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Nature (London), ISSN 1476-4687, 2012, Volume 490, Issue 7418, pp. 107 - 111
Detection of microbial products by host inflammasomes is an important mechanism of innate immune surveillance. Inflammasomes activate the caspase-1 (CASP1)... 
CYTOSOLIC PHOSPHOLIPASE A | FLAGELLIN | III SECRETION APPARATUS | MECHANISM | MICE DEFICIENT | MULTIDISCIPLINARY SCIENCES | NLRC4 INFLAMMASOME | INFECTION | PYROPTOSIS | CASPASE-1 ACTIVATION | IMMUNE RECOGNITION | Inflammation - pathology | Inflammasomes - metabolism | Hematocrit | Salmonella Infections - immunology | Eicosanoids - biosynthesis | Caspase 1 - metabolism | Male | Inflammation - metabolism | Time Factors | Flagellin - metabolism | Bacterial Toxins - genetics | Antigens, Bacterial - chemistry | Neuronal Apoptosis-Inhibitory Protein - deficiency | Macrophages, Peritoneal - immunology | Calcium-Binding Proteins - deficiency | Interleukin-1beta | Bacterial Toxins - chemistry | Apoptosis Regulatory Proteins - metabolism | Cyclooxygenase 1 - deficiency | Body Fluids - metabolism | Caspase 1 - deficiency | Recombinant Fusion Proteins - genetics | Cytosol - metabolism | Death | Mice | Antigens, Bacterial - metabolism | Capillary Permeability | Peritoneal Cavity | Legionella pneumophila | Intestines - metabolism | Antigens, Bacterial - genetics | Recombinant Fusion Proteins - metabolism | Peritoneal Lavage | Apoptosis Regulatory Proteins - deficiency | Flagellin - genetics | Female | Interleukin-18 | Calcium Signaling | Calcium-Binding Proteins - metabolism | Flagellin - immunology | Salmonella typhimurium - immunology | Mice, Inbred C57BL | Inflammation - immunology | Body Temperature | Neuronal Apoptosis-Inhibitory Protein - metabolism | Immunity, Innate - immunology | Bacterial Toxins - metabolism | Animals | Eicosanoids - metabolism | Fluid Shifts | Cellular signal transduction | Research | Properties | Bacterial proteins | Flagella (Microbiology) | Immune system | Proteins | Bone marrow | Pathology | Infections | Biosynthesis | Rodents
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2007, Volume 282, Issue 26, pp. 18810 - 18818
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 01/2013, Volume 110, Issue 5, pp. 1851 - 1856
A flagellin-independent caspase-1 activation pathway that does not require NAIP5 or NRLC4 is induced by the intracellular pathogen Legionella pneumophila. Here... 
Cytoskeletal Proteins | Flagellin | Immunoblotting | Legionella pneumophila | Macrophages | Adaptor Proteins, Vesicular Transport | Necrosis | Receptor, Interferon alpha-beta | Caspase 1 | Carrier Proteins | Calcium-Binding Proteins | Cytokines | Mice, Inbred C57BL | Cells, Cultured | Myeloid Differentiation Factor 88 | Mice, Knockout | Host-Pathogen Interactions | Animals | Apoptosis Regulatory Proteins | Bone Marrow Cells | Mice | Caspases | Enzyme Activation | Mutation | Apoptosis | Cell death | Innate immunity | Inflammasome | PATTERN-RECOGNITION | innate immunity | cell death | inflammasome | MULTIDISCIPLINARY SCIENCES | NLRP3 INFLAMMASOME ACTIVATION | INFECTION | RECEPTORS | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Adaptor Proteins, Vesicular Transport - genetics | Caspase 1 - metabolism | Legionella pneumophila - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Caspases - metabolism | Flagellin - genetics | Flagellin - metabolism | Apoptosis Regulatory Proteins - genetics | Cytoskeletal Proteins - metabolism | Receptor, Interferon alpha-beta - genetics | Macrophages - microbiology | Receptor, Interferon alpha-beta - metabolism | Calcium-Binding Proteins - metabolism | Cytokines - metabolism | Caspases - genetics | Myeloid Differentiation Factor 88 - genetics | Macrophages - cytology | Legionella pneumophila - metabolism | Apoptosis Regulatory Proteins - metabolism | Carrier Proteins - genetics | Macrophages - metabolism | Carrier Proteins - metabolism | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Bone Marrow Cells - microbiology | Legionella pneumophila - physiology | Myeloid Differentiation Factor 88 - metabolism | Bone Marrow Cells - metabolism | Calcium-Binding Proteins - genetics | Genetic aspects | Research | Properties | Immunological research | Biological Sciences
Journal Article
BioMed research international, ISSN 2314-6141, 2018, Volume 2018, pp. 1 - 12
Preterm birth is the primary cause of perinatal morbidity and mortality worldwide. Inflammation induces a cascade of events leading to preterm birth by... 
