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1. Full Text Narrow therapeutic index drugs: a clinical pharmacological consideration to flecainide
by Tamargo, Juan and Le Heuzey, Jean-Yves and Mabo, Phillipe
European Journal of Clinical Pharmacology, ISSN 0031-6970, 5/2015, Volume 71, Issue 5, pp. 549 - 567
The therapeutic index (TI) is the range of doses at which a medication is effective without unacceptable adverse events. Drugs with a narrow TI (NTIDs) have a... 
Generic drugs | Antiarrhythmic drugs | Biomedicine | Bioequivalence | Narrow therapeutic index | Safety | Pharmacology/Toxicology | Flecainide | INTRAVENOUS FLECAINIDE | VENTRICULAR-TACHYCARDIA | GENERIC FORMULATIONS | ELECTRICAL CARDIOVERSION | PLASMA-CONCENTRATIONS | PAROXYSMAL ATRIAL-FIBRILLATION | PHARMACOLOGY & PHARMACY | ANTIARRHYTHMIC THERAPY | CYP2D6 GENOTYPE | ORAL FLECAINIDE | SINUS RHYTHM | Dose-Response Relationship, Drug | Flecainide - adverse effects | Drugs, Generic - adverse effects | Drugs, Generic - pharmacokinetics | Drugs, Generic - pharmacology | Humans | Flecainide - pharmacokinetics | Flecainide - pharmacology | Practice Guidelines as Topic | Therapeutic Equivalency | Drugs | Health aspects | Cardiac arrhythmia | Side effects | Pharmacology | Index Medicus | Life Sciences | Bioengineering | Pharmaceutical sciences | Review
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2. Full Text Flecainide Therapy Reduces Exercise-Induced Ventricular Arrhythmias in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia
by van der Werf, Christian, MD and Kannankeril, Prince J., MD, MSCI and Sacher, Frederic, MD and Krahn, Andrew D., MD and Viskin, Sami, MD and Leenhardt, Antoine, MD and Shimizu, Wataru, MD, PhD and Sumitomo, Naokata, MD and Fish, Frank A., MD and Bhuiyan, Zahurul A., MD, PhD and Willems, Albert R., MD, PhD and van der Veen, Maurits J., MD, PhD and Watanabe, Hiroshi, MD, PhD and Laborderie, Julien, MD and Haïssaguerre, Michel, MD and Knollmann, Björn C., MD, PhD and Wilde, Arthur A.M., MD, PhD
Journal of the American College of Cardiology, ISSN 0735-1097, 2011, Volume 57, Issue 22, pp. 2244 - 2254
Objectives This study evaluated the efficacy and safety of flecainide in addition to conventional drug therapy in patients with catecholaminergic polymorphic... 
Cardiovascular | Internal Medicine | ventricular arrhythmia | antiarrhythmia agents | catecholaminergic polymorphic ventricular tachycardia | CARDIAC & CARDIOVASCULAR SYSTEMS | SUDDEN-DEATH | FOLLOW-UP | RECEPTOR CA2+ RELEASE | DEPOLARIZATION | THRESHOLD | CHANNEL | FAMILIES | RYR2 MUTATIONS | CASQ2 | CARDIAC SYMPATHETIC DENERVATION | Arrhythmias, Cardiac - prevention & control | Flecainide - administration & dosage | Tachycardia, Ventricular - drug therapy | Anti-Arrhythmia Agents - pharmacology | Humans | Middle Aged | Male | Flecainide - pharmacology | Anti-Arrhythmia Agents - therapeutic use | Anti-Arrhythmia Agents - administration & dosage | Dose-Response Relationship, Drug | Young Adult | Exercise Test | Defibrillators, Implantable | Adolescent | Adult | Female | Aged | Retrospective Studies | Child | Flecainide - therapeutic use | Heart failure | Medical colleges | Care and treatment | Implants, Artificial | Prosthesis | Cardiac patients | Ventricular tachycardia | Cardiology | Flecainide | Cardiac arrhythmia | Heart attacks | Exercise | Defibrillators
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3. Full Text Impact of Na.sup.+ channel blockers on transmural dispersion of refractoriness and arrhythmic susceptibility in guinea-pig left ventricle
by Osadchii, Oleg E
European Journal of Pharmacology, ISSN 0014-2999, 09/2012, Volume 691, Issue 1-3, p. 173
Tachycardia | Flecainide
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4. Full Text Radiofrequency Ablation as Initial Therapy in Paroxysmal Atrial Fibrillation
by Cosedis Nielsen, Jens and Johannessen, Arne and Raatikainen, Pekka and Hindricks, Gerhard and Walfridsson, Håkan and Kongstad, Ole and Pehrson, Steen and Englund, Anders and Hartikainen, Juha and Mortensen, Leif Spange and Hansen, Peter Steen and Kardiologi and Cardiology and Lund University and Lunds universitet
The New England Journal of Medicine, ISSN 0028-4793, 10/2012, Volume 367, Issue 17, pp. 1587 - 1595
In this trial, patients with symptomatic paroxysmal atrial fibrillation were assigned to either radiofrequency ablation or antiarrhythmic drug therapy as... 
