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1. Full Text Serotonin 2A receptor agonist binding in the human brain with [11C]Cimbi-36: Test–retest reproducibility and head-to-head comparison with the antagonist [18F]altanserin
by Ettrup, Anders and Svarer, Claus and McMahon, Brenda and da Cunha-Bang, Sofi and Lehel, Szabolcs and Møller, Kirsten and Dyssegaard, Agnete and Ganz, Melanie and Beliveau, Vincent and Jørgensen, Louise Møller and Gillings, Nic and Knudsen, Gitte Moos
NeuroImage (Orlando, Fla.), ISSN 1053-8119, 04/2016, Volume 130, pp. 167 - 174
Neuroimaging | Agonist | 5-HT | Positron emission tomography | Radiotracer evaluation | Test–retest variability | Test-retest variability | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Radiology, Nuclear Medicine & Medical Imaging | Science & Technology | Serotonin 5-HT2 Receptor Agonists - pharmacokinetics | Humans | Ketanserin - analogs & derivatives | Male | Benzylamines - metabolism | Brain - metabolism | Young Adult | Radiopharmaceuticals - metabolism | Fluorine Radioisotopes - pharmacokinetics | Phenethylamines - pharmacokinetics | Female | Serotonin 5-HT2 Receptor Agonists - metabolism | Neuroimaging - methods | Reproducibility of Results | Radiopharmaceuticals - pharmacokinetics | Carbon Radioisotopes - pharmacokinetics | Phenethylamines - metabolism | Positron-Emission Tomography - methods | Serotonin 5-HT2 Receptor Antagonists - pharmacokinetics | Ketanserin - metabolism | Ketanserin - pharmacokinetics | Serotonin 5-HT2 Receptor Antagonists - metabolism | Fluorine Radioisotopes - metabolism | Carbon Radioisotopes - metabolism | Benzylamines - pharmacokinetics | Phenols | Brain | Serotonin | Analysis | Choroid plexus | Medical imaging | Lysergic acid diethylamide--LSD | Cortex | Radioisotopes | Serotonin S2 receptors | Tomography | Receptor density | Agonists | Hippocampus | Index Medicus
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2. Full Text Comparison Study of [18F]FAl-NOTA-PRGD2, [18F]FPPRGD2, and [68Ga]Ga-NOTA-PRGD2 for PET Imaging of U87MG Tumors in Mice
by Lang, Lixin and Li, Weihua and Guo, Ning and Ma, Ying and Zhu, Lei and Kiesewetter, Dale O and Shen, Baozhong and Niu, Gang and Chen, Xiaoyuan
Bioconjugate chemistry, ISSN 1043-1802, 12/2011, Volume 22, Issue 12, pp. 2415 - 2422
Humans | Oligopeptides - pharmacokinetics | Neoplasms - diagnosis | Gallium Radioisotopes - chemistry | Positron-Emission Tomography - methods | Animals | Fluorine Radioisotopes - pharmacokinetics | Heterocyclic Compounds - chemistry | Cell Line, Tumor | Gallium Radioisotopes - pharmacokinetics | Heterocyclic Compounds - pharmacokinetics | Mice | Fluorine Radioisotopes - chemistry | Oligopeptides - chemistry | Comparative studies | Tomography | Angiogenesis | Peptides | Rodents | Tumors | Index Medicus | Ga-68 | Arg-Gly-Asp (RGD) peptide | integrin αvβ3 | fluorine-aluminum complex | positron emission tomography (PET) | F-18
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3. Full Text Identification of Three Novel Radiotracers for Imaging Aggregated Tau in Alzheimer’s Disease with Positron Emission Tomography
by Gobbi, Luca C and Knust, Henner and Körner, Matthias and Honer, Michael and Czech, Christian and Belli, Sara and Muri, Dieter and Edelmann, Martin R and Hartung, Thomas and Erbsmehl, Isabella and Grall-Ulsemer, Sandra and Koblet, Andreas and Rueher, Marianne and Steiner, Sandra and Ravert, Hayden T and Mathews, William B and Holt, Daniel P and Kuwabara, Hiroto and Valentine, Heather and Dannals, Robert F and Wong, Dean F and Borroni, Edilio
