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Journal of Neuroscience, ISSN 0270-6474, 05/2012, Volume 32, Issue 22, pp. 7477 - 7492
Adult zebrafish show a remarkable capacity to regenerate their spinal column after injury, an ability that stands in stark contrast to the limited repair that... 
MOTOR-NEURON REGENERATION | RETINAL GANGLION-CELLS | TRANSGENIC ZEBRAFISH | FUNCTIONAL RECOVERY | AXONAL REGENERATION | REACTIVE ASTROCYTES | CULTURED ASTROCYTES | FIBROBLAST-GROWTH-FACTOR | ADULT ZEBRAFISH | ASTROGLIAL CELLS | NEUROSCIENCES | Glial Fibrillary Acidic Protein - genetics | Mitogen-Activated Protein Kinase Kinases - genetics | Nestin | Humans | Nerve Regeneration - physiology | Fibroblast Growth Factor 2 - pharmacology | Motor Activity - drug effects | Ki-67 Antigen - metabolism | Green Fluorescent Proteins - genetics | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Cell Movement - genetics | Recovery of Function | Neuroglia - drug effects | Spinal Cord Injuries - pathology | Cell Differentiation - genetics | Mitogen-Activated Protein Kinase Kinases - metabolism | Dextrans | Time Factors | Intermediate Filament Proteins - genetics | Fibroblast Growth Factor 3 - metabolism | Bromodeoxyuridine - metabolism | Fibroblast Growth Factor 8 - pharmacology | Disease Models, Animal | Fibroblast Growth Factor 3 - genetics | Animals, Genetically Modified | Gene Expression Regulation - genetics | Zebrafish Proteins - metabolism | Enzyme Inhibitors - pharmacology | Neuroglia - physiology | Zebrafish | Signal Transduction - genetics | Nerve Tissue Proteins - genetics | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Cell Movement - drug effects | Motor Activity - genetics | Pyrroles - pharmacology | Animals | Analysis of Variance | Signal Transduction - drug effects | Cell Differentiation - drug effects | Rhodamines | Nerve Regeneration - drug effects | Cell Proliferation - drug effects | Spinal Cord Injuries - physiopathology | Zebrafish Proteins - genetics | Intermediate Filament Proteins - metabolism | RNA, Messenger | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 07/2013, Volume 19, Issue 13, pp. 3693 - 3702
Journal Article
Science, ISSN 0036-8075, 9/2012, Volume 337, Issue 6099, pp. 1231 - 1235
The brain tumor glioblastoma multiforme (GBM) is among the most lethal forms of human cancer. Here, we report that a small subset of GBMs (3.1%; 3 of 97 tumors... 
Exons | Neurons | Genes | REPORTS | Stem cells | Aneuploidy | Chromosomes | Cells | Tumors | Daughter cells | Cancer | ANEUPLOIDY | SELECTIVE INHIBITOR | POTENT | MULTIDISCIPLINARY SCIENCES | CANCER | RECEPTOR TYROSINE KINASE | DISCOVERY | CHROMOSOMAL INSTABILITY | FAMILY | Microtubule-Associated Proteins - chemistry | Neoplasm Transplantation | Translocation, Genetic | Oncogene Proteins, Fusion - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - chemistry | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Mitosis | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - antagonists & inhibitors | Fetal Proteins - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Brain Neoplasms - metabolism | Oncogene Proteins, Fusion - chemistry | Spindle Apparatus - metabolism | Glioblastoma - genetics | Oncogene Fusion | Glioblastoma - metabolism | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Nuclear Proteins - genetics | Chromosomal Instability | Pyrazoles - pharmacology | Protein Structure, Tertiary | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Enzyme Inhibitors - pharmacology | Brain Neoplasms - genetics | Nuclear Proteins - metabolism | Pyrimidines - pharmacology | Nuclear Proteins - chemistry | Piperazines - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Cell Transformation, Neoplastic | Oncogene Proteins, Fusion - genetics | Fetal Proteins - genetics | Mice | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Fetal Proteins - chemistry | Physiological aspects | Development and progression | Fibroblast growth factors | Genetic aspects | Research | Health aspects | Glioblastoma multiforme | Proteins | Kinases | Brain cancer | Genomics | Pharmaceutical sciences | Index Medicus
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2014, Volume 20, Issue 15, pp. 4107 - 4114
Purpose: The fibroblast growth factor receptor (FGFR)-3 fusion genes have been recently demonstrated in a subset of non-small cell lung cancer (NSCLC). To aid... 