TRIAL | MEDICINE, GENERAL & INTERNAL | MANAGEMENT | EFFICACY | SUBSTRATE | PULMONARY VEIN ABLATION | GUIDELINES | CATHETER ABLATION | COMPLICATIONS | SOCIETY | ANTIARRHYTHMIC-DRUG THERAPY | Follow-Up Studies | Atrial Fibrillation - drug therapy | Humans | Middle Aged | Propafenone - adverse effects | Cost of Illness | Male | Treatment Outcome | Anti-Arrhythmia Agents - therapeutic use | Atrial Fibrillation - surgery | Flecainide - adverse effects | Anti-Arrhythmia Agents - adverse effects | Atrial Flutter - diagnosis | Intention to Treat Analysis | Statistics, Nonparametric | Quality of Life | Female | Aged | Propafenone - therapeutic use | Catheter Ablation - adverse effects | Atrial Fibrillation - diagnosis | Electrocardiography, Ambulatory | Flecainide - therapeutic use | Care and treatment | Usage | Atrial fibrillation | Patient outcomes | Anti-arrhythmia drugs | Radiofrequency ablation | Dosage and administration | Drug therapy | Heart | Fees & charges | Cardiac arrhythmia | Stroke | Arrhythmia | Platelet-activating factor | Cardiovascular disease | Grants | Patients | Catheters | Manuscripts | Tamponade | Fibrillation | Motivation | Electrocardiography | Drug dosages | Antiarrhythmic agents | Veins & arteries | Kardiologi | Clinical Medicine | Cardiac and Cardiovascular Systems | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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5. Full Text Twenty-five years in the making: flecainide is safe and effective for the management of atrial fibrillation
by Aliot, Etienne and Capucci, Alessano and Crijns, Harry J and Goette, Aneas and Tamargo, Juan
Europace, ISSN 1099-5129, 02/2011, Volume 13, Issue 2, pp. 161 - 173
Atrial fibrillation (AF) is the most common arrhythmia in clinical practise and its prevalence is increasing. Over the last 25 years, flecainide has been used... 
Remodelling | Cardioversion | Safety | Flecainide | Atrial fibrillation | Sinus rhythm maintenance | RHYTHM-CONTROL | ACTION-POTENTIALS | INTRAVENOUS FLECAINIDE | CARDIAC & CARDIOVASCULAR SYSTEMS | ELECTROPHYSIOLOGIC PROPERTIES | FOLLOW-UP | GUINEA-PIG | ELECTRICAL CARDIOVERSION | EURO HEART SURVEY | QUALITY-OF-LIFE | SINUS RHYTHM | Flecainide - adverse effects | Prevalence | Atrial Fibrillation - epidemiology | Anti-Arrhythmia Agents - adverse effects | Atrial Fibrillation - drug therapy | Humans | Treatment Outcome | Anti-Arrhythmia Agents - therapeutic use | Flecainide - therapeutic use | Review
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6. Full Text EP04.11: Transplacental treatment of fetal supraventricular tachycardia with a combination of sotalol and flecainide
by Kwon, J and Shin, J and Park, I
Ultrasound in Obstetrics & Gynecology, ISSN 0960-7692, 09/2015, Volume 46, Issue S1, pp. 197 - 197
Drug therapy | Flecainide | Tachycardia
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7. Full Text Be careful in using flecainide by hemodialyzed patients
by Montagnac, Richard and Schoen, ERic and Aliouche, CameLia-Pop and Schillinger, Francis
Nephrologie & Therapeutique, ISSN 1769-7255, 12/2006, Volume 2, Issue 7, p. 442
Les troubles du rythme frequemment observes chez les insuffisants renaux chroniques peuvent amener a prescrire des antiarythmiques, parmi lesquels l'acetate de... 
