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1. Full Text Fibroblast Growth Factor 23 and Mortality among Patients Undergoing Hemodialysis
by Gutiérrez, Orlando M and Mannstadt, Michael and Isakova, Tamara and Rauh-Hain, Jose Alejandro and Tamez, Hector and Shah, Anand and Smith, Kelsey and Lee, Hang and Thadhani, Ravi and Jüppner, Harald and Wolf, Myles
The New England Journal of Medicine, ISSN 0028-4793, 08/2008, Volume 359, Issue 6, pp. 584 - 592
This study involving patients in whom hemodialysis was being initiated shows that increased levels of fibroblast growth factor 23 (FGF-23), a hormone that... 
VITAMIN-D | MEDICINE, GENERAL & INTERNAL | DIALYSIS PATIENTS | VASCULAR CALCIFICATION | MAINTENANCE HEMODIALYSIS | MINERAL METABOLISM | DOMINANT HYPOPHOSPHATEMIC RICKETS | FIBROBLAST GROWTH FACTOR-23 | CHRONIC KIDNEY-DISEASE | ONCOGENIC OSTEOMALACIA | STAGE RENAL-DISEASE | Kidney Failure, Chronic - mortality | Multivariate Analysis | Prospective Studies | Humans | Middle Aged | Risk Factors | Proportional Hazards Models | Male | Biomarkers - blood | Kidney Failure, Chronic - ethnology | Case-Control Studies | Kidney Failure, Chronic - therapy | Kidney Failure, Chronic - blood | Renal Dialysis - mortality | Fibroblast Growth Factors - blood | Phosphates - blood | Female | Aged | Continental Population Groups | Odds Ratio | Fibroblast growth factors | Hemodialysis | Health aspects | Risk factors | Phosphates | Kidney diseases | Mortality | Index Medicus | Abridged Index Medicus
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2. Full Text Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease
by Isakova, Tamara and Wahl, Patricia and Vargas, Gabriela S and Gutiérrez, Orlando M and Scialla, Julia and Xie, Huiliang and Appleby, Dina and Nessel, Lisa and Bellovich, Keith and Chen, Jing and Hamm, Lee and Gadegbeku, Crystal and Horwitz, Edward and Townsend, Raymond R and Anderson, Cheryl A.M and Lash, James P and Hsu, Chi-yuan and Leonard, Mary B and Wolf, Myles and on behalf of the Chronic Renal Insufficiency Cohort (CRIC) Study Group and CRIC Study Grp and on behalf of the Chronic Renal Insufficiency Cohort (CRIC) Study Group
Kidney International, ISSN 0085-2538, 06/2011, Volume 79, Issue 12, pp. 1370 - 1378
Fibroblast growth factor 23 (FGF23) regulates phosphorus metabolism and is a strong predictor of mortality in dialysis patients. FGF23 is thought to be an... 
phosphate | FGF23 | chronic kidney disease | MORTALITY | VITAMIN-D | KLOTHO | FIBROBLAST-GROWTH-FACTOR-23 | SECONDARY HYPERPARATHYROIDISM | FGF RECEPTOR | PATHOGENESIS | CALCIUM | UROLOGY & NEPHROLOGY | PHOSPHORUS-METABOLISM | CHRONIC-RENAL-FAILURE | Predictive Value of Tests | Up-Regulation | Biomarkers - urine | Prospective Studies | United States | Humans | Middle Aged | Hyperparathyroidism, Secondary - physiopathology | Male | Parathyroid Hormone - blood | Renal Insufficiency, Chronic - complications | Hyperparathyroidism, Secondary - urine | Hyperphosphatemia - blood | Time