X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (69322) 69322
Newspaper Article (1200) 1200
Newsletter (1165) 1165
Book Chapter (201) 201
Government Document (49) 49
Dissertation (41) 41
Publication (16) 16
Trade Publication Article (16) 16
Magazine Article (12) 12
Book / eBook (11) 11
Conference Proceeding (11) 11
Web Resource (5) 5
Book Review (2) 2
Reference (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (37809) 37809
animals (34340) 34340
fibroblasts (24281) 24281
mice (18152) 18152
cell biology (15313) 15313
expression (13882) 13882
male (13664) 13664
cells, cultured (13359) 13359
female (13105) 13105
gene expression (10611) 10611
proteins (10300) 10300
fibroblasts - metabolism (10215) 10215
biochemistry & molecular biology (9307) 9307
signal transduction (9131) 9131
oncology (8367) 8367
research (8326) 8326
fibroblast growth factors (8036) 8036
rats (7946) 7946
growth factors (7848) 7848
cancer (7689) 7689
analysis (6582) 6582
cells (6571) 6571
apoptosis (6538) 6538
research article (6534) 6534
stem cells (6533) 6533
multidisciplinary sciences (6463) 6463
medicine (6125) 6125
cell line (5908) 5908
activation (5905) 5905
inflammation (5735) 5735
differentiation (5732) 5732
cell proliferation (5716) 5716
kinases (5603) 5603
adult (5500) 5500
fibroblasts - drug effects (5380) 5380
angiogenesis (5379) 5379
phosphorylation (5355) 5355
collagen (5325) 5325
physiological aspects (5292) 5292
fibroblasts - cytology (5229) 5229
middle aged (5208) 5208
gene-expression (5069) 5069
proliferation (4861) 4861
rodents (4861) 4861
cytokines (4760) 4760
in-vitro (4702) 4702
fibrosis (4687) 4687
science (4659) 4659
immunohistochemistry (4633) 4633
biology (4601) 4601
tumors (4458) 4458
medicine, research & experimental (4428) 4428
genetic aspects (4325) 4325
physiology (4200) 4200
mutation (4196) 4196
growth (4154) 4154
fibroblast-growth-factor (4140) 4140
cell differentiation (4124) 4124
fibroblast growth factor (3978) 3978
health aspects (3975) 3975
receptor (3872) 3872
aged (3713) 3713
extracellular matrix (3693) 3693
developmental biology (3675) 3675
neurosciences (3604) 3604
genes (3598) 3598
cell line, tumor (3596) 3596
mice, inbred c57bl (3479) 3479
immunology (3454) 3454
rna, messenger - metabolism (3248) 3248
studies (3196) 3196
metastasis (3191) 3191
care and treatment (3174) 3174
wound healing (3124) 3124
fibroblasts - pathology (3041) 3041
skin (3019) 3019
cell growth (2972) 2972
endocrinology & metabolism (2971) 2971
inhibition (2916) 2916
growth-factor (2904) 2904
disease models, animal (2892) 2892
protein (2887) 2887
cell proliferation - drug effects (2868) 2868
receptors (2868) 2868
cell culture (2857) 2857
pathology (2826) 2826
biochemistry (2775) 2775
blotting, western (2758) 2758
time factors (2756) 2756
vascular endothelial growth factor (2753) 2753
genetics & heredity (2726) 2726
in-vivo (2710) 2710
gene (2682) 2682
gene expression regulation (2672) 2672
mice, knockout (2671) 2671
disease (2645) 2645
reverse transcriptase polymerase chain reaction (2635) 2635
fibroblast growth factors - metabolism (2555) 2555
cell cycle (2550) 2550
signal transduction - drug effects (2549) 2549
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (71817) 71817
Japanese (348) 348
Chinese (144) 144
German (52) 52
French (35) 35
Portuguese (15) 15
Russian (14) 14
Polish (11) 11
Korean (10) 10
Spanish (10) 10
Hungarian (3) 3
Bosnian (1) 1
Czech (1) 1
Dutch (1) 1
Norwegian (1) 1
Persian (1) 1
Slovenian (1) 1
Swedish (1) 1
Turkish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2014, Volume 111, Issue 45, pp. E4869 - E4877
The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation... 
Structure-based drug design | Drug discovery | Cancer drug resistance | Kinase inhibitor | structure-based drug design | WILD-TYPE | MULTIDISCIPLINARY SCIENCES | BCR-ABL | GROWTH-FACTOR RECEPTORS | DRUG-RESISTANCE | kinase inhibitor | LUNG-CANCER | GENE FUSIONS | cancer drug resistance | SELECTIVE INHIBITOR | drug discovery | THERAPEUTIC TARGET | FACTOR RECEPTOR 4 | REGULATES PROLIFERATION | Receptor, Fibroblast Growth Factor, Type 4 - chemistry | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | ErbB Receptors - genetics | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Mutation, Missense | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Protein Kinase Inhibitors - chemistry | Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Binding Sites | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Neoplasms - enzymology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | ErbB Receptors - chemistry | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Neoplasms - pathology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Biological Sciences | PNAS Plus
Journal Article
Annals of oncology, ISSN 0923-7534, 2014, Volume 25, Issue 3, pp. 552 - 563
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2013, Volume 58, Issue 1, pp. 155 - 168
.... Tight regulation of BA transporters via nuclear receptors is necessary to maintain proper BA homeostasis... 
