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Diabetologia, ISSN 0012-186X, 2005, Volume 48, Issue 11, pp. 2365 - 2375
Aims/hypothesis Intake of n-3 polyunsaturated fatty acids reduces adipose tissue mass, preferentially in the abdomen. The more pronounced effect of... 
activated protein-kinase | linolenic acid | cpt-i | messenger-rna | gene-expression | coactivator pgc-1-alpha | metabolism | adipose-tissue | dietary fish-oil | obesity | Medicine | Mitochondria | Adipose tissue | n -3 Polyunsaturated fatty acids | PGC-1 | Flax-seed oil | Metabolism | Fish oil | PPARGC1A | Carnitine palmitoyltransferase 1 | n-3 Polyunsaturated fatty acids | ACTIVATED PROTEIN-KINASE | mitochondria | DIETARY FISH-OIL | fish oil | adipose tissue | LINOLENIC ACID | OBESITY | MESSENGER-RNA | carnitine palmitoyltransferase 1 | CPT-I | n-3 polyunsaturated fatty acids | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | flax-seed oil | COACTIVATOR PGC-1-ALPHA | ADIPOSE-TISSUE | Epididymis - metabolism | Carnitine O-Palmitoyltransferase - genetics | Trans-Activators - drug effects | Male | NF-E2-Related Factor 1 - genetics | Adipocytes - drug effects | Mitochondrial Proteins - drug effects | alpha-Linolenic Acid - pharmacology | Adipose Tissue - metabolism | Subcutaneous Fat - metabolism | Eicosapentaenoic Acid - pharmacology | Mitochondrial Proteins - metabolism | NF-E2-Related Factor 1 - drug effects | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Subcutaneous Fat - drug effects | Trans-Activators - genetics | Carnitine O-Palmitoyltransferase - drug effects | Epididymis - drug effects | Oxidation-Reduction | Mice, Inbred C57BL | Cells, Cultured | Fatty Acids, Unsaturated - pharmacology | Mitochondria - metabolism | Fatty Acids, Unsaturated - metabolism | Mitochondria - drug effects | Gene Expression Regulation - drug effects | Docosahexaenoic Acids - pharmacology | Animals | Fatty Acids, Unsaturated - isolation & purification | Adipocytes - metabolism | Lipogenesis - drug effects | Obesity - prevention & control | Mice | Transcription Factors | Adipose Tissue - drug effects | Fish Oils - chemistry
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2013, Volume 288, Issue 33, pp. 24173 - 24188
The oil from flax (Linum usitatissimum L.) has high amounts of alpha-linolenic acid (ALA; 18:3(cis Delta 9,12,15)) and is one of the richest sources of omega-3... 
ARABIDOPSIS-THALIANA | TRIACYLGLYCEROL BIOSYNTHESIS | LIPID-SYNTHESIS | FUNCTIONAL EXPRESSION | BRASSICA-NAPUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLYUNSATURATED FATTY-ACIDS | TRANSGENIC PLANTS | ENDOPLASMIC-RETICULUM | SACCHAROMYCES-CEREVISIAE | ALPHA-LINOLENIC ACID | Organ Specificity - drug effects | Flax - genetics | Gas Chromatography-Mass Spectrometry | Triglycerides - biosynthesis | Saccharomyces cerevisiae - genetics | Seeds - enzymology | Esters - metabolism | Saccharomyces cerevisiae - drug effects | Gene Expression Profiling | Acyltransferases - metabolism | Acyltransferases - genetics | Genetic Complementation Test | alpha-Linolenic Acid - pharmacology | Organ Specificity - genetics | Biocatalysis - drug effects | Plants, Genetically Modified | Recombination, Genetic - genetics | Real-Time Polymerase Chain Reaction | Arabidopsis - drug effects | Seeds - drug effects | Seeds - genetics | Flax - enzymology | Mutation - genetics | Flax - drug effects | Arabidopsis - genetics | Gene Expression Regulation, Plant - drug effects | Phenotype | Substrate Specificity - drug effects | Genes, Plant - genetics | Plant Oils - metabolism | Diacylglycerol O-Acyltransferase - metabolism | Recombination, Genetic - drug effects | Saccharomyces cerevisiae - growth & development | Metabolic Engineering | Molecular Genetics | Phospholipid:diacylglycerol Acyltransferases | Triacylglycerol | Lipids | Lipid Metabolism | Plant Molecular Biology | Flax | α-Linolenic Acid
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, p. e30571
Background: In experimental models, hypothalamic inflammation is an early and determining factor in the installation and progression of obesity.... 