Factors | Phosphates - urine | Phosphates - blood | Female | Hyperphosphatemia - urine | Renal Insufficiency, Chronic - diagnosis | Severity of Illness Index | Glomerular Filtration Rate | Phosphorus, Dietary - metabolism | Biomarkers - blood | Renal Insufficiency, Chronic - physiopathology | Renal Insufficiency, Chronic - blood | Hyperparathyroidism, Secondary - blood | Hyperparathyroidism, Secondary - diagnosis | Fibroblast Growth Factors - blood | Hyperphosphatemia - etiology | Aged | Hyperparathyroidism, Secondary - etiology | Hyperphosphatemia - physiopathology | Hyperphosphatemia - diagnosis | Renal Insufficiency, Chronic - urine | Index Medicus
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3. Full Text Fibroblast Growth Factor 23 and Inflammation in CKD
by Jair Munoz Mendoza and Tamara Isakova and Ana C. Ricardo and Huiliang Xie and Sankar D. Navaneethan and Amanda H. Anderson and Lydia A. Bazzano and Dawei Xie and Matthias Kretzler and Lisa Nessel and L. Lee Hamm and Lavinia Negrea and Mary B. Leonard and Dominic Raj and Myles Wolf and for the Chronic Renal Insufficiency Cohort and Chronic Renal Insufficiency Cohort and for the Chronic Renal Insufficiency Cohort
Clinical Journal of the American Society of Nephrology, ISSN 1555-9041, 07/2012, Volume 7, Issue 7, pp. 1155 - 1162
Background and objectives Levels of fibroblast growth factor 23 (FGF23) and inflammatory markers are commonly elevated in CKD, and each is associated with... 
PHOSPHATE | VITAMIN-D METABOLISM | VASCULAR CALCIFICATION | HEMODIALYSIS-PATIENTS | UROLOGY & NEPHROLOGY | CHRONIC KIDNEY-DISEASE | INSUFFICIENCY COHORT | EXPRESSION | LEFT-VENTRICULAR HYPERTROPHY | FAT MASS | CHRONIC-RENAL-FAILURE | Prospective Studies | Cross-Sectional Studies | Humans | Middle Aged | Male | Renal Insufficiency, Chronic - complications | Inflammation - etiology | Inflammation - blood | Renal Insufficiency, Chronic - blood | Fibroblast Growth Factors - blood | Female | C-Reactive Protein - analysis | Fibroblast Growth Factors - physiology | Index Medicus | Original
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4. Full Text Fibroblast growth factor 23 is not associated with and does not induce arterial calcification
by Scialla, Julia J and Lau, Wei Ling and Reilly, Muredach P and Isakova, Tamara and Yang, Hsueh-Ying and Crouthamel, Matthew H and Chavkin, Nicholas W and Rahman, Mahboob and Wahl, Patricia and Amaral, Ansel P and Hamano, Takayuki and Master, Stephen R and Nessel, Lisa and Chai, Boyang and Xie, Dawei and Kallem, Radhakrishna R and Chen, Jing and Lash, James P and Kusek, John W and Budoff, Matthew J and Giachelli, Cecilia M and Wolf, Myles and Chronic Renal Insufficiency Cohort and Chronic Renal Insufficiency Cohort Study Investigators
Kidney International, ISSN 0085-2538, 06/2013, Volume 83, Issue 6, pp. 1159 - 1168
Elevated fibroblast growth factor 23 (FGF23) is associated with cardiovascular disease in patients with chronic kidney disease. As a potential mediating... 
