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fluoroalkylation (339) 339
chemistry, organic (281) 281
chemistry, multidisciplinary (150) 150
fluorine (150) 150
trifluoromethylation (145) 145
chemistry, inorganic & nuclear (98) 98
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photoredox catalysis (45) 45
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medicinal chemistry (40) 40
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activation (23) 23
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copper-mediated difluoromethylation (21) 21
functionalization (21) 21
perfluoroalkyl iodides (21) 21
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difluoroalkylation (20) 20
esters (20) 20
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hydrocarbons, fluorinated - chemistry (20) 20
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arylboronic acids (19) 19
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efficient (19) 19
fluoroalkoxylation (19) 19
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alkene (18) 18
heterocycles (18) 18
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chemical synthesis (17) 17
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ethyl bromodifluoroacetate (17) 17
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conjugate addition (14) 14
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fluorobismethane (14) 14
hydrocarbons, fluorinated - chemical synthesis (14) 14
nickel (14) 14
pet (14) 14
c-h trifluoromethylation (13) 13
chemistry, physical (13) 13
cross-coupling (13) 13
design (13) 13
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Organic Letters, ISSN 1523-7060, 01/2019, Volume 21, Issue 2, pp. 584 - 588
An expeditious, high-yielding synthesis of rare alpha-fluoroepoxides and alpha-fluoroaziridines through the addition of the unkown fluoroiodomethyllithium... 
CARBENOIDS | STABILITY | FLUOROALKYLATION | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | FLUORINE | MONOFLUOROMETHYLATION | NUCLEOPHILIC FLUOROMETHYLATION | HOMOLOGATION | STRAIGHTFORWARD ACCESS | EPOXIDATION
Journal Article
Organic Letters, ISSN 1523-7060, 04/2018, Volume 20, Issue 7, pp. 1735 - 1739
A novel and efficient photoinduced synthesis of C6-polyfunctionalized phenanthridines from three-component reactions of isocyanides, alkynes and sulfinic acids... 
2-ISOCYANOBIPHENYLS | VINYL SULFONES | ALKYLATION | FLUOROALKYLATION | CHEMISTRY, ORGANIC | EDA COMPLEXES | TERMINAL ALKYNES | OXIDATIVE CYCLIZATION | INHIBITORS | DERIVATIVES | METAL-FREE
Journal Article
Chemical communications (Cambridge, England), ISSN 1359-7345, 04/2015, Volume 51, Issue 33, pp. 7222 - 7225
A novel visible light promoted carbodifluoroalkylation of allylic alcohols is disclosed. A series of difluoro 1,5-dicarbonyl compounds were obtained through a... 
Propanols - chemistry | Catalysis | Benzene Derivatives - chemistry | Light | Alkylation | Photochemical Processes
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 03/2016, Volume 55, Issue 10, pp. 3491 - 3495
The first example of nickel‐catalyzed decarboxylative fluoroalkylation of α,β‐unsaturated carboxylic acids has been developed with commonly available... 
nickel | fluoroalkylation | radicals | olefins | synthetic methods
Journal Article
Organic Letters, ISSN 1523-7060, 01/2017, Volume 19, Issue 1, pp. 146 - 149
A practical and straightforward synthetic route to construct a variety of 3-CF2/CF3-containing chromones via photoredox catalysis was developed. This novel... 
MEDICINAL CHEMISTRY | ASYMMETRIC FLUORINATION | ALKENES | HETEROARENES | ALPHA-TRIFLUOROMETHYLATION | ACIDS | COMPLEXES | ORGANOCATALYSIS | CHEMISTRY, ORGANIC | FLUOROALKYLATION REACTIONS | PHOTOREDOX CATALYSIS
Journal Article
by Zhu, ZF and Zhang, MM and Liu, F
ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, 02/2019, Volume 17, Issue 6, pp. 1531 - 1534
An efficient and mild method was developed for the synthesis of 6-alkylated phenanthridines upon visible light irradiation. Bench-stable and easily handled... 
CROSS-COUPLINGS | FLUOROALKYLATION | PHENANTHRIDINE | CHEMISTRY, ORGANIC | REDOX-ACTIVE ESTERS | DERIVATIVES | N-HETEROCYCLES
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 08/2008, Volume 49, Issue 34, pp. 5006 - 5008
A hypervalent iodine(III)-CF SO Ph compound (3) has been successfully prepared with selective nucleophilic reaction using PhSO CF SiMe reagent, and this... 
Hypervalent iodine compound | Fluorine | Elctrophilic fluoroalkylation
Journal Article
Organic Letters, ISSN 1523-7060, 01/2014, Volume 16, Issue 1, pp. 54 - 57
Direct N-difluoromethylation of imidazoles and benzimidazoles has been achieved using TMS-CF3 (the Ruppert–Prakash reagent) under neutral conditions.... 
FUNCTIONALIZATION | IODIDES | HETEROCYCLES | COPPER-MEDIATED DIFLUOROMETHYLATION | FLUOROALKYLATION | CHEMISTRY, ORGANIC | FLUORINE | ARYL | CHLORODIFLUOROMETHANE
Journal Article
Organic Letters, ISSN 1523-7060, 06/2016, Volume 18, Issue 12, pp. 2880 - 2882
A decarboxylating alkynylation of α,α-difluoroarylacetic acids with ethynylbenziodoxolone reagents is reported. AgNO3 serves as the catalyst and K2S2O8 as the... 
