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1. Full Text Saliva versus Plasma Pharmacokinetics: Theory and Application of a Salivary Excretion Classification System
by Idkaidek, Nasir and Arafat, Tawfiq
Molecular pharmaceutics, ISSN 1543-8384, 08/2012, Volume 9, Issue 8, pp. 2358 - 2363
Salivary Excretion Classification System | effective permeability | pharmacokinetics | protein binding | bioequivalence | SimCYP | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Quinolines - blood | Acetates - blood | Fluorobenzenes - pharmacokinetics | Hydrochlorothiazide - pharmacokinetics | Triazoles - blood | Piroxicam - blood | Azithromycin - blood | Humans | Losartan - blood | Saliva - secretion | Male | Naphthalenes - blood | Benzhydryl Compounds - blood | Fluorobenzenes - pharmacology | Quinolines - pharmacokinetics | Sulfonamides - blood | Azithromycin - pharmacokinetics | Tolterodine Tartrate | Female | Triazoles - pharmacokinetics | Naphthalenes - pharmacokinetics | Piroxicam - analogs & derivatives | Sitagliptin Phosphate | Hydrochlorothiazide - blood | Losartan - pharmacokinetics | Benzhydryl Compounds - pharmacokinetics | Metformin - blood | Cresols - blood | Phenylpropanolamine - blood | Metformin - pharmacokinetics | Rosuvastatin Calcium | Cloxacillin - pharmacokinetics | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Sulfonamides - pharmacokinetics | Cinacalcet Hydrochloride | Cloxacillin - blood | Saliva - metabolism | Pyrazines - pharmacokinetics | Piroxicam - pharmacokinetics | Pyrimidines - pharmacokinetics | Cresols - pharmacokinetics | Anthraquinones - blood | Anthraquinones - pharmacokinetics | Phenylpropanolamine - pharmacokinetics | Pyrazines - blood | Acetates - pharmacokinetics | Index Medicus
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2. Full Text ABCG2 Polymorphism Markedly Affects the Pharmacokinetics of Atorvastatin and Rosuvastatin
by Keskitalo, JE and Zolk, O and Fromm, MF and Kurkinen, KJ and Neuvonen, PJ and Niemi, M
Clinical pharmacology and therapeutics, ISSN 0009-9236, 08/2009, Volume 86, Issue 2, pp. 197 - 203
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Fluorobenzenes - pharmacokinetics | Pyrroles - pharmacokinetics | Pyrroles - urine | Area Under Curve | Drug Resistance, Multiple | Pyrimidines - blood | Heptanoic Acids - pharmacokinetics | Humans | Male | Reference Values | Fluorobenzenes - administration & dosage | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Sulfonamides - blood | ATP-Binding Cassette Transporters - genetics | Sulfonamides - urine | Pyrroles - administration & dosage | Fluorobenzenes - urine | Heptanoic Acids - administration & dosage | Adult | Female | Fluorobenzenes - blood | Neoplasm Proteins - genetics | European Continental Ancestry Group - genetics | Pyrimidines - administration & dosage | Rosuvastatin Calcium | Genotype | Linear Models | Pyrroles - blood | Sulfonamides - pharmacokinetics | Cross-Over Studies | Atorvastatin Calcium | Anticholesteremic Agents - pharmacokinetics | Heptanoic Acids - urine | Finland | Pyrimidines - pharmacokinetics | Polymorphism, Single Nucleotide | Pyrimidines - urine | Heptanoic Acids - blood | Sulfonamides - administration & dosage | Index Medicus | Abridged Index Medicus
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3. Full Text Evaluation of drug interactions of GSK1292263 (a GPR119 agonist) with statins: from in vitro data to clinical study design
by Polli, Joseph W and Hussey, Elizabeth and Bush, Mark and Generaux, Grant and Smith, Glenn and Collins, David and McMullen, Susan and Turner, Nancy and Nunez, Derek J
Xenobiotica, ISSN 0049-8254, 6/2013, Volume 43, Issue 6, pp. 498 - 508
P-glycoprotein | BCRP | transporters | Cytochrome P450 | OATP | dyslipidemia | diabetes | pharmacogenetics | Pharmacogenetics | Dyslipidemia | Transporters | Diabetes | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Fluorobenzenes - pharmacokinetics | Pyrroles - pharmacokinetics | Simvastatin - adverse effects | Pyrimidines - blood | Humans | Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood | Middle Aged | Male | Heptanoic Acids - adverse effects | Simvastatin - pharmacology | Fluorobenzenes - pharmacology | Young Adult | Drug Interactions | Piperidines - pharmacology | Oxadiazoles - pharmacology | Madin Darby Canine Kidney Cells | Pyrroles - adverse effects | Oxadiazoles - pharmacokinetics | Heptanoic Acids - pharmacology | Mesylates - blood | Troleandomycin - adverse effects | Rosuvastatin Calcium | Mesylates - adverse effects | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Simvastatin - analogs & derivatives | Sulfonamides - pharmacokinetics | Oxadiazoles - adverse effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Cytochrome P-450 CYP3A - metabolism | Adolescent | Atorvastatin | Pyrimidines - pharmacokinetics | Oxadiazoles - blood | Demography | Heptanoic Acids - pharmacokinetics | Mesylates - pharmacokinetics | Simvastatin - blood | Piperidines - blood | Troleandomycin - pharmacokinetics | Dose-Response Relationship, Drug | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Sulfonamides - blood | Reference Standards | Adult | Female | Piperidines - pharmacokinetics | Troleandomycin - pharmacology | Fluorobenzenes - blood | Pyrroles - blood | Simvastatin - pharmacokinetics | Pyrroles - pharmacology | Animals | Cytochrome P-450 CYP3A Inhibitors | Mesylates - pharmacology | Piperidines - adverse effects | Dogs | Pyrimidines - adverse effects | Sulfonamides - adverse effects | Aged | Fluorobenzenes - adverse effects | Heptanoic Acids - blood | Index Medicus
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4. Full Text Different Effects of SLCO1B1 Polymorphism on the Pharmacokinetics of Atorvastatin and Rosuvastatin
by Pasanen, M K and Fredrikson, H and Neuvonen, P J and Niemi, M
Clinical pharmacology and therapeutics, ISSN 0009-9236, 12/2007, Volume 82, Issue 6, pp. 726 - 733
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Fluorobenzenes - pharmacokinetics | Prospective Studies | Pyrroles - pharmacokinetics | Area Under Curve | Pyrimidines - blood | Heptanoic Acids - pharmacokinetics | Humans | Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood | Male | Reference Values | Fluorobenzenes - administration & dosage | Organic Anion Transporters - metabolism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Sulfonamides - blood | Organic Anion Transporters - genetics | Pyrroles - administration & dosage | Heptanoic Acids - administration & dosage | Adult | Female | Fluorobenzenes - blood | European Continental Ancestry Group - genetics | Administration, Oral | Pyrimidines - administration & dosage | Liver - metabolism | Rosuvastatin Calcium | Genotype | Pyrroles - blood | Sulfonamides - pharmacokinetics | Polymorphism, Genetic | Atorvastatin Calcium | Pyrimidines - pharmacokinetics | Solute Carrier Organic Anion Transporter Family Member 1b1 | Heptanoic Acids - blood | Sulfonamides - administration & dosage | Index Medicus | Abridged Index Medicus
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5. Full Text The influence of SLCO1B1 (OATP1B1) gene polymorphisms on response to statin therapy
by Romaine, S.P.R and Bailey, K.M and Hall, A.S and Balmforth, A.J
The pharmacogenomics journal, ISSN 1470-269X, 02/2010, Volume 10, Issue 1, pp. 1 - 11
SLCO1B1 | Statin | Transporter | Cholesterol | Myopathy | Polymorphism | Pharmacology & Pharmacy | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Haplotypes | Fluorobenzenes - pharmacokinetics | Pyrroles - pharmacokinetics | Heptanoic Acids - pharmacokinetics | Humans | Liver | Hepatocytes - metabolism | Hypercholesterolemia - drug therapy | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Organic Anion Transporters - genetics | Pharmacogenetics | Gene Frequency | Rosuvastatin Calcium | Simvastatin - pharmacokinetics | Anticholesteremic Agents - adverse effects | Sulfonamides - pharmacokinetics | Atorvastatin Calcium | Anticholesteremic Agents - pharmacokinetics | Asian Continental Ancestry Group | Anticholesteremic Agents - therapeutic use | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Pyrimidines - pharmacokinetics | Polymorphism, Single Nucleotide | HeLa Cells | Solute Carrier Organic Anion Transporter Family Member 1b1 | Pravastatin - pharmacokinetics | Research | Health aspects | Coronary heart disease | Genetic polymorphisms | Statins | Risk factors | Index Medicus
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6. Full Text Pharmacokinetics of cobicistat boosted‐elvitegravir administered in combination with rosuvastatin
by Custodio, Joseph M and Wang, Hui and Hao, Jia and Lepist, Eve‐Irene and Ray, Adrian S and Andrews, Jessica and Ling, Kah Hiing J and Cheng, Andrew and Kearney, Brian P and Ramanathan, Srinivasan
Journal of clinical pharmacology, ISSN 0091-2700, 06/2014, Volume 54, Issue 6, pp. 649 - 656
