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Autophagy, ISSN 1554-8627, 09/2011, Volume 7, Issue 9, pp. 1045 - 1051
Multiple stress pathways result in the induction of autophagy and apoptosis. Current methods (e.g., protein gel blot, microscopy) do not offer quantitative... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Autophagy | Multispectral imaging cytometry | Influenza | New methodology | Apoptosis | influenza | CROSS-TALK | new methodology | autophagy | BECLIN 1 | multispectral imaging cytometry | apoptosis | CELL-DEATH | CELL BIOLOGY | Leukocytes, Mononuclear - metabolism | Image Cytometry - methods | Apoptosis - drug effects | Apoptosis - radiation effects | Autophagy - radiation effects | Microtubule-Associated Proteins - metabolism | Humans | Autophagy - drug effects | Lysosomes - radiation effects | Chloroquine - pharmacology | Lysosomes - metabolism | Ultraviolet Rays | Time Factors | Leukocytes, Mononuclear - radiation effects | Signal Transduction - radiation effects | Fibroblasts - metabolism | Lysosomes - drug effects | Leukocytes, Mononuclear - drug effects | Animals | Fibroblasts - radiation effects | Signal Transduction - drug effects | Embryo, Mammalian - cytology | Fibroblasts - drug effects | Leukocytes, Mononuclear - cytology | Fibroblasts - cytology | Mice | Autophagy/radiation effects | Signal Transduction/radiation effects | Image Cytometry/methods | Autophagy/drug effects | Life Sciences | Lysosomes/drug effects | Immunology | Fibroblasts/metabolism | Leukocytes, Mononuclear/radiation effects | Fibroblasts/drug effects | Leukocytes, Mononuclear/metabolism | Apoptosis/radiation effects | Leukocytes, Mononuclear/drug effects | Fibroblasts/cytology | Apoptosis/drug effects | Fibroblasts/radiation effects | Lysosomes/metabolism | Leukocytes, Mononuclear/cytology | Signal Transduction/drug effects | Chloroquine/pharmacology | Embryo, Mammalian/cytology | Lysosomes/radiation effects | Microtubule-Associated Proteins/metabolism
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2011, Volume 108, Issue 4, pp. 1609 - 1614
Radiation therapy can result in bone injury with the development of fractures and often can lead to delayed and nonunion of bone... 
Femur | Free radicals | Stem cells | Irradiation | Bone marrow | Bones | Physical trauma | Bone marrow cells | Radiation damage | Mesenchymal stem cells | CFU-fibroblast | Self-renewal | Angiography | Repopulation | Differentiation | MIGRATION | CAPACITY | differentiation | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | OSTEOGENESIS | self-renewal | angiography | CHEMOTHERAPY | TRANSPLANTATION | ORIGIN | ENGRAFTMENT | THERAPY | repopulation | Femur - pathology | Leukocyte Common Antigens - metabolism | Mesenchymal Stromal Cells - radiation effects | Blood Vessels - pathology | Bone Marrow - radiation effects | Blood Vessels - radiation effects | Radiation Injuries, Experimental - etiology | Free Radicals - metabolism | Antigens, Ly - metabolism | Colony-Forming Units Assay | Membrane Proteins - metabolism | Radiation Injuries, Experimental - metabolism | Osteoblasts - radiation effects | Femur - metabolism | Mice, Inbred C57BL | Bone Marrow Cells - pathology | Mesenchymal Stromal Cells - metabolism | Thiobarbituric Acid Reactive Substances - metabolism | Bone Marrow Cells - radiation effects | Radiation Injuries, Experimental - pathology | Fibroblasts - pathology | Femur - radiation effects | Integrin beta1 - metabolism | Osteoblasts - pathology | Animals | Fibroblasts - radiation effects | Bone Marrow - pathology | Mice | Mesenchymal Stromal Cells - pathology | Bone Marrow Cells - metabolism | Physiological aspects | Complications and side effects | Stem cell research | Care and treatment | Radiotherapy | Biological Sciences
Journal Article
International Journal of Oral & Maxillofacial Surgery, ISSN 0901-5027, 2013, Volume 42, Issue 8, pp. 939 - 948
...) as a model for studying the acute effects of ionizing radiation (IR) on the oral mucosa. TEM and native non-keratinizing oral mucosa (NNOM... 
