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Nature Medicine, ISSN 1078-8956, 11/2015, Volume 21, Issue 11, pp. 1326 - 1331
Mechanical allodynia, induced by normally innocuous low-threshold mechanical stimulation, represents a cardinal feature of neuropathic pain. Blockade or... 
MEDICINE, RESEARCH & EXPERIMENTAL | FLAGELLIN | NOCICEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TACTILE ALLODYNIA | INNATE | RATS | SPINAL-CORD | NERVE INJURY | CELL BIOLOGY | TOLL-LIKE RECEPTOR-5 | ITCH | PRIMARY SENSORY NEURONS | Lidocaine - pharmacology | Neuralgia - genetics | Capsaicin - pharmacology | Toll-Like Receptor 5 - genetics | Humans | Middle Aged | Neuralgia - metabolism | Male | Neurons - cytology | Ganglia, Spinal - cytology | Anesthetics, Local - pharmacology | Antineoplastic Agents - toxicity | Sensory System Agents - pharmacology | Flagellin - pharmacology | Paclitaxel - toxicity | Neuralgia - etiology | Nerve Fibers, Unmyelinated - drug effects | Adult | Female | Neurons - metabolism | Neurons - drug effects | Nerve Fibers, Myelinated - metabolism | Peripheral Nerve Injuries - complications | Hyperalgesia - metabolism | Nerve Fibers, Myelinated - drug effects | Mice, Knockout | Lidocaine - analogs & derivatives | Animals | Hyperalgesia - genetics | Hyperalgesia - etiology | Aged | Mice | Ganglia, Spinal - drug effects | Neurofilament Proteins - metabolism | Diabetic Neuropathies - complications | Ganglia, Spinal - metabolism | Genetically modified mice | Care and treatment | Pain | Dorsal root ganglia | Management | Research | TLR5 | Chronic pain | Pharmacology | Neurological disorders | Pain management | Immune system | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2008, Volume 283, Issue 36, pp. 24748 - 24759
The generation of reactive oxygen species is a central feature of inflammation that results in the oxidation of host phospholipids. Oxidized phospholipids,... 
ACTIVATION | ESCHERICHIA-COLI LIPOPOLYSACCHARIDE | INDUCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIPID RAFTS | ENDOTHELIAL-CELLS | LOW-DENSITY-LIPOPROTEIN | HEME OXYGENASE-1 | MONOCYTE CHEMOTACTIC PROTEIN-1 | OXIDATION-PRODUCTS | T-LYMPHOCYTES | Phosphatidylcholines - immunology | Reactive Oxygen Species - metabolism | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - metabolism | Lymphocyte Antigen 96 - metabolism | Humans | Tumor Necrosis Factor-alpha - genetics | Macrophages, Peritoneal - cytology | Flagellin - pharmacology | Lymphocyte Antigen 96 - agonists | Oxidation-Reduction - drug effects | Tumor Necrosis Factor-alpha - immunology | Toll-Like Receptor 4 - agonists | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Carrier Proteins - immunology | Guanosine - analogs & derivatives | Poly I-C - pharmacology | Macrophages, Peritoneal - immunology | Toll-Like Receptor 4 - genetics | Lipopolysaccharide Receptors - immunology | Toll-Like Receptor 4 - immunology | p38 Mitogen-Activated Protein Kinases - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | I-kappa B Kinase - immunology | Mice | Mice, Inbred BALB C | Macrophages, Peritoneal - metabolism | Oligodeoxyribonucleotides - pharmacology | Immunologic Factors - pharmacology | Lymphocyte Antigen 96 - immunology | Tumor Necrosis Factor-alpha - metabolism | Toll-Like Receptor 2 - agonists | Acute-Phase Proteins - genetics | Lipopolysaccharide Receptors - metabolism | Lymphocyte Antigen 96 - genetics | Carrier Proteins - agonists | I-kappa B Kinase - metabolism | Reactive Oxygen Species - immunology | Female | Membrane Glycoproteins - immunology | Cell Line | Acute-Phase Proteins - metabolism | Phosphatidylcholines - pharmacology | Membrane Glycoproteins - agonists | p38 Mitogen-Activated Protein Kinases - genetics | I-kappa B Kinase - genetics | Membrane Glycoproteins - genetics | Carrier Proteins - genetics | Phosphatidylcholines - genetics | Animals | Carrier Proteins - metabolism | RNA - pharmacology | Guanosine - pharmacology | Lipopolysaccharide Receptors - genetics | Signal Transduction - physiology | Acute-Phase Proteins - agonists | Acute-Phase Proteins - immunology | Index Medicus | Lipids and Lipoproteins | Metabolism, Regulation, and Signaling
Journal Article
Leukemia, ISSN 0887-6924, 06/2006, Volume 20, Issue 6, pp. 1138 - 1144
Multiple myeloma (MM) is an incurable B-cell malignancy characterized by (a)ccumulation of malignant plasma cells in bone marrow (BM) and recurrent or... 