Flecainide
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8. Full Text ATRIAL FIBRILLATION: HOW LONG HAS IT BEEN? REPLY
by deSouza, IS and Benabbas, R
JOURNAL OF EMERGENCY MEDICINE, ISSN 0736-4679, 10/2018, Volume 55, Issue 4, pp. 571 - 571
FLECAINIDE | EMERGENCY MEDICINE | IMMEDIATE CARDIOVERSION
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9. Full Text Stability‐indicating chromatographic methods for determination of flecainide acetate in the presence of its degradation products; isolation and identification of two of its impurities
by El‐Ragehy, Nariman A and Hassan, Nagiba Y and Tantawy, Mahmoud A and Abdelkawy, Mohamed
Biomedical Chromatography, ISSN 0269-3879, 10/2016, Volume 30, Issue 10, pp. 1541 - 1548
In this work, two stability‐indicating chromatographic methods have been developed and validated for determination of flecainide acetate (an antiarrhythmic... 
flecainide acetate | TLC‐densitometry | flecainide impurity B | flecainide impurity D | HPLC | TLC-densitometry | CHEMISTRY, ANALYTICAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | MASS-SPECTROMETRY | WHOLE-BLOOD | EXTRACTION | LIQUID-CHROMATOGRAPHY | PHARMACOLOGY & PHARMACY | SEPARATION | ANTIARRHYTHMIC-DRUGS | Reference Standards | Reproducibility of Results | Chromatography, High Pressure Liquid - methods | Chromatography, Thin Layer - methods | Anti-Arrhythmia Agents - analysis | Flecainide - analysis | Spectrophotometry, Ultraviolet | Esters | Flecainide | Methods | High performance liquid chromatography
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10. Effects of potassium channel and Na super(+)-Ca super(2+) exchange blockers on the responses of slowly adapting pulmonary stretch receptors to hyperinflation in flecainide-treated rats
by Matsumoto, S and Nishikawa, T and Yoshida, S and Ikeda, M and Tanimoto, T and Saiki, C and Takeda, M
British Journal of Pharmacology, ISSN 0007-1188, 10/2001, Volume 134, Issue 3, pp. 682 - 690
The effects of K super(+) channel blockers, such as 4-aminopyridine (4-AP) and tetraethylammonium (TEA), and a reverse-mode Na super(+)-Ca super(2+) exchange... 
flecainide
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11. Full Text Double Whammy: A Fatal Case of Sodium Channel and Beta Blocker Overdose Unresponsive to VA-ECMO
by Dean, D and Baltarowich, L
CLINICAL TOXICOLOGY, ISSN 1556-3650, 10/2019, Volume 57, Issue 10, pp. 944 - 944
ECMO | overdose | TOXICOLOGY | Flecainide
Conference Proceeding
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12. Full Text Fatal Flecainide Overdose
by Mostafa, AMT and Ershad, M and Dela Cruz, M and Vearrier, D
CLINICAL TOXICOLOGY, ISSN 1556-3650, 10/2019, Volume 57, Issue 10, pp. 1002 - 1003
overdose | antiarrhythmic | TOXICOLOGY | Flecainide
Conference Proceeding
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13. Full Text Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor
by Bannister, Mark L and Alvarez‐Laviada, Anita and Thomas, N Lowri and Mason, Sammy A and Coleman, Sharon and Plessis, Christo L and Moran, Abbygail T and Neill‐Hall, David and Osman, Hasnah and Bagley, Mark C and MacLeod, Kenneth T and George, Christopher H and Williams, Alan J
British Journal of Pharmacology, ISSN 0007-1188, 08/2016, Volume 173, Issue 15, pp. 2446 - 2459
Background and PurposeFlecainide is a use-dependent blocker of cardiac Na+ channels. Mechanistic analysis of this block showed that the cationic form of... 
