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Molecular Neurobiology, ISSN 0893-7648, 11/2016, Volume 53, Issue 9, pp. 6459 - 6475
We investigated the effects of an acute intrastriatal QUIN administration on cellular redox and bioenergetics homeostasis, as well as on important signaling... 
Signaling pathways | Neurology | Energy metabolism | Neurosciences | Biomedicine | Redox homeostasis | Glutaric acidemia | Neurobiology | Inflammatory response | Quinolinic acid | Cell Biology | PLASMA-MEMBRANES | 3-HYDROXYGLUTARIC ACID | NMDA RECEPTORS | NITRIC-OXIDE SYNTHASE | FACTOR-KAPPA-B | GLUTAMATE UPTAKE | NEUROSCIENCES | CEREBRAL-CORTEX | PRIMARY NEURONAL CULTURES | ANTIOXIDANT RESPONSE ELEMENT | CREATINE-KINASE | Brain Diseases, Metabolic - pathology | Glutaryl-CoA Dehydrogenase - metabolism | Glutathione - metabolism | Antioxidants - metabolism | Fluoresceins - metabolism | Nitrites - metabolism | NF-kappa B - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Electron Transport Complex IV - metabolism | Amino Acid Metabolism, Inborn Errors - metabolism | Sulfhydryl Compounds - metabolism | Neostriatum - drug effects | Lipid Peroxidation - drug effects | Neostriatum - metabolism | Quinolinic Acid - administration & dosage | Quinolinic Acid - toxicity | Amino Acid Metabolism, Inborn Errors - pathology | Brain Diseases, Metabolic - enzymology | Proto-Oncogene Proteins c-akt - metabolism | Superoxide Dismutase - metabolism | Malondialdehyde - metabolism | Glutathione Peroxidase - metabolism | Neostriatum - pathology | Oxidation-Reduction | Brain Diseases, Metabolic - metabolism | Mice, Knockout | Nitrates - metabolism | Animals | Lactates - metabolism | Diet | Signal Transduction - drug effects | Models, Biological | NF-E2-Related Factor 2 - metabolism | Oxidative Stress - drug effects | Amino Acid Metabolism, Inborn Errors - enzymology | Energy Metabolism - drug effects | Glutaryl-CoA Dehydrogenase - deficiency | Antioxidants | Lysine | Creatine kinase | Glutathione transferase | Physiological aspects | Superoxide | Inflammation | Creatine | Homeostasis | Signal transduction | Oxidative stress | Bioenergetics | Index Medicus
Journal Article
Cellular Signalling, ISSN 0898-6568, 04/2013, Volume 25, Issue 4, pp. 931 - 938
The interleukin-6 (IL-6)/Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway mediates cell proliferation and migration.... 
Cytoskeleton | p27 | Gastric cancer | Migration | Invasion | Signal transducer and activator of transcription 3 | P27 | ACTIVATION | E-CADHERIN | BETA-CATENIN | INTERLEUKIN-6 | IL-6 | CELL BIOLOGY | OVEREXPRESSION | SIGNALING PATHWAY | SKP2 | CARCINOMA | CYCLE | Up-Regulation | Cell Proliferation | Cadherins - metabolism | Humans | Stomach Neoplasms - metabolism | Sp1 Transcription Factor - metabolism | Stomach Neoplasms - pathology | rhoA GTP-Binding Protein - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - antagonists & inhibitors | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Matrix Metalloproteinase 9 - metabolism | Microtubules - metabolism | RNA Interference | Janus Kinase 2 - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Focal Adhesion Kinase 1 - metabolism | Interleukin-6 - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Signal Transduction | Matrix Metalloproteinase 2 - metabolism | Down-Regulation | S-Phase Kinase-Associated Proteins - metabolism | Cell Adhesion | GPI-Linked Proteins - metabolism | Cell Line, Tumor | STAT3 Transcription Factor - antagonists & inhibitors | Stathmin - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - genetics | RNA, Small Interfering - metabolism | Phosphates | Enzymes | Cysteine | Analysis | Fluorescein | Cancer cells | Tubulins | Stomach cancer | Enzyme-linked immunosorbent assay | Cancer | Index Medicus
Journal Article
Gastroenterology, ISSN 0016-5085, 2011, Volume 141, Issue 2, pp. 731 - 741.e4
Background & Aims Animal studies have indicated that pancreatic exocrine acinar cells have phenotypic plasticity. In rodents, acinar cells can differentiate... 