Journal of medicinal chemistry, ISSN 0022-2623, 09/2017, Volume 60, Issue 17, pp. 7350 - 7370
Carbon Radioisotopes - pharmacokinetics | Humans | Male | Positron-Emission Tomography - methods | Pyrimidines - chemistry | Papio | Carbon Radioisotopes - chemistry | Animals | Fluorine Radioisotopes - pharmacokinetics | Protein Aggregation, Pathological - diagnostic imaging | Pyrimidines - pharmacokinetics | Mice | tau Proteins - analysis | Alzheimer Disease - diagnostic imaging | Fluorine Radioisotopes - chemistry | Index Medicus
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4. Full Text The role of radiotracer imaging in Parkinson disease
by Ravina, B and Eidelberg, D and Ahlskog, J.E and Albin, R.L and Brooks, D.J and Carbon, M and Dhawan, V and Feigin, A and Fahn, S and Guttman, M and Gwinn-Hardy, K and McFarland, H and Innis, R and Katz, R.G and Kieburtz, K and Kish, S.J and Lange, N and Langston, J.W and Marek, K and Morin, L and Moy, C and Murphy, D and Oertel, W.H and Oliver, G and Palesch, Y and Powers, W and Seibyl, J and Sethi, K.D and Shults, C.W and Sheehy, P and Stoessl, A.J and Holloway, R
Neurology, ISSN 0028-3878, 01/2005, Volume 64, Issue 2, pp. 208 - 215
Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neurology | Radiodiagnosis. Nmr imagery. Nmr spectrometry | Investigative techniques, diagnostic techniques (general aspects) | Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases | Biological and medical sciences | Nervous system | Medical sciences | Parkinson Disease - therapy | Fluorodeoxyglucose F18 - pharmacokinetics | Prognosis | Humans | Dihydroxyphenylalanine - analogs & derivatives | Tomography, Emission-Computed, Single-Photon | Positron-Emission Tomography | Dihydroxyphenylalanine - pharmacokinetics | Substantia Nigra - metabolism | Corpus Striatum - metabolism | Tetrabenazine - pharmacokinetics | Fluorine Radioisotopes - pharmacokinetics | Biotransformation | Dopamine - metabolism | Tetrabenazine - analogs & derivatives | Parkinson Disease - diagnostic imaging | Radiopharmaceuticals - pharmacokinetics | Neurons - chemistry | Receptors, Dopamine - metabolism | Carbon Radioisotopes - pharmacokinetics | Cocaine - pharmacokinetics | Iodine Radioisotopes - pharmacokinetics | Cocaine - analogs & derivatives | Forecasting | Neurons - diagnostic imaging | Substantia Nigra - diagnostic imaging | Biomarkers | Parkinson Disease - diagnosis | Clinical Trials as Topic - methods | Corpus Striatum - diagnostic imaging | Blood-Brain Barrier | Index Medicus | Abridged Index Medicus
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5. Full Text Development of a (18) F-labeled tetrazine with favorable pharmacokinetics for bioorthogonal PET imaging
by Denk, Christoph and Denk, Christoph and Svatunek, Dennis and Svatunek, Dennis and Filip, Thomas and Filip, Thomas and Wanek, Thomas and Wanek, Thomas and Lumpi, Daniel and Lumpi, Daniel and Fröhlich, Johannes and Fröhlich, Johannes and Kuntner, Claudia and Kuntner, Claudia and Mikula, Hannes and Mikula, Hannes
Angewandte Chemie (International ed.), ISSN 1433-7851, 2014, Volume 53, Issue 36, pp. 9655 - 9659
