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Radiation Research, ISSN 0033-7587, 01/2018, Volume 189, Issue 1, pp. 32 - 43
There is experimental evidence that ultrasoft X rays (0.1-5 keV) show a higher biological effectiveness than high-energy photons. Similar to high-LET... 
INDUCED DNA-DAMAGE | DOUBLE-STRAND BREAKS | GAMMA-RAYS | INACTIVATION | LOW-ENERGY ELECTRONS | BIOPHYSICS | HUMAN-FIBROBLASTS | CHINESE-HAMSTER | BIOLOGY | HAMSTER V79-4 CELLS | CULTURED-MAMMALIAN-CELLS | BIOPHYSICAL MODELS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Usage | Models | Health aspects | X-rays | Index Medicus | Space life sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2011, Volume 108, Issue 4, pp. 1609 - 1614
Radiation therapy can result in bone injury with the development of fractures and often can lead to delayed and nonunion of bone. There is no prevention or... 
Femur | Free radicals | Stem cells | Irradiation | Bone marrow | Bones | Physical trauma | Bone marrow cells | Radiation damage | Mesenchymal stem cells | CFU-fibroblast | Self-renewal | Angiography | Repopulation | Differentiation | MIGRATION | CAPACITY | differentiation | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | OSTEOGENESIS | self-renewal | angiography | CHEMOTHERAPY | TRANSPLANTATION | ORIGIN | ENGRAFTMENT | THERAPY | repopulation | Femur - pathology | Leukocyte Common Antigens - metabolism | Mesenchymal Stromal Cells - radiation effects | Blood Vessels - pathology | Bone Marrow - radiation effects | Blood Vessels - radiation effects | Radiation Injuries, Experimental - etiology | Free Radicals - metabolism | Antigens, Ly - metabolism | Colony-Forming Units Assay | Membrane Proteins - metabolism | Radiation Injuries, Experimental - metabolism | Osteoblasts - radiation effects | Femur - metabolism | Mice, Inbred C57BL | Bone Marrow Cells - pathology | Mesenchymal Stromal Cells - metabolism | Thiobarbituric Acid Reactive Substances - metabolism | Bone Marrow Cells - radiation effects | Radiation Injuries, Experimental - pathology | Fibroblasts - pathology | Femur - radiation effects | Integrin beta1 - metabolism | Osteoblasts - pathology | Animals | Fibroblasts - radiation effects | Bone Marrow - pathology | Mice | Mesenchymal Stromal Cells - pathology | Bone Marrow Cells - metabolism | Physiological aspects | Complications and side effects | Stem cell research | Care and treatment | Radiotherapy | Studies | Fractures | Medical imaging | Rodents | Physiology | Radiation therapy | Index Medicus | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2016, Volume 11, Issue 8, pp. e0159998 - e0159998
Recent research found that Tiron was an effective antioxidant that could act as the intracellular reactive oxygen species (ROS) scavenger or alleviate the... 
IRRADIATION | OXIDATIVE STRESS | HUMAN SKIN | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | MECHANISMS | SODIUM 4,5-DIHYDROXYBENZENE-1,3-DISULFONATE | INDUCTION | C-JUN | NF-KAPPA-B | PROTEIN-KINASES | Promoter Regions, Genetic - radiation effects | Binding Sites - radiation effects | Humans | Transcriptional Activation - drug effects | Skin Aging - radiation effects | 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt - pharmacology | Promoter Regions, Genetic - drug effects | Transcription Factor AP-1 - metabolism | Dermis - drug effects | Cytoprotection - drug effects | Signal Transduction - radiation effects | Dermis - cytology | Matrix Metalloproteinase 1 - genetics | Fibroblasts - metabolism | MAP Kinase Signaling System - radiation effects | Dermis - metabolism | Skin Aging - drug effects | Transcriptional Activation - radiation effects | Cells, Cultured | Dermis - radiation effects | Matrix Metalloproteinase 3 - metabolism | Antioxidants - pharmacology | Ultraviolet Rays - adverse effects | MAP Kinase Signaling System - drug effects | Fibroblasts - radiation effects | Signal Transduction - drug effects | Fibroblasts - drug effects | Transcription Factor AP-1 - radiation effects | Cytoprotection - genetics | Matrix Metalloproteinase 1 - metabolism | Cytoprotection - radiation effects | Matrix Metalloproteinase 3 - genetics | Genetic aspects | Skin | Genetic transcription | RNA | Analysis | Enzyme-linked immunosorbent assay | Oxidative stress | Reactive oxygen species | Transcription factors | Senescence | Oncology | Activation | Matrix metalloproteinase | Kinases | Proteins | Antioxidants | Signal transduction | Consent | Transcription activation | Fibroblasts | Aging | Biocompatibility | Metalloproteinase | Interstitial collagenase | Stromelysin 1 | Wound healing | U.V. radiation | Activator protein 1 | MAP kinase | Gene expression | Medicine | Signaling | Collagen | In vivo methods and tests | Binding sites | Apoptosis | Index Medicus
Journal Article
Biomaterials, ISSN 0142-9612, 2011, Volume 32, Issue 32, pp. 8161 - 8171
Abstract We describe in this study the positive influences on in vitro and in vivo osteogenesis of photo-cured hyaluronic acid (HA) hydrogels loaded with... 
