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Biochemical and Biophysical Research Communications, ISSN 0006-291X, 12/2017, Volume 494, Issue 1-2, pp. 402 - 408
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, pp. e48734 - e48734
The basis for mammalian lens fiber cell organization, transparency, and biomechanical properties has contributions from two specialized cytoskeletal systems:... 
CONFINED COMPRESSION | CRYSTALLINE LENS | FILAMENT PROTEIN CP49 | BEADED FILAMENT | BOVINE ARTICULAR-CARTILAGE | MULTIDISCIPLINARY SCIENCES | MEMBRANE SKELETON | DOMINANT CONGENITAL CATARACT | CHINESE FAMILY | INTERMEDIATE-FILAMENTS | BFSP2 MUTATION | Tropomodulin - physiology | Mutagenesis, Site-Directed | Mice, Inbred C57BL | Actins - metabolism | Intermediate Filament Proteins - physiology | Lens, Crystalline - ultrastructure | Cytoskeleton - ultrastructure | Tropomodulin - genetics | Mice, Inbred Strains | Tropomodulin - metabolism | Biomechanical Phenomena | Animals | Eye Proteins - metabolism | Lens, Crystalline - physiology | Cell Shape | Intermediate Filament Proteins - genetics | Cytoskeleton - physiology | Eye Proteins - physiology | Mice | Eye Proteins - genetics | Optics and Photonics | Intermediate Filament Proteins - metabolism | Lens, Crystalline - cytology | Biomechanics | Physiological aspects | Muscle proteins | Actin | Intermediate filament proteins | Membrane proteins | Spectrin | Cataracts | Bioengineering | Transparency | Filensin | Biology | Synergism | Proteins | Clonal deletion | Filaments | Biomechanical engineering | Deletion | Stiffness | Physiology | Age | Tropomyosin | Light scattering | Mechanical properties | Gene expression | Geometry | Musculoskeletal system | Microscopy | Morphology | Cytoskeleton | Lenses | Index Medicus
Journal Article
Molecular Vision, ISSN 1090-0535, 09/2017, Volume 23, pp. 638 - 648
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, pp. e95507 - e95507
alpha A-crystallin and alpha B-crystallin are members of the small heat shock protein family and function as molecular chaperones and major lens structural... 
AUTOSOMAL-DOMINANT CATARACT | EPITHELIAL-CELLS | AGE-RELATED-CHANGES | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | COMPARATIVE PROTEOMIC ANALYSIS | GAMMA-CRYSTALLIN | BETA-CRYSTALLIN | EYE LENS | MASS-SPECTROMETRY | HEAT-SHOCK-PROTEIN | alpha-Crystallin B Chain - genetics | Crystallins - metabolism | Calpain - metabolism | Gelsolin - metabolism | Lens, Crystalline - metabolism | alpha-Crystallin B Chain - metabolism | Crystallins - genetics | Calpain - genetics | Mice, Knockout | alpha-Crystallin A Chain - genetics | Muscle Proteins - genetics | Animals | Eye Proteins - metabolism | alpha-Crystallin A Chain - metabolism | Mice, Mutant Strains | Mass Spectrometry | Intermediate Filament Proteins - genetics | Muscle Proteins - metabolism | Gelsolin - genetics | Mice | Eye Proteins - genetics | Intermediate Filament Proteins - metabolism | Cataracts | Cytochrome | Glutamate dehydrogenase | Creatine kinase | Genomics | Filensin | Acidification | Biochemistry | Chaperones | Kinases | Creatine | Degradation | Proteins | Spectrometry | Phosphoglycerate mutase | Actin | Histones | Hemoglobin | Gelsolin | Age | Phosphopyruvate hydratase | Crystal structure | Structural proteins | Heat shock proteins | Crosslinking | Calpain | Abundance | Crystallinity | Substrates | Medicine | Cytochrome c | Crystallin | Proteomics | Scientific imaging | In vivo methods and tests | Genetic engineering | Mutation | Mass spectrometry | Lenses | Heat shock | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, pp. e64676 - e64676
Homeostasis of intracellular calcium is crucial for lens cytoarchitecture and transparency, however, the identity of specific channel proteins regulating... 
PROTEIN-KINASE-C | ASPIRIN-LIKE ANALGESICS | GAP-JUNCTIONS | EPITHELIAL-CELLS | MULTIDISCIPLINARY SCIENCES | CATARACT FORMATION | CA2+ CHANNELS | GENE-EXPRESSION | RAT LENS | DIABETIC-RATS | WATER PERMEABILITY | Felodipine - pharmacology | Nifedipine - pharmacology | Gene Expression - drug effects | beta-Crystallin B Chain - metabolism | Mice, Inbred C57BL | Connexins - genetics | Lens, Crystalline - metabolism | Aquaporins - metabolism | Immunoblotting | Male | Calcium Channel Blockers - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Connexins - metabolism | Animals | Calcium Channels, L-Type - genetics | Eye Proteins - metabolism | Female | Mice | Myosin Light Chains - metabolism | Calcium Channels, L-Type - metabolism | Eye Proteins - genetics | Phosphorylation - drug effects | Lens, Crystalline - drug effects | Proteins | Cataract | Calcium channels | Myosin | Heat shock proteins | Gene expression | Protein binding | Nifedipine | Felodipine | Cataracts | Spectrin | Phosphorylation | Transparency | Calcium | Epithelial cells | Homeostasis | Filensin | Cytotoxicity | Chains | Kinases | Channels | Calcium influx | Cell adhesion & migration | Fibers | Analgesics | Actin | Rodents | Cell cycle | Inhibition | Light levels | Calcium homeostasis | Calcium (intracellular) | Aquaporins | Cortex | Mechanical properties | Mass spectroscopy | Cultures | Pharmacology | Epithelium | Medicine | Polymerase chain reaction | DNA microarrays | Crystallin | Calcium channels (L-type) | Cytoskeleton | Connexins | Intracellular | Immunofluorescence | Mass spectrometry | Binding sites | Lenses | Index Medicus
Journal Article
Investigative Ophthalmology & Visual Science, ISSN 0146-0404, 07/2007, Volume 48, Issue 7, pp. 3269 - 3276
Journal Article
EXPERIMENTAL EYE RESEARCH, ISSN 0014-4835, 03/2003, Volume 76, Issue 3, pp. 385 - 391
In this report, the phenotype associated with the first targeted knockout of the lens specific intermediate filament gene CP49 is described. Several surprising... 
knockout | CHICK LENS | cataract | cytoskeleton | lens | beaded filament | IDENTIFICATION | KERATIN-18 | intermediate filament | GENE | VIMENTIN | OPHTHALMOLOGY | DOMINANT CONGENITAL CATARACT | DIFFERENTIATION | FILENSIN | TRANSGENIC MICE
Journal Article
Journal Article
Biomacromolecules, ISSN 1525-7797, 11/2004, Volume 5, Issue 6, pp. 2165 - 2175
The objective of this study is to investigate the influence of point mutations on the structural stability of coiled coil fragments of the human hair... 
DOMAIN | POLYMER SCIENCE | HELIX TERMINATION MOTIF | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | DENATURATION | MONILETHRIX | T4 LYSOZYME | INTERMEDIATE-FILAMENT PROTEIN | SIMULATION ANALYSIS | MUTATIONS | COILED-COIL | FILENSIN | Protein Structure, Terti