Plasma cells | Proliferation | Survival | Toll-like receptor | Multiple myeloma | CPG OLIGODEOXYNUCLEOTIDES | IMMUNE-RESPONSE | multiple myeloma | ACTIVATION | proliferation | survival | plasma cells | ENDOGENOUS LIGANDS | BLOOD MONONUCLEAR-CELLS | PLASMA-CELLS | STAGING SYSTEM | MEMORY B-CELLS | MESSENGER-RNA | ONCOLOGY | toll-like receptor | HEMATOLOGY | NF-KAPPA-B | RNA, Messenger - immunology | Interleukin-6 - antagonists & inhibitors | Humans | Multiple Myeloma - immunology | Gene Expression Profiling | Proteoglycans - drug effects | Flagellin - pharmacology | Toll-Like Receptors - drug effects | Membrane Glycoproteins - immunology | Interleukin-6 - metabolism | RNA, Messenger - drug effects | Cell Survival - drug effects | Poly I-C - pharmacology | Syndecans | Proteoglycans - immunology | Dipeptides - pharmacology | RNA, Messenger - genetics | Toll-Like Receptors - immunology | Imidazoles - pharmacology | Cell Survival - immunology | Reverse Transcriptase Polymerase Chain Reaction | Interleukin-6 - pharmacology | Lipoproteins - pharmacology | Toll-Like Receptors - genetics | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Membrane Glycoproteins - drug effects | Ligands | Cell Proliferation - drug effects | Oligodeoxyribonucleotides - pharmacology | Oligopeptides - pharmacology | Lipopeptides | Multiple Myeloma - genetics | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, pp. e60769 - e60769
Programmed cell death (PCD) is a crucial process for plant innate immunity and development. In plant innate immunity, PCD is believed to prevent the spread of... 
DEFENSE | ARABIDOPSIS-THALIANA | ACTIVATED PROTEIN-KINASE | SALICYLIC-ACID | MULTIDISCIPLINARY SCIENCES | TRANSGENIC PLANTS | STRESS | JASMONIC ACID | DISEASE RESISTANCE | III SECRETION SYSTEM | INNATE IMMUNITY | Peptide Elongation Factor Tu - pharmacology | Mitogen-Activated Protein Kinase Kinases - genetics | Salicylic Acid - metabolism | Cell Death - immunology | Mitogen-Activated Protein Kinase Kinases - immunology | Arabidopsis - immunology | Peptide Fragments - pharmacology | Ethylenes - metabolism | Flagellin - pharmacology | Salicylic Acid - pharmacology | Plant Immunity - drug effects | Mitogen-Activated Protein Kinases - immunology | Cell Death - drug effects | Ethylenes - pharmacology | Fumonisins - pharmacology | Arabidopsis Proteins - genetics | Arabidopsis - drug effects | Signal Transduction | Gene Expression Regulation, Plant - immunology | Arabidopsis Proteins - immunology | Chitin - pharmacology | Arabidopsis - genetics | Oxylipins - metabolism | Bacterial Proteins - pharmacology | Gene Expression Regulation, Plant - drug effects | Cyclopentanes - metabolism | Mitogen-Activated Protein Kinases - genetics | Mycotoxins - pharmacology | Plant Growth Regulators - metabolism | Plant Growth Regulators - pharmacology | Physiological aspects | Research | Cell death | Arabidopsis | Immunity | Phosphorylation | Genomics | Plant biology | Flagellin | Innate immunity | Biosynthesis | Kinases | Proteins | Bacteria | Trends | Jasmonic acid | Elongation | Pathogens | Salicylic acid | Cell walls | Mortality | Elongation factor EF-Tu | Chitin | Pattern recognition | Mutants | Studies | Signaling | Fumonisin B1 | Molecular modelling | Acids | Mutation | Fitness | Apoptosis | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 01/2014, Volume 192, Issue 2, pp. 763 - 770
Inflammasomes are large cytoplasmic multiprotein complexes that activate caspase-1 in response to diverse intracellular danger signals. Inflammasome components... 