Gastroenterology and Hepatology | Gallstones | Liver cancer | Bile acids | Fatty liver disease | Cholestasis | Liver regeneration | RAT-LIVER | SALT EXPORT PUMP | GROWTH-FACTOR 19 | ORGANIC ANION TRANSPORTERS | 90-PERCENT PARTIAL-HEPATECTOMY | URSODEOXYCHOLIC ACID | PRIMARY BILIARY-CIRRHOSIS | FARNESOID-X-RECEPTOR | GASTROENTEROLOGY & HEPATOLOGY | PHOSPHOLIPID-ASSOCIATED CHOLELITHIASIS | FAMILIAL INTRAHEPATIC CHOLESTASIS | Animals | Carrier Proteins - metabolism | Cholestasis - metabolism | Membrane Glycoproteins - metabolism | Humans | Liver - metabolism | Bile Acids and Salts - metabolism | Liver Diseases - metabolism | Liver Regeneration - physiology | Receptors, Cytoplasmic and Nuclear - metabolism | Drug resistance in microorganisms | Corticosteroids | Glucagon | Calcifediol | Ursodiol | Deoxycholic acid | Epidermal growth factor | Vitamin D | Physiological aspects | Fibroblast growth factors | Alfacalcidol | IBABP (FABP6, ILBP), intestinal bile acid-binding protein, fatty acid-binding protein 6 | PFIC, progressive familial intrahepatic cholestasis | TNFα, tumor necrosis factor α | 3 (human) | SRC2, p160 steroid receptor coactivator | NAFLD, non-alcoholic fatty liver disease | BA, bile acid | bile acid receptor | 8, cholesterol efflux pump, ATP-binding cassette, subfamily G, member 5 | UDCA, ursodeoxycholic acid | LRH-1 (NR5A2), liver receptor homolog-1 | LCA, lithocholic acid | LXRα (NR1H3), liver X receptor alpha | PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma | OSTαβ, organic solute transporter alpha | ABCG5 | AMPK, AMP activated protein kinase | NASH, non-alcoholic steatohepatitis | SHP (NR0B2), short heterodimer partner | OATP1A2 (SLCO1A2, OATP1, OATP-A, SLC21A3), solute carrier organic anion transporter family, member 1A2 | EGFR, epidermal growth factor receptor | IL6, interleukin 6 | TGR5, G protein-coupled bile acid receptor | PH, partial hepatectomy | AE2, anion exchanger 2 | PSC, primary sclerosing cholangitis | OATP1B1 (SLCO1B1, OATP2, OATP-C, SLC21A6), solute carrier organic anion transporter family, member 1B1 | RARα (NR1B1), retinoic acid receptor alpha | GLP-1, glucagon like peptide 1 | VDR (NR1I1), vitamin D receptor. Please note that for the convenience of better readability and clarity, abbreviations for transporters and nuclear receptors were capitalized throughout this article when symbols were identical for human and rodents | MRP2 (ABCC2), multidrug resistance-associated protein 2, ATP-binding cassette, subfamily C, member 2 | NTCP (SLC10A1), sodium | CAR (NR1I3), constitutive androstane receptor | taurocholate cotransporting polypeptide, solute carrier family 10, member 1 | PPARα (NR1C1), peroxisome proliferator-activated receptor alpha | Review | GR (NR3C1), glucocorticoid receptor | Bile acids, Cholestasis, Fatty liver disease, Gallstones, Liver regeneration, Liver cancer | 19, fibroblast growth factor 15 | Mdr2 | ICP, intrahepatic cholestasis of pregnancy | BRIC, benign recurrent intrahepatic cholestasis | OATP1B3 (SLCO1B3, OATP8, SLC21A8), solute carrier organic anion transporter family, member 1B3 | MRP3 (ABCC3), multidrug resistance-associated protein 3, ATP-binding cassette, subfamily C, member 3 | beta | MDR1 (ABCB1), p-glycoprotein, ATP-binding cassette, subfamily B, member 1 | norUDCA, norursodeoxycholic acid | 6-ECDCA, 6-ethylchenodeoxycholic acid | FXR (NR1H4), farnesoid X receptor | BCRP (ABCG2), breast cancer resistance protein, ATP-binding cassette, subfamily G, member 2 | HNF4α (NR2A1), hepatocyte nuclear factor 4 alpha | PBC, primary biliary cirrhosis | MDR3 (ABCB4), multidrug resistance protein 2 (rodents) | HNF1α, hepatocyte nuclear factor 1 alpha | NR, nuclear receptor | FGF15 | RXRα (NR2B1), retinoid X receptor alpha | PXR (NR1I2), pregnane X receptor | BSEP (ABCB11), bile salt export pump | HCC, hepatocellular carcinoma | MRP4 (ABCC4), multidrug resistance-associated protein 4, ATP-binding cassette, subfamily C, member 4 | TPN, total parenteral nutrition
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 545, Issue 7653, pp. 224 - 228
...(1). Although much is known about vascular endothelial growth factor (VEGF)-dependent regulation of vascular development and metabolism(2,3... 