ALKENES | ARYL BORONIC ACIDS | ORGANOBORONS | ALPHA-ARYLATION | FLUOROALKYLATION | CHEMISTRY, ORGANIC | ALIPHATIC CARBOXYLIC-ACIDS | ALKYNES | DIFLUOROALKYLATION | ACCESS | TRIFLUOROMETHYLATION
Journal Article
Organic Letters, ISSN 1523-7060, 06/2015, Volume 17, Issue 12, pp. 3086 - 3089
The first palladium-catalyzed direct monofluoromethylation of arylboronic esters to produce monofluoromethyl arenes is reported. The reaction is typically... 
ARYL BROMIDES | ACTIVATION | FACILE ACCESS | LIGANDS | ACIDS | COPPER-MEDIATED DIFLUOROMETHYLATION | FLUOROALKYLATION | CHEMISTRY, ORGANIC | FLUORINE | TRIFLUOROMETHYLATION
Journal Article
by Yu, XX and Zhou, Y and Ma, XX and Song, QL
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 07/2019, Volume 55, Issue 56, pp. 8079 - 8082
An efficient transition metal-free annulation of amidine with ethyl bromodifluoroacetate to access 2,4-disubstituted-1,3,5-triazines is firstly presented. The... 
DIFLUOROMETHYLATION | FLUOROALKYLATION | COMPLEXES | BIOLOGICAL EVALUATION | DIFLUOROALKYLATION | ALKYNES | EFFICIENT | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | ARYLBORONIC ACIDS | CYCLIZATION
Journal Article
Organic Letters, ISSN 1523-7060, 07/2016, Volume 18, Issue 13, pp. 3246 - 3249
Visible-light-induced arylthiofluoroalkylations of unactivated heteroaromatics and alkenes have been developed utilizing readily available arylthiofluoroalkyl... 
MEDICINAL CHEMISTRY | ALPHA-FLUOROCARBOCATIONS | FLUOROALKYLATION | COMPLEXES | REACTIVITY | CHEMISTRY, ORGANIC | FLUORINE | DIRADICAL SYNTHONS | DERIVATIVES | PHOTOREDOX CATALYSIS | TRIFLUOROMETHYLATION
Journal Article
Accounts of Chemical Research, ISSN 0001-4842, 05/2018, Volume 51, Issue 5, pp. 1272 - 1280
Conspectus Compounds containing a difluoromethylene unit have gained increasing attention due to their utility in drug design. Classic methods for the... 
MEDICINAL CHEMISTRY | PHOSPHONIUM SALTS | ACYL CHLORIDES | LIGHT | CARBONYL-COMPOUNDS | FLUORINE | ALDEHYDES | NUCLEOPHILIC DIFLUOROMETHYLATION | FLUOROALKYLATION REACTIONS | CHEMISTRY, MULTIDISCIPLINARY | DIFLUORINATED ORGANOZINC REAGENTS
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 05/2017, Volume 23, Issue 27, pp. 6462 - 6462
Selective and irreversible labeling of a cysteine present in artificial retro‐aldolase is achieved by employing modular tetrafluoroalkylation reagents based on... 
hypervalent iodine | bioconjugation | enzymes | fluoroalkylation | cysteine | fluorine | Reagents
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 06/2019, Volume 84, Issue 11, pp. 7388 - 7394
Visible-light-promoted oxo-difluoroalkylation (acetylation and acetamidation) of alkenes with dimethyl sulfoxide as both the solvent and the oxidant was... 
OXIDATION | IODIDES | KETONES | ENOL ETHERS | PHARMACEUTICALS | CONSTRUCTION | FLUOROALKYLATION | CHEMISTRY, ORGANIC | ACCESS | DIFUNCTIONALIZATIONS | CYCLIZATION
Journal Article
Organic Letters, ISSN 1523-7060, 01/2019, Volume 21, Issue 1, pp. 138 - 141
Organic dye-catalyzed visible light induced hydroperfluoroalkylation of unactivated alkenes is described. Hydroperfluoroalkylation proceeds selectively and is... 
ASYMMETRIC FLUORINATION | IODIDES | HETEROARENES | RADICAL PERFLUOROALKYLATION | HYDROTRIFLUOROMETHYLATION | ARENES | CHEMISTRY, ORGANIC | OLEFINS | FLUOROALKYLATION REACTIONS | CYCLIZATION | TRIFLUOROMETHYLATION
Journal Article
by Luo, XW and Fan, ZN and Zhang, B and Chen, C and Xi, CJ
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 09/2019, Volume 55, Issue 73, pp. 10980 - 10983
Photoredox-catalyzed direct keto-difluoroacetylation of styrenes with (fluorosulfonyl)difluoroacetate and dimethyl sulfoxide as an oxidant is disclosed. A... 
OXIDATION | DIFLUOROMETHYLATION | FACILE SYNTHESIS | PHARMACEUTICALS | FLUOROALKYLATION | FLUORINE | DIFLUOROALKYLATION | CHEMISTRY, MULTIDISCIPLINARY | ACCESS | TRIFLUOROMETHYLATION
Journal Article
Chemical Science, ISSN 2041-6520, 2019, Volume 10, Issue 11, pp. 3181 - 3185
An electrochemical difluoromethylation triggered lactonization of alkenes was developed for the first time. This protocol employs readily prepared CF2HSO2Na as... 
DIFUNCTIONALIZATION | HETEROARENES | ACTIVATION | COPPER-MEDIATED DIFLUOROMETHYLATION | FLUOROALKYLATION | RADICAL TRIFLUOROMETHYLATION | ARYL | C-H FUNCTIONALIZATION | CHEMISTRY, MULTIDISCIPLINARY | CARBOXYLIC-ACIDS | STRATEGIES
Journal Article
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