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Journal Article
Clinical cancer research, ISSN 1557-3265, 2006, Volume 12, Issue 8, pp. 2640 - 2646
Purpose: Tumor necrosis factor-related apoptosis–inducing ligand (TRAIL/Apo2L) exhibits potent antitumor activity on systemic administration in nonhuman... 
apoptosis | TRAIL | primary human hepatocytes | chemotherapy | in-vivo | tumoricidal activity | monoclonal-antibody | hepatocellular-carcinoma cells | human hepatocytes | receptor | death | nf-kappa-b | family | apoptosis-inducing ligand | HEPATOCELLULAR-CARCINOMA CELLS | APOPTOSIS-INDUCING LIGAND | ONCOLOGY | HUMAN HEPATOCYTES | IN-VIVO | RECEPTOR | TUMORICIDAL ACTIVITY | MONOCLONAL-ANTIBODY | DEATH | NF-KAPPA-B | FAMILY | Immunohistochemistry | Apoptosis Regulatory Proteins - pharmacology | Apoptosis - drug effects | Gene Expression - genetics | Humans | Tumor Necrosis Factor-alpha - genetics | GPI-Linked Proteins | Apoptosis - genetics | Deoxycytidine - pharmacology | Hepatocytes - metabolism | Receptors, TNF-Related Apoptosis-Inducing Ligand | Organoplatinum Compounds - pharmacology | Receptors, Tumor Necrosis Factor, Member 10c | Dose-Response Relationship, Drug | Tumor Necrosis Factor Decoy Receptors | Hepatocytes - cytology | TNF-Related Apoptosis-Inducing Ligand | Time Factors | Apoptosis Regulatory Proteins - genetics | Antineoplastic Agents - pharmacology | Hepatocytes - drug effects | Camptothecin - analogs & derivatives | Receptors, Tumor Necrosis Factor - genetics | Receptors, Tumor Necrosis Factor - metabolism | Cell Survival - drug effects | Membrane Glycoproteins - pharmacology | Cells, Cultured | Etoposide - pharmacology | Cisplatin - pharmacology | Recombinant Proteins - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Membrane Glycoproteins - genetics | Tumor Necrosis Factor-alpha - pharmacology | Cell Line, Tumor | Fluorouracil - pharmacology | Camptothecin - pharmacology | Deoxycytidine - analogs & derivatives
Journal Article
Clinical cancer research, ISSN 1557-3265, 2005, Volume 11, Issue 20, pp. 7508 - 7515
Purpose: BRCA2, FANCC , and FANCG gene mutations are present in a subset of pancreatic cancer. Defects in these genes could lead to hypersensitivity to... 
BRCA1, BRCA2 | Xenograft models | DNA damage and repair mechanisms | Pharmacogenetics/pharmacogenomics | Gastrointestinal cancers: other | GENE-MUTATIONS | LUNG-CANCER | FUNCTIONAL-ACTIVITY | ONCOLOGY | ABL TYROSINE KINASE | MITOMYCIN-C | PANCREATIC-CANCER | RANDOMIZED-TRIAL | PHASE-II | COMPLEMENTATION GROUP | CARCINOMA | Paclitaxel - pharmacology | Apoptosis - drug effects | Cross-Linking Reagents - pharmacology | Humans | Deoxycytidine - pharmacology | Chlorambucil - pharmacology | Fanconi Anemia Complementation Group C Protein - genetics | Dose-Response Relationship, Drug | Pancreatic Neoplasms - drug therapy | Caspases - metabolism | Fanconi Anemia Complementation Group G Protein - genetics | Time Factors | Cross-Linking Reagents - therapeutic use | Fanconi Anemia Complementation Group G Protein - deficiency | Inhibitory Concentration 50 | Female | Antineoplastic Agents - pharmacology | Melphalan - pharmacology | Cell Survival - drug effects | Fanconi Anemia Complementation Group Proteins - deficiency | Mitomycin - therapeutic use | Pancreatic Neoplasms - pathology | Fanconi Anemia Complementation Group Proteins - genetics | Etoposide - pharmacology | Pancreatic Neoplasms - genetics | Cisplatin - pharmacology | Xenograft Model Antitumor Assays - methods | Mitomycin - pharmacology | Animals | Mice, Nude | Cell Line, Tumor | Fanconi Anemia Complementation Group C Protein - deficiency | BRCA2 Protein - deficiency | Fluorouracil - pharmacology | Mice | Vinblastine - pharmacology | Mutation | Cell Cycle - drug effects | BRCA2 Protein - genetics | Deoxycytidine - analogs & derivatives | Doxorubicin - pharmacology
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 3/2009, Volume 63, Issue 4, pp. 691 - 701
Cannabinoids (CBs) have been found to exert antiproliferative effects upon a variety of cancer cells, including colorectal carcinoma cells. However, little is... 