PRO-LABOR MEDIATORS | MEDICINE, RESEARCH & EXPERIMENTAL | TOLL-LIKE RECEPTOR-2 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | FACTOR-KAPPA-B | PROINFLAMMATORY CYTOKINES | UP-REGULATION | EXPRESSION | HUMAN FETAL MEMBRANES | PRETERM LABOR | TRANSCRIPTIONAL REPRESSOR | ACID-BINDING ACTIVITY | Humans | Premature Birth - metabolism | NF-kappa B - metabolism | RNA, Messenger - metabolism | Kv Channel-Interacting Proteins - metabolism | Pregnancy | Inflammation - metabolism | Intercellular Adhesion Molecule-1 - metabolism | Matrix Metalloproteinase 9 - metabolism | Amnion - metabolism | Term Birth - metabolism | Interleukin-1beta - metabolism | Myometrium - metabolism | Flagellin - metabolism | Inflammation Mediators - metabolism | Extraembryonic Membranes - metabolism | Female | Chemokine CCL2 - metabolism | Interleukin-8 - metabolism | Interleukin-6 - metabolism | Chorioamnionitis - metabolism | RNA, Small Interfering - metabolism | Inflammation | RNA | Comparative analysis | Infants (Premature) | Health aspects | Membranes | Chorioamnionitis | Transcription | Premature birth | Flagellin | Infections | Biology | Birth | Tissues | Interleukin 6 | Interleukin 8 | Deoxyribonucleic acid--DNA | NF-κB protein | Myometrium | Cytokines | Intercellular adhesion molecule 1 | Fetuses | Gynecology | Double-stranded RNA | siRNA | Poly (I:C) | Metabolism | Gene expression | Obstetrics | Morbidity | Gelatinase B | Studies | Womens health | Preeclampsia | Amnion | Ligands | Monocyte chemoattractant protein 1 | Chemokines | Endocrinology
Journal Article
International immunology, ISSN 1460-2377, 2007, Volume 19, Issue 4, pp. 345 - 354
Forkhead box P3 (FOXP3) is currently thought to be the most specific marker for naturally occurring CD4+CD25+ T regulatory cells (nTregs). In mice, expression... 
INTERLEUKIN-2 | TGF-BETA | T cell activation | transcription factors | INDUCTION | IMMUNOLOGY | T cells | REGULATORY-CELLS | TRANSCRIPTION FACTOR FOXP3 | COSTIMULATION | GENERATION | FLOW-CYTOMETRY | DIFFERENTIATION | human | EXPRESSION | tolerance | T-Lymphocyte Subsets - immunology | Cysteine - analogs & derivatives | T-Lymphocytes, Regulatory - metabolism | Cell Proliferation | Coculture Techniques | Humans | Clonal Anergy | Receptors, Nerve Growth Factor - metabolism | Interferon-gamma - metabolism | Antigens, CD - metabolism | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Flagellin - pharmacology | Lymphocyte Activation - immunology | Forkhead Transcription Factors - metabolism | T-Lymphocyte Subsets - drug effects | Cysteine - pharmacology | Antigens, Differentiation - metabolism | Interleukin-2 - metabolism | Receptors, Tumor Necrosis Factor - metabolism | Cell Line | Cytokines - metabolism | Lectins, C-Type | Toll-Like Receptors - immunology | CD4-Positive T-Lymphocytes - metabolism | Glucocorticoid-Induced TNFR-Related Protein | Antigens, Differentiation, T-Lymphocyte - metabolism | CD28 Antigens - immunology | Antibodies - pharmacology | CTLA-4 Antigen | T-Lymphocytes, Regulatory - drug effects | Interleukin-2 Receptor alpha Subunit - metabolism | Lipoproteins - pharmacology | T-Lymphocyte Subsets - metabolism | Interleukin-7 Receptor alpha Subunit - metabolism | CD3 Complex - immunology | Interleukin-2 - pharmacology | CD4-Positive T-Lymphocytes - drug effects
Journal Article
Scientific reports, ISSN 2045-2322, 12/2015, Volume 5, Issue 1, p. 17935
Inflammasomes are cytoplasmic, multiprotein complexes that trigger caspase-1 activation and IL-1 beta maturation in response to diverse stimuli. Although... 