Gastroenterology and Hepatology | Metaplasia | Reprogramming | Exocrine Pancreas | Tissue Engineering | BETA-CELLS | INTRAEPITHELIAL NEOPLASIA | HUMAN EXOCRINE PANCREAS | ADULT HUMAN PANCREAS | IN-VITRO | NOTCH SIGNALING PATHWAY | GENERATION | MICE | GROWTH-FACTOR | DIFFERENTIATION | GASTROENTEROLOGY & HEPATOLOGY | Cell Proliferation | Chymotrypsin - metabolism | Humans | Glycoproteins - metabolism | Carbonic Anhydrase II - metabolism | Ki-67 Antigen - metabolism | Cell Transdifferentiation - genetics | RNA, Messenger - metabolism | Pancreatic Ducts - metabolism | Antigens, CD - metabolism | Cell Transdifferentiation - physiology | Peptides - metabolism | Pancreas, Exocrine - cytology | Cell Lineage - genetics | Genes, Reporter | Hepatocyte Nuclear Factor 1-beta - metabolism | Plant Lectins - pharmacokinetics | Biomarkers - metabolism | SOX9 Transcription Factor - metabolism | Green Fluorescent Proteins - metabolism | Promoter Regions, Genetic | Pancreatic Ducts - cytology | Transduction, Genetic | Cell Survival | Cells, Cultured | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Signal Transduction - genetics | AC133 Antigen | Cell Lineage - physiology | Phenotype | Signal Transduction - physiology | Pancreas, Exocrine - metabolism | Keratin-19 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Keratin | Epidermal growth factor | Analysis | Fluorescein | Fluorescence | Cystic fibrosis | Diabetes | Universities and colleges | Research | Protein kinases | Index Medicus | Abridged Index Medicus
Journal Article
JAMA Ophthalmology, ISSN 2168-6165, 02/2013, Volume 131, Issue 2, pp. 160 - 165
OBJECTIVE To evaluate the association between vitreous fluid levels of inflammatory factors and macular edema in patients with branch retinal vein occlusion... 
C-REACTIVE PROTEIN | EPITHELIUM-DERIVED FACTOR | SIGNALING PATHWAYS | ACUTE MYOCARDIAL-INFARCTION | OPHTHALMOLOGY | SMOOTH-MUSCLE-CELLS | NF-KAPPA-B | ADHESION MOLECULE-1 ICAM-1 | TRANSCRIPTION FACTOR | ENDOTHELIAL GROWTH-FACTOR | LONG PENTRAXIN PTX3 | Capillary Permeability | Humans | Male | Nerve Growth Factors - metabolism | Vascular Endothelial Growth Factor A - metabolism | Case-Control Studies | C-Reactive Protein - metabolism | Vitreous Body - metabolism | Inflammation Mediators - metabolism | Retinal Vein Occlusion - surgery | Female | Vitrectomy | Chemokine CCL2 - metabolism | Retrospective Studies | Interleukin-6 - metabolism | Fluorescein Angiography | Biomarkers - metabolism | Enzyme-Linked Immunosorbent Assay | Serpins - metabolism | Tomography, Optical Coherence | Retinal Vein - metabolism | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Macular Edema - metabolism | Intercellular Adhesion Molecule-1 - metabolism | Eye Proteins - metabolism | Macular Edema - surgery | Aged | Serum Amyloid P-Component - metabolism | Retinal Vein Occlusion - metabolism | Complications and side effects | Usage | Eye diseases | Research | Diagnosis | Retinal diseases | Vascular endothelial growth factor | Coherence (Optics) | Risk factors | Enzyme-linked immunosorbent assay | Index Medicus | Abridged Index Medicus
Journal Article
Molecular and Cellular Biochemistry, ISSN 0300-8177, 2/2007, Volume 296, Issue 1, pp. 85 - 95
Many studies have been performed with the aim of developing effective resistance modulators to overcome the multidrug resistance (MDR) of human cancers. Potent... 