phosphate | chronic kidney disease | vascular smooth muscle | fibroblast growth factor 23 | vascular calcification | Vascular calcification | Chronic kidney disease | Vascular smooth muscle | Fibroblast growth factor 23 | Phosphate | CORONARY CALCIFICATION | PHOSPHATE COTRANSPORTER | VASCULAR CALCIFICATION | HEMODIALYSIS-PATIENTS | UROLOGY & NEPHROLOGY | RENAL-INSUFFICIENCY COHORT | MUSCLE-CELL CALCIFICATION | LEFT-VENTRICULAR HYPERTROPHY | CHRONIC-KIDNEY-DISEASE | BASE-LINE CHARACTERISTICS | TRANSGENIC MICE | Aortic Diseases - diagnostic imaging | Coronary Vessels - diagnostic imaging | Multivariate Analysis | United States - epidemiology | Up-Regulation | Prevalence | Prospective Studies | Muscle, Smooth, Vascular - metabolism | Calcium - metabolism | Humans | Middle Aged | Renal Insufficiency, Chronic - diagnostic imaging | Aortic Diseases - blood | Glucuronidase - metabolism | Fibroblast Growth Factors - genetics | Vascular Calcification - diagnostic imaging | Male | Tomography, X-Ray Computed | RNA, Messenger - metabolism | Coronary Artery Disease - blood | Coronary Vessels - metabolism | Renal Insufficiency, Chronic - epidemiology | Young Adult | Aortography - methods | Coronary Angiography - methods | Time Factors | Phosphates - blood | Adult | Female | Myocytes, Smooth Muscle - metabolism | Severity of Illness Index | Aortic Diseases - epidemiology | Risk Factors | Vascular Calcification - blood | Cells, Cultured | Aorta, Thoracic - metabolism | Logistic Models | Chi-Square Distribution | Renal Insufficiency, Chronic - blood | Coronary Artery Disease - diagnostic imaging | Animals | Glucuronidase - genetics | Fibroblast Growth Factors - blood | Vascular Calcification - epidemiology | Aged | Coronary Artery Disease - epidemiology | Mice | Aorta, Thoracic - diagnostic imaging | Index Medicus
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5. Full Text Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production
by David, Valentin and Martin, Aline and Isakova, Tamara and Spaulding, Christina and Qi, Lixin and Ramirez, Veronica and Zumbrennen-Bullough, Kimberly B and Sun, Chia Chi and Lin, Herbert Y and Babitt, Jodie L and Wolf, Myles
Kidney International, ISSN 0085-2538, 01/2016, Volume 89, Issue 1, pp. 135 - 146
Circulating levels of fibroblast growth factor 23 (FGF23) are elevated in patients with chronic kidney disease (CKD), but the mechanisms are poorly understood.... 
hypoxia | bone | mineral metabolism | inflammation | FGF23 | anemia | FAMILIAL TUMORAL CALCINOSIS | VITAMIN-D | BONE LOSS | SYNOVIAL FIBROBLASTS | MOUSE MODEL | FGF23 ELEVATION | UROLOGY & NEPHROLOGY | PARATHYROID-HORMONE | CHRONIC KIDNEY-DISEASE | Interleukin-1beta - pharmacology | Fibroblast Growth Factors - genetics | RNA, Messenger - metabolism | Autoantigens - genetics | Inflammation - blood | Renal Insufficiency, Chronic - metabolism | Fibroblast Growth Factors - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Iron - deficiency | Transcription, Genetic | Iron - blood | RNA, Messenger - drug effects | Cell Line | Deferoxamine - pharmacology | Mesenchymal Stromal Cells - drug effects | Femur - metabolism | Mice, Inbred C57BL | Mesenchymal Stromal Cells - metabolism | Fibroblast Growth Factors - drug effects | Siderophores - pharmacology | Mice, Knockout | Renal Insufficiency, Chronic - blood | Animals | Fibroblast Growth Factors - blood | Collagen Type IV - genetics | Mice | Index Medicus
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6. Full Text Elevated fibroblast growth factor 23 is a risk factor for kidney transplant loss and mortality
by Wolf, Myles and Molnar, Miklos Z and Amaral, Ansel P and Czira, Maria E and Rudas, Anna and Ujszaszi, Akos and Kiss, Istvan and Rosivall, Laszlo and Kosa, Janos and Lakatos, Peter and Kovesdy, Csaba P and Mucsi, Istvan
Journal of the American Society of Nephrology, ISSN 1046-6673, 05/2011, Volume 22, Issue 5, pp. 956 - 966
An increased circulating level of fibroblast growth factor 23 (FGF23) is an independent risk factor for mortality, cardiovascular disease, and progression of... 