ALK | GLIOBLASTOMA | ONCOLOGY | ADENOCARCINOMAS | RET FUSIONS | MUTATIONS | REARRANGEMENTS | CARCINOMA | ROS1 | Oncogene Proteins, Fusion - metabolism | Adenocarcinoma - pathology | Prognosis | Prospective Studies | Follow-Up Studies | Microtubule-Associated Proteins - genetics | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Lung Neoplasms - mortality | Microtubule-Associated Proteins - metabolism | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Lung Neoplasms - pathology | Male | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Immunoenzyme Techniques | Carcinoma, Squamous Cell - mortality | Carcinoma, Non-Small-Cell Lung - classification | Female | Adenocarcinoma - genetics | Real-Time Polymerase Chain Reaction | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Carcinoma, Non-Small-Cell Lung - genetics | RNA, Messenger - genetics | Survival Rate | Reverse Transcriptase Polymerase Chain Reaction | Carcinoma, Non-Small-Cell Lung - mortality | Lung Neoplasms - classification | Oncogene Proteins, Fusion - genetics | Adaptor Proteins, Signal Transducing - genetics | Aged | Adaptor Proteins, Signal Transducing - metabolism | Neoplasm Staging | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Adenocarcinoma - mortality | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 11, pp. e14117 - e14117
Despite initial and sometimes dramatic responses of specific NSCLC tumors to EGFR TKIs, nearly all will develop resistance and relapse. Gene expression... 
Fibroblast Growth Factor 7 - pharmacology | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Coculture Techniques | Humans | Lung Neoplasms - metabolism | Fibroblast Growth Factor 2 - pharmacology | Lung Neoplasms - pathology | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Fibroblasts - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Drug Resistance, Neoplasm - genetics | Signal Transduction - drug effects | Fibroblasts - drug effects | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Fibroblasts - cytology | Protein Kinase Inhibitors - pharmacology | Quinazolines - pharmacology | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Tyrosine | Phenols | Fibroblast growth factors | RNA | Analysis | Luciferase | Fibroblast growth factor | Biotechnology | Transcription | Gene regulation | Lung cancer | Biology | Kinases | Cell adhesion & migration | Morphogenesis | Epidermal growth factor | Fibroblast growth factor receptor 7 | Gefitinib | Protein-tyrosine kinase | Fibroblast growth factor receptor 2 | Fibroblast growth factor 2 | Epidermal growth factor receptors | Extracellular signal-regulated kinase | Gene expression | Src protein | Self sufficiency | Pulmonary hypertension | Studies | Signaling | Inhibitors | Cell lines | Monoclonal antibodies | Ligands | Mutation | Tumors | Fibroblast growth factor receptors | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 10/2012, Volume 490, Issue 7419, pp. 278 - 282
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 05/2011, Volume 31, Issue 10, pp. 2079 - 2089
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
MORPHOGENESIS | LABEL-RETAINING CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | I RECEPTOR | TEETH | RECEPTOR ALK5 | GENERATION | DIFFERENTIATION | SKIN | MOUSE INCISORS | CELL BIOLOGY | Fibroblast Growth Factor 10 - pharmacology | Protein-Serine-Threonine Kinases - deficiency | Wnt1 Protein - genetics | Peptide Fragments | Receptors, Transforming Growth Factor beta - genetics | Cell Proliferation | Bromodeoxyuridine | Stem Cells - cytology | Activating Transcription Factor 2 - genetics | Fibroblast Growth Factor 9 - genetics | Epithelial Cells - physiology | Incisor - cytology | Polymerase Chain Reaction | Incisor - growth & development | Fibroblast Growth Factor 3 - metabolism | Cell Differentiation | Fibroblast Growth Factor 10 - genetics | Epithelial Cells - cytology | Organ Culture Techniques | Protein-Serine-Threonine Kinases - metabolism | Fibroblast Growth Factor 10 - metabolism | Fibroblast Growth Factor 3 - genetics | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Genotype | Mice, Transgenic | Fibroblast Growth Factor 9 - metabolism | Animals | Transforming Growth Factor beta - genetics | Receptors, Transforming Growth Factor beta - metabolism | Stem Cells - physiology | Mesoderm - metabolism | Mice | Transforming Growth Factor beta - metabolism | Receptors, Transforming Growth Factor beta - deficiency | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 05/2017, Volume 545, Issue 7653, pp. 224 - 241
Blood and lymphatic vasculatures are intimately involved in tissue oxygenation and fluid homeostasis maintenance. Assembly of these vascular networks involves... 