pharmacokinetics | organic anion transporting polypeptide | breast cancer resistance protein | Stribild | statins | elvitegravir | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Anti-HIV Agents - pharmacology | Fluorobenzenes - pharmacokinetics | Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors | Pyrimidines - blood | Humans | Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood | Male | Neoplasm Proteins - antagonists & inhibitors | Carbamates - pharmacokinetics | Fluorobenzenes - pharmacology | Drug Interactions | Organic Anion Transporters, Sodium-Independent - metabolism | Quinolones - pharmacokinetics | Madin Darby Canine Kidney Cells | Solute Carrier Organic Anion Transporter Family Member 1B3 | Carbamates - pharmacology | Organic Anion Transporters - antagonists & inhibitors | Rosuvastatin Calcium | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Sulfonamides - pharmacokinetics | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Pyrimidines - pharmacokinetics | Solute Carrier Organic Anion Transporter Family Member 1b1 | Cobicistat | ATP-Binding Cassette Transporters - antagonists & inhibitors | Thiazoles - blood | Cricetulus | Quinolones - pharmacology | Neoplasm Proteins - metabolism | Organic Anion Transporters - metabolism | Thiazoles - pharmacokinetics | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Quinolones - blood | Sulfonamides - blood | ATP-Binding Cassette Transporters - metabolism | Adult | Female | Anti-HIV Agents - blood | Drug Therapy, Combination | Fluorobenzenes - blood | CHO Cells | Carbamates - blood | Animals | Anti-HIV Agents - pharmacokinetics | Dogs | Thiazoles - pharmacology | Drug Combinations | Rosuvastatin | Dosage and administration | Pharmacokinetics | Analysis | Confidence intervals | Index Medicus
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7. Full Text Functional Characterization of Mouse Organic Anion Transporting Peptide 1a4 in the Uptake and Efflux of Drugs Across the Blood-Brain Barrier
by Atsushi Ose and Hiroyuki Kusuhara and Chihiro Endo and Kimio Tohyama and Mari Miyajima and Satoshi Kitamura and Yuichi Sugiyama
Drug metabolism and disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 168 - 176
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Fluorobenzenes - pharmacokinetics | Gene Expression - genetics | Pyrimidines - blood | Humans | Ion Pumps - genetics | Fluorobenzenes - administration & dosage | Quinolines - administration & dosage | Pyrimidines - metabolism | Brain - metabolism | Quinolines - pharmacokinetics | Choroid Plexus - blood supply | ATP-Binding Cassette Transporters - genetics | Ochratoxins - administration & dosage | Cell Membrane - metabolism | Cerebral Cortex - drug effects | Capillaries - metabolism | Fluorobenzenes - metabolism | Tetrahydroisoquinolines - pharmacology | Organic Cation Transport Proteins - metabolism | Pravastatin - metabolism | Liver - metabolism | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Taurocholic Acid - administration & dosage | Pravastatin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Pyrimidines - pharmacokinetics | Mice | Kinetics | Organic Cation Transport Proteins - genetics | Pravastatin - pharmacokinetics | Sulfonamides - administration & dosage | Quinolines - blood | Digoxin - metabolism | Taurocholic Acid - metabolism | Choroid Plexus - metabolism | Taurocholic Acid - blood | Ochratoxins - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Ochratoxins - metabolism | Cerebral Cortex - metabolism | Organic Anion Transporters - metabolism | Brain - blood supply | Sulfonamides - blood | Organic Anion Transporters - genetics | Transfection | Fluorobenzenes - blood | Enkephalin, D-Penicillamine (2,5)- - pharmacokinetics | Recombinant Proteins - metabolism | Cell Line | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Recombinant Proteins - genetics | Blood-Brain Barrier - drug effects | Digoxin - pharmacokinetics | Quinolines - metabolism | Taurocholic Acid - pharmacokinetics | Liver - blood supply | Pharmaceutical Preparations - metabolism | Animals | Digoxin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - metabolism | Acridines - pharmacology | Sulfonamides - metabolism | Index Medicus
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8. Full Text Self nanoemulsifying drug delivery system (SNEDDS) of Rosuvastatin calcium: Design, formulation, bioavailability and pharmacokinetic evaluation
by Balakumar, Krishnamoorthy and Raghavan, Chellan Vijaya and selvan, Natarajan Tamil and prasad, Ranganathan Hari and Abdu, Siyad
Colloids and surfaces, B, Biointerfaces, ISSN 0927-7765, 12/2013, Volume 112, pp. 337 - 343
