factor receptor 1 | Vascular endothelial growth factor | Growth factors | Fibroblast growth factor receptor 2 | Cancer | Thyroid | Fibroblast growth factor receptors
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 12/2017, Volume 19, Issue 12, pp. 1762 - 1772
Aims To assess the safety, tolerability, pharmacokinetics and pharmacodynamics of PF‐05231023, a long‐acting fibroblast growth factor 21 (FGF21) analogue, in... 
fibroblast growth factor 21 | IGF‐1 | blood pressure | heart rate | type 2 diabetes | bone biomarkers | IGF-1 | FATTY LIVER-DISEASE | ENERGY-EXPENDITURE | PF-05231023 | PROFILE | PHARMACOKINETICS | ENDOCRINOLOGY & METABOLISM | MICE | FGF21 | Hypertriglyceridemia - drug therapy | Fibroblast Growth Factors - adverse effects | Follow-Up Studies | Obesity - drug therapy | Species Specificity | Humans | Middle Aged | Half-Life | Anti-Obesity Agents - adverse effects | Male | Obesity - blood | Anti-Obesity Agents - therapeutic use | Bone Remodeling - drug effects | Delayed-Action Preparations - administration & dosage | Dose-Response Relationship, Drug | Anti-Obesity Agents - pharmacokinetics | Antibodies, Monoclonal, Humanized - administration & dosage | Antibodies, Monoclonal, Humanized - pharmacokinetics | Fibroblast Growth Factors - administration & dosage | Hypertension - chemically induced | Delayed-Action Preparations - pharmacokinetics | Female | Drug Resistance | Fibroblast Growth Factors - therapeutic use | Body Mass Index | Severity of Illness Index | Antibodies, Monoclonal, Humanized - adverse effects | Hypolipidemic Agents - adverse effects | Anti-Obesity Agents - administration & dosage | Antibodies, Monoclonal, Humanized - therapeutic use | Double-Blind Method | Drug Administration Schedule | Obesity - complications | Biomarkers - blood | Hypertension - physiopathology | Hypertriglyceridemia - blood | Animals | Fibroblast Growth Factors - pharmacokinetics | Delayed-Action Preparations - adverse effects | Hypertriglyceridemia - complications | Hypolipidemic Agents - administration & dosage | Delayed-Action Preparations - therapeutic use | Hypolipidemic Agents - therapeutic use | Infusions, Intravenous | Hypolipidemic Agents - pharmacokinetics | Type 2 diabetes | Obesity | Heart beat | Blood cholesterol | Collagen | Analysis | Body weight | Primates | Fibroblast growth factors | Blood pressure | Fibroblast growth factor | Pharmacodynamics | Diabetes mellitus | Homeostasis | Lipids | Triglycerides | Body weight loss | Bone turnover | Monkeys & apes | Cholesterol | Adiponectin | Heart rate | Rodents | Fibroblasts | Atorvastatin | Lead | Safety | Pharmacokinetics | Growth factors | Diabetes mellitus (non-insulin dependent) | Lipoproteins (high density)
Journal Article
Journal Article
The Journal of Nutritional Biochemistry, ISSN 0955-2863, 11/2017, Volume 49, pp. 71 - 79
Excess carbohydrate intake causes obesity in humans. On the other hand, acute administration of fructose, glucose or sucrose in experimental animals has been... 
Energy expenditure | ChREBP | GLP-1 | Sucrose diet | FGF21 | BETA-KLOTHO | GLUCOSE-INTOLERANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARBOHYDRATE | ELEMENT-BINDING PROTEIN | INSULIN | NUTRITION & DIETETICS | FRUCTOSE | METABOLIC-ACTIVITY | ADIPOSE-TISSUE THERMOGENESIS | INDUCED OBESITY | CIRCULATING FGF21 | Receptor, Fibroblast Growth Factor, Type 1 - agonists | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Adipose Tissue, White - metabolism | Fibroblast Growth Factors - genetics | Male | Starch - adverse effects | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Liver - growth & development | Fibroblast Growth Factors - metabolism | Gene Expression Regulation, Developmental | Fibroblast Growth Factors - agonists | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Weight Gain | Reproducibility of Results | Uncoupling Protein 1 - agonists | Uncoupling Protein 1 - genetics | Nuclear Proteins - agonists | Membrane Proteins - genetics | Uncoupling Protein 1 - metabolism | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | Nuclear Proteins - metabolism | Transcription Factors - genetics | Organ Specificity | Membrane Proteins - agonists | Transcription Factors - metabolism | Animals | Energy Metabolism | Fibroblast Growth Factors - blood | Adipose Tissue, White - growth & development | Adipose Tissue, Brown - growth & development | Dietary Sucrose - adverse effects | Adipose Tissue, Brown - metabolism | Diet, Carbohydrate Loading - adverse effects | Transcription Factors - agonists | Medical colleges | RNA | Liver | Body weight | Fibroblast growth factors | Glucose | Statistics | Glucose tolerance tests | Fructose | Dextrose | Protein binding
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2013, Volume 49, Issue 9, pp. 2161 - 2169
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 02/2015, Volume 372, Issue 7, pp. 621 - 630