bioorthogonal chemistry | click chemistry | imaging agents | kinetics | tetrazines | Bridged Bicyclo Compounds - chemical synthesis | Radiopharmaceuticals - pharmacokinetics | Humans | Positron-Emission Tomography - methods | Cycloaddition Reaction | Tissue Distribution | Magnetic Resonance Imaging | Animals | Fluorine Radioisotopes - pharmacokinetics | Heterocyclic Compounds - chemistry | Isotope Labeling | Female | Heterocyclic Compounds - pharmacokinetics | Mice | Mice, Inbred BALB C | Index Medicus
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6. Full Text Comparison of the pharmacokinetics between L-BPA and L-FBPA using the same administration dose and protocol: A validation study for the theranostic approach using [ 18 F]-L-FBPA positron emission tomography in boron neutron capture therapy
by Watanabe, Tsubasa and Hattori, Yoshihide and Ohta, Youichiro and Ishimura, Miki and Nakagawa, Yosuke and Sanada, Yu and Tanaka, Hiroki and Fukutani, Satoshi and Masunaga, Shin-ichiro and Hiraoka, Masahiro and Ono, Koji and Suzuki, Minoru and Kirihata, Mitsunori
BMC cancer, ISSN 1471-2407, 11/2016, Volume 16, Issue 1, pp. 859 - 859
F]-L-FBPA | Boron concentration | FBPA | L-BPA | Boron neutron capture therapy | Life Sciences & Biomedicine | Oncology | Science & Technology | Tissue Distribution | Animals | Fluorine Radioisotopes - pharmacokinetics | Fluorine Radioisotopes - administration & dosage | Boron Neutron Capture Therapy | Female | Neoplasms - radiotherapy | Mice | Positron-Emission Tomography | Fluorine Radioisotopes - chemistry | Neoplasms - diagnostic imaging | Disease Models, Animal | Usage | PET imaging | Boron-neutron capture therapy | Analysis | Radiation | Pharmacokinetics | Health aspects | Index Medicus
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7. Full Text Next Generation of SiFAlin-Based TATE Derivatives for PET Imaging of SSTR-Positive Tumors: Influence of Molecular Design on In Vitro SSTR Binding and In Vivo Pharmacokinetics
by Litau, S and Niedermoser, S and Vogler, N and Roscher, M and Schirrmacher, R and Fricker, G and Wängler, B and Wängler, C
Bioconjugate chemistry, ISSN 1043-1802, 12/2015, Volume 26, Issue 12, pp. 2350 - 2359
Neoplasms - metabolism | Cell Line | Fluorides - pharmacokinetics | Silicon - metabolism | Fluorides - metabolism | Humans | Silicon - pharmacokinetics | Models, Molecular | Neoplasms - diagnosis | Positron-Emission Tomography - methods | Neoplasms - diagnostic imaging | Peptides, Cyclic - chemistry | Peptides, Cyclic - metabolism | Peptides, Cyclic - pharmacokinetics | Fluorides - chemistry | Animals | Fluorine Radioisotopes - pharmacokinetics | Mice, Nude | Cell Line, Tumor | Fluorine Radioisotopes - metabolism | Receptors, Somatostatin - metabolism | Fluorine Radioisotopes - chemistry | Silicon - chemistry | Proteins | Tomography | Pharmacology | Peptides | Reaction kinetics | Tumors | Index Medicus
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8. Full Text Brain and Plasma Pharmacokinetics of Aripiprazole in Patients With Schizophrenia: An [ 18 F]Fallypride PET Study
by Gründer, Gerhard and Fellows, Christine and Janouschek, Hildegard and Veselinovic, Tanja and Boy, Christian and Bröcheler, Anno and Kirschbaum, Katrin M and Hellmann, Sandra and Spreckelmeyer, Katja M and Hiemke, Christoph and Rösch, Frank and Schaefer, Wolfgang M and Vernaleken, Ingo
The American journal of psychiatry, ISSN 0002-953X, 08/2008, Volume 165, Issue 8, pp. 988 - 995