ASC | OXYGEN SPECIES PRODUCTION | STIMULATION | CASPASE-1 | MULTIDISCIPLINARY SCIENCES | SALMONELLA | IL-1-BETA | UNCOUPLING PROTEIN-2 | NALP3 INFLAMMASOME | CELL-DEATH | BETA | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Ion Channels - genetics | Caspase 1 - metabolism | Mitochondrial Proteins - genetics | Lipopolysaccharides - immunology | Autophagy - drug effects | Mitochondrial Proteins - metabolism | Flagellin - metabolism | Macrophages - immunology | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Peritonitis - etiology | Flagellin - immunology | Pneumonia - etiology | Cytokines - metabolism | Macrophage Activation - immunology | Apoptosis Regulatory Proteins - chemistry | Peritonitis - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Ion Channels - metabolism | Iridoids - pharmacology | CARD Signaling Adaptor Proteins | Chemokines - metabolism | Mice | Uncoupling Protein 2 | Pneumonia - metabolism | Protein Multimerization - drug effects | Mitochondrial uncoupling protein 2 | Oligomerization | Neutrophils | Aluminum sulfate | Caspase | Flagellin | IL-1β | Autophagy | Inflammatory diseases | Caspase-1 | Lipopolysaccharides | Genipin | Lungs | Peritonitis | Phagocytosis
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2009, Volume 323, Issue 5910, pp. 95 - 101
The perception of pathogen or microbe-associated molecular pattern molecules by plants triggers a basal defense response analogous to animal innate immunity... 
Hydrolysis | Pathogens | Molecules | Genes | Glucosinolates | Biosynthesis | Research Articles | Plants | Pretreatment | Seedlings | Plant cells | NONHOST RESISTANCE | ABC TRANSPORTER | PHYTOCHELATIN SYNTHASE | THALIANA | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | GLUTATHIONE-DEFICIENT MUTANT | CELL WALL | ABSCISIC-ACID | METAL-BINDING PEPTIDES | DISEASE RESISTANCE | Genes, Plant | Glucans - biosynthesis | Salicylic Acid - metabolism | Aminoacyltransferases - genetics | Arabidopsis - immunology | Glucosinolates - metabolism | Ethylenes - metabolism | Arabidopsis Proteins - metabolism | Indoles - metabolism | Salicylic Acid - pharmacology | ATP-Binding Cassette Transporters - genetics | Peptide Fragments - immunology | Gene Expression Regulation, Plant | ATP-Binding Cassette Transporters - metabolism | Indoles - pharmacology | Arabidopsis Proteins - genetics | Flagellin - immunology | Signal Transduction | N-Glycosyl Hydrolases - genetics | Transcription Factors - genetics | Immunity, Innate | Arabidopsis - metabolism | N-Glycosyl Hydrolases - metabolism | Arabidopsis - genetics | Transcription Factors - metabolism | Arabidopsis - microbiology | Aminoacyltransferases - metabolism | Glycoside Hydrolases - metabolism | Mutation | Immune response | Arabidopsis | Plant immunology | Physiological aspects | Research | Properties | Plant metabolites | Genetics | Molecular biology | Metabolism | Botany
Journal Article
Science (American Association for the Advancement of Science), ISSN 0036-8075, 12/2016, Volume 354, Issue 6318, pp. 1427 - 1430
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2004, Volume 279, Issue 41, pp. 42984 - 42992
The capacity of non-pathogenic enteric bacteria to induce a pro-inflammatory response is under debate in terms of its effect on the symbiosis between the... 
TOLL-LIKE RECEPTOR-4 | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE IMMUNE-RESPONSE | GENE-EXPRESSION | LIPOPOLYSACCHARIDE | BACTERIAL FLAGELLIN | INFECTION | NF-KAPPA-B | REGULATED EXPRESSION | INTERLEUKIN-8 | Ileum - pathology | Intestinal Mucosa - metabolism | Membrane Glycoproteins - metabolism | Enterocytes - metabolism | Humans | Membrane Glycoproteins - chemistry | Lipopolysaccharides - metabolism | Culture Media, Conditioned - pharmacology | NF-kappa B - metabolism | Chemokine CCL20 | RNA, Messenger - metabolism | Toll-Like Receptor 5 | Toll-Like Receptors | Cell Nucleus - metabolism | Transfection | Time Factors | Escherichia coli - metabolism | Flagellin - chemistry | Flagellin - metabolism | Antigens, Differentiation - metabolism | Receptors, Cell Surface - chemistry | Transcription, Genetic | Interleukin-8 - metabolism | Epithelial Cells - cytology | Caco-2 Cells | Cell Line | Cytokines - metabolism | Enzyme-Linked Immunosorbent Assay | Signal Transduction | Macrophage Inflammatory Proteins - metabolism | Cells, Cultured | Receptors, Cell Surface - metabolism | Inflammation | Myeloid Differentiation Factor 88 | Reverse Transcriptase Polymerase Chain Reaction | Plasmids - metabolism | Mice, Inbred C3H | Adaptor Proteins, Signal Transducing | Phenotype | Animals | Biopsy | Mice | Mutation | Receptors, Immunologic - metabolism | Chemokines, CC - metabolism | Life Sciences
Journal Article
The Journal of nutritional biochemistry, ISSN 0955-2863, 2013, Volume 24, Issue 9, pp. 1609 - 1615
The therapeutic effects of probiotic treatment in alcoholic liver disease (ALD) have been studied in both patients and experimental animal models. Although the... 