ANTHRAX LETHAL TOXIN | MULTIPLE-MYELOMA | KINASE-KINASE | KAPPA-B ACTIVATION | CASPASE-1 | INFLAMMATION | DISEASE | SUSCEPTIBILITY | IMMUNOLOGY | CANCER-THERAPY | ACUTE PROMYELOCYTIC LEUKEMIA | Arsenites - pharmacology | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Caspase 1 - metabolism | Flagellin - pharmacology | Proteolysis - drug effects | Inflammasomes - drug effects | Interleukin-1beta - metabolism | Cell Death - drug effects | Nitrogen Oxides - metabolism | Neutrophils - metabolism | Calcium-Binding Proteins - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Immunity, Innate - drug effects | Arsenicals - pharmacology | Neutrophils - drug effects | Antigens, Bacterial - pharmacology | Nuclear Proteins - metabolism | Sodium Compounds - pharmacology | Neuronal Apoptosis-Inhibitory Protein - metabolism | Apoptosis Regulatory Proteins - metabolism | Transcription Factors - metabolism | Oxides - pharmacology | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Signal Transduction - drug effects | Bacterial Toxins - pharmacology | Macrophages - drug effects | Mice | Mice, Inbred BALB C | Nigericin - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Promyelocytic Leukemia Protein | Index Medicus | Abridged Index Medicus
Journal Article
Plant Physiology, ISSN 0032-0889, 6/2011, Volume 156, Issue 2, pp. 726 - 740
Piriformospora indica is a root-colonizing basidiomycete that confers a wide range of beneficial traits to its host. The fungus shows a biotrophic growth phase... 
Fungi | Pathogens | Microbial colonization | Cell death | Plant roots | Hyphae | Innate immunity | Plants | Gene expression | Plant cells | PLANTS INTERACTING WITH OTHER ORGANISMS | DEFENSE | SALICYLIC-ACID | THALIANA | PLANT-CELLS | PSEUDOMONAS-SYRINGAE | MECHANISMS | JASMONIC ACID | DISEASE RESISTANCE | HYPERSENSITIVE RESPONSE | CELL-DEATH | PLANT SCIENCES | Organ Specificity - drug effects | Arabidopsis - immunology | Basidiomycota - drug effects | Plant Roots - ultrastructure | Organ Specificity - immunology | Receptors, Pattern Recognition - metabolism | Salicylic Acid - pharmacology | Flagellin - metabolism | Plant Immunity - drug effects | Glucans - metabolism | Cell Death - drug effects | Basidiomycota - growth & development | Immunity, Innate - drug effects | Arabidopsis - ultrastructure | Plant Roots - cytology | Cyclopentanes - pharmacology | Plant Roots - microbiology | Arabidopsis - genetics | Arabidopsis - microbiology | Immunity, Innate - immunology | Gene Expression Regulation, Plant - drug effects | Glucosinolates - pharmacology | Models, Biological | Plant Roots - immunology | Oxylipins - pharmacology | Gibberellins - pharmacology | Plant Immunity - immunology | Plant Growth Regulators - pharmacology | Arabidopsis thaliana | Physiological aspects | Roots (Botany) | Research | Immunity | Index Medicus
Journal Article
Acta Biomaterialia, ISSN 1742-7061, 09/2016, Volume 42, pp. 66 - 76
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2016, Volume 11, Issue 3, pp. e0151350 - e0151350
Journal Article
The Journal of Immunology, ISSN 0022-1767, 11/2003, Volume 171, Issue 10, pp. 4984 - 4989
Dendritic cells (DCs) are pivotal in determining the class of an adaptive immune response. However, the molecular mechanisms within DCs that determine this... 