PHOSPHATE | VITAMIN-D | PHOSPHORUS | FGF-23 | DISEASE | UROLOGY & NEPHROLOGY | HEMODIALYSIS | RENAL-TRANSPLANTATION | RECIPIENTS | FGF23 | DIALYSIS | Glomerular Filtration Rate | Prospective Studies | Humans | Middle Aged | Risk Factors | Male | Parathyroid Hormone - blood | Transplantation, Homologous | Fibroblast Growth Factors - blood | Phosphates - blood | Adult | Female | Kidney Transplantation - mortality | Aged | Hemoglobins - analysis | Fibroblast Growth Factors - physiology | Kidney Transplantation - adverse effects | Index Medicus | Clinical Research
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7. Full Text Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease
by Singh, Saurav and Grabner, Alexander and Yanucil, Christopher and Schramm, Karla and Czaya, Brian and Krick, Stefanie and Czaja, Mark J and Bartz, Rene and Abraham, Reimar and Di Marco, Giovana S and Brand, Marcus and Wolf, Myles and Faul, Christian
Kidney International, ISSN 0085-2538, 11/2016, Volume 90, Issue 5, pp. 985 - 996
Patients with chronic kidney disease (CKD) develop increased levels of the phosphate-regulating hormone, fibroblast growth factor (FGF) 23, that are associated... 
chronic kidney disease | calcineurin | inflammation | FGF23 | hepatocytes | C-REACTIVE PROTEIN | BILE-ACID SYNTHESIS | FACTOR RECEPTOR | LEFT-VENTRICULAR HYPERTROPHY | SIGNAL-TRANSDUCTION | HEPATOCELLULAR-CARCINOMA | CARDIAC-HYPERTROPHY | HEMODIALYSIS-PATIENTS | UROLOGY & NEPHROLOGY | MINERAL METABOLISM | STAGE RENAL-DISEASE | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Phospholipase C gamma - metabolism | Cytokines - metabolism | Signal Transduction | Humans | NFATC Transcription Factors - metabolism | Glucuronidase - metabolism | Rats | Hepatocytes - metabolism | Renal Insufficiency, Chronic - metabolism | Fibroblast Growth Factors - metabolism | Inflammation - metabolism | Animals | Mice | Primary Cell Culture | Calcineurin - metabolism | Index Medicus
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8. Full Text Fibroblast Growth Factor 23 and Risks of Mortality and End-Stage Renal Disease in Patients With Chronic Kidney Disease
by Isakova, Tamara and Xie, Huiliang and Yang, Wei and Xie, Dawei and Anderson, Amanda Hyre and Scialla, Julia and Wahl, Patricia and Gutiérrez, Orlando M and Steigerwalt, Susan and He, Jiang and Schwartz, Stanley and Lo, Joan and Ojo, Akinlolu and Sondheimer, James and Hsu, Chi-yuan and Lash, James and Leonard, Mary and Kusek, John W and Feldman, Harold I and Wolf, Myles and Chronic Renal Insufficiency Cohort (CRIC) Study Group, for the and CRIC Study Grp and Chronic Renal Insufficiency Cohort (CRIC) Study Group
JAMA, ISSN 0098-7484, 06/2011, Volume 305, Issue 23, pp. 2432 - 2439
CONTEXT A high level of the phosphate-regulating hormone fibroblast growth factor 23 (FGF-23) is associated with mortality in patients with end-stage renal... 
PHOSPHORUS | MEDICINE, GENERAL & INTERNAL | FIBROBLAST-GROWTH-FACTOR-23 | VASCULAR DYSFUNCTION | PARATHYROID-HORMONE | HEMODIALYSIS | DEATH | PROGRESSION | FGF RECEPTOR | CALCITRIOL | PREDICTION | Kidney Failure, Chronic - mortality | Glomerular Filtration Rate | Prognosis | Prospective Studies | Outcome Assessment (Health Care) | Humans | Middle Aged | Risk Factors | Kidney Diseases - mortality | Male | Biomarkers - blood | Disease Progression | Kidney Failure, Chronic - blood | Fibroblast Growth Factors - blood | Female | Aged | Kidney Diseases - blood | Chronic Disease | Care and treatment | Patient outcomes | Fibroblast growth factors | Kidney diseases | Diagnosis | Health aspects | Risk factors | Hormones | Mortality | Chronic illnesses | Index Medicus | Abridged Index Medicus
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9. Fibroblast growth factor 23 and Klotho contribute to airway inflammation
by Krick, Stefanie and Grabner, Alexander and Baumlin, Nathalie and Yanucil, Christopher and Helton, Scott and Grosche, Astrid and Sailland, Juliette and Geraghty, Patrick and Viera, Liliana and Russell, Derek W and Wells, J. Michael and Xu, Xin and Gaggar, Amit and Barnes, Jarrod and King, Gwendalyn D and Campos, Michael and Faul, Christian and Salathe, Matthias
European Respiratory Journal, ISSN 0903-1936, 07/2018, Volume 52, Issue 1, pp. 1800236 - 1800236
Circulating levels of fibroblast growth factor (FGF) 23 are associated with systemic inflammation and increased mortality in chronic kidney disease.... 
