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Cell Metabolism, ISSN 1550-4131, 03/2016, Volume 23, Issue 3, pp. 427 - 440
Journal Article
Journal Article
SCIENCE TRANSLATIONAL MEDICINE, ISSN 1946-6234, 07/2014, Volume 6, Issue 247, pp. 247ra100 - 247ra100
Hepatic accumulation of bile acids is central to the pathogenesis of cholestatic liver diseases. Endocrine hormone fibroblast growth factor 19 (FGF19) may... 
MEDICINE, RESEARCH & EXPERIMENTAL | HEPATOCELLULAR-CARCINOMA | HORMONE | INTRAHEPATIC CHOLESTASIS | PRIMARY BILIARY-CIRRHOSIS | FARNESOID-X-RECEPTOR | FIBROBLAST-GROWTH-FACTOR | BILE-ACID SYNTHESIS | MICE | EXPRESSION | CANCER | CELL BIOLOGY | Recombinant Proteins - therapeutic use | Fibroblast Growth Factors - adverse effects | Liver - pathology | Humans | Middle Aged | Fibroblast Growth Factors - genetics | Male | Cholagogues and Choleretics - adverse effects | Cholestenones - blood | Fibroblast Growth Factors - biosynthesis | Cholestasis, Intrahepatic - drug therapy | Healthy Volunteers | RNA, Messenger - metabolism | Cholagogues and Choleretics - therapeutic use | Genetic Variation | Young Adult | Liver - drug effects | Adult | Liver Neoplasms - pathology | Cholestasis, Extrahepatic - pathology | Disease Models, Animal | Fibroblast Growth Factors - therapeutic use | Gene Transfer Techniques | Cholestasis, Intrahepatic - genetics | Double-Blind Method | Liver Neoplasms - genetics | Risk Assessment | Cholestasis, Intrahepatic - pathology | Down-Regulation | Liver - metabolism | Bile Acids and Salts - metabolism | Biomarkers - blood | Cholestasis, Extrahepatic - genetics | Gene Expression Regulation, Enzymologic | Cholagogues and Choleretics - pharmacokinetics | Cholesterol 7-alpha-Hydroxylase - genetics | Cholestasis, Intrahepatic - metabolism | Animals | Fibroblast Growth Factors - pharmacokinetics | Cholesterol 7-alpha-Hydroxylase - metabolism | Liver Neoplasms - metabolism | Mice | Cholestasis, Extrahepatic - metabolism | Australia | Cholestasis, Extrahepatic - drug therapy | Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 05/2015, Volume 131, Issue 21, pp. 1861 - 1871
BACKGROUND—Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity. It acts... 
Fibroblast growth factor 21 | Hormones | Adipokines | Atherosclerosis | atherosclerosis | fibroblast growth factor 21 | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | LIPID-METABOLISM | hormones | PGC-1-ALPHA | INSULIN SENSITIVITY | PROTECTS | ENERGY-EXPENDITURE | LIVER | PERIPHERAL VASCULAR DISEASE | adipokines | EXPRESSION | TRANSGENIC MICE | FGF21 | Recombinant Proteins - therapeutic use | Adiponectin - biosynthesis | Apolipoproteins E - deficiency | Atherosclerosis - genetics | Adipocytes - drug effects | Adiponectin - physiology | Sterol Regulatory Element Binding Protein 2 - biosynthesis | Membrane Proteins - deficiency | RNA, Messenger - biosynthesis | Liver - drug effects | Membrane Proteins - physiology | Adiponectin - genetics | Adiponectin - deficiency | Sterol Regulatory Element Binding Protein 2 - genetics | Fibroblast Growth Factors - therapeutic use | Hyperlipoproteinemia Type II - complications | Atherosclerosis - drug therapy | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Fibroblast Growth Factors - deficiency | Atherosclerosis - metabolism | Sterol Regulatory Element Binding Protein 2 - physiology | Mice, Knockout | Gene Expression Regulation - drug effects | Hyperlipoproteinemia Type II - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - physiology | Animals | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - drug effects | Adipocytes - metabolism | Membrane Proteins - drug effects | Endothelium, Vascular - pathology | Mice | Cholesterol - biosynthesis | Atherosclerosis - prevention & control | Hyperlipoproteinemia Type II - genetics | Index Medicus | Abridged Index Medicus | 134 | 147 | 90 | Original
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 12/2017, Volume 19, Issue 12, pp. 1762 - 1772
Aims: To assess the safety, tolerability, pharmacokinetics and pharmacodynamics of PF-05231023, a long-acting fibroblast growth factor 21 (FGF21) analogue, in... 