Advanced Basic Science | Dentistry | Bone tissue regeneration | Hydrogel | Hyaluronic acid | Photopolymerization | Simvastatin | NANOPARTICLES | CELLS | IN-VITRO | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | Cell Death - radiation effects | Methacrylates - chemistry | RNA, Messenger - metabolism | Simvastatin - pharmacology | Spectroscopy, Fourier Transform Infrared | Tissue Scaffolds - chemistry | Polymerization - drug effects | Light | Surface Properties - drug effects | Methacrylates - chemical synthesis | Rheology - radiation effects | Cell Death - drug effects | Surface Properties - radiation effects | Osteogenesis - genetics | Bone Regeneration - drug effects | Cell Line | Cell Survival - drug effects | Rabbits | Calcification, Physiologic - drug effects | Polymerization - radiation effects | Osteogenesis - drug effects | RNA, Messenger - genetics | Hyaluronic Acid - chemistry | Calcification, Physiologic - radiation effects | Osteogenesis - radiation effects | Reverse Transcriptase Polymerase Chain Reaction | Cell Survival - radiation effects | Animals | Fibroblasts - radiation effects | Fibroblasts - drug effects | Cell Proliferation - drug effects | Fibroblasts - cytology | Mice | Kinetics | Hydrogels - chemistry | Rheology - drug effects | Cell Proliferation - radiation effects | Biological products | Antilipemic agents | Biomedical engineering | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 09/2017, Volume 77, Issue 18, pp. 5054 - 5067
Elderly cancer patients treated with ionizing radiation (IR) or chemotherapy experience more frequent and greater normal tissue toxicity relative to younger... 
GENOMIC INSTABILITY | COMPLEX I | SKELETAL-MUSCLE | OXIDATIVE STRESS | ONCOLOGY | FREE-RADICAL THEORY | DNA-DAMAGE | DOUBLE-STRAND BREAKS | SKIN | IONIZING-RADIATION | CANCER | Age Factors | Oxidative Stress | Apoptosis - drug effects | Apoptosis - radiation effects | Membrane Potential, Mitochondrial - radiation effects | Humans | Male | Membrane Potential, Mitochondrial - drug effects | Young Adult | Antineoplastic Agents - adverse effects | Superoxides - metabolism | Mitochondria - radiation effects | Adult | Skin - pathology | Superoxide Dismutase - metabolism | Radiation, Ionizing | Mice, Inbred C57BL | Cells, Cultured | Mitochondria - drug effects | Mitochondria - pathology | Fibroblasts - pathology | Animals | Fibroblasts - radiation effects | Skin - radiation effects | Fibroblasts - drug effects | Cisplatin - adverse effects | Aged | Cell Proliferation - drug effects | Mice | Skin - drug effects | Cell Proliferation - radiation effects | Elderly people | Toxicity | DNA damage | Superoxide dismutase | Tissues | Cancer therapies | Electron transport chain | Mitochondria | Ionizing radiation | Platinum | Fibroblasts | Radiation injuries | Membrane potential | Age | Deoxyribonucleic acid--DNA | Killing | Health risks | I.R. radiation | Superoxide | Radiation therapy | Patients | Chemotherapy | Injury prevention | Skin | Electron transport | Elderly | Cancer | Geriatrics | Index Medicus | Superoxide dismutase mimics | Radiation
Journal Article
Brain Research, ISSN 0006-8993, 2009, Volume 1311, pp. 189 - 196
Journal Article
Experimental Dermatology, ISSN 0906-6705, 2009, Volume 18, Issue 6, pp. 553 - 561
Solar ultraviolet (UV) radiation, particularly its UVB (290-320 nm) component, is the primary cause of many adverse biological effects including photoageing... 