GLUCOSE-HOMEOSTASIS | ENERGY | INHIBITION | FOOD-INTAKE | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | SENSITIVITY | LEPTIN RECEPTOR | ACCUMULATION | BRAIN | Gene Expression - drug effects | Rats, Wistar | Receptors, G-Protein-Coupled - metabolism | Immunoblotting | Male | Olive Oil | Inflammation - blood | Dietary Fats - administration & dosage | Obesity - etiology | Weight Gain - drug effects | Fatty Acids - blood | Hypothalamus - drug effects | Plant Oils - administration & dosage | Pro-Opiomelanocortin - genetics | Fatty Acids - metabolism | Fatty Acids, Omega-3 - administration & dosage | Dietary Fats - adverse effects | Fatty Acids - chemistry | Insulin Resistance | Rats | Obesity - physiopathology | Hypothalamus - pathology | Reverse Transcriptase Polymerase Chain Reaction | Inflammation - etiology | Nerve Tissue Proteins - genetics | Eating - drug effects | Animals | Hypothalamus - metabolism | Signal Transduction - drug effects | Obesity - prevention & control | Dietary Fats, Unsaturated - administration & dosage | Inflammation - prevention & control | Mice | Obesity | Brain | Unsaturated fatty acids | Diet | Analysis | Insulin resistance | Cellular signal transduction | Inflammation | Olive oil | Animal models | Adipose tissue | Laboratories | Proopiomelanocortin | Hypothalamus | Signal transduction | Rodents | Nutrients | Tumor necrosis factor-TNF | Food | Medical research | Internal medicine | Neurons | Pharmacology | Injection | Metabolism | Insulin | Fatty acids | Medicine | Thermogenesis | Body mass | Food intake | Leptin | Transduction | Diabetes | Fats and oils | Flax
Journal Article
Journal of the Science of Food and Agriculture, ISSN 0022-5142, 03/2013, Volume 93, Issue 5, pp. 1016 - 1025
BACKGROUND: Current scenarios of global climate change predict a significant increase in ultraviolet B (UV‐B) and tropospheric ozone (O3) in the near future.... 
seed quality | fatty acids | sUV‐B | Linum usitatissimum L | yield | SUV-B | Yield | Fatty acids | Seed quality | O | PROTEIN | FATTY-ACID-COMPOSITION | FOOD SCIENCE & TECHNOLOGY | WHEAT | RADIATION | ORYZA-SATIVA L | RESPONSES | POLLUTION | sUV-B | GROWTH | AGRICULTURE, MULTIDISCIPLINARY | CHEMISTRY, APPLIED | IMPACTS | PHOTOSYNTHESIS | Carbohydrate Metabolism - drug effects | Flax - growth & development | Seeds - radiation effects | Food Quality | Air - analysis | Species Specificity | Flax - metabolism | Fruit - drug effects | Crops, Agricultural - growth & development | Fruit - radiation effects | Oxidants, Photochemical - analysis | Crops, Agricultural - radiation effects | Seeds - growth & development | Gametogenesis, Plant - radiation effects | Minerals - metabolism | Oxidants, Photochemical - adverse effects | Protein Biosynthesis - radiation effects | Fatty Acids - metabolism | Fruit - metabolism | Ozone - adverse effects | Seeds - metabolism | Seeds - drug effects | Crops, Agricultural - drug effects | Seed Storage Proteins - biosynthesis | Fatty Acids - analysis | Gametogenesis, Plant - drug effects | Ozone - analysis | Flax - radiation effects | Flax - drug effects | Linseed Oil - chemistry | Ultraviolet Rays - adverse effects | India | Carbohydrate Metabolism - radiation effects | Fruit - growth & development | Climate Change | Protein Biosynthesis - drug effects | Crops, Agricultural - metabolism | Seeds | Greenhouse effect | Global temperature changes | Air pollution | Sport-utility vehicles | Cultivars
Journal Article
Ecotoxicology and Environmental Safety, ISSN 0147-6513, 2010, Volume 73, Issue 5, pp. 1004 - 1011
Journal Article
Plant Physiology, ISSN 0032-0889, 4/2016, Volume 170, Issue 4, pp. 1917 - 1928
Journal Article
International Immunopharmacology, ISSN 1567-5769, 09/2015, Volume 28, Issue 1, pp. 751 - 763
Objective of the present investigation was to study the effect of the flax lignan concentrate (FLC) and Omega-3-fatty acid (O-3-FA) on myocardial apoptosis,... 
Antioxidants | Flax lignan concentrate | TNF-α | VEGF | ROS | Cardiac hypertrophy | Electrocardiography | Omega-3-fatty acid | Apoptosis | ALCOHOLIC NEUROPATHY | TNF-alpha | DIETARY FLAXSEED | IMMUNOLOGY | LEFT-VENTRICULAR HYPERTROPHY | BLOOD-PRESSURE | ISCHEMIA-REPERFUSION INJURY | CARDIOMYOCYTE APOPTOSIS | SECOISOLARICIRESINOL DIGLUCOSIDE | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | INDUCED CARDIAC-HYPERTROPHY | ENDOTHELIAL GROWTH-FACTOR | Aortic Valve Stenosis - drug therapy | Rats, Wistar | Apoptosis - drug effects | Male | Lignans - therapeutic use | Plant Extracts - administration & dosage | Seeds - chemistry | Drug Therapy, Combination | Cardiomyopathy, Hypertrophic - etiology | Disease Models, Animal | Fatty Acids, Omega-3 - administration & dosage | Cardiomyopathy, Hypertrophic - metabolism | Ventricular Function, Left - drug effects | Plant Extracts - isolation & purification | Flax - chemistry | Lignans - isolation & purification | Lignans - administration & dosage | Aortic Valve Stenosis - complications | Animals | Aortic Valve Stenosis - pathology | Fatty Acids, Omega-3 - therapeutic use | Aortic Valve Stenosis - metabolism | Hemodynamics - drug effects | Cardiomyopathy, Hypertrophic - prevention & control | Oxidative Stress - drug effects | Plant Extracts - therapeutic use | Cardiomyopathy, Hypertrophic - pathology | Heart | Oxidative stress | Vascular endothelial growth factor | Fatty acids | Hypertrophy
Journal Article