fibroblast growth factor 21 | blood pressure | 1 | heart rate | type 2 diabetes | bone biomarkers | IGF | IGF-1 | FATTY LIVER-DISEASE | ENERGY-EXPENDITURE | PF-05231023 | PROFILE | PHARMACOKINETICS | ENDOCRINOLOGY & METABOLISM | MICE | FGF21 | Hypertriglyceridemia - drug therapy | Fibroblast Growth Factors - adverse effects | Follow-Up Studies | Obesity - drug therapy | Species Specificity | Humans | Middle Aged | Half-Life | Anti-Obesity Agents - adverse effects | Male | Obesity - blood | Anti-Obesity Agents - therapeutic use | Bone Remodeling - drug effects | Delayed-Action Preparations - administration & dosage | Dose-Response Relationship, Drug | Anti-Obesity Agents - pharmacokinetics | Antibodies, Monoclonal, Humanized - administration & dosage | Antibodies, Monoclonal, Humanized - pharmacokinetics | Fibroblast Growth Factors - administration & dosage | Hypertension - chemically induced | Delayed-Action Preparations - pharmacokinetics | Female | Drug Resistance | Fibroblast Growth Factors - therapeutic use | Body Mass Index | Severity of Illness Index | Antibodies, Monoclonal, Humanized - adverse effects | Hypolipidemic Agents - adverse effects | Anti-Obesity Agents - administration & dosage | Antibodies, Monoclonal, Humanized - therapeutic use | Double-Blind Method | Drug Administration Schedule | Obesity - complications | Biomarkers - blood | Hypertension - physiopathology | Hypertriglyceridemia - blood | Animals | Fibroblast Growth Factors - pharmacokinetics | Delayed-Action Preparations - adverse effects | Hypertriglyceridemia - complications | Hypolipidemic Agents - administration & dosage | Delayed-Action Preparations - therapeutic use | Hypolipidemic Agents - therapeutic use | Infusions, Intravenous | Hypolipidemic Agents - pharmacokinetics | Type 2 diabetes | Obesity | Heart beat | Blood cholesterol | Collagen | Analysis | Body weight | Primates | Fibroblast growth factors | Blood pressure | Fibroblast growth factor | Pharmacodynamics | Diabetes mellitus | Homeostasis | Lipids | Triglycerides | Body weight loss | Bone turnover | Monkeys & apes | Cholesterol | Adiponectin | Heart rate | Rodents | Fibroblasts | Atorvastatin | Lead | Safety | Pharmacokinetics | Growth factors | Diabetes mellitus (non-insulin dependent) | Lipoproteins (high density) | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 09/2013, Volume 18, Issue 3, pp. 307 - 309
FGF21 is a protein with multiple metabolic actions, currently a bright star beckoning on the metabolic disease therapeutic horizon. present the first clinical... 
ENDOCRINOLOGY & METABOLISM | CELL BIOLOGY | Female | Male | Obesity - drug therapy | Diabetes Mellitus, Type 2 - drug therapy | Humans | Fibroblast Growth Factors - therapeutic use | Glucose metabolism | Fibroblast growth factors | Glucose | Health aspects | Body weight | Dextrose | Index Medicus
Journal Article
Endocrinology, ISSN 0013-7227, 09/2013, Volume 154, Issue 9, pp. 3366 - 3376
Despite the emerging importance of fibroblast growth factor 21 (FGF21) as a metabolic hormone regulating energy balance, its direct effects on renal function... 
