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Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7572, pp. 263 - 267
Colorectal cancer is the third most common cancer worldwide, with 1.2 million patients diagnosed annually. In late-stage colorectal cancer, the most commonly... 
PANITUMUMAB | THERAPY | MULTIDISCIPLINARY SCIENCES | SEQUENCE | ACQUIRED-RESISTANCE | SOMATIC MUTATION | IDENTIFICATION | GENE COPY NUMBER | ACTIVATING MUTATIONS | BREAST | INSIGHTS | Receptor, Epidermal Growth Factor - genetics | Receptor, ErbB-2 - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Genomics | Humans | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Cetuximab - therapeutic use | Molecular Targeted Therapy | Receptor, Fibroblast Growth Factor, Type 1 - genetics | MAP Kinase Kinase 1 - genetics | Colorectal Neoplasms - drug therapy | Female | Antineoplastic Agents - pharmacology | Insulin Receptor Substrate Proteins - genetics | Colorectal Neoplasms - metabolism | Antibodies, Monoclonal - pharmacology | Cetuximab - pharmacology | DNA Copy Number Variations - genetics | Mutation - genetics | Genome, Human - genetics | Receptor, Epidermal Growth Factor - chemistry | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Exome - genetics | Animals | Receptor, Platelet-Derived Growth Factor alpha - genetics | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Drug Resistance, Neoplasm - drug effects | Care and treatment | Gene mutations | Colorectal cancer | Drug metabolism | Genetic aspects | Identification and classification | Health aspects | Proteins | Epidermal growth factor | Genes | Clinical trials | Mutation | Kinases | Cancer therapies | Tumors | Index Medicus
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 01/2017, Volume 35, Issue 2, pp. 157 - 157
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2007, Volume 117, Issue 12, pp. 4003 - 4008
Phosphate homeostasis is maintained by a counterbalance between efflux from the kidney and influx from intestine and bone. FGF23 is a bone-derived phosphaturic... 
PHOSPHATE | MEDICINE, RESEARCH & EXPERIMENTAL | HORMONE GENE-EXPRESSION | IN-VIVO | CALCIUM | GROWTH | KLOTHO PROTEIN | SECONDARY HYPERPARATHYROIDISM | VITAMIN-D-RECEPTOR | DOMINANT HYPOPHOSPHATEMIC RICKETS | MICE | MAP Kinase Signaling System - physiology | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Fibroblast Growth Factors - genetics | Intestines - metabolism | Parathyroid Hormone - genetics | Fibroblast Growth Factors - metabolism | Parathyroid Glands - cytology | RNA, Messenger - biosynthesis | Kidney - metabolism | Parathyroid Hormone - biosynthesis | Bone and Bones - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Early Growth Response Protein 1 - genetics | Receptors, Fibroblast Growth Factor - genetics | Homeostasis - drug effects | Mitogen-Activated Protein Kinase 3 - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | RNA, Messenger - genetics | Cells, Cultured | Gene Expression Regulation - physiology | Rats | Fibroblast Growth Factors - pharmacology | Gene Expression Regulation - drug effects | Phosphates - metabolism | Animals | Glucuronidase - biosynthesis | MAP Kinase Signaling System - drug effects | Early Growth Response Protein 1 - biosynthesis | Glucuronidase - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Homeostasis - physiology | Receptors, Fibroblast Growth Factor - metabolism | Vitamin D - metabolism | Protein Kinase Inhibitors - pharmacology | Mitogen-Activated Protein Kinase 1 - metabolism | Parathyroid Glands - metabolism | Homeostasis | Parathyroid glands | Fibroblast growth factors | Dosage and administration | Genetic aspects | Research | Health aspects | Index Medicus | Abridged Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 12/2015, Volume 22, Issue 6, pp. 1020 - 1032
Chronic kidney disease (CKD) is a worldwide public health threat that increases risk of death due to cardiovascular complications, including left ventricular... 