COMMON MOLECULAR DETERMINANTS | DEPENDENT BLOCK | POLYMORPHIC VENTRICULAR-TACHYCARDIA | AMMONIUM CATIONS | CONCISE GUIDE | TRIPLE MODE | LOCAL-ANESTHETICS | NA+ CHANNELS | PHARMACOLOGY & PHARMACY | GATED ION CHANNELS | CA2+-RELEASE CHANNEL | Calcium - metabolism | Sarcoplasmic Reticulum - drug effects | Humans | Cells, Cultured | Rats | Male | Ryanodine Receptor Calcium Release Channel - metabolism | Flecainide - pharmacology | Structure-Activity Relationship | Rats, Sprague-Dawley | Sarcoplasmic Reticulum - secretion | Dose-Response Relationship, Drug | Flecainide - analogs & derivatives | Animals | Myocytes, Cardiac - drug effects | HEK293 Cells | Myocytes, Cardiac - metabolism | Flecainide - chemistry | Molecular Structure | Physiological aspects | Tachycardia | Flecainide | Analysis | Calcium | Rodents | Research Papers | Research Paper
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14. Full Text Flecainide acetate for the treatment of atrial and ventricular arrhythmias
by Apostolakis, Stavros and Oeff, Michael and Tebbe, Ulrich and Fabritz, Larissa and Breithardt, Günter and Kirchhof, Paulus
Expert Opinion on Pharmacotherapy, ISSN 1465-6566, 02/2013, Volume 14, Issue 3, pp. 347 - 357
Introduction: Flecainide is a class Ic antiarrhythmic agent available in Europe since 1982. The clinical development program of flecainide provided good data... 
ventricular tachyarrhythmia | atrial fibrillation | flecainide | safety | cardioversion | efficacy | Cardioversion | Efficacy | Safety | Flecainide | Atrial fibrillation | Ventricular tachyarrhythmia | FIBRILLATION | INTRAVENOUS FLECAINIDE | MANAGEMENT | CONVERSION | ELECTRICAL CARDIOVERSION | PHARMACOLOGY & PHARMACY | ANTIARRHYTHMIC THERAPY | LONG-TERM EFFICACY | SINUS RHYTHM | ORAL FLECAINIDE | Tachycardia, Supraventricular - drug therapy | Atrial Fibrillation - drug therapy | Tachycardia, Ventricular - drug therapy | Humans | Anti-Arrhythmia Agents - therapeutic use | Atrial Fibrillation - physiopathology | Arrhythmias, Cardiac - physiopathology | Flecainide - adverse effects | Arrhythmias, Cardiac - drug therapy | Tachycardia, Ventricular - physiopathology | Animals | Anti-Arrhythmia Agents - adverse effects | Tachycardia, Supraventricular - physiopathology | Flecainide - therapeutic use | Practice Guidelines as Topic
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15. Flecainide reverses neuropathic pain and suppresses ectopic nerve discharge in rats
by Ichimata, Masahiko and Kitano, Takaaki and Ikebe, Haruyoshi and Iwasaka, Hideo and Noguchi, Takayuki
Neuroreport, ISSN 0959-4965, 07/2001, Volume 12, Issue 9, pp. 1869 - 1873
We investigated effects of flecainide, a Class IC sodium channel blocker, in the rat chronic constrictive injury (CCI) and ectopic nerve discharge models. In... 
flecainide
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16. Full Text Clinical effectiveness of a systematic “pill-in-the-pocket” approach for the management of paroxysmal atrial fibrillation
by Andrade, Jason G and MacGillivray, Jenny and Macle, Laurent and Yao, Ren Jie Robert and Bennett, Matthew and Fordyce, Christopher B and Hawkins, Nathaniel and Krahn, Andrew and Jue, John and Ramanathan, Krishnan and Tsang, Teresa and Gin, Ken and Deyell, Marc W
Heart Rhythm, ISSN 1547-5271, 01/2018, Volume 15, Issue 1, pp. 9 - 16
For patients with symptomatic, sustained atrial fibrillation (AF), a “pill-in-the-pocket” antiarrhythmic drug (PIP-AAD) strategy has been proposed to reduce... 