Cannabinoids | Biomedicine | 5-Fluorouracil | Polyunsaturated fatty acids | Colorectal cancer | Cancer Research | Oncology | Cytotoxicity | Pharmacology/Toxicology | MOLECULAR CHARACTERIZATION | ACTIVATION | TUMOR ANGIOGENESIS | CERAMIDE | CANCER | ONCOLOGY | VANILLOID RECEPTORS | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | ARACHIDONYLETHANOLAMIDE ANANDAMIDE | ADENYLATE-CYCLASE | EXPRESSION | Adenocarcinoma - pathology | Oxidative Stress | Cannabinoid Receptor Antagonists | Colonic Neoplasms - drug therapy | Humans | Nitric Oxide Synthase - antagonists & inhibitors | Colonic Neoplasms - metabolism | Receptors, Cannabinoid - metabolism | Adenocarcinoma - metabolism | Neuroprotective Agents - pharmacology | Piperidines - pharmacology | Dronabinol - analogs & derivatives | Antimetabolites, Antineoplastic - pharmacology | Tumor Cells, Cultured | Dronabinol - pharmacology | Drug Therapy, Combination | Cyclic AMP - metabolism | Pyrazoles - pharmacology | Thymidine - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Cell Survival - drug effects | Enzyme Inhibitors - pharmacology | Fatty Acids, Unsaturated - pharmacology | Antioxidants - pharmacology | Adenocarcinoma - drug therapy | Cannabinoids - pharmacology | Drug Synergism | Colonic Neoplasms - pathology | Cell Proliferation - drug effects | Fluorouracil - pharmacology | Neurosciences | Care and treatment | Carcinoma | Fluorescence | Arachidonic acid | Glycine | Unsaturated fatty acids | Analysis | Nitric oxide | Phenols | Omega-3 fatty acids | Fluorouracil | Cancer | Index Medicus
Journal Article
Clinical and experimental pharmacology & physiology, ISSN 1440-1681, 01/2004, Volume 31, Issue 1-2, pp. 65 - 69
Journal Article
PloS one, ISSN 1932-6203, 06/2016, Volume 11, Issue 6, p. e0156540
Background Terpinen-4-ol, a naturally occurring monoterpene is the main bioactive component of tea-tree oil and has been shown to have many biological... 
CELLS | PERILLYL ALCOHOL | MULTIDISCIPLINARY SCIENCES | GENE-THERAPY | COMPONENT | CD24 | TEA TREE OIL | Gastrointestinal Neoplasms - drug therapy | Humans | Tea Tree Oil - chemistry | Antineoplastic Agents, Phytogenic - chemistry | Cetuximab - pharmacology | Deoxycytidine - pharmacology | Organoplatinum Compounds - pharmacology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Terpenes - pharmacology | Xenograft Model Antitumor Assays | Gastrointestinal Neoplasms - pathology | Terpenes - chemistry | Animals | Oxaliplatin | Erlotinib Hydrochloride - pharmacology | Cell Line, Tumor | Fluorouracil - pharmacology | Mice | Antineoplastic Agents, Phytogenic - pharmacology | Deoxycytidine - analogs & derivatives | Gastrointestinal Neoplasms - metabolism | Antimitotic agents | Usage | Chemotherapy | Gastrointestinal cancer | Patient outcomes | Colorectal cancer | Dosage and administration | Drug therapy | Antineoplastic agents | Essences and essential oils | Cancer | Cell proliferation | Flow cytometry | Terpinene | Gemcitabine | Laboratories | Colorectal carcinoma | Xenotransplantation | Lung cancer | Cancer therapies | Anticancer properties | Biological effects | Gastroenterology | Xenografts | Cell cycle | Biocompatibility | Inhibition | Pancreas | Gastric cancer | Epidermal growth factor receptors | Melanoma | Pharmacology | Gene expression | Chemical compounds | Molecular chains | Disease prevention | Cell death | Pancreatic cancer | Monoclonal antibodies | Oils & fats | Antitumor activity | Light microscopy | Gene therapy | Molecular biology | Prostate cancer | Prostate | Tumors | Apoptosis
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 8/2011, Volume 68, Issue 2, pp. 445 - 455
The natural flavonoid fisetin was recently identified as a lead compound that stabilizes endothelial cell microtubules. In this study, we investigated the... 