SIGNAL-TRANSDUCTION | MORTALITY | FACTOR FAMILY | KLOTHO | POINT MUTATION | TYROSINE KINASE | ENDOCRINOLOGY & METABOLISM | CHRONIC KIDNEY-DISEASE | CANCER PROGRESSION | EXPRESSION | FGF RECEPTOR | CELL BIOLOGY | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Humans | Glucuronidase - metabolism | Fibroblast Growth Factors - genetics | Male | Renal Insufficiency, Chronic - metabolism | Fibroblast Growth Factors - metabolism | Hypertrophy, Left Ventricular - pathology | HEK293 Cells | Receptor, Fibroblast Growth Factor, Type 4 - deficiency | Female | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Disease Models, Animal | Phospholipase C gamma - metabolism | Mutagenesis, Site-Directed | Myocytes, Cardiac - cytology | Signal Transduction | Hypertrophy, Left Ventricular - metabolism | Mice, Inbred C57BL | NFATC Transcription Factors - metabolism | Cells, Cultured | Rats | Rats, Sprague-Dawley | Gene Knock-In Techniques | Mice, Knockout | Renal Insufficiency, Chronic - pathology | Animals | Glucuronidase - genetics | Myocytes, Cardiac - metabolism | Mice | Calcineurin - metabolism | Hypertension | Medical colleges | Chronic kidney failure | Heart enlargement | Stem cells | Physiological aspects | Fibroblast growth factors | Phospholipases | Drug discovery | T cells | Health aspects | Heart | Resveratrol | Development and progression | Kidney diseases | Cells | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 06/2017, Volume 25, Issue 6, pp. 1374 - 1389.e6
Journal Article
Gut, ISSN 0017-5749, 07/2016, Volume 65, Issue 7, pp. 1202 - 1214
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2014, Volume 111, Issue 45, pp. E4869 - E4877
The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation.... 
Structure-based drug design | Drug discovery | Cancer drug resistance | Kinase inhibitor | structure-based drug design | WILD-TYPE | MULTIDISCIPLINARY SCIENCES | BCR-ABL | GROWTH-FACTOR RECEPTORS | DRUG-RESISTANCE | kinase inhibitor | LUNG-CANCER | GENE FUSIONS | cancer drug resistance | SELECTIVE INHIBITOR | drug discovery | THERAPEUTIC TARGET | FACTOR RECEPTOR 4 | REGULATES PROLIFERATION | Receptor, Fibroblast Growth Factor, Type 4 - chemistry | Receptor, Epidermal Growth Factor - genetics | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Mutation, Missense | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Protein Kinase Inhibitors - chemistry | Receptor, Epidermal Growth Factor - metabolism | Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Binding Sites | Neoplasms - enzymology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Receptor, Epidermal Growth Factor - chemistry | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Neoplasms - pathology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Amino acids | T cell receptors | Mutation | Kinases | Binding sites | Adenosine triphosphatase | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2014, Volume 289, Issue 43, pp. 29751 - 29765
Background: Although both are involved in metabolic homeostasis, the interconnection between ER stress and FGF21 remains incompletely understood. Results:... 
BETA-KLOTHO | PPAR-ALPHA | Fibroblast Growth Factor (FGF) | FATTY LIVER-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INSULIN SENSITIVITY | Unfolded Protein Response (UPR) | Liver Metabolism | ENERGY-EXPENDITURE | ER Stress | Hepatocyte | METABOLIC REGULATOR | MESSENGER-RNA | TRANSCRIPTION FACTOR | FGF21 | Organ Specificity - drug effects | Non-alcoholic Fatty Liver Disease - pathology | Transcription, Genetic - drug effects | Transcriptional Activation - genetics | Fatty Liver - pathology | Humans | Transcriptional Activation - drug effects | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Fibroblast Growth Factors - genetics | Molecular Sequence Data | Hepatocytes - pathology | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Hepatocytes - metabolism | Endoplasmic Reticulum Stress - genetics | Promoter Regions, Genetic - genetics | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Fibroblast Growth Factors - metabolism | Organ Specificity - genetics | Base Sequence | Hepatocytes - drug effects | Protein-Serine-Threonine Kinases - metabolism | Fatty Liver - genetics | Unfolded Protein Response - drug effects | Endoribonucleases - metabolism | Unfolded Protein Response - genetics | Mice, Inbred C57BL | Non-alcoholic Fatty Liver Disease - metabolism | Signal Transduction - genetics | Recombinant Proteins - pharmacology | Enzyme Activation - drug effects | Regulatory Factor X Transcription Factors | Hep G2 Cells | Transcription Factors - metabolism | Animals | Diet | Signal Transduction - drug effects | Mice, Obese | Index Medicus | Molecular Biophysics
Journal Article
Nature, ISSN 0028-0836, 12/2015, Volume 528, Issue 7581, pp. 272 - 275
Journal Article