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Wiley interdisciplinary reviews. Developmental biology, ISSN 1759-7684, 2015, Volume 4, Issue 3, pp. 215 - 266
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs... 
FAMILIAL TUMORAL CALCINOSIS | LIGAND-BINDING SPECIFICITY | NEGATIVE-FEEDBACK-REGULATION | FACTOR HOMOLOGOUS FACTORS | APICAL ECTODERMAL RIDGE | GONADOTROPIN-RELEASING-HORMONE | FACTOR RECEPTOR 4 | POTENTIAL THERAPEUTIC TARGET | DEVELOPMENTAL BIOLOGY | HEPARAN-SULFATE PROTEOGLYCANS | EPITHELIAL-MESENCHYMAL INTERACTIONS | Humans | Cell Proliferation - physiology | Embryonic Development - physiology | Cell Movement - physiology | Fibroblast Growth Factors - metabolism | Animals | Models, Biological | Homeostasis - physiology | Receptors, Fibroblast Growth Factor - metabolism | Signal Transduction - physiology | Organogenesis - physiology | Energy Metabolism - physiology | Cell Differentiation - physiology | Voltage-Gated Sodium Channels - metabolism | Pattern formation | Fibroblast growth factor | Congenital defects | Intracellular signalling | AKT protein | Nervous system | Kinases | Cofactors | Proteins | Signal transduction | Embryogenesis | Developmental stages | Fibroblasts | Sodium channels (voltage-gated) | Growth factors | Protein-tyrosine kinase | Adaptor proteins | Tyrosine | Sodium channels | Cell survival | MAP kinase | Metabolism | Progenitor cells | 1-Phosphatidylinositol 3-kinase | Organogenesis | Stem cells | Intracellular | Metabolic disorders | Cancer | Advanced Reviews
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2014, Volume 111, Issue 45, pp. E4869 - E4877
The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation... 
Structure-based drug design | Drug discovery | Cancer drug resistance | Kinase inhibitor | structure-based drug design | WILD-TYPE | MULTIDISCIPLINARY SCIENCES | BCR-ABL | GROWTH-FACTOR RECEPTORS | DRUG-RESISTANCE | kinase inhibitor | LUNG-CANCER | GENE FUSIONS | cancer drug resistance | SELECTIVE INHIBITOR | drug discovery | THERAPEUTIC TARGET | FACTOR RECEPTOR 4 | REGULATES PROLIFERATION | Receptor, Fibroblast Growth Factor, Type 4 - chemistry | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | ErbB Receptors - genetics | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Mutation, Missense | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Protein Kinase Inhibitors - chemistry | Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Binding Sites | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Neoplasms - enzymology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | ErbB Receptors - chemistry | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Neoplasms - pathology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Biological Sciences | PNAS Plus
Journal Article
Journal of clinical oncology, ISSN 1527-7755, 2017, Volume 35, Issue 2, pp. 157 - 165
Journal Article
Annals of oncology, ISSN 0923-7534, 2014, Volume 25, Issue 3, pp. 552 - 563