HELPER-CELL | IMMUNE-RESPONSE | LIGANDS | DNA | IN-VIVO | GENE-EXPRESSION | INNATE | SUBSETS | IMMUNOLOGY | PATHOGENS | Toll-Like Receptor 2 | Phosphorylation | Adjuvants, Immunologic - pharmacology | Toll-Like Receptor 4 | Helminth Proteins - pharmacology | Monocytes - cytology | Dendritic Cells - immunology | Humans | Monocytes - metabolism | Monocytes - immunology | Th1 Cells - immunology | Toll-Like Receptor 5 | MAP Kinase Signaling System - immunology | Flagellin - pharmacology | Th1 Cells - metabolism | Toll-Like Receptors | Membrane Glycoproteins - physiology | T-Lymphocytes, Helper-Inducer - immunology | Interleukin-12 - antagonists & inhibitors | T-Lymphocytes, Helper-Inducer - enzymology | Receptors, Cell Surface - physiology | p38 Mitogen-Activated Protein Kinases | Dendritic Cells - metabolism | Interleukin-12 - biosynthesis | Antigens, Helminth | T-Lymphocytes, Helper-Inducer - metabolism | Mitogen-Activated Protein Kinase 1 - physiology | Dipeptides - pharmacology | Cells, Cultured | Membrane Glycoproteins - agonists | Proto-Oncogene Proteins c-fos - metabolism | Receptors, Cell Surface - agonists | Escherichia coli - immunology | Protein Subunits - biosynthesis | Mitogen-Activated Protein Kinase 8 | Mitogen-Activated Protein Kinases - physiology | Lipoproteins - pharmacology | Lipopolysaccharides - pharmacology | Protein Subunits - antagonists & inhibitors | Proto-Oncogene Proteins c-fos - physiology | Mitogen-Activated Protein Kinase 3 | Index Medicus | Abridged Index Medicus
Journal Article
International Immunology, ISSN 0953-8178, 4/2007, Volume 19, Issue 4, pp. 345 - 354
Forkhead box P3 (FOXP3) is currently thought to be the most specific marker for naturally occurring CD4+CD25+ T regulatory cells (nTregs). In mice, expression... 
INTERLEUKIN-2 | TGF-BETA | T cell activation | transcription factors | INDUCTION | IMMUNOLOGY | T cells | REGULATORY-CELLS | TRANSCRIPTION FACTOR FOXP3 | COSTIMULATION | GENERATION | FLOW-CYTOMETRY | DIFFERENTIATION | human | EXPRESSION | tolerance | T-Lymphocyte Subsets - immunology | Cysteine - analogs & derivatives | T-Lymphocytes, Regulatory - metabolism | Cell Proliferation | Coculture Techniques | Humans | Clonal Anergy | Receptors, Nerve Growth Factor - metabolism | Interferon-gamma - metabolism | Antigens, CD - metabolism | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Flagellin - pharmacology | Lymphocyte Activation - immunology | Forkhead Transcription Factors - metabolism | T-Lymphocyte Subsets - drug effects | Cysteine - pharmacology | Antigens, Differentiation - metabolism | Interleukin-2 - metabolism | Receptors, Tumor Necrosis Factor - metabolism | Cell Line | Cytokines - metabolism | Lectins, C-Type | Toll-Like Receptors - immunology | CD4-Positive T-Lymphocytes - metabolism | Glucocorticoid-Induced TNFR-Related Protein | Antigens, Differentiation, T-Lymphocyte - metabolism | CD28 Antigens - immunology | Antibodies - pharmacology | CTLA-4 Antigen | T-Lymphocytes, Regulatory - drug effects | Interleukin-2 Receptor alpha Subunit - metabolism | Lipoproteins - pharmacology | T-Lymphocyte Subsets - metabolism | Interleukin-7 Receptor alpha Subunit - metabolism | CD3 Complex - immunology | Interleukin-2 - pharmacology | CD4-Positive T-Lymphocytes - drug effects | Index Medicus
Journal Article