Photoageing | Ultraviolet radiation | Matrix metalloproteinases | Human reconstituted skin | Pomegranate | DNA damage | CUTANEOUS CARCINOGENESIS | CELL NUCLEAR ANTIGEN | DNA-DAMAGE | INDUCED OXIDATIVE DAMAGE | KAPPA-B | RADIATION-INDUCED IMMUNOSUPPRESSION | DERMATOLOGY | ultraviolet radiation | pomegranate | photoageing | PUNICA-GRANATUM POMEGRANATE | human reconstituted skin | BOTANICAL ANTIOXIDANTS | DERMAL FIBROBLASTS | HUMAN EPIDERMAL-KERATINOCYTES | matrix metalloproteinases | Matrix Metalloproteinases - genetics | Keratinocytes - radiation effects | Plant Extracts - pharmacology | Skin - metabolism | Coculture Techniques | Humans | Proto-Oncogene Proteins c-jun - biosynthesis | Proto-Oncogene Proteins c-fos - biosynthesis | Male | Protein Processing, Post-Translational - drug effects | Enzyme Induction - drug effects | Radiation-Protective Agents - pharmacology | Radiation-Protective Agents - isolation & purification | Oxidative Stress - radiation effects | Phosphorylation - drug effects | Drug Evaluation, Preclinical | Infant, Newborn | Matrix Metalloproteinases - biosynthesis | Organoids - radiation effects | DNA Damage - drug effects | Punicaceae - chemistry | Plant Oils - pharmacology | Protein Processing, Post-Translational - radiation effects | Plant Extracts - isolation & purification | Plant Oils - isolation & purification | Tropoelastin - biosynthesis | Ultraviolet Rays - adverse effects | Phosphorylation - radiation effects | Fibroblasts - radiation effects | Keratinocytes - drug effects | Tropoelastin - genetics | Skin - radiation effects | Fibroblasts - drug effects | Organoids - drug effects | Proto-Oncogene Proteins c-fos - genetics | Oxidative Stress - drug effects | DNA Damage - radiation effects | Enzyme Induction - radiation effects | Skin - drug effects | Antioxidants | Immunohistochemistry | Carbocyclic compounds | Anthocyanin | Tannins | Pyrimidines | DNA | Guanosine | Radiation | Chromophores | Skin cancer | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, pp. e105263 - e105263
Despite their preponderance amongst the ultraviolet (UV) range received on Earth, the biological impacts of longwave UVA1 rays (340-400 nm) upon human skin... 
IN-VITRO | CYCLOBUTANE PYRIMIDINE DIMERS | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | LANGERHANS CELL DEPLETION | CONTACT HYPERSENSITIVITY | GENE-EXPRESSION | BASAL LAYER | HUMAN-EPIDERMIS | DELAYED-TYPE HYPERSENSITIVITY | HUMAN KERATINOCYTES | Epidermis - metabolism | Lipid Peroxidation - radiation effects | Epidermis - radiation effects | Reactive Oxygen Species - metabolism | Apoptosis - radiation effects | Keratinocytes - radiation effects | Skin - metabolism | Humans | Up-Regulation - radiation effects | Radiation | Down-Regulation - radiation effects | Gene Expression - radiation effects | Ultraviolet Rays - adverse effects | Fibroblasts - radiation effects | Keratinocytes - metabolism | Skin - radiation effects | Oxidative Stress - radiation effects | DNA Damage - radiation effects | Fibroblasts - metabolism | Oxidative stress | Reactive oxygen species | Genes | Gene regulation | DNA damage | Lipid peroxidation | Homeostasis | Lipids | Innate immunity | Genomes | Immunity | Carcinogenesis | Proteins | Glucose metabolism | Carcinogens | Biological effects | Pathways | Fibroblasts | Aging | Extracellular matrix | Lipid metabolism | Damage accumulation | Public health | Injury analysis | Deoxyribonucleic acid--DNA | Peroxidation | Thymine | Heat shock proteins | Keratinocytes | Exposure | Light therapy | Gene expression | Metabolism | Biological diversity | Immunosuppression | Ultraviolet radiation | Sunburn & sun tanning | Nitric oxide | Skin | Dimers | Apoptosis | Heat shock | Cancer | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2013, Volume 87, Issue 5, pp. 1171 - 1178
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 02/2018, Volume 19, Issue 2, p. 496
Suberoylanilide hydroxamic acid (SAHA) is a histone deacetylase inhibitor, which has been widely utilized throughout the cancer research field. SAHA-induced... 