GENE-EXPRESSION DATA | MAINTENANCE | MULTIDISCIPLINARY SCIENCES | MOUSE | LYMPHANGIOGENESIS | ENDOTHELIAL-CELL METABOLISM | MECHANISMS | GROWTH-FACTOR | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Cell Proliferation | Lymphatic Vessels - cytology | Signal Transduction | Endothelial Cells - metabolism | Mice, Inbred C57BL | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Proto-Oncogene Proteins c-myc - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Fibroblast Growth Factors - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - deficiency | Lymphatic Vessels - metabolism | Animals | Receptor, Fibroblast Growth Factor, Type 3 - deficiency | Endothelial Cells - cytology | Glycolysis | Female | Mice | Hexokinase - metabolism | Lymphangiogenesis | Neovascularization, Physiologic | Cell Movement | Fibroblast growth factors | Metabolism | Observations | Health aspects | Cell proliferation | Fibroblast growth factor | Leukocyte migration | c-Myc protein | Homeostasis | Biology | Myc protein | Kinases | Blood | Defects | Angiogenesis | Control | Cell growth | Metabolites | Rodents | Fibroblast growth factor receptor 1 | Vascular endothelial growth factor | Growth factors | Medical research | Enzymes | Grants | Hexokinase | Endothelial cells | Endothelium | Signaling | Oxygenation | Cell migration | Fibroblast growth factor receptors | Index Medicus
Journal Article
Hepatology, ISSN 0270-9139, 04/2013, Volume 57, Issue 4, pp. 1407 - 1415
The response rate to sorafenib in hepatocellular carcinoma (HCC) is relatively low (0.7%‐3%), however, rapid and drastic tumor regression is occasionally... 
GROWTH-FACTOR RECEPTOR | GEFITINIB | GENE | GASTRIC-CANCER | MUTATIONS | COMPARATIVE GENOMIC HYBRIDIZATION | ANTITUMOR-ACTIVITY | GASTROENTEROLOGY & HEPATOLOGY | CLINICAL-RESPONSE | FEATURES | Niacinamide - analogs & derivatives | Carcinoma, Hepatocellular - epidemiology | Humans | Middle Aged | Male | Transplantation, Heterologous | Antineoplastic Agents - therapeutic use | Carcinoma, Hepatocellular - secondary | Incidence | Fibroblast Growth Factor 4 - genetics | Lung Neoplasms - secondary | Aged, 80 and over | Adult | Female | Fibroblast Growth Factor 3 - metabolism | Liver Neoplasms - pathology | Antineoplastic Agents - pharmacology | Retrospective Studies | Gene Expression Regulation, Neoplastic - drug effects | Fibroblast Growth Factor 4 - metabolism | Gene Expression Regulation, Neoplastic - genetics | Fibroblast Growth Factor 3 - genetics | Liver Neoplasms - drug therapy | Niacinamide - therapeutic use | Phenylurea Compounds - therapeutic use | Treatment Outcome | DNA, Neoplasm - drug effects | Gene Amplification - drug effects | Animals | Lung Neoplasms - epidemiology | Mice, Nude | Cell Line, Tumor | Aged | Gene Amplification - genetics | Mice | Mice, Inbred BALB C | Phenylurea Compounds - pharmacology | DNA, Neoplasm - genetics | Niacinamide - pharmacology | In Vitro Techniques | Liver cancer | Hepatology | Tumors | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2017, Volume 23, Issue 15, pp. 4323 - 4334
Purpose: Dual blockade of HER2 with trastuzumab and lapatinib or pertuzumab has been shown to be superior to single-agent trastuzumab. However, a significant... 