Probiotics | Alcohol | Inflammation | TNF | Liver | TRANSCRIPTION FACTORS | OXIDATIVE STRESS | CYTOKINE RESPONSES | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHRONIC ETHANOL | NECROSIS-FACTOR-ALPHA | BLOOD MONONUCLEAR-CELLS | CHROMOGENIC ASSAY | NUTRITION & DIETETICS | MESSENGER-RNA | TOLL-LIKE RECEPTORS | Probiotics - administration & dosage | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Leukocytes, Mononuclear - metabolism | Intestinal Mucosa - metabolism | Liver - pathology | Phosphorylation | Toll-Like Receptor 5 - genetics | Humans | Lipopolysaccharides - metabolism | Male | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | Gram-Negative Bacteria - metabolism | RNA, Messenger - metabolism | Lipopolysaccharides - adverse effects | Liver Diseases, Alcoholic - therapy | Flagellin - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Flagellin - adverse effects | Lactobacillus rhamnosus | Endotoxins - metabolism | Liver Diseases, Alcoholic - pathology | Toll-Like Receptor 5 - metabolism | Ethanol - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - metabolism | Inflammation - therapy | Macrophages - metabolism | Animals | Intestines - microbiology | Probiotics - therapeutic use | Mice | Endotoxins - adverse effects
Journal Article
Journal of investigative dermatology, ISSN 0022-202X, 2007, Volume 127, Issue 2, pp. 331 - 341
Keratinocytes are continuously in contact with external stimuli and have the capacity to produce several soluble mediators. Pathogen-associated molecular... 
TOLL-LIKE-RECEPTORS | DOUBLE-STRANDED-RNA | DENDRITIC CELLS | SKIN-ASSOCIATED CHEMOKINE | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | INNATE IMMUNE-RESPONSE | INFLAMMATORY PROTEIN 3-ALPHA | NECROSIS-FACTOR-ALPHA | FACTOR-KAPPA-B | HUMAN EPIDERMAL-KERATINOCYTES | DERMATOLOGY | Oligonucleotides - genetics | Phosphorylation | Toll-Like Receptor 5 - genetics | Humans | Toll-Like Receptor 9 - genetics | I-kappa B Proteins - metabolism | RNA, Messenger - metabolism | Flagellin - pharmacology | Tissue Distribution | Cell Nucleus - metabolism | Protein Isoforms - metabolism | Biological Transport | Oligonucleotides - pharmacology | Toll-Like Receptor 3 - genetics | Toll-Like Receptors - metabolism | Chemokine CXCL9 | Toll-Like Receptor 5 - metabolism | Poly I-C - pharmacology | Cytokines - metabolism | Cells, Cultured | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 3 - metabolism | Toll-Like Receptor 4 - metabolism | Chemokine CXCL10 | Transcription Factor RelA - metabolism | Keratinocytes - metabolism | Toll-Like Receptors - genetics | Chemokines, CXC - metabolism | Lipopolysaccharides - pharmacology | CpG Islands | Ligands | Chemokines - metabolism | Toll-Like Receptor 9 - metabolism | CD40 antigen | Oligonucleotides | Flagellin | mRNA | intercellular adhesion molecule 1 | Immunity | Lipopolysaccharides | CXC chemokines | CCL20 protein | Toll-like receptors | CpG islands | TLR7 protein | Dermatology | Keratinocytes | Nuclear transport | Stress | TLR3 protein | TLR9 protein | TLR1 protein | External stimuli | CXCL10 protein | Histocompatibility antigen HLA | Interferon | Internet | Monocyte chemoattractant protein 1 | Tumor necrosis factor- alpha
Journal Article
American journal of respiratory cell and molecular biology, ISSN 1535-4989, 2004, Volume 30, Issue 5, pp. 627 - 634
Journal Article