Fisetin | Lewis lung carcinoma | Angiogenesis | Antitumour activity | Cyclophosphamide | Medicine & Public Health | Cancer Research | Oncology | Cytotoxicity | EA·hy 926 endothelial cells | Pharmacology/Toxicology | Flavonoid | EA•hy 926 endothelial cells | APOPTOSIS | ANTIINFLAMMATORY ACTIVITY | CELL-CYCLE ARREST | PROLIFERATION | FLUOROURACIL | CANCER | IN-VITRO | ONCOLOGY | ENDOTHELIAL-CELLS | PHARMACOLOGY & PHARMACY | EA.hy 926 endothelial cells | INHIBITORS | NIH 3T3 Cells | Cyclophosphamide - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Tubulin Modulators - pharmacology | Humans | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Antineoplastic Agents, Alkylating - pharmacology | Flavonoids - adverse effects | Antineoplastic Agents, Alkylating - administration & dosage | Cyclophosphamide - adverse effects | Cyclophosphamide - therapeutic use | Flavonoids - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Angiogenesis Inhibitors - administration & dosage | Antineoplastic Agents, Phytogenic - administration & dosage | Angiogenesis Inhibitors - therapeutic use | Flavonoids - administration & dosage | Tubulin Modulators - administration & dosage | Female | Flavonoids - pharmacology | Antineoplastic Agents, Phytogenic - therapeutic use | Angiogenesis Inhibitors - adverse effects | Antineoplastic Agents, Phytogenic - adverse effects | Cell Line | Cell Survival - drug effects | Tubulin Modulators - adverse effects | Mice, Inbred C57BL | Angiogenesis Inhibitors - pharmacology | Tubulin Modulators - therapeutic use | Carcinoma, Lewis Lung - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Cell Movement - drug effects | Animals | Tumor Burden - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Endothelial Cells - cytology | Neovascularization, Pathologic - drug therapy | Cyclophosphamide - pharmacology | Carcinoma, Lewis Lung - pathology | Cell Proliferation - drug effects | Mice | Antineoplastic Agents, Alkylating - adverse effects | Antineoplastic Agents, Phytogenic - pharmacology | Cell Cycle - drug effects | Endothelial Cells - drug effects | Antimitotic agents | Flavonoids | Flavones | Lung cancer | Bioflavonoids | Accountants | Drug therapy, Combination | Universities and colleges | Antineoplastic agents | Endothelium | Tumors | Index Medicus | cytology | Antineoplastic Agents, Phytogenic | pathology | Cell Proliferation | Endothelial Cells | Tubulin Modulators | Neovascularization, Pathologic | fisetin | administration & dosage | pharmacology | flavonoid | Carcinoma, Lewis Lung | Antineoplastic Agents, Alkylating | cytotoxicity | drug therapy | Cell Survival | angiogenesis | Antineoplastic Combined Chemotherapy Protocols | drug effects | Tumor Burden | Angiogenesis Inhibitors | EA.hy 926 | Cell Cycle | antitumour activity | adverse effects | therapeutic use | Cell Movement
Journal Article
Cancer Letters, ISSN 0304-3835, 2011, Volume 309, Issue 2, pp. 228 - 235
Highlights ► Pemetrexed-resistant non-small cell lung cancer cell lines have not been reported. ► They remained sensitive to docetaxel, vinorelbine,... 