Surgery | tissue engineering | cytokines | keratinocytes | oral mucosa | DNA damage | SURGERY | CELLS | 53BP1 | PROLIFERATION | DENTISTRY, ORAL SURGERY & MEDICINE | EXPRESSION | TGF-BETA-1 | EQUIVALENT | Gamma Rays | Cell Adhesion - radiation effects | Integrin alpha6 - analysis | Intracellular Signaling Peptides and Proteins - radiation effects | Keratinocytes - radiation effects | Humans | Middle Aged | DNA Repair - radiation effects | Integrin alpha6 - radiation effects | Male | Rad51 Recombinase - analysis | Basement Membrane - radiation effects | Epithelium - radiation effects | Interleukin-1beta - radiation effects | Keratin-19 - radiation effects | Mouth Mucosa - radiation effects | Integrin beta4 - analysis | Keratin-19 - analysis | Female | Cell Culture Techniques | Transforming Growth Factor beta1 - analysis | Connective Tissue - radiation effects | Tissue Engineering | Cell Differentiation - radiation effects | Mouth Mucosa - cytology | Integrin beta4 - radiation effects | Interleukin-1beta - analysis | Intracellular Signaling Peptides and Proteins - analysis | Desmoglein 3 - analysis | Vimentin - radiation effects | Radiation Dosage | Collagen Type IV - analysis | Vimentin - analysis | Desmoglein 3 - radiation effects | Fibroblasts - radiation effects | Rad51 Recombinase - radiation effects | Transforming Growth Factor beta1 - radiation effects | Collagen Type IV - radiation effects | Tumor Suppressor p53-Binding Protein 1 | DNA Damage - radiation effects | Cell Proliferation - radiation effects | Enzymes | Tissue engineering | Transforming growth factors | Keratin | Surgery, Plastic | Nuclear radiation | Analysis | Bone morphogenetic proteins | Tumor proteins | Enzyme-linked immunosorbent assay | Integrins | Protein binding
Journal Article
PloS one, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, pp. e105263 - e105263
...) upon human skin have not been investigated so thoroughly. Nevertheless, recent studies have proven their harmful effects and involvement in carcinogenesis and immunosuppression... 
IN-VITRO | CYCLOBUTANE PYRIMIDINE DIMERS | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | LANGERHANS CELL DEPLETION | CONTACT HYPERSENSITIVITY | GENE-EXPRESSION | BASAL LAYER | HUMAN-EPIDERMIS | DELAYED-TYPE HYPERSENSITIVITY | HUMAN KERATINOCYTES | Epidermis - metabolism | Lipid Peroxidation - radiation effects | Epidermis - radiation effects | Reactive Oxygen Species - metabolism | Apoptosis - radiation effects | Keratinocytes - radiation effects | Skin - metabolism | Humans | Up-Regulation - radiation effects | Radiation | Down-Regulation - radiation effects | Gene Expression - radiation effects | Ultraviolet Rays - adverse effects | Fibroblasts - radiation effects | Keratinocytes - metabolism | Skin - radiation effects | Oxidative Stress - radiation effects | DNA Damage - radiation effects | Fibroblasts - metabolism | Oxidative stress | Reactive oxygen species | Genes | Gene regulation | DNA damage | Lipid peroxidation | Homeostasis | Lipids | Innate immunity | Genomes | Biodiversity | Immunity | Carcinogenesis | Proteins | Glucose metabolism | Carcinogens | Biological effects | Pathways | Fibroblasts | Aging | Extracellular matrix | Lipid metabolism | Damage accumulation | Public health | Injury analysis | Deoxyribonucleic acid--DNA | Peroxidation | Oxygen | Thymine | Heat shock proteins | Keratinocytes | Exposure | Light therapy | Gene expression | Metabolism | Immunosuppression | Ultraviolet radiation | Sunburn & sun tanning | Nitric oxide | Skin | Dimers | Cellular stress response | Apoptosis | Heat shock | Cancer | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Radiation research, ISSN 0033-7587, 2013, Volume 179, Issue 1, pp. 53 - 61
.... In this study, we demonstrate annexin A2 nuclear translocation in human skin organotypic culture and murine epidermal cells after exposure to X radiation (10–200 cGy... 
Ionizing radiation | Cell nucleus | Epidermal cells | Genes | Keratinocytes | Skin | Signals | Directional control | Annexins | Radiation dosage | TISSUE MODEL | PROTEIN | HUMAN SKIN KERATINOCYTES | ALPHA-PARTICLE | BIOPHYSICS | DOSE IONIZING-RADIATION | PROSTATE-CANCER CELLS | BIOLOGY | GENE-EXPRESSION | HUMAN FIBROBLASTS | STEM-CELL | NF-KAPPA-B | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Transcription, Genetic - drug effects | Cell Death - radiation effects | Skin - cytology | Humans | Annexin A2 - deficiency | Transcription, Genetic - radiation effects | NF-kappa B - metabolism | Stem Cells - cytology | Transcriptome - radiation effects | Stress, Physiological - radiation effects | Cell Differentiation - genetics | Cell Death - genetics | Cell Nucleus - radiation effects | Stress, Physiological - drug effects | Cell Death - drug effects | Homeostasis - drug effects | Active Transport, Cell Nucleus - genetics | Active Transport, Cell Nucleus - radiation effects | Cell Differentiation - radiation effects | Stress, Physiological - genetics | Gene Silencing | Stem Cells - radiation effects | Radiation Tolerance - genetics | Homeostasis - radiation effects | Transcriptome - drug effects | X-Rays - adverse effects | Radiation Tolerance - drug effects | Tumor Necrosis Factor-alpha - pharmacology | Animals | Annexin A2 - genetics | Cell Differentiation - drug effects | Active Transport, Cell Nucleus - drug effects | Stem Cells - drug effects | Mice | Cell Nucleus - drug effects | Annexin A2 - metabolism | Homeostasis - genetics | RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT
Journal Article
Biomaterials, ISSN 0142-9612, 2011, Volume 32, Issue 32, pp. 8161 - 8171
Abstract We describe in this study the positive influences on in vitro and in vivo osteogenesis of photo-cured hyaluronic acid (HA) hydrogels loaded with... 