GENE-EXPRESSION DATA | MAINTENANCE | MULTIDISCIPLINARY SCIENCES | MOUSE | LYMPHANGIOGENESIS | ENDOTHELIAL-CELL METABOLISM | MECHANISMS | GROWTH-FACTOR | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Cell Proliferation | Lymphatic Vessels - cytology | Signal Transduction | Endothelial Cells - metabolism | Mice, Inbred C57BL | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Proto-Oncogene Proteins c-myc - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Fibroblast Growth Factors - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - deficiency | Lymphatic Vessels - metabolism | Animals | Receptor, Fibroblast Growth Factor, Type 3 - deficiency | Endothelial Cells - cytology | Glycolysis | Female | Mice | Hexokinase - metabolism | Lymphangiogenesis | Neovascularization, Physiologic | Cell Movement | Fibroblast growth factors | Metabolism | Observations | Health aspects | Cell proliferation | Fibroblast growth factor | Leukocyte migration | c-Myc protein | Homeostasis | Biology | Myc protein | Kinases | Blood | Defects | Angiogenesis | Control | Cell growth | Metabolites | Rodents | Fibroblast growth factor receptor 1 | Vascular endothelial growth factor | Growth factors | Medical research | Enzymes | Grants | Hexokinase | Endothelial cells | Endothelium | Signaling | Oxygenation | Cell migration | Fibroblast growth factor receptors
Journal Article
Nature (London), ISSN 1476-4687, 2015, Volume 526, Issue 7572, pp. 263 - 267
.... In late-stage colorectal cancer, the most commonly used targeted therapies are the monoclonal antibodies cetuximab and panitumumab, which prevent epidermal growth factor receptor (EGFR) activation(1... 
PANITUMUMAB | THERAPY | MULTIDISCIPLINARY SCIENCES | SEQUENCE | ACQUIRED-RESISTANCE | SOMATIC MUTATION | IDENTIFICATION | GENE COPY NUMBER | ACTIVATING MUTATIONS | BREAST | INSIGHTS | Receptor, Epidermal Growth Factor - genetics | Receptor, ErbB-2 - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Genomics | Humans | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Cetuximab - therapeutic use | Molecular Targeted Therapy | Receptor, Fibroblast Growth Factor, Type 1 - genetics | MAP Kinase Kinase 1 - genetics | Colorectal Neoplasms - drug therapy | Female | Antineoplastic Agents - pharmacology | Insulin Receptor Substrate Proteins - genetics | Colorectal Neoplasms - metabolism | Antibodies, Monoclonal - pharmacology | Cetuximab - pharmacology | DNA Copy Number Variations - genetics | Mutation - genetics | Genome, Human - genetics | Receptor, Epidermal Growth Factor - chemistry | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Exome - genetics | Animals | Receptor, Platelet-Derived Growth Factor alpha - genetics | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Drug Resistance, Neoplasm - drug effects | Care and treatment | Gene mutations | Colorectal cancer | Drug metabolism | Genetic aspects | Identification and classification | Health aspects | Proteins | Epidermal growth factor | Genes | Clinical trials | Mutation | Kinases | Cancer therapies | Tumors
Journal Article
Wiley interdisciplinary reviews. Developmental biology, ISSN 1759-7684, 2015, Volume 4, Issue 3, pp. 215 - 266
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs... 
FAMILIAL TUMORAL CALCINOSIS | LIGAND-BINDING SPECIFICITY | NEGATIVE-FEEDBACK-REGULATION | FACTOR HOMOLOGOUS FACTORS | APICAL ECTODERMAL RIDGE | GONADOTROPIN-RELEASING-HORMONE | FACTOR RECEPTOR 4 | POTENTIAL THERAPEUTIC TARGET | DEVELOPMENTAL BIOLOGY | HEPARAN-SULFATE PROTEOGLYCANS | EPITHELIAL-MESENCHYMAL INTERACTIONS | Humans | Cell Proliferation - physiology | Embryonic Development - physiology | Cell Movement - physiology | Fibroblast Growth Factors - metabolism | Animals | Models, Biological | Homeostasis - physiology | Receptors, Fibroblast Growth Factor - metabolism | Signal Transduction - physiology | Organogenesis - physiology | Energy Metabolism - physiology | Cell Differentiation - physiology | Voltage-Gated Sodium Channels - metabolism | Pattern formation | Fibroblast growth factor | Congenital defects | Intracellular signalling | AKT protein | Nervous system | Kinases | Cofactors | Proteins | Signal transduction | Embryogenesis | Developmental stages | Fibroblasts | Sodium channels (voltage-gated) | Growth factors | Protein-tyrosine kinase | Adaptor proteins | Tyrosine | Sodium channels | Cell survival | MAP kinase | Metabolism | Progenitor cells | 1-Phosphatidylinositol 3-kinase | Organogenesis | Stem cells | Intracellular | Metabolic disorders | Cancer | Advanced Reviews
Journal Article