Psycholeptics: tranquillizer, neuroleptic | Psychology. Psychoanalysis. Psychiatry | Psychopharmacology | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Neuropharmacology | Brain - diagnostic imaging | Antipsychotic Agents - blood | Humans | Middle Aged | Receptors, Dopamine D3 - metabolism | Male | Positron-Emission Tomography | Aripiprazole | Receptors, Dopamine D2 - metabolism | Brain - metabolism | Quinolones - blood | Antipsychotic Agents - therapeutic use | Quinolones - pharmacokinetics | Quinolones - therapeutic use | Pyrrolidines | Adult | Female | Piperazines - pharmacokinetics | Piperazines - blood | Binding Sites | Piperazines - therapeutic use | Antipsychotic Agents - pharmacokinetics | Schizophrenia - diagnostic imaging | Benzamides | Fluorine Radioisotopes | Schizophrenia - drug therapy | Psychotropic drugs | Studies | Plasma | Physical examinations | Brain | Side effects | Schizophrenia | Nuclear chemistry | Pharmacology | Index Medicus | Abridged Index Medicus
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9. Full Text Synthesis and Imaging Validation of [18F]MDL100907 Enabled by Ni-Mediated Fluorination
by Ren, Hong and Wey, Hsiao-Ying and Strebl, Martin and Neelamegam, Ramesh and Ritter, Tobias and Hooker, Jacob M
ACS chemical neuroscience, ISSN 1948-7193, 05/2014, Volume 5, Issue 7, pp. 611 - 615
serotonin receptors | nickel-mediated | MDL100907 | PET imaging | Biochemistry & Molecular Biology | Neurosciences | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Neurosciences & Neurology | Chemistry, Medicinal | Science & Technology | Brain - diagnostic imaging | Fluorobenzenes - pharmacokinetics | Radiopharmaceuticals - pharmacokinetics | Carbon Radioisotopes - pharmacokinetics | Positron-Emission Tomography | Fluorobenzenes - chemical synthesis | Papio anubis | Piperidines - chemical synthesis | Serotonin 5-HT2 Receptor Antagonists - pharmacokinetics | Radiopharmaceuticals - chemical synthesis | Brain - metabolism | Magnetic Resonance Imaging | Serotonin 5-HT2 Receptor Antagonists - chemical synthesis | Carbon Radioisotopes - chemistry | Animals | Fluorine Radioisotopes - pharmacokinetics | Time Factors | Halogenation | Piperidines - pharmacokinetics | Fluorine Radioisotopes - chemistry | Receptor, Serotonin, 5-HT2A - metabolism | Index Medicus
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10. Full Text (R)- and (S)- 18 F-labeled 2-arylbenzofurans with improved pharmacokinetics as β-amyloid imaging probes
by Song, Jia and Zhang, Xiaoyang and Zhao, Yunling and Yang, Hui and Zhang, Jinming and Zhang, Xiaojun and Dai, Jiapei and Cui, Mengchao
European journal of medicinal chemistry, ISSN 0223-5234, 07/2017, Volume 134, pp. 271 - 280
Brain - diagnostic imaging | Humans | Mice, Inbred C57BL | Male | Positron-Emission Tomography - methods | Mice, Inbred ICR | Benzofurans - chemistry | Benzofurans - pharmacokinetics | Tissue Distribution | Animals | Fluorine Radioisotopes - pharmacokinetics | Plaque, Amyloid - diagnostic imaging | Amyloid beta-Peptides - analysis | Mice | Alzheimer Disease - diagnostic imaging | Fluorine Radioisotopes - chemistry
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11. Full Text Synthesis and in Vitro and in Vivo Evaluation of SiFA-Tagged Bombesin and RGD Peptides as Tumor Imaging Probes for Positron Emission Tomography
by Lindner, Simon and Michler, Christina and Leidner, Stephanie and Rensch, Christian and Wängler, Carmen and Schirrmacher, Ralf and Bartenstein, Peter and Wängler, Björn
Bioconjugate chemistry, ISSN 1043-1802, 04/2014, Volume 25, Issue 4, pp. 738 - 749