CELLS | ONCOGENE | SOLID TUMORS | TRASTUZUMAB | ONCOLOGY | CCND1 AMPLIFICATION | GROWTH | ACQUIRED-RESISTANCE | OPEN-LABEL | KINASE INHIBITOR LAPATINIB | ERBB RECEPTORS | Receptor, ErbB-2 - genetics | Humans | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Antibodies, Monoclonal, Humanized - administration & dosage | Female | Quinazolines - administration & dosage | Receptor, ErbB-2 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic - drug effects | Lapatinib | Fibroblast Growth Factor 3 - antagonists & inhibitors | Fibroblast Growth Factor 3 - genetics | Antineoplastic Combined Chemotherapy Protocols | Trastuzumab - administration & dosage | Breast Neoplasms - drug therapy | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Xenograft Model Antitumor Assays | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Neoadjuvant Therapy - adverse effects | Mice | Drug Resistance, Neoplasm - drug effects | Phosphorylation | Copy number | Statistical methods | Kinases | Xenografts | Fibroblast growth factor receptor 1 | Protein-tyrosine kinase | Tyrosine | Fibroblast growth factor 3 | Statistical analysis | Breast cancer | Gene expression | Patients | ErbB-2 protein | Fibroblast growth factor 4 | Amplification | Signaling | Gene amplification | Inhibitors | Experimental design | Breast | Trastuzumab | Tumors | Cancer | Fibroblast growth factor receptors | Index Medicus | trastuzumab | breast cancer | drug resistance | HER2 | FGFR
Journal Article
Developmental Biology, ISSN 0012-1606, 06/2014, Volume 390, Issue 1, pp. 1 - 13
The bones of the vertebrate face develop from transient embryonic branchial arches that are populated by cranial neural crest cells. We have characterized a... 
Craniofacial development | Pharyngeal arch | FGF | Neural Crest | SONIC HEDGEHOG | HEAD ECTODERM | DEVELOPMENTAL BIOLOGY | FOREGUT ENDODERM | CRANIAL NEURAL CREST | CELL-MIGRATION | GENOME-WIDE | JAW DEVELOPMENT | 1ST BRANCHIAL ARCH | MOLECULAR-MECHANISMS | Ectoderm - embryology | Embryo, Nonmammalian - cytology | Embryo, Nonmammalian - metabolism | Fibroblast Growth Factors - genetics | Apoptosis - genetics | Embryo, Nonmammalian - embryology | Endoderm - embryology | Mice, 129 Strain | Zebrafish - embryology | Cell Movement - genetics | Embryo, Mammalian - metabolism | Gene Knockdown Techniques | Neural Crest - metabolism | Fibroblast Growth Factor 8 - metabolism | Fibroblast Growth Factors - metabolism | Ectoderm - metabolism | In Situ Hybridization | Endoderm - cytology | Forkhead Transcription Factors - metabolism | Gene Expression Regulation, Developmental | Fibroblast Growth Factor 3 - metabolism | Fibroblast Growth Factor 8 - genetics | Neural Crest - cytology | Fibroblast Growth Factor 3 - genetics | Animals, Genetically Modified | Branchial Region - metabolism | Zebrafish Proteins - metabolism | Signal Transduction - genetics | Forkhead Transcription Factors - genetics | Zebrafish - genetics | Endoderm - metabolism | Mice, Knockout | Ectoderm - cytology | Animals | Embryo, Mammalian - embryology | Embryo, Mammalian - cytology | Neural Crest - embryology | Zebrafish - metabolism | Mice | Zebrafish Proteins - genetics | Body Patterning - genetics | Branchial Region - embryology | Genetic research | Fibroblast growth factors | DNA binding proteins | Developmental biology | Cells | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 02/2016, Volume 7, Issue 1, pp. 10605 - 10605
Journal Article