EPITHELIAL-CELLS | PATHWAY | RESPIRATORY SYSTEM | DISEASE | RECEPTOR | IL-1-BETA | ALPHA-KLOTHO | INDUCTION | FGF23 | LEFT-VENTRICULAR HYPERTROPHY | COPD | Inflammation - pathology | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Lung - pathology | Epithelial Cells - metabolism | Smoke - adverse effects | Humans | Middle Aged | Glucuronidase - metabolism | Male | Mice, Knockout | Animals | Glucuronidase - genetics | Fibroblast Growth Factors - blood | Pulmonary Disease, Chronic Obstructive - blood | Adult | Female | Aged | Mice | Pulmonary Disease, Chronic Obstructive - metabolism | Fibroblast growth factor | Fibroblast growth factor 23 | Epithelial cells | Lung diseases | Inflammation | Epithelium | Phospholipase C | Respiratory tract | Phospholipase | Klotho protein | Rodents | Obstructive lung disease | Fibroblasts | Fibroblast growth factor receptor 4 | Respiratory tract diseases | Chronic obstructive pulmonary disease | Growth factors | Cigarette smoke | Fibroblast growth factor receptors
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10. Full Text Fibroblast growth factor 23: fueling the fire
by Hanudel, Mark and Jüppner, Harald and Salusky, Isidro B
Kidney International, ISSN 0085-2538, 11/2016, Volume 90, Issue 5, pp. 928 - 930
In chronic kidney disease, systemic inflammation is common and associated with mortality. The present study demonstrates that fibroblast growth factor 23... 
MORTALITY | UROLOGY & NEPHROLOGY | CHRONIC KIDNEY-DISEASE | CKD | LEFT-VENTRICULAR HYPERTROPHY | Renal Insufficiency, Chronic | Inflammation | Fibroblast Growth Factors | Hepatocytes | Humans | Index Medicus
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11. Full Text Soluble Klotho protects against uremic cardiomyopathy independently of fibroblast growth factor 23 and phosphate
by Xie, Jian and Yoon, Joonho and An, Sung-Wan and Kuro-o, Makoto and Huang, Chou-Long
Journal of the American Society of Nephrology, ISSN 1046-6673, 05/2015, Volume 26, Issue 5, pp. 1150 - 1160
Cardiac hypertrophy occurs in up to 95% of patients with CKD and increases their risk for cardiovascular death. In the kidney, full-length membranous Klotho... 
MUTANT MICE | TRPV5 CHANNEL | EMERGING ROLE | MORTALITY RISK | MOUSE | DOWN-REGULATION | UROLOGY & NEPHROLOGY | ALPHA-KLOTHO | CHRONIC KIDNEY-DISEASE | FGF23 | LEFT-VENTRICULAR HYPERTROPHY | Cardiomyopathies - blood | Risk Factors | Cardiomyopathies - pathology | Male | Myocardium - pathology | Glucuronidase - blood | Renal Insufficiency, Chronic - complications | Cardiomyopathies - etiology | Renal Insufficiency, Chronic - blood | Animals | Fibroblast Growth Factors - blood | Myocardium - metabolism | Fibrosis | TRPC Cation Channels - metabolism | Phosphates - blood | Mice | Disease Models, Animal | Index Medicus | renal failure | heart failure | signaling | Basic Research
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