Humans | Silicon - pharmacokinetics | Male | Fluorine Radioisotopes - pharmacokinetics | Molecular Probes - metabolism | Molecular Probes - pharmacokinetics | Female | Molecular Structure | Tumor Cells, Cultured | Bombesin - chemistry | Fluorine Radioisotopes - chemistry | Oligopeptides - chemistry | Silicon - metabolism | Oligopeptides - pharmacokinetics | Molecular Imaging - methods | Molecular Probes - chemical synthesis | Oligopeptides - metabolism | Positron-Emission Tomography - methods | Mice, SCID | Molecular Probes - chemistry | Animals | Mice, Nude | Fluorine Radioisotopes - metabolism | Mice | Neoplasms, Experimental - metabolism | Bombesin - pharmacokinetics | Bombesin - metabolism | Silicon - chemistry | Chemistry | Medical imaging | Peptides | Positrons | Tomography | Chemical synthesis | Tumors | Index Medicus
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12. Full Text Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo
by Venneti, Sriram and Dunphy, Mark P and Zhang, Hanwen and Pitter, Kenneth L and Zanzonico, Patrick and Campos, Carl and Carlin, Sean D and La Rocca, Gaspare and Lyashchenko, Serge and Ploessl, Karl and Rohle, Daniel and Omuro, Antonio M and Cross, Justin R and Brennan, Cameron W and Weber, Wolfgang A and Holland, Eric C and Mellinghoff, Ingo K and Kung, Hank F and Lewis, Jason S and Thompson, Craig B
Science translational medicine, ISSN 1946-6234, 02/2015, Volume 7, Issue 274, pp. 274ra17 - 274ra17
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Fluorine Radioisotopes - pharmacokinetics | Glioma - pathology | Humans | Brain Neoplasms - pathology | Fluorine Radioisotopes - metabolism | Glutamine - metabolism | Positron-Emission Tomography | Glutamine - pharmacokinetics | Brain Neoplasms - metabolism | Disease Progression | Blood-Brain Barrier | Glioma - metabolism | Index Medicus
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13. Full Text Discovery of N‑(4‑[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer
by Rombouts, Frederik J. R and Declercq, Lieven and Andrés, José-Ignacio and Bottelbergs, Astrid and Chen, Lu and Iturrino, Laura and Leenaerts, Joseph E and Mariën, Jonas and Song, Fengbin and Wintmolders, Cindy and Wuyts, Stijn and Xia, Chunfang A and te Riele, Paula and Bormans, Guy and Vandenberghe, Rik and Kolb, Hartmuth and Moechars, Diederik
Journal of medicinal chemistry, ISSN 0022-2623, 03/2019, Volume 62, Issue 6, pp. 2974 - 2987
Isoquinolines - pharmacokinetics | Rats, Wistar | Pyridines - chemistry | Humans | Cells, Cultured | Pyridines - pharmacokinetics | Rats | tau Proteins - metabolism | Male | Macaca mulatta | Positron-Emission Tomography | Structure-Activity Relationship | Hepatocytes - metabolism | Drug Discovery | Isoquinolines - chemistry | Animals | Fluorine Radioisotopes - pharmacokinetics | Alzheimer Disease - metabolism | Fluorine Radioisotopes - metabolism | Female | Alzheimer Disease - diagnostic imaging | Fluorine Radioisotopes - chemistry | Index Medicus
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14. Full Text Pharmacokinetic Characterization of [18F]UCB‑H PET Radiopharmaceutical in the Rat Brain
by Becker, Guillaume and Warnier, Corentin and Serrano, Maria Elisa and Bahri, Mohamed Ali and Mercier, Joël and Lemaire, Christian and Salmon, Eric and Luxen, André and Plenevaux, Alain
Molecular pharmaceutics, ISSN 1543-8384, 08/2017, Volume 14, Issue 8, pp. 2719 - 2725