Life Sciences | Biochemistry, general | P-glycoprotein | tetrahydrocurcumin | multidrug resistance | ATP hydrolysis | drug transport | Oncology | Medical Biochemistry | Cardiology | chemosensitivity | ABC transporter | Drug transport | Multidrug resistance | Chemosensitivity | Tetrahydrocurcumin | MECHANISM | INVOLVEMENT | CHEMOPREVENTIVE AGENT CURCUMIN | CATALYTIC TRANSITION-STATE | CELL BIOLOGY | MICROORGANISMS | BREAST-CANCER CELLS | IN-VITRO | INHIBITION | PROTECTIVE ROLE | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Vinblastine - metabolism | Curcumin - analogs & derivatives | Fluorides - metabolism | Curcumin - chemistry | Fluoresceins - metabolism | Humans | Chlorophyll - analogs & derivatives | Fluorescent Dyes - metabolism | Drug Resistance, Neoplasm | Curcumin - metabolism | Neoplasm Proteins - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 | Organic Anion Transporters - metabolism | Antineoplastic Agents - metabolism | Beryllium - metabolism | Adenosine Triphosphate - metabolism | ATP-Binding Cassette Transporters - metabolism | Molecular Structure | Drug Resistance, Multiple - physiology | Mitoxantrone - metabolism | Etoposide - metabolism | Chlorophyll - metabolism | Antineoplastic Agents - chemistry | Rhodamine 123 - metabolism | Cell Line, Tumor | ATP Binding Cassette Transporter, Sub-Family B | Multidrug Resistance-Associated Proteins - metabolism | Proteins | Medical research | Binding sites | Index Medicus
Journal Article
Neurochemistry International, ISSN 0197-0186, 2009, Volume 54, Issue 3, pp. 253 - 263
Blood–brain barrier (BBB) characteristics are induced and maintained by cross-talk between brain microvessel endothelial cells and neighbouring elements of the... 
Astrocytes | Pericytes | In vitro BBB model (rat) | Tight junction | Transendothelial electrical resistance | Co-culture | P-Glycoprotein | Drug permeability | Blood–brain barrier | Brain endothelial cells | Blood-brain barrier | DRUG | PERMEABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANGIOPOIETIN-1 | INDUCTION | GLIAL-CELLS | NEUROSCIENCES | MESSENGER-RNA | IN-VITRO MODEL | CULTURES | EXPRESSION | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Pericytes - ultrastructure | Phosphoproteins - metabolism | Blood-Brain Barrier - ultrastructure | Occludin | Microcirculation - physiology | Endothelial Cells - ultrastructure | Membrane Proteins - metabolism | Capillaries - metabolism | Rhodamine 123 - pharmacokinetics | Tight Junctions - metabolism | Microscopy, Electron, Transmission | Capillaries - ultrastructure | Endothelial Cells - metabolism | Pericytes - metabolism | Cells, Cultured | Rats | Claudin-5 | Cerebral Arteries - ultrastructure | Membrane Potentials - physiology | Blood-Brain Barrier - metabolism | Astrocytes - ultrastructure | Tight Junctions - ultrastructure | Animals | Carrier Proteins - metabolism | Zonula Occludens-1 Protein | Cell Membrane Permeability - physiology | Cerebral Arteries - metabolism | Models, Biological | Cell Membrane Permeability - drug effects | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Astrocytes - metabolism | Proteins | Drug resistance in microorganisms | Brain | Fluorescein | Physiological aspects | Glucose | Universities and colleges | Permeability | Dextrose | Endothelium | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2005, Volume 280, Issue 17, pp. 16916 - 16924
Recent studies have demonstrated that the tumor suppressor PTEN ( p hosphatase and ten sin homolog deleted from chromosome 10), the antagonist of the... 
SIGNAL-TRANSDUCTION | INDUCIBLE FACTOR 1-ALPHA | REDOX REGULATION | PHOSPHATIDYLINOSITOL 3-KINASE/AKT PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-TYROSINE PHOSPHATASES | HYDROGEN-PEROXIDE | MATRIX-METALLOPROTEINASE EXPRESSION | TUMOR-SUPPRESSOR PTEN | ENDOTHELIAL GROWTH-FACTOR | PHOSPHORYLATION SITES | Fluoresceins - pharmacology | Phosphatidylinositol Phosphates - metabolism | Coloring Agents - pharmacology | Humans | Neovascularization, Pathologic | Phosphatidylinositol 3-Kinases - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Oxygen - metabolism | Transfection | PTEN Phosphohydrolase | Time Factors | Cell Membrane - metabolism | Protein-Serine-Threonine Kinases - metabolism | Superoxide Dismutase - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Promoter Regions, Genetic | Tumor Suppressor Proteins - metabolism | Oxidation-Reduction | Signal Transduction | Endothelial Cells - metabolism | Hydrogen Peroxide - pharmacology | Mitochondria - metabolism | Chick Embryo | Plasmids - metabolism | Blotting, Western | Hydrogen Peroxide - metabolism | Catalase - metabolism | Proto-Oncogene Proteins c-akt | Microscopy, Confocal | Phenotype | Animals | Models, Biological | Cell Line, Tumor | Phosphoric Monoester Hydrolases - metabolism | Index Medicus
Journal Article
Brain, ISSN 0006-8950, 2011, Volume 134, Issue 5, pp. 1331 - 1343
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, pp. e0173301 - e0173301
We aimed to investigate the expressions of three Th17-associated cytokines, interleukin (IL)-17A, IL-6 and IL-23, in protein and mRNA levels and their... 
