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Nature, ISSN 0028-0836, 01/2018, Volume 553, Issue 7689, pp. 461 - 466
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2014, Volume 111, Issue 45, pp. E4869 - E4877
The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation.... 
Structure-based drug design | Drug discovery | Cancer drug resistance | Kinase inhibitor | structure-based drug design | WILD-TYPE | MULTIDISCIPLINARY SCIENCES | BCR-ABL | GROWTH-FACTOR RECEPTORS | DRUG-RESISTANCE | kinase inhibitor | LUNG-CANCER | GENE FUSIONS | cancer drug resistance | SELECTIVE INHIBITOR | drug discovery | THERAPEUTIC TARGET | FACTOR RECEPTOR 4 | REGULATES PROLIFERATION | Receptor, Fibroblast Growth Factor, Type 4 - chemistry | Receptor, Epidermal Growth Factor - genetics | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Mutation, Missense | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Protein Kinase Inhibitors - chemistry | Receptor, Epidermal Growth Factor - metabolism | Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Binding Sites | Neoplasms - enzymology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Receptor, Epidermal Growth Factor - chemistry | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Neoplasms - pathology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Biological Sciences | PNAS Plus
Journal Article
Nature, ISSN 0028-0836, 01/2018, Volume 553, Issue 7689, pp. 501 - 505
Journal Article
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 01/2003, Volume 23, Issue 1, pp. 14 - 25
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
ACTIVATION | PROTEIN-KINASE-B | GENE | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | MICE | DIFFERENTIATION | LIGAND | EXPRESSION | DROSOPHILA EYE | CELL BIOLOGY | Endothelium, Vascular - cytology | Endothelial Growth Factors - metabolism | Vascular Endothelial Growth Factors | Humans | Protein-Serine-Threonine Kinases | Fibroblast Growth Factor 2 - pharmacology | Cell Survival - genetics | Endothelium, Vascular - drug effects | Endothelial Growth Factors - pharmacology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Vascular Endothelial Growth Factor Receptor-2 - genetics | Phosphatidylinositol 3-Kinases - drug effects | Lymphokines - metabolism | Cell Survival - drug effects | Vascular Endothelial Growth Factor Receptor-2 - drug effects | Signal Transduction | Membrane Proteins - genetics | Enzyme Inhibitors - pharmacology | Solubility | Recombinant Proteins - chemistry | Cell Division - drug effects | Lymphokines - chemistry | Vascular Endothelial Growth Factor Receptor-1 - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Transcription Factors | Vascular Endothelial Growth Factor A | Intercellular Signaling Peptides and Proteins - chemistry | Receptors, Cell Surface | Endothelial Growth Factors - chemistry | Phosphatidylinositol 3-Kinases - metabolism | Arteries - cytology | Endothelium, Vascular - physiology | Intercellular Signaling Peptides and Proteins - metabolism | Receptors, Notch | Arteries - physiology | Fibroblast Growth Factor 2 - metabolism | Flavonoids - pharmacology | Membrane Proteins - metabolism | Lymphokines - pharmacology | Vascular Endothelial Growth Factor Receptor-1 - genetics | Cell Division - genetics | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - drug effects | Cells, Cultured | Gene Expression Regulation | Intracellular Signaling Peptides and Proteins | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Proto-Oncogene Proteins - genetics | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Proto-Oncogene Proteins c-akt | Receptor, Notch1 | Neovascularization, Physiologic | Receptor, Notch4 | Cell Growth and Development
Journal Article
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 03/2011, Volume 150, Issue 2, pp. 157 - 163
Growth factors are potent molecules that regulate cell functions including survival, self renewal, differentiation and proliferation. High-efficacy delivery of... 
Delivery vehicle | Self assembly | Heparin | Growth factors | Controlled release | MATRIX | GLYCOSAMINOGLYCANS | TISSUE | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY-SYSTEM | AFFINITY | POLYSACCHARIDES | DEGRADATION | PHARMACOLOGY & PHARMACY | HEPARAN-SULFATE | PROTEINS | BINDING | Fibroblast Growth Factor 2 - chemistry | Humans | Fibroblast Growth Factor 2 - pharmacology | Intercellular Signaling Peptides and Proteins - chemistry | Polyethylenes - chemical synthesis | Biological Availability | Neurons - cytology | PC12 Cells | Azo Compounds - chemistry | Methylene Blue - analogs & derivatives | Nerve Growth Factor - administration & dosage | Intercellular Signaling Peptides and Proteins - pharmacokinetics | Nerve Growth Factor - chemistry | Light | Scattering, Radiation | Intercellular Signaling Peptides and Proteins - administration & dosage | Polyethylenes - chemistry | Microscopy, Electron, Scanning | Polyamines - chemistry | Epoxy Resins - chemistry | Cells, Cultured | Nerve Growth Factor - pharmacology | Rats | Nerve Growth Factor - pharmacokinetics | Fibroblast Growth Factor 2 - administration & dosage | Static Electricity | Arginine - chemistry | Particle Size | Animals | Benzenesulfonates - chemistry | Cell Differentiation - drug effects | Endothelial Cells - cytology | Intercellular Signaling Peptides and Proteins - pharmacology | Fibroblast Growth Factor 2 - pharmacokinetics | Cell Proliferation - drug effects | Aspartic Acid - chemistry | Drug Delivery Systems - methods | Methylene Blue - chemistry | Heparin - chemistry | Endothelial Cells - drug effects | Polyamines - chemical synthesis | Nerve growth factor | Fibroblast growth factors | Product enhancement
Journal Article