[ | chirality | F]UCB-H | population-based input function | SV2A | PET | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Brain - metabolism | Reproducibility of Results | Animals | Radiopharmaceuticals - pharmacokinetics | Rats | Male | Positron-Emission Tomography | Fluorine Radioisotopes - chemistry | Pyrrolidinones - chemistry | Index Medicus
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15. Full Text Pharmacokinetics of [18F]flutemetamol in wild-type rodents and its binding to beta amyloid deposits in a mouse model of Alzheimer’s disease
by Snellman, Anniina and Rokka, Johanna and Lopez-Picon, Francisco R and Eskola, Olli and Wilson, Ian and Farrar, Gill and Scheinin, Mika and Solin, Olof and Rinne, Juha O and Haaparanta-Solin, Merja
European journal of nuclear medicine and molecular imaging, ISSN 1619-7070, 11/2012, Volume 39, Issue 11, pp. 1784 - 1795
Medicine & Public Health | Alzheimer’s disease | Orthopedics | Oncology | Nuclear Medicine | Cardiology | Imaging / Radiology | Positron emission tomography | [ 18 F]Flutemetamol | [ 11 C]PIB | C]PIB | F] Flutemetamol | Alzheimer's disease | Life Sciences & Biomedicine | Radiology, Nuclear Medicine & Medical Imaging | Science & Technology | Radiopharmaceuticals - pharmacokinetics | Mice, Inbred C57BL | Rats | Mice, Transgenic | Positron-Emission Tomography | Aniline Compounds - pharmacokinetics | Benzothiazoles - pharmacokinetics | Rats, Sprague-Dawley | Thiazoles - pharmacokinetics | Tissue Distribution | Animals | Fluorine Radioisotopes - pharmacokinetics | Amyloid beta-Peptides - metabolism | Mice | Alzheimer Disease - diagnostic imaging | Alzheimer Disease - genetics | Disease Models, Animal | Pharmacology | Medical imaging | Alzheimers disease | Rodents | Index Medicus
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16. Full Text High Affinity Radiopharmaceuticals Based Upon Lansoprazole for PET Imaging of Aggregated Tau in Alzheimer’s Disease and Progressive Supranuclear Palsy: Synthesis, Preclinical Evaluation, and Lead Selection
by Fawaz, Maria V and Brooks, Allen F and Rodnick, Melissa E and Carpenter, Garrett M and Shao, Xia and Desmond, Timothy J and Sherman, Phillip and Quesada, Carole A and Hockley, Brian G and Kilbourn, Michael R and Albin, Roger L and Frey, Kirk A and Scott, Peter J. H
ACS chemical neuroscience, ISSN 1948-7193, 06/2014, Volume 5, Issue 8, pp. 718 - 730
Biochemistry & Molecular Biology | Neurosciences | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Neurosciences & Neurology | Chemistry, Medicinal | Science & Technology | Lansoprazole - pharmacokinetics | Brain - diagnostic imaging | Humans | tau Proteins - metabolism | Radiopharmaceuticals - chemical synthesis | Brain - metabolism | Carbon Radioisotopes - chemistry | Fluorine Radioisotopes - pharmacokinetics | Lansoprazole - chemistry | Amyloid beta-Peptides - metabolism | Primates | Supranuclear Palsy, Progressive - diagnostic imaging | Drug Evaluation, Preclinical | Fluorine Radioisotopes - chemistry | Peptide Fragments - metabolism | Radiopharmaceuticals - chemistry | Radiopharmaceuticals - pharmacokinetics | Carbon Radioisotopes - pharmacokinetics | Rats | Positron-Emission Tomography - methods | Autoradiography | Animals | Alzheimer Disease - metabolism | Supranuclear Palsy, Progressive - metabolism | Mice | Alzheimer Disease - diagnostic imaging | Index Medicus
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