TEARS | INTERLEUKIN-17 | SIGNS | MULTIDISCIPLINARY SCIENCES | PATHOGENIC T(H)17 CELLS | SYMPTOMS | DIAGNOSTIC-TESTS | DIFFERENTIATION | SJOGREN-SYNDROME | Biomarkers - metabolism | Cytokines - metabolism | Humans | Middle Aged | Tears - metabolism | Sjogren's Syndrome - metabolism | RNA, Messenger - metabolism | Case-Control Studies | Conjunctiva - metabolism | Cornea - metabolism | Interleukin-17 - metabolism | Interleukin-23 - metabolism | Th17 Cells - metabolism | Dry Eye Syndromes - metabolism | Female | Aged | Interleukin-6 - metabolism | Fluorescein - metabolism | Eye diseases | Care and treatment | Genetic aspects | Research | Interleukins | Gene expression | Pathogenesis | Chains (polymeric) | Assaying | Metastases | Eye | Proteins | Signal transduction | Histopathology | Surgery | Classification | Tubes | Eye (anatomy) | Breakup | Bioindicators | Diagnosis | Public health | Antigens | Bovine serum albumin | Evaluation | Cytokines | Interleukin 12 | Time measurement | Epithelium | Patients | Interleukin 17 | Studies | Hospitals | Biomarkers | Collection | Infiltration | Colitis | Cornea | Sjogren's syndrome | Conferences | Transforming growth factor-b | Glands | Antibodies | Staining | Clinical trials | Scoring | mRNA | Infections | Tissues | Inflammatory diseases | Interleukin 6 | Biomedical materials | Lymphocytes | Rodents | Quality | Interleukin 1 | Tumor necrosis factor-TNF | Children | Rubber | Interleukin 8 | Hypertension | Desiccants | Diabetes mellitus | Inflammation | Evaporation | Chronic fatigue syndrome | CD4 antigen | Blindness | In vivo methods and tests | Differentiation | Index Medicus
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 2005, Volume 39, Issue 5, pp. 619 - 630
The effects of the dietary antioxidant acetylcysteine (NAC) on alcoholic liver damage were examined in a total enteral nutrition (TEN) model of ethanol... 
Lipid peroxidation | Alcohol | N-Acetylcysteine | Cytokines | Hepatotoxicity | Adducts | alcohol | OXIDATIVE STRESS | ACID | LIPID-PEROXIDATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | EXTRACT PROTECTS | ENDOTOXIN | lipid peroxidation | INDUCED LIVER-INJURY | N-acetylcysteine | adducts | hepatotoxicity | DISEASE | ENDOCRINOLOGY & METABOLISM | KUPFFER CELLS | cytokines | TNF-ALPHA | Immunohistochemistry | Tumor Necrosis Factor-alpha - metabolism | Liver - pathology | Oxidative Stress | Glutathione - metabolism | Antioxidants - metabolism | Oxidants - metabolism | Lipopolysaccharides - metabolism | Male | Lymphotoxin-alpha - metabolism | Cytochrome P-450 CYP2E1 - metabolism | Aldehydes - metabolism | RNA, Messenger - metabolism | Necrosis | Central Nervous System Depressants - pharmacology | Immune System | Liver - drug effects | Time Factors | Cattle | Kupffer Cells - metabolism | Ethanol - urine | Lipopolysaccharide Receptors - biosynthesis | Malondialdehyde - metabolism | Ethanol - metabolism | Cytokines - metabolism | Liver - metabolism | Rats | Enteral Nutrition | Inflammation | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Ethanol - pharmacology | Animals | Acetylcysteine - pharmacology | Cytosol - metabolism | Lipid Peroxidation | Liver diseases | Cytochrome P-450 | Acetylcysteine | Antibodies | Superoxide dismutase | Superoxide | Transforming growth factors | Fatty acids | Antioxidants | Viral antibodies | Messenger RNA | Fluorescein | Physiological aspects | Tumors | Index Medicus
Journal Article