Antiarrhythmic | Cardioversion | Flecainide | Propafenone | Atrial fibrillation
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17. Full Text Outpatient treatment of recent-onset atrial fibrillation with the "pill-in-the-pocket" approach
by Alboni, Paolo and Botto, Giovanni L and Baldi, Nicola and Luzi, Mario and Russo, Vitantonio and Gianfranchi, Lorella and Marchi, Paola and Calzolari, Massimo and Solano, Alberto and Baroffio, Raffaele and Gaggioli, Germano
New England Journal of Medicine, ISSN 0028-4793, 12/2004, Volume 351, Issue 23, pp. 2384 - 2391
In-hospital administration of flecainide and propafenone in a single oral loading dose has been shown to be effective and superior to placebo in terminating... 
Heart Failure - complications | Prospective Studies | Follow-Up Studies | Administration, Oral | Atrial Fibrillation - drug therapy | Flecainide - administration & dosage | Humans | Middle Aged | Propafenone - adverse effects | Atrial Fibrillation - complications | Heart Failure - physiopathology | Male | Anti-Arrhythmia Agents - therapeutic use | Anti-Arrhythmia Agents - administration & dosage | Ambulatory Care | Feasibility Studies | Flecainide - adverse effects | Stroke Volume | Self Administration | Anti-Arrhythmia Agents - adverse effects | Female | Propafenone - administration & dosage | Propafenone - therapeutic use | Flecainide - therapeutic use | Atrial fibrillation | Ambulatory medical care | Research | Heart rate | Studies | Cardiac arrhythmia | Cardiovascular disease | Emergency medical care | Hospitalization | Drug dosages | Catheters
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18. Full Text Efficacy and safety of flecainide for ventricular arrhythmias in patients with Andersen-Tawil syndrome with KCNJ2 mutations
by Miyamoto, Koji, MD and Aiba, Takeshi, MD, PhD and Kimura, Hiromi, MD, PhD and Hayashi, Hideki, MD, PhD and Ohno, Seiko, MD, PhD and Yasuoka, Chie, MD, PhD and Tanioka, Yoshihito, MD, PhD and Tsuchiya, Takeshi, MD, PhD and Yoshida, Yoko, MD and Hayashi, Hiroshi, MD and Tsuboi, Ippei, MD and Nakajima, Ikutaro, MD and Ishibashi, Kohei, MD and Okamura, Hideo, MD and Noda, Takashi, MD, PhD and Ishihara, Masaharu, MD, PhD and Anzai, Toshihisa, MD, PhD and Yasuda, Satoshi, MD, PhD and Miyamoto, Yoshihiro, MD, PhD and Kamakura, Shiro, MD, PhD and Kusano, Kengo, MD, PhD and Ogawa, Hisao, MD, PhD and Horie, Minoru, MD, PhD and Shimizu, Wataru, MD, PhD
Heart Rhythm, ISSN 1547-5271, 2015, Volume 12, Issue 3, pp. 596 - 603
Background Andersen-Tawil syndrome (ATS) is an autosomal dominant genetic or sporadic disorder characterized by ventricular arrhythmias (VAs), periodic... 
Cardiovascular | Ventricular arrhythmia | Mutation | Flecainide | Andersen-Tawil syndrome | Long QT | PERIODIC PARALYSIS | RECTIFICATION | CARDIAC & CARDIOVASCULAR SYSTEMS | GENOTYPE | KIR2.1 | CARDIOMYOPATHY | TACHYCARDIA | MODEL | CARDIAC EXCITABILITY | U-WAVE | VERAPAMIL | Follow-Up Studies | Syncope - epidemiology | Flecainide - administration & dosage | Humans | Young Adult | Ventricular Premature Complexes - physiopathology | Adult | Ventricular Premature Complexes - epidemiology | Andersen Syndrome - complications | Andersen Syndrome - physiopathology | Administration, Oral | Tachycardia, Ventricular - drug therapy | Heart Arrest - epidemiology | Tachycardia, Ventricular - etiology | Potassium Channels, Inwardly Rectifying - genetics | Treatment Outcome | Anti-Arrhythmia Agents - therapeutic use | Flecainide - adverse effects | Syncope - prevention & control | Tachycardia, Ventricular - physiopathology | Ventricular Premature Complexes - drug therapy | Heart Arrest - prevention & control | Adolescent | Andersen Syndrome - genetics | Electrocardiography, Ambulatory | Flecainide - therapeutic use | Sects | Care and treatment | Genetic aspects | Arrhythmia | College graduates | Heart | Medical research | Tachycardia | Medicine, Experimental
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