KIDNEY-DISEASE | OXIDATIVE STRESS | OBESITY | LIPID-METABOLISM | RAT-KIDNEY | ENDOCRINOLOGY & METABOLISM | FACTOR RECEPTORS | DIABETIC-NEPHROPATHY | EXPRESSION | FGF21 | Recombinant Proteins - therapeutic use | Kidney - pathology | Hypoglycemic Agents - metabolism | Adipose Tissue, White - metabolism | Fibroblast Growth Factors - genetics | Male | Diabetes Mellitus, Type 2 - metabolism | Mesangial Cells - drug effects | Fibroblast Growth Factors - metabolism | Kidney - metabolism | Hypoglycemic Agents - administration & dosage | Mice, Mutant Strains | Lipid Peroxidation - drug effects | Adiponectin - metabolism | Diabetes Mellitus, Type 2 - complications | Hyperlipidemias - complications | Fibroblast Growth Factors - therapeutic use | Hypoglycemic Agents - therapeutic use | Recombinant Proteins - metabolism | Kidney - drug effects | Mice, Inbred C57BL | Insulin Resistance | Receptors, Fibroblast Growth Factor - biosynthesis | Mesangial Cells - cytology | Fibroblast Growth Factors - pharmacology | Kidney - cytology | Mesangial Cells - metabolism | Recombinant Proteins - pharmacology | Hyperlipidemias - prevention & control | Hypoglycemic Agents - pharmacology | Adiponectin - blood | Gene Expression Regulation - drug effects | Diabetic Retinopathy - prevention & control | Animals | MAP Kinase Signaling System - drug effects | Receptors, Fibroblast Growth Factor - metabolism | Mesangial Cells - pathology | Mice | Diabetes Mellitus, Type 2 - pathology | Oxidative Stress - drug effects | Diabetes Mellitus, Type 2 - drug therapy | Adipose Tissue, White - drug effects | Crosses, Genetic | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 10/2017, Volume 32, Issue 10, pp. 2062 - 2073
Fibroblast growth factor 23 (FGF23) is the causative factor of X-linked hypophosphatemia (XLH), a genetic disorder effecting 1:20,000 that is characterized by... 
PHOSPHATE | OSTEOMALACIA | 1,25D | X‐LINKED HYPOPHOSPHATEMIA | FIBROBLAST GROWTH FACTOR 23 | X-LINKED HYPOPHOSPHATEMIA | PROTEOLYTIC CLEAVAGE | HOMEOSTASIS | KLOTHO | VITAMIN-D METABOLISM | RECEPTOR | FIBROBLAST-GROWTH-FACTOR | D-RESISTANT RICKETS | FGF-23 | HYP MICE | IN-VIVO | ENDOCRINOLOGY & METABOLISM | Bone and Bones - pathology | Calcification, Physiologic - drug effects | Rats, Wistar | Familial Hypophosphatemic Rickets - drug therapy | Humans | Familial Hypophosphatemic Rickets - diagnostic imaging | Recombinant Proteins - pharmacology | Calcitriol - blood | Bone and Bones - drug effects | Peptides - pharmacology | Calcium - blood | Fibroblast Growth Factors - chemistry | Bone Density - drug effects | Familial Hypophosphatemic Rickets - blood | Animals | Renal Reabsorption - drug effects | Bone and Bones - diagnostic imaging | Calcitriol - pharmacology | HEK293 Cells | Cancellous Bone - pathology | Phosphates - blood | Mice | Disease Models, Animal | Fibroblast Growth Factors - therapeutic use | Phosphates | Chronic diseases | Physiological aspects | Hypophosphatemia | Health aspects | Analysis | Fibroblast growth factor | Excretion | Animal models | Calcium | Fibroblast growth factor 23 | Toxicity | Syngeneic grafts | Reabsorption | Dihydroxyvitamin D | Injection | Cell surface | Rickets | Klotho protein | Mineralization | Phosphate | Osteomalacia | Fibroblast growth factor receptors | Index Medicus
Journal Article