Proton | SAHA | Carbon ions | CARBON-ION RADIOTHERAPY | SUBEROYLANILIDE HYDROXAMIC ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | CHEMISTRY, MULTIDISCIPLINARY | carbon ions | POTENTIALLY LETHAL DAMAGE | GAMMA-H2AX FOCI | STEM-LIKE CELLS | CHINESE-HAMSTER CELLS | X-RAY-SENSITIVITY | HOMOLOGOUS RECOMBINATION | IONIZING-RADIATION | proton | A549 Cells | Cell Survival - drug effects | DNA Repair - drug effects | Biomarkers, Tumor - analysis | Humans | Hydroxamic Acids - adverse effects | Radiation-Sensitizing Agents - pharmacology | Elementary Particles - therapeutic use | Gamma Rays - therapeutic use | Radiation-Sensitizing Agents - adverse effects | Photons - therapeutic use | DNA Breaks, Double-Stranded - drug effects | Fibroblasts - drug effects | Histone Deacetylase Inhibitors - pharmacology | Neoplasms - radiotherapy | Cell Proliferation - drug effects | Cell Cycle - drug effects | Hydroxamic Acids - pharmacology | Histone Deacetylase Inhibitors - adverse effects | Histone deacetylase | Radiation effects | DNA damage | Hydroxamic acid | Replication protein A | Exposure | Lung carcinoma | Protein A | DNA repair | Inhibitors | Radiosensitization | Linear energy transfer (LET) | Cell lines | Cell cycle | Fibroblasts | Pretreatment | Repair | Radiation damage | Deoxyribonucleic acid--DNA | Cancer | G1 phase | Index Medicus
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 08/2018, Volume 352, pp. 87 - 96
Previously, we proved that caffeic acid (CA), a major dietary phenolic acid, prevents skin carcinogenesis by modulating inflammatory signaling in mouse skin.... 
UV radiation | Photocarcinogenesis | Nucleotide excision repair | Caffeic acid | INDUCED DNA-DAMAGE | ACTIVATION | CELLS IN-VITRO | DIETARY PHYTOCHEMICALS | KINASE | MECHANISMS | CANCER | NUCLEOTIDE EXCISION-REPAIR | FERULIC ACID | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PROGRESSION | Cell Transformation, Neoplastic - radiation effects | Fibroblasts - enzymology | Neoplasms, Radiation-Induced - enzymology | Apoptosis - drug effects | Humans | Neoplasms, Experimental - enzymology | Caffeic Acids - pharmacology | Neoplasms, Experimental - pathology | Skin Neoplasms - enzymology | Skin Neoplasms - prevention & control | DNA Repair Enzymes - metabolism | Neoplasms, Radiation-Induced - prevention & control | Oxidative Stress - radiation effects | Signal Transduction - radiation effects | Neoplasms, Radiation-Induced - pathology | Anticarcinogenic Agents - pharmacology | Skin - pathology | DNA Damage - drug effects | Skin Neoplasms - pathology | DNA Repair - drug effects | Neoplasms, Experimental - prevention & control | PTEN Phosphohydrolase - metabolism | Fibroblasts - pathology | Skin - enzymology | Cell Transformation, Neoplastic - metabolism | Ultraviolet Rays - adverse effects | Animals | Fibroblasts - radiation effects | Signal Transduction - drug effects | Skin - radiation effects | Fibroblasts - drug effects | Mice | Cell Transformation, Neoplastic - drug effects | Oxidative Stress - drug effects | Cell Transformation, Neoplastic - pathology | Skin - drug effects | Proteins | Skin | Cell death | DNA repair | DNA damage | Radiation | Index Medicus
Journal Article