Hematology, Oncology and Palliative Medicine | Resistance | Thymidylate synthase | Pemetrexed | Non-small cell lung cancer | CARBOPLATIN | REDUCED FOLATE CARRIER | ANTIFOLATE | CHEMOTHERAPY | LY231514 | CISPLATIN PLUS GEMCITABINE | ONCOLOGY | RANDOMIZED PHASE-III | EXPRESSION | Cell Proliferation | Taxoids - pharmacology | Adenocarcinoma of Lung | Guanine - analogs & derivatives | Humans | Lung Neoplasms - metabolism | Immunoblotting | Adenocarcinoma - metabolism | Vinblastine - analogs & derivatives | Guanine - pharmacology | Thymidylate Synthase - biosynthesis | Adenocarcinoma - genetics | Antineoplastic Agents - pharmacology | Phosphoribosylglycinamide Formyltransferase - genetics | Camptothecin - analogs & derivatives | Lung Neoplasms - genetics | Gene Expression | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Docetaxel | Cisplatin - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Tetrahydrofolate Dehydrogenase - biosynthesis | Thymidylate Synthase - genetics | Irinotecan | Drug Resistance, Neoplasm - genetics | Glutamates - pharmacology | Cell Line, Tumor | Fluorouracil - pharmacology | Vinblastine - pharmacology | Camptothecin - pharmacology | Folic Acid Antagonists - pharmacology | Vinorelbine | Tetrahydrofolate Dehydrogenase - genetics | Lung cancer, Non-small cell | Fluorouracil | Index Medicus
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 08/2011, Volume 12, Issue 3, pp. 229 - 238
Quinacrine has been widely explored in treatment of malaria, giardiasis, and rheumatic diseases. We find that quinacrine stabilizes p53 and induces... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Tumor xenograft | Quinacrine | TRAIL | Sorafenib | Hepatocellular carcinoma | Apoptosis | p53 | sorafenib | INDUCED APOPTOSIS | tumor xenograft | apoptosis | DEATH | AUTOPHAGY | quinacrine | THERAPY | ONCOLOGY | PLEURAL EFFUSIONS | DRUGS | NF-KAPPA-B | hepatocellular carcinoma | Niacinamide - analogs & derivatives | Microtubule-Associated Proteins - metabolism | Humans | Cytoplasm - metabolism | Deoxycytidine - pharmacology | Phenylurea Compounds | Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Benzenesulfonates - pharmacology | Genes, p53 | Quinacrine - pharmacology | Carcinoma, Hepatocellular - drug therapy | Cell Nucleus - metabolism | TNF-Related Apoptosis-Inducing Ligand - pharmacology | Female | Liver Neoplasms - pathology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Tumor Cells, Cultured | Camptothecin - analogs & derivatives | Liver Neoplasms - drug therapy | Etoposide - pharmacology | Drug Synergism | Xenograft Model Antitumor Assays | Irinotecan | Animals | Myeloid Cell Leukemia Sequence 1 Protein | Carcinoma, Hepatocellular - pathology | Fluorouracil - pharmacology | Mice | Pyridines - pharmacology | RNA, Small Interfering | Cell Nucleus - drug effects | Camptothecin - pharmacology | Cytoplasm - drug effects | Deoxycytidine - analogs & derivatives | Doxorubicin - pharmacology | Quinacrine - pharmacokinetics
Journal Article
Cancer Biology & Therapy, ISSN 1555-8576, 2014, Volume 9, Issue 7, pp. 514 - 522
Journal Article
Journal Article
Toxicology and applied pharmacology, ISSN 0041-008X, 10/2015, Volume 288, Issue 2, pp. 258 - 268
4-Acetylantroquinonol B (4-AAQB), closely related to the better known antroquinonol, is a bioactive isolate of the mycelia of Antrodia camphorata, a Taiwanese... 
Cancer progression | Chemotherapy | 4-Acetylantroquinonol B | Cancer stem cells | Antrodia camphorata | Colorectal cancer | HEPATOCELLULAR-CARCINOMA CELLS | APOPTOSIS | OXIDATIVE STRESS | ACTIVATION | PLUS IRINOTECAN | ALDEHYDE DEHYDROGENASE | MYCELIUM | PROLIFERATION | ANTROQUINONOL | GROWTH | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Neoplastic Stem Cells - drug effects | Colorectal Neoplasms - genetics | Humans | Drug Resistance, Neoplasm | Organoplatinum Compounds - pharmacology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Neoplastic Stem Cells - metabolism | Time Factors | Colorectal Neoplasms - drug therapy | Neoplastic Stem Cells - pathology | Gene Expression Regulation, Neoplastic - drug effects | Spheroids, Cellular | Colorectal Neoplasms - metabolism | HCT116 Cells | 4-Butyrolactone - pharmacology | Tumor Burden | Cyclohexanones - pharmacology | Mice, SCID | HT29 Cells | Xenograft Model Antitumor Assays | Phenotype | Animals | Signal Transduction - drug effects | Mice, Inbred NOD | Cell Proliferation - drug effects | Fluorouracil - pharmacology | 4-Butyrolactone - analogs & derivatives | Antineoplastic Agents, Phytogenic - pharmacology | Colorectal Neoplasms - pathology | Leucovorin - pharmacology | Development and progression | Genetic aspects | Cellular signal transduction | Tumors | Cancer | Index Medicus | PHENOTYPE | SIGNALS | CELL PROLIFERATION | TUMOR CELLS | IN VIVO | 60 APPLIED LIFE SCIENCES | CHEMOTHERAPY | FLUOROURACILS | MAINTENANCE | TYROSINE | INFLAMMATION | CARCINOMAS | PHOSPHOTRANSFERASES | STEM CELLS | RECEPTORS | MUSHROOMS
Journal Article