Rosuvastatin calcium | Pharmacokinetic study | Bioavailability | SNEDDS | Poorly water soluble drug | Self nanoemulsifying drug delivery system | Physical Sciences | Chemistry | Materials Science | Life Sciences & Biomedicine | Technology | Materials Science, Biomaterials | Biophysics | Chemistry, Physical | Science & Technology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Fluorobenzenes - pharmacokinetics | Chemistry, Pharmaceutical - methods | Emulsions | Rats, Wistar | Pyrimidines - blood | Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood | Biological Availability | Male | Fluorobenzenes - administration & dosage | Chromatography, High Pressure Liquid | Drug Carriers - chemistry | Drug Delivery Systems | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Sulfonamides - blood | Fluorobenzenes - blood | Surface-Active Agents | Oils | Pyrimidines - administration & dosage | Solubility | Rats | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Particle Size | Animals | Membrane Potentials | Nanostructures - chemistry | Pyrimidines - pharmacokinetics | Sulfonamides - administration & dosage | Drugs | Drugstores | Drug delivery systems | Analysis | Antilipemic agents | Vehicles | Index Medicus | Calcium | Zeta potential | Mathematical models | Droplets | Nanostructure
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9. Full Text Marked Alteration of Rosuvastatin Pharmacokinetics in Healthy Chinese with ABCG2 34G > A and 421C > A Homozygote or Compound Heterozygote
by Wan, Zirui and Wang, Guo and Li, Tailin and Xu, Biaobo and Pei, Qi and Peng, Yan and Sun, Hong and Cheng, Lijuan and Zeng, Ying and Yang, Guoping and Zhu, Yuan-Shan
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 09/2015, Volume 354, Issue 3, pp. 310 - 315
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Fluorobenzenes - pharmacokinetics | Gene Frequency - genetics | Humans | Asian Continental Ancestry Group - genetics | Rosuvastatin Calcium | Genotype | Male | Sulfonamides - pharmacokinetics | Cytochrome P-450 CYP2C9 - genetics | Young Adult | Homozygote | Organic Anion Transporters - genetics | ATP-Binding Cassette Transporters - genetics | Genetic Variation - drug effects | Adolescent | Pyrimidines - pharmacokinetics | Adult | Heterozygote | Gene Frequency - drug effects | Genetic Variation - genetics | Neoplasm Proteins - genetics | Solute Carrier Organic Anion Transporter Family Member 1b1 | Index Medicus
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10. Full Text Rosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environment
by Lee, Edmund and Ryan, Stephen and Birmingham, Bruce and Zalikowski, Julie and March, Ruth and Ambrose, Helen and Moore, Rachael and Lee, Caroline and Chen, Yusong and Schneck, Dennis
Clinical pharmacology and therapeutics, ISSN 0009-9236, 10/2005, Volume 78, Issue 4, pp. 330 - 341
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Fluorobenzenes - pharmacokinetics | Prospective Studies | Singapore | Area Under Curve | Pyrimidines - blood | Humans | Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood | Asian Continental Ancestry Group - genetics | Half-Life | Male | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Sulfonamides - blood | Organic Anion Transporters - genetics | Adult | Female | Fluorobenzenes - blood | European Continental Ancestry Group - genetics | Gene Frequency | Rosuvastatin Calcium | Genotype | Sulfonamides - pharmacokinetics | Diet | Pyrimidines - pharmacokinetics | Environment | Polymorphism, Single Nucleotide | Solute Carrier Organic Anion Transporter Family Member 1b1 | Index Medicus | Abridged Index Medicus
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11. Full Text The effect of gemfibrozil on the pharmacokinetics of rosuvastatin
by Schneck, Dennis W and Birmingham, Bruce K and Zalikowski, Julie A and Mitchell, Patrick D and Wang, Yi and Martin, Paul D and Lasseter, Kenneth C and Brown, Colin D. A and Windass, Amy S and Raza, Ali
Clinical pharmacology and therapeutics, ISSN 0009-9236, 05/2004, Volume 75, Issue 5, pp. 455 - 463
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Medical sciences | General and cellular metabolism. Vitamins | Pharmacology. Drug treatments | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Xenopus | Fluorobenzenes - pharmacokinetics | Area Under Curve | Humans | Male | Reference Values | Fluorobenzenes - administration & dosage | Organic Anion Transporters - metabolism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Cell Line - drug effects | Drug Interactions | Oocytes - drug effects | Adult | Female | Gemfibrozil - administration & dosage | Cell Line - metabolism | Double-Blind Method | Drug Administration Schedule | Administration, Oral | Oocytes - metabolism | Pyrimidines - administration & dosage | Rosuvastatin Calcium | Gemfibrozil - pharmacology | Hypolipidemic Agents - pharmacology | Sulfonamides - pharmacokinetics | Cross-Over Studies | Animals | Hypolipidemic Agents - administration & dosage | Pyrimidines - pharmacokinetics | Sulfonamides - administration & dosage | Index Medicus | Abridged Index Medicus
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