Advanced Basic Science | Dentistry | Bone tissue regeneration | Hydrogel | Hyaluronic acid | Photopolymerization | Simvastatin | NANOPARTICLES | CELLS | IN-VITRO | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | Cell Death - radiation effects | Methacrylates - chemistry | RNA, Messenger - metabolism | Simvastatin - pharmacology | Spectroscopy, Fourier Transform Infrared | Tissue Scaffolds - chemistry | Polymerization - drug effects | Light | Surface Properties - drug effects | Methacrylates - chemical synthesis | Rheology - radiation effects | Cell Death - drug effects | Surface Properties - radiation effects | Osteogenesis - genetics | Bone Regeneration - drug effects | Cell Line | Cell Survival - drug effects | Rabbits | Calcification, Physiologic - drug effects | Polymerization - radiation effects | Osteogenesis - drug effects | RNA, Messenger - genetics | Hyaluronic Acid - chemistry | Calcification, Physiologic - radiation effects | Osteogenesis - radiation effects | Reverse Transcriptase Polymerase Chain Reaction | Cell Survival - radiation effects | Animals | Fibroblasts - radiation effects | Fibroblasts - drug effects | Cell Proliferation - drug effects | Fibroblasts - cytology | Mice | Kinetics | Hydrogels - chemistry | Rheology - drug effects | Cell Proliferation - radiation effects | Biological products | Antilipemic agents | Biomedical engineering
Journal Article
Brain Research, ISSN 0006-8993, 2009, Volume 1311, pp. 189 - 196
Journal Article
International journal of radiation oncology, biology, physics, ISSN 0360-3016, 2013, Volume 87, Issue 5, pp. 1171 - 1178
Journal Article
Nature communications, ISSN 2041-1723, 2018, Volume 9, Issue 1, pp. 2783 - 14
...) deletion invokes radiation-induced genomic instability in neighboring epithelium. In these animals, a single dose of whole-body radiation causes focal mammary lobuloalveolar hyperplasia through paracrine epidermal growth factor receptor (EGFR... 
BREAST-CANCER | NUCLEAR PTEN | CONTRALATERAL BREAST | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | FOLLOW-UP | DNA-REPAIR | TUMOR MICROENVIRONMENT | MOUSE MODELS | FIBROBLASTS | RADIATION-THERAPY | Epithelial Cells - metabolism | Gamma Rays - adverse effects | Epithelial Cells - drug effects | Humans | ErbB Receptors - genetics | Gene Expression Regulation, Neoplastic | Mammary Glands, Human - metabolism | Mammary Neoplasms, Experimental - metabolism | Mammary Neoplasms, Experimental - genetics | Breast Neoplasms - metabolism | Mammary Neoplasms, Experimental - pathology | Stromal Cells - drug effects | Genomic Instability - drug effects | Female | Antineoplastic Agents - pharmacology | Mammary Glands, Human - radiation effects | Mammary Glands, Human - drug effects | Genomic Instability - radiation effects | PTEN Phosphohydrolase - genetics | Epithelial Cells - radiation effects | PTEN Phosphohydrolase - deficiency | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Signal Transduction | Stromal Cells - metabolism | Radiation Tolerance - genetics | Mammary Neoplasms, Experimental - radiotherapy | Mammary Glands, Animal - drug effects | Mammary Glands, Animal - radiation effects | Breast Neoplasms - radiotherapy | Animals | Breast Neoplasms - genetics | Mammary Glands, Animal - metabolism | Breast Neoplasms - pathology | Cell Transformation, Neoplastic | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Cell Proliferation - radiation effects | Stromal Cells - radiation effects | Hyperplasia | Radiation | Paracrine signalling | Homology | Genomic instability | Epidermal growth factor | Clonal deletion | Tumorigenesis | Inhibition | Mammary gland | Tensin | Radiation effects | Stability | Epidermal growth factor receptors | Stroma | Risk reduction | Mammary glands | Breast cancer | Radiation therapy | Epithelium | Patients | Radiation dosage | Diagnostic systems | PTEN protein | Cancer